8spa

Structural insights into cellular control of the human CPEB3 prion, functionally regulated by a labile-amyloid-forming segment

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Cytoplasmic polyadenylation element-binding protein 3

Homo sapiens

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein homooligomer	Homooligomer	Protein 5	No other associated polymer	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CPEB3_HUMAN
Isoform	Q8NE35-2
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–49； UniProt 103–151 Author chain B； PDBConstruct 1–49； UniProt 103–151 Author chain C； PDBConstruct 1–49； UniProt 103–151 Author chain D； PDBConstruct 1–49； UniProt 103–151 Author chain E； PDBConstruct 1–49； UniProt 103–151

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	8spa
Deposition date deposition_date	2023-05-02
Structure title title	Structural insights into cellular control of the human CPEB3 prion, functionally regulated by a labile-amyloid-forming segment
Keywords keywords	prion, amyloid, reversible, helical, PROTEIN FIBRIL; PROTEIN FIBRIL
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8spa__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8spa__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

8spa__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	19.33 Å
Rg (electron density)	18.52 Å
Total Rg	19.45 Å
Atom count	1870
Residues	245
Excluded volume	32805 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`8spa__assembly_1__model_1`	pentameric （5）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	3.00 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	40329

Description description	Cytoplasmic polyadenylation element-binding protein 3
Molecular weight formula_weight	5279.8 kDa
Source method src_method	man
Copy count entity_count	5

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C,D,E
Atom count atom_count	1870

Structural insights into cellular control of the human CPEB3 prion, functionally regulated by a labile-amyloid-forming segment

1. Protein Identity and Related Structures Protein Identity & Related Structures

Cytoplasmic polyadenylation element-binding protein 3

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

8spa__assembly_1__model_1

8spa__assembly_1__model_1 | I(q)

8spa__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

冷冻电镜 EM 3D

5. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

7. Citations (1)

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	;Escherichia coli 'BL21-Gold(DE3)pLysS AG' ;

Structural insights into cellular control of the human CPEB3 prion, functionally regulated by a labile-amyloid-forming segment

1. Protein Identity and Related Structures Protein Identity & Related Structures

Cytoplasmic polyadenylation element-binding protein 3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

8spa__assembly_1__model_1

8spa__assembly_1__model_1 | I(q)

8spa__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

冷冻电镜 EM 3D

5. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

7. Citations (1)