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8w50

Crystal structure of DNA binding and cleavage core of human topoisomerase 2-alpha in a DNA binding-competent conformation

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA topoisomerase 2-alpha

Homo sapiens

UniProt P11388

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 SULFATE ION × 3 water × 2 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1zxm 1zxn 1zxn 4r1f 4r1f 8w50 8w50 9bq6 9bq7 9bq9 9bqb

11 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4fm9 5gwk 6zy5 6zy6 6zy7 6zy8

6 assemblies

View Construct and Data Evidence
UniProt name TOP2A_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 27–786； UniProt 429–1188 Author chain B； PDBConstruct 27–786； UniProt 429–1188 Author chain C； PDBConstruct 27–786； UniProt 429–1188 Author chain D； PDBConstruct 27–786； UniProt 429–1188

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8w50
Deposition date deposition_date2023-08-25
Structure title titleCrystal structure of DNA binding and cleavage core of human topoisomerase 2-alpha in a DNA binding-competent conformation
Keywords keywordseukaryotic DNA topoisomerase G-segment DNA binding cleavage center assembly, DNA BINDING PROTEIN; DNA BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8w50__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8w50__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8w50__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）37.87 Å
Rg (electron density)37.08 Å
Total Rg37.61 Å
Atom count11156
Residues1445
Excluded volume199030 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8w50__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 8w50__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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7. Citations (1)