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8vxf

Structure of Casein kinase I isoform delta (CK1d) complexed with inhibitor 15

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Casein kinase I isoform delta

Homo sapiens

UniProt P48730

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 (2P,3P,8S)-2-(5-fluoropyridin-2-yl)-6,6-dimethyl-3-(1H-pyrazolo[3,4-b]pyridin-4-yl)-6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazine × 1 water × 1 Consistent with protein count
2 Protein monomer Monomer Protein 1 (2P,3P,8S)-2-(5-fluoropyridin-2-yl)-6,6-dimethyl-3-(1H-pyrazolo[3,4-b]pyridin-4-yl)-6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazine × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3uys 3uys 3uys 3uys 3uyt 3uyt 3uyt 3uyt 3uzp 3uzp 4hgt 4hgt

92 assemblies; showing the first 12

Homodimer
3uys 3uys 3uyt 3uyt 3uzp 4hnf 4kb8 4kb8 4kba 4kba 4kbc 4kbc

22 assemblies; showing the first 12

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6ru6 6ru7 6ru7 6ru8 6ru8 6ru8 6ru8 8d7m 8d7m 8d7n 8d7n 8d7o

15 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name KC1D_HUMAN
Isoform —
PDB entities 1, 2
Chains and sequence ranges Author chain A； PDBConstruct 2–300； UniProt 1–299 Author chain B； PDBConstruct 2–300； UniProt 1–299

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8vxf
Deposition date deposition_date2024-02-04
Structure title titleStructure of Casein kinase I isoform delta (CK1d) complexed with inhibitor 15
Keywords keywordsCK1D, KINASE, TRANSFERASE, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex; TRANSFERASE/TRANSFERASE INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8vxf__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8vxf__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8vxf__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）20.43 Å
Rg (electron density)19.29 Å
Total Rg20.30 Å
Atom count2324
Residues289
Excluded volume41323 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8vxf__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 8vxf__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)