SAXSdb — 8bhq

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Gamma-aminobutyric acid receptor subunit alpha-5

Homo sapiens

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein homooligomer Homooligomer Protein × 5 PDB declaration: pentameric（5） Consistent with protein copy count	Chain A； UniProt 32–315 Chain A； UniProt 424–450 Chain B； UniProt 32–315 Chain B； UniProt 424–450 Chain C； UniProt 32–315 Chain C； UniProt 424–450 Chain D； UniProt 32–315 Chain D； UniProt 424–450 Chain E； UniProt 32–315 Chain E； UniProt 424–450	Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ;	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 QR3 2-[[5-methyl-3-(6-methylpyridazin-3-yl)-1,2-oxazol-4-yl]methyl]-5-(5-oxa-2-azaspiro[3.5]nonan-2-yl)pyridazin-3-one × 5	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 3.30 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB	Difference from Current Entry 8BHQ	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5O8F Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 and pregnanolone Deposited 2017-06-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 10 PDB declaration: decameric	Chain A 261–346（86 aa） Chain A 424–462（39 aa） Chain B 261–346（86 aa） Chain B 424–462（39 aa） Chain C 261–346（86 aa） Chain C 424–462（39 aa） Chain D 261–346（86 aa） Chain D 424–462（39 aa） Chain E 261–346（86 aa） Chain E 424–462（39 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 P9N Pregnanolone × 5	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.6；277 K；14% PEG 6000, 0.1M N-(2-Acetamido)iminodiacetic acid (ADA), 7.6 mM 4-Cyclohexyl-1-Butyl-beta-D-Maltoside (CYMAL-4)	Resolution 3.20 Å R-free 0.242
5OJM Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 Deposited 2017-07-21	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 10 PDB declaration: decameric	Chain A 257–346（90 aa） Chain A 424–462（39 aa） Chain B 257–346（90 aa） Chain B 424–462（39 aa） Chain C 257–346（90 aa） Chain C 424–462（39 aa） Chain D 257–346（90 aa） Chain D 424–462（39 aa） Chain E 257–346（90 aa） Chain E 424–462（39 aa）	Not recorded	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.8；277.15 K；14% poly-ethylene glycol (PEG) 5000, 0.08M magnesium acetate, 0.1M sodium citrate, 1mM ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA)	Resolution 3.30 Å R-free 0.250
6A96 Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25 Deposited 2018-07-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric	Chain A 1–346（346 aa） Chain A 424–462（39 aa）	Not recorded	ABU GAMMA-AMINO-BUTANOIC ACID × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.51 Å
8BEJ GABA-A receptor a5 homomer - a5V3 - APO Deposited 2022-10-21	Different construct Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 32–345（314 aa） Chain A 424–450（27 aa） Chain B 32–345（314 aa） Chain B 424–450（27 aa） Chain C 32–345（314 aa） Chain C 424–450（27 aa） Chain D 32–345（314 aa） Chain D 424–450（27 aa） Chain E 32–345（314 aa） Chain E 424–450（27 aa）	Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ;	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.24 Å
8BGI GABA-A receptor a5 homomer - a5V1 - Flumazenil Deposited 2022-10-27	Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 32–346（315 aa） Chain A 424–450（27 aa） Chain B 32–346（315 aa） Chain B 424–450（27 aa） Chain C 32–346（315 aa） Chain C 424–450（27 aa） Chain D 32–346（315 aa） Chain D 424–450（27 aa） Chain E 32–346（315 aa） Chain E 424–450（27 aa）	Not recorded	SO4 SULFATE ION × 29 FYP ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate × 5 P9N Pregnanolone × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；279 K；19 % PEG 1000 0.1 M sodium chloride 0.15 M ammonium sulfate 0.1 M 2-(N-morpholino)ethanesulfonic acid (MES) pH 6.5 25 mM Sucrose monodecanoate detergent (sucrose monocaprate)	Resolution 2.56 Å R-free 0.277
8BHA GABA-A receptor a5 homomer - a5V3 - Basmisanil - HR Deposited 2022-10-30	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 32–315（284 aa） Chain A 424–450（27 aa） Chain B 32–315（284 aa） Chain B 424–450（27 aa） Chain C 32–315（284 aa） Chain C 424–450（27 aa） Chain D 32–315（284 aa） Chain D 424–450（27 aa） Chain E 32–315（284 aa） Chain E 424–450（27 aa）	Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ;	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 QI0 Basmisanil × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.67 Å
