9obi

Room Temperature X-Ray Structure of HIV-1 Protease in Complex with Inhibitor GRL-075-24A

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Protease

Human immunodeficiency virus 1

UniProt Q5RZ08

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 ;(1S,5S,7S)-7-(2-methoxyphenyl)-8-oxaspiro[4.5]decan-1-yl {(2S,3R)-3-hydroxy-4-[(4-methoxybenzene-1-sulfonyl)(2-methylpropyl)amino]-1-phenylbutan-2-yl}carbamate ; × 1 water × 2 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 2 ;(1S,5S,7S)-7-(2-methoxyphenyl)-8-oxaspiro[4.5]decan-1-yl {(2S,3R)-3-hydroxy-4-[(4-methoxybenzene-1-sulfonyl)(2-methylpropyl)amino]-1-phenylbutan-2-yl}carbamate ; × 1 water × 2 Consistent with protein count
3 Protein homooligomer Homooligomer Protein 2 ;(1S,5S,7S)-7-(2-methoxyphenyl)-8-oxaspiro[4.5]decan-1-yl {(2S,3R)-3-hydroxy-4-[(4-methoxybenzene-1-sulfonyl)(2-methylpropyl)amino]-1-phenylbutan-2-yl}carbamate ; × 1 CHLORIDE ION × 1 water × 2 Consistent with protein count
4 Protein homooligomer Homooligomer Protein 2 ;(1S,5S,7S)-7-(2-methoxyphenyl)-8-oxaspiro[4.5]decan-1-yl {(2S,3R)-3-hydroxy-4-[(4-methoxybenzene-1-sulfonyl)(2-methylpropyl)amino]-1-phenylbutan-2-yl}carbamate ; × 1 CHLORIDE ION × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name Q5RZ08_9HIV1
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A; PDBConstruct 1–99; UniProt 1–99 Author chain B; PDBConstruct 1–99; UniProt 1–99 Author chain C; PDBConstruct 1–99; UniProt 1–99 Author chain D; PDBConstruct 1–99; UniProt 1–99 Author chain E; PDBConstruct 1–99; UniProt 1–99 Author chain F; PDBConstruct 1–99; UniProt 1–99 Author chain G; PDBConstruct 1–99; UniProt 1–99 Author chain H; PDBConstruct 1–99; UniProt 1–99

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9obi
Deposition date deposition_date2025-04-22
Last revision last_revision2025-07-23
Structure title titleRoom Temperature X-Ray Structure of HIV-1 Protease in Complex with Inhibitor GRL-075-24A
Keywords keywordsAspartic protease, enzyme-inhibitor complex, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex; HYDROLASE/HYDROLASE INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9obi__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9obi__assembly_3__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9obi__assembly_3__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)18.19 Å
Rg (electron density)17.29 Å
Total Rg18.40 Å
Atom count1562
Residues198
Excluded volume28406 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9obi__assembly_1__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 9obi__assembly_2__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 9obi__assembly_3__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 9obi__assembly_4__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)