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9p0q

Structure of PYCR1 complexed with the allosteric inhibitor 1-benzyl-1H-1,3-benzodiazole-2-sulfonic acid

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Pyrroline-5-carboxylate reductase 1, mitochondrial

Homo sapiens

UniProt P32322

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 10 1-benzyl-1H-1,3-benzimidazole-2-sulfonic acid × 14 SULFATE ION × 10 water × 10 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2ger 2ger 2ger 2ger 2ger 2gr9 2gr9 2gr9 2gr9 2gr9 2gra 2gra

15 assemblies; showing the first 12

Homodimer
2ger 2ger 2gr9 2gr9 2gr9 2gra 2gra 5uat 5uat 5uat 5uau 5uau

22 assemblies; showing the first 12

Homotetramer

None

Other homooligomers
2izz 5uat 5uau 5uav 5uaw 5uax 6xoz 6xp0 6xp1 6xp2 6xp3 8dkg

44 assemblies; showing the first 12

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name P5CR1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 23–316； UniProt 1–294 Author chain B； PDBConstruct 23–316； UniProt 1–294 Author chain C； PDBConstruct 23–316； UniProt 1–294 Author chain D； PDBConstruct 23–316； UniProt 1–294 Author chain E； PDBConstruct 23–316； UniProt 1–294

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9p0q
Deposition date deposition_date2025-06-07
Structure title titleStructure of PYCR1 complexed with the allosteric inhibitor 1-benzyl-1H-1,3-benzodiazole-2-sulfonic acid
Keywords keywordsAMINO-ACID BIOSYNTHESIS, OXIDOREDUCTASE, PROLINE BIOSYNTHESIS, INHIBITOR, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex; OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9p0q__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9p0q__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9p0q__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）42.53 Å
Rg (electron density)41.80 Å
Total Rg42.10 Å
Atom count19856
Residues2760
Excluded volume352770 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9p0q__assembly_1__model_1 decameric （10） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)