8BHB GABA-A receptor a5 homomer - a5V3 - RO154513 Deposited 2022-10-30	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 32–315（284 aa） Chain A 424–450（27 aa） Chain B 32–315（284 aa） Chain B 424–450（27 aa） Chain C 32–315（284 aa） Chain C 424–450（27 aa） Chain D 32–315（284 aa） Chain D 424–450（27 aa） Chain E 32–315（284 aa） Chain E 424–450（27 aa）	Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ;	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 EIE ethyl 8-[(azanylidene-$l^{4}-azanylidene)amino]-5-methyl-6-oxidanylidene-4~{H}-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.54 Å
8BHG GABA-A receptor a5 heteromer - a5V2 - Bretazenil Deposited 2022-10-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric	Chain A 32–451（420 aa） Chain C 32–451（420 aa） Chain D 32–451（420 aa） Chain E 32–451（420 aa）	Mutation：;I79M,T82N,V98I,R101A,S103T,N121D,L123R,L124V,S126D,K127Q,G138D,I142F,N145W,L152M,L155I,E156W,D157N,T160R,L161V,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,N121D,L123R,L124V,S126D,K127Q,G138D,I142F,N145W,L152M,L155I,E156W,D157N,T160R,L161V,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,N121D,L123R,L124V,S126D,K127Q,G138D,I142F,N145W,L152M,L155I,E156W,D157N,T160R,L161V,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,N121D,L123R,L124V,S126D,K127Q,G138D,I142F,N145W,L152M,L155I,E156W,D157N,T160R,L161V,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ;	QMU Bretazenil × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 NO3 NITRATE ION × 3 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；279 K；22% PEG 400 0.37M potassium nitrate 0.1 M 2-(N-morpholino)ethanesulfonic acid (MES) pH 6.5	Resolution 2.39 Å R-free 0.283
8BHI GABA-A receptor a5 homomer - a5V3 - RO5211223 Deposited 2022-10-31	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 32–315（284 aa） Chain A 424–450（27 aa） Chain B 32–315（284 aa） Chain B 424–450（27 aa） Chain C 32–315（284 aa） Chain C 424–450（27 aa） Chain D 32–315（284 aa） Chain D 424–450（27 aa） Chain E 32–315（284 aa） Chain E 424–450（27 aa）	Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ;	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 QKF [1,1-bis(oxidanylidene)-1,4-thiazinan-4-yl]-[6-[[5-methyl-3-(6-methylpyridin-3-yl)-1,2-oxazol-4-yl]methoxy]pyridin-3-yl]methanone × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.67 Å
8BHK GABA-A receptor a5 homomer - a5V3 - Diazepam Deposited 2022-10-31	Different ligand/ion	Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 32–315（284 aa） Chain A 424–450（27 aa） Chain B 32–315（284 aa） Chain B 424–450（27 aa） Chain C 32–315（284 aa） Chain C 424–450（27 aa） Chain D 32–315（284 aa） Chain D 424–450（27 aa） Chain E 32–315（284 aa） Chain E 424–450（27 aa）	Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ;	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 DZP 7-CHLORO-1-METHYL-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.30 Å
8BHM GABA-A receptor a5 homomer - a5V3 - DMCM Deposited 2022-10-31	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 32–315（284 aa） Chain A 424–450（27 aa） Chain B 32–315（284 aa） Chain B 424–450（27 aa） Chain C 32–315（284 aa） Chain C 424–450（27 aa） Chain D 32–315（284 aa） Chain D 424–450（27 aa） Chain E 32–315（284 aa） Chain E 424–450（27 aa）	Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ;	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 R63 methyl 4-ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylate × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.95 Å
8BHO GABA-A receptor a5 homomer - a5V3 - L655708 Deposited 2022-10-31	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 32–315（284 aa） Chain A 424–450（27 aa） Chain B 32–315（284 aa） Chain B 424–450（27 aa） Chain C 32–315（284 aa） Chain C 424–450（27 aa） Chain D 32–315（284 aa） Chain D 424–450（27 aa） Chain E 32–315（284 aa） Chain E 424–450（27 aa）	Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ;	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 QMJ ethyl (7~{S})-15-methoxy-12-oxidanylidene-2,4,11-triazatetracyclo[11.4.0.0^{2,6}.0^{7,11}]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.93 Å
