9q75

Crystal structure of T. cruzi EIF4E5 in complex with EIF4G1 peptide and cap-4.

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Putative Eukaryotic translation initiation factor 4E type 5

Trypanosoma cruzi Dm28c

UniProt A0A2V2XI07

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 2 Eukaryotic translation initiation factor 4 gamma 1 × 1 (A0A2V2UXK5) SULFATE ION × 3 water × 2 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 2 Eukaryotic translation initiation factor 4 gamma 1 × 1 (A0A2V2UXK5) SULFATE ION × 1 ;2-amino-9-[(2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(S)-({(2R,3R,4R,5R)-3-{[(R)-{[(2R,3R,4R,5R)-3-{[(S)-{[(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-{[(S)-hydroxy{[(2R,3R,4R,5R)-3-hydroxy-4-methoxy-5-(3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methoxy}phosphoryl]oxy}-4-methoxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}-5-(6-amino-9H-purin-9-yl)-4-methoxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}-5-[6-(dimethylamino)-9H-purin-9-yl]-4-methoxytetrahydrofuran-2-yl}methoxy)(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxytetrahydrofuran-2-yl]-7-methyl-6-oxo-6,9-dihydro-3H-purin-7-ium ; × 1 water × 2 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 2 Eukaryotic translation initiation factor 4 gamma 1 × 1 (A0A2V2UXK5) SULFATE ION × 1 ;2-amino-9-[(2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(S)-({(2R,3R,4R,5R)-3-{[(R)-{[(2R,3R,4R,5R)-3-{[(S)-{[(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-{[(S)-hydroxy{[(2R,3R,4R,5R)-3-hydroxy-4-methoxy-5-(3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methoxy}phosphoryl]oxy}-4-methoxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}-5-(6-amino-9H-purin-9-yl)-4-methoxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}-5-[6-(dimethylamino)-9H-purin-9-yl]-4-methoxytetrahydrofuran-2-yl}methoxy)(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxytetrahydