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9b18

EV-D68 in complex with inhibitor Jun11-53-7

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Capsid protein VP1

OrganismNot specified

UniProt A0A097BW12

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 240 viral protein 2 × 60 （A0A0A7X639） Capsid protein VP4 × 60 （Q68T42） (4M)-4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-N-({4-[(propan-2-yl)oxy]phenyl}methyl)quinolin-8-amine × 60 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 viral protein 2 × 1 （A0A0A7X639） Capsid protein VP4 × 1 （Q68T42） (4M)-4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-N-({4-[(propan-2-yl)oxy]phenyl}methyl)quinolin-8-amine × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 20 viral protein 2 × 5 （A0A0A7X639） Capsid protein VP4 × 5 （Q68T42） (4M)-4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-N-({4-[(propan-2-yl)oxy]phenyl}methyl)quinolin-8-amine × 5 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 24 viral protein 2 × 6 （A0A0A7X639） Capsid protein VP4 × 6 （Q68T42） (4M)-4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-N-({4-[(propan-2-yl)oxy]phenyl}methyl)quinolin-8-amine × 6 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 4 viral protein 2 × 1 （A0A0A7X639） Capsid protein VP4 × 1 （Q68T42） (4M)-4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-N-({4-[(propan-2-yl)oxy]phenyl}methyl)quinolin-8-amine × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
8fl5 8fl5

2 assemblies

Homodimer

None

Homotetramer
7t9p 7t9p 7taf 7taf 7tag 7tag 7tah 7tah 7taj 7taj

10 assemblies

Other homooligomers
7t9p 7t9p 7t9p 7taf 7taf 7taf 7tag 7tag 7tag 7tah 7tah 7tah

15 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
6crp 6crp 6crp 6crp 6crp 6crr 6crr 6crr 6crr 6crr 6crs 6crs

110 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name A0A097BW12_HED68
Isoform —
PDB entities 1, 2
Chains and sequence ranges Author chain A； PDBConstruct 1–309； UniProt 553–861 Author chain B； PDBConstruct 1–247； UniProt 318–564

viral protein 2

OrganismNot specified

UniProt A0A0A7X639

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 240 Capsid protein VP1 × 60 （A0A097BW12） viral protein 3 × 60 （A0A097BW12） Capsid protein VP4 × 60 （Q68T42） (4M)-4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-N-({4-[(propan-2-yl)oxy]phenyl}methyl)quinolin-8-amine × 60 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 Capsid protein VP1 × 1 （A0A097BW12） viral protein 3 × 1 （A0A097BW12） Capsid protein VP4 × 1 （Q68T42） (4M)-4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-N-({4-[(propan-2-yl)oxy]phenyl}methyl)quinolin-8-amine × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 20 Capsid protein VP1 × 5 （A0A097BW12） viral protein 3 × 5 （A0A097BW12） Capsid protein VP4 × 5 （Q68T42） (4M)-4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-N-({4-[(propan-2-yl)oxy]phenyl}methyl)quinolin-8-amine × 5 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 24 Capsid protein VP1 × 6 （A0A097BW12） viral protein 3 × 6 （A0A097BW12） Capsid protein VP4 × 6 （Q68T42） (4M)-4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-N-({4-[(propan-2-yl)oxy]phenyl}methyl)quinolin-8-amine × 6 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 4 Capsid protein VP1 × 1 （A0A097BW12） viral protein 3 × 1 （A0A097BW12） Capsid protein VP4 × 1 （Q68T42） (4M)-4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-N-({4-[(propan-2-yl)oxy]phenyl}methyl)quinolin-8-amine × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6aj0 6aj0 6aj0 6aj0 6aj0 6aj2 6aj2 6aj2 6aj2 6aj2 6aj3 6aj3

60 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name A0A0A7X639_9ENTO
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–248； UniProt 70–317

Capsid protein VP4

OrganismNot specified

UniProt Q68T42

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 240 Capsid protein VP1 × 60 （A0A097BW12） viral protein 3 × 60 （A0A097BW12） viral protein 2 × 60 （A0A0A7X639） (4M)-4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-N-({4-[(propan-2-yl)oxy]phenyl}methyl)quinolin-8-amine × 60 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 Capsid protein VP1 × 1 （A0A097BW12） viral protein 3 × 1 （A0A097BW12） viral protein 2 × 1 （A0A0A7X639） (4M)-4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-N-({4-[(propan-2-yl)oxy]phenyl}methyl)quinolin-8-amine × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 20 Capsid protein VP1 × 5 （A0A097BW12） viral protein 3 × 5 （A0A097BW12） viral protein 2 × 5 （A0A0A7X639） (4M)-4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-N-({4-[(propan-2-yl)oxy]phenyl}methyl)quinolin-8-amine × 5 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 24 Capsid protein VP1 × 6 （A0A097BW12） viral protein 3 × 6 （A0A097BW12） viral protein 2 × 6 （A0A0A7X639） (4M)-4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-N-({4-[(propan-2-yl)oxy]phenyl}methyl)quinolin-8-amine × 6 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 4 Capsid protein VP1 × 1 （A0A097BW12） viral protein 3 × 1 （A0A097BW12） viral protein 2 × 1 （A0A0A7X639） (4M)-4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-N-({4-[(propan-2-yl)oxy]phenyl}methyl)quinolin-8-amine × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
29hm 29hm 7gnv 7gnv 7gnw 7gnw 7gnx 7gnx 7gny 7gny 7gnz 7gnz

210 assemblies; showing the first 12

Homodimer
8cnx

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4wm7 4wm7 4wm7 4wm7 4wm7 4wm7 4wm8 4wm8 4wm8 4wm8 4wm8 4wm8

66 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name POLG_HED68
Isoform —
PDB entities 4
Chains and sequence ranges Author chain D； PDBConstruct 1–69； UniProt 1–69

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9b18
Deposition date deposition_date2024-03-13
Structure title titleEV-D68 in complex with inhibitor Jun11-53-7
Keywords keywordsEV-D68, Inhibitor, VIRUS, Structural Genomics, Center for Structural Biology of Infectious Diseases, CSBID; VIRUS
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9b18__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9b18__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 1010 1011 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9b18__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）0.00 Å
Rg (electron density)132.30 Å
Total Rg132.40 Å
Atom count381180
Residues48720
Excluded volume6770300 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9b18__assembly_1__model_1 240-meric （240） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 9b18__assembly_2__model_1 tetrameric （4） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
3 1 9b18__assembly_3__model_1 eicosameric （20） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
4 1 9b18__assembly_4__model_1 24-meric （24） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
5 1 9b18__assembly_5__model_1 tetrameric （4） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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7. Citations (1)