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8w7h

Purine Nucleoside Phosphorylase in complex with MMV000848

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Purine nucleoside phosphorylase

Plasmodium falciparum 3D7

UniProt Q8I3X4

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 6 (2R)-1-(9H-carbazol-9-yl)-3-(cyclopentylamino)propan-2-ol × 6 1,2-ETHANEDIOL × 6 SODIUM ION × 12 PHOSPHATE ION × 6 water × 6 Consistent with protein count
2 Protein monomer Monomer Protein 1 (2R)-1-(9H-carbazol-9-yl)-3-(cyclopentylamino)propan-2-ol × 1 1,2-ETHANEDIOL × 1 SODIUM ION × 2 PHOSPHATE ION × 1 water × 1 Consistent with protein count
3 Protein monomer Monomer Protein 1 (2R)-1-(9H-carbazol-9-yl)-3-(cyclopentylamino)propan-2-ol × 1 1,2-ETHANEDIOL × 1 SODIUM ION × 2 PHOSPHATE ION × 1 water × 1 Consistent with protein count
4 Protein monomer Monomer Protein 1 (2R)-1-(9H-carbazol-9-yl)-3-(cyclopentylamino)propan-2-ol × 1 1,2-ETHANEDIOL × 1 SODIUM ION × 2 PHOSPHATE ION × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1sq6 8w7h 8w7h 8w7h

4 assemblies

Homodimer
1nw4 1nw4 1nw4 1nw4 1nw4 1nw4

6 assemblies

Homotetramer

None

Other homooligomers
1nw4 1q1g 1sq6 3enz 3fow 8w7h

6 assemblies

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name PNPH_PLAF7
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–245； UniProt 1–245

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8w7h
Deposition date deposition_date2023-08-30
Structure title titlePurine Nucleoside Phosphorylase in complex with MMV000848
Keywords keywordsProtein binding, TRANSFERASE-inhibitor complex; TRANSFERASE/INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8w7h__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8w7h__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8w7h__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）34.26 Å
Rg (electron density)33.73 Å
Total Rg34.34 Å
Atom count10800
Residues1392
Excluded volume194980 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8w7h__assembly_1__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 8w7h__assembly_2__model_1 monomeric （1） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
3 1 8w7h__assembly_3__model_1 monomeric （1） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
4 1 8w7h__assembly_4__model_1 monomeric （1） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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7. Citations (1)