8BHR GABA-A receptor a5 homomer - a5V3 - RO7015738 Deposited 2022-10-31	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 32–315（284 aa） Chain A 424–450（27 aa） Chain B 32–315（284 aa） Chain B 424–450（27 aa） Chain C 32–315（284 aa） Chain C 424–450（27 aa） Chain D 32–315（284 aa） Chain D 424–450（27 aa） Chain E 32–315（284 aa） Chain E 424–450（27 aa）	Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ;	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 QM7 6-[[5-methyl-3-(6-methylpyridin-3-yl)-1,2-oxazol-4-yl]methoxy]-~{N}-[(2~{S})-1-oxidanylpentan-2-yl]pyridine-3-carboxamide × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.38 Å
8BHS GABA-A receptor a5 homomer - a5V3 - RO4938581 Deposited 2022-10-31	Different construct Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric	Chain A 32–346（315 aa） Chain A 424–450（27 aa） Chain B 32–346（315 aa） Chain B 424–450（27 aa） Chain C 32–346（315 aa） Chain C 424–450（27 aa） Chain D 32–346（315 aa） Chain D 424–450（27 aa） Chain E 32–346（315 aa） Chain E 424–450（27 aa）	Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ; Mutation：;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ;	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 QK9 5-[bis(fluoranyl)methyl]-15-bromanyl-2,4,8,9,11-pentazatetracyclo[11.4.0.0^{2,6}.0^{8,12}]heptadeca-1(13),3,5,9,11,14,16-heptaene × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.24 Å
9HAA a5b3 GABAA Receptor resting state Deposited 2024-11-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric	Chain A 33–346（314 aa） Chain A 421–462（42 aa） Chain D 33–346（314 aa） Chain D 421–462（42 aa）	Not recorded	BUA butanoic acid × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 ZN ZINC ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5；20 mM HEPES, 100 mM NaCl, 2 mM Fluorinated Fos-choline 8, 0.005% LMNG, 0.0005% CHS cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.14 Å
9HNQ a5b3 GABAA Receptor bound to GABA and Mb25 in desensitized state in detergent micelles Deposited 2024-12-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric	Chain A 33–346（314 aa） Chain A 421–462（42 aa） Chain D 33–346（314 aa） Chain D 421–462（42 aa）	Not recorded	ABU GAMMA-AMINO-BUTANOIC ACID × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5；20 mM HEPES, 100 mM NaCl, 0.005% LMNG, 0.0005% CHS cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.81 Å
9HNR a5b3 GABAA Receptor in 1 a5 to 4 b3 stoichiometry in desensitized state Deposited 2024-12-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric	Chain A 33–346（314 aa） Chain A 421–462（42 aa）	Not recorded	ABU GAMMA-AMINO-BUTANOIC ACID × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.17 Å
9HNS a5b3 GABAAR bound to GABA and Mb25 in a desensitized state in saposin nanodiscs after long GABA treatment Deposited 2024-12-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric	Chain A 33–346（314 aa） Chain A 421–462（42 aa） Chain D 33–346（314 aa） Chain D 421–462（42 aa）	Not recorded	ABU GAMMA-AMINO-BUTANOIC ACID × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9HNT a5b3 GABAAR bound to Etomidate, GABA, and Mb25 in a desensitized state in saposin nanodiscs Deposited 2024-12-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric	Chain A 33–346（314 aa） Chain A 421–462（42 aa） Chain D 33–346（314 aa） Chain D 421–462（42 aa）	Not recorded	V8D Etomidate × 2 ABU GAMMA-AMINO-BUTANOIC ACID × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.32 Å
9HUM a5b3 GABAAR bound to GABA and Mb25 in a desensitized state in saposin nanodiscs after short GABA treatment Deposited 2024-12-23	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric	Chain A 33–345（313 aa） Chain A 421–462（42 aa） Chain D 33–345（313 aa） Chain D 421–462（42 aa）	Not recorded	ABU GAMMA-AMINO-BUTANOIC ACID × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.35 Å
9RL5 a5b3 GABAAR bound to Topiramate, GABA, and Mb25 in a desensitized state in saposin nanodiscs Deposited 2025-06-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric	Chain A 33–346（314 aa） Chain A 421–462（42 aa） Chain D 33–346（314 aa） Chain D 421–462（42 aa）	Not recorded	ABU GAMMA-AMINO-BUTANOIC ACID × 2 TOR [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
9RPB a5b3 GABAAR bound to GABA, and Mb25 in a desensitized state in saposin nanodiscs, topiramate-free Deposited 2025-06-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric	Chain A 33–346（314 aa） Chain A 421–462（42 aa） Chain D 33–346（314 aa） Chain D 421–462（42 aa）	Not recorded	ABU GAMMA-AMINO-BUTANOIC ACID × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å

