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9bv7

Crystal structure of human CYP3A4 in complex with SJ000310315

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Cytochrome P450 3A4

Homo sapiens

UniProt P08684

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 PROTOPORPHYRIN IX CONTAINING FE × 1 3-(2-chlorophenyl)-N-{[(2S,7M)-7-(pyridin-3-yl)-2,3-dihydro-1-benzofuran-2-yl]methyl}propanamide × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1tqn 1w0e 1w0f 1w0g 2j0d 2j0d 2v0m 2v0m 2v0m 2v0m 3nxu 3nxu

53 assemblies; showing the first 12

Homodimer
5g5j 5vc0 5vcc 5vcd 5vce 5vcg 6bd7 6bd8 6bdh 6bdi 6bdm 6ma6

71 assemblies; showing the first 12

Homotetramer
1tqn 4i3q 4i4g 4i4h 4ny4 5vc0 5vcc 5vcd 5vce 5vcg 6bcz 6bd5

27 assemblies; showing the first 12

Other homooligomers
5te8

1 assemblies

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name CP3A4_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 3–482； UniProt 24–503

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9bv7
Deposition date deposition_date2024-05-20
Structure title titleCrystal structure of human CYP3A4 in complex with SJ000310315
Keywords keywords;Cytochrome P450 3A4, CYP3A4, CYP3A4-selective inhibitor, drug metabolizing enzyme, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex ;; OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9bv7__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9bv7__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9bv7__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）23.30 Å
Rg (electron density)22.13 Å
Total Rg22.99 Å
Atom count3568
Residues464
Excluded volume63958 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9bv7__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)