8rm9

Cryo-EM structure of human islet amyloid polypeptide (hIAPP) mutant S28P, polymorph 2

Method: ELECTRON MICROSCOPY
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

Islet amyloid polypeptide

OrganismNot specified

UniProt P10997

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 15 No other associated polymer Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name IAPP_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain c; PDBConstruct 1–37; UniProt 34–70 Author chain d; PDBConstruct 1–37; UniProt 34–70 Author chain e; PDBConstruct 1–37; UniProt 34–70 Author chain f; PDBConstruct 1–37; UniProt 34–70 Author chain g; PDBConstruct 1–37; UniProt 34–70 Author chain n; PDBConstruct 1–37; UniProt 34–70 Author chain o; PDBConstruct 1–37; UniProt 34–70 Author chain p; PDBConstruct 1–37; UniProt 34–70 Author chain q; PDBConstruct 1–37; UniProt 34–70 Author chain r; PDBConstruct 1–37; UniProt 34–70 Author chain s; PDBConstruct 1–37; UniProt 34–70 Author chain t; PDBConstruct 1–37; UniProt 34–70 Author chain u; PDBConstruct 1–37; UniProt 34–70 Author chain v; PDBConstruct 1–37; UniProt 34–70 Author chain w; PDBConstruct 1–37; UniProt 34–70

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id8rm9
Deposition date deposition_date2024-01-05
Structure title titleCryo-EM structure of human islet amyloid polypeptide (hIAPP) mutant S28P, polymorph 2
Keywords keywordsamyloid, PROTEIN FIBRIL; PROTEIN FIBRIL
Experimental Method methodELECTRON MICROSCOPY
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8rm9__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8rm9__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8rm9__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)24.41 Å
Rg (electron density)23.38 Å
Total Rg24.35 Å
Atom count6125
Residues425
Excluded volume54930 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8rm9__assembly_1__model_1 15-meric (15) Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (1)

▶

7. Citations (1)