22 other PDB entries and 22 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	GBRA5_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–284； UniProt 32–315 Author chain A； PDBConstruct 323–349； UniProt 424–450 Author chain B； PDBConstruct 1–284； UniProt 32–315 Author chain B； PDBConstruct 323–349； UniProt 424–450 Author chain C； PDBConstruct 1–284； UniProt 32–315 Author chain C； PDBConstruct 323–349； UniProt 424–450 Author chain D； PDBConstruct 1–284； UniProt 32–315 Author chain D； PDBConstruct 323–349； UniProt 424–450 Author chain E； PDBConstruct 1–284； UniProt 32–315 Author chain E； PDBConstruct 323–349； UniProt 424–450

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	8bhq
Deposition date deposition_date	2022-10-31
Structure title title	GABA-A receptor a5 homomer - a5V3 - RO7172670
Keywords keywords	pLGIC GABA Neurotransmission, MEMBRANE PROTEIN; MEMBRANE PROTEIN
Experimental Method method	ELECTRON MICROSCOPY

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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier	39.25 Å
Radius of gyration Rg (electron density) rg_electron	38.86 Å
Forward intensity I(0) i0	531431000.00
Molecular weight molecular_weight	195720.0 kDa
Excluded volume excluded_volume	247710 Å³
Envelope volume envelope_volume	326340 Å³
Hydration-shell volume shell_volume	68860 Å³
Envelope diameter envelope_diameter	127.3 Å
Shell Rg shell_rg	45.85 Å
Envelope Rg envelope_rg	38.24 Å
Shape Rg shape_rg	38.84 Å
Total Rg total_rg	39.32 Å
Total atoms total_atoms	27400
Residues n_residues	1680
Spherical-harmonic order n_harmonics	20
q range q_range	— – 0.5000 Å⁻¹
Data points n_points	101
Shell type shell_type	directional
Solvent electron density solvent_density	0.3340 e/Å³
Shell contrast contrast_shell	0.0300 e/Å³
CRYSOL version crysol_version	4.1.3

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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax	128.5 Å
Rg (real space) rg_real	39.14 Å
Rg uncertainty (real space) rg_real_error	0.78 Å
I(0) (real space) i0_real	5.3140e+08
I(0) uncertainty (real space) i0_real_error	8.7000e+06
Rg (reciprocal space) rg_reciprocal	39.21 Å
I(0) (reciprocal space) i0_reciprocal	531500000.0000
Solution quality estimate total_estimate	0.8756
Solution quality rating solution_quality	GOOD a GOOD solution
P(r) peaks n_peaks	1
Primary peak position r_peak_primary	48.2 Å
Skewness Skewness skewness	0.319
Kurtosis Kurtosis kurtosis	-0.299
Angular range angular_range	— – 0.2000 Å⁻¹
Current regularization parameter α current_alpha	0.0000
Highest regularization parameter α highest_alpha	83970000.0000
Real-space data points n_real_points	41
GNOM version gnom_version	4.1.3
Quality Criteria quality_criteria	AN1: 0.000; Oscil: 0.828; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.996; Smooth: 0.898

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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (3)

Entity 1 Entity 1 polymer

Description description	Gamma-aminobutyric acid receptor subunit alpha-5
Molecular weight formula_weight	41057.9 kDa
Mutation mutation	;I79M,T82N,V98I,R101A,S103T,I142F,N145W,K151R,L152M,L155I,E156W,D157N,T160R,L161V,M165L,Q176D,A184E,H185Q,A186N,P287A,I336L,T340F,F344I,V335I ;
Source method src_method	man
Copy count entity_count	5

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C,D,E
Atom count atom_count	27400

QMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDMYVNSFGPVSDTEMEYTIDIFFAQTWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSFAHWMTTPNRMLRIWNDGRVLYTLRLTISAECPMDLEDFPMDEQNCPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVAARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALLEFAFVNYITKSQPARAAKIDKMSRIVFPILFGTFNLVYWATYLNGTTETSQVAPA

来源 Source

来源生物 organism	Homo sapiens
通用名 common_name	human
NCBI Class编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	Homo sapiens

Entity 2 Entity 2 non-polymer

Description description	2-acetamido-2-deoxy-beta-D-glucopyranose
Molecular weight formula_weight	221.2 kDa
Source method src_method	syn
Copy count entity_count	5

Entity 3 Entity 3 non-polymer

Description description	2-[[5-methyl-3-(6-methylpyridazin-3-yl)-1,2-oxazol-4-yl]methyl]-5-(5-oxa-2-azaspiro[3.5]nonan-2-yl)pyridazin-3-one
Molecular weight formula_weight	408.5 kDa
Source method src_method	syn
Copy count entity_count	5

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8. Citations (1)

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Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	3.30 Å
Resolution测定方法 resolution_method	—
颗粒数 num_particles	35250

fit	/app/data/saxs_computation/bh/8bhq/8bhq.fit
pddf	/app/data/pr_computation/bh/8bhq/8bhq.pr.out
profile	/app/data/saxs_computation/bh/8bhq/8bhq.dat

GABA-A receptor a5 homomer - a5V3 - RO7172670

1. Protein Identity and Related Structures Protein Identity & Related Structures

Gamma-aminobutyric acid receptor subunit alpha-5

State in the Current Structure

Other States of the Same Protein in the Database

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

2. Structure Basics 2. Structure Basics

3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

5. Crystallography and Experiment 5. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

冷冻电镜 EM 3D