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8jo0

The Cryo-EM structure of a heptameric CED-4/CED-3 catalytic complex

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Cell death protein 4

Caenorhabditis elegans

UniProt P30429

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 13 MAGNESIUM ION × 7 ADENOSINE-5'-TRIPHOSPHATE × 7 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
3lqq 3lqr 8jns 8jo0

4 assemblies

Heteromeric or nucleic-acid complex
2a5y 4m9s 4m9x 4m9y 4m9z 8jol

6 assemblies

View Construct and Data Evidence
UniProt name CED4_CAEEL
Isoform —
PDB entities 1, 2
Chains and sequence ranges Author chain H； PDBConstruct 1–110； UniProt 1–110 Author chain I； PDBConstruct 1–110； UniProt 1–110 Author chain J； PDBConstruct 1–110； UniProt 1–110 Author chain K； PDBConstruct 1–110； UniProt 1–110 Author chain L； PDBConstruct 1–110； UniProt 1–110 Author chain M； PDBConstruct 1–110； UniProt 1–110 Author chain A； PDBConstruct 1–549； UniProt 1–549 Author chain B； PDBConstruct 1–549； UniProt 1–549 Author chain C； PDBConstruct 1–549； UniProt 1–549 Author chain D； PDBConstruct 1–549； UniProt 1–549 Author chain E； PDBConstruct 1–549； UniProt 1–549 Author chain F； PDBConstruct 1–549； UniProt 1–549 Author chain G； PDBConstruct 1–549； UniProt 1–549

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8jo0
Deposition date deposition_date2023-06-06
Structure title titleThe Cryo-EM structure of a heptameric CED-4/CED-3 catalytic complex
Keywords keywordsCED-4, CED-3 catalytic domain, APOPTOSIS; APOPTOSIS
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8jo0__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8jo0__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8jo0__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）54.16 Å
Rg (electron density)53.72 Å
Total Rg53.78 Å
Atom count27362
Residues3382
Excluded volume490590 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8jo0__assembly_1__model_1 tridecameric （13） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 6 domains

CATH v4.4 (6 domains)

Domain ID domain_id8jo0H01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id8jo0I01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id8jo0J01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id8jo0K01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id8jo0L01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
Domain ID domain_id8jo0M01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology533 — Death Domain, Fas
Homologous superfamily homologous superfamily10 — Death Domain, Fas
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7. Citations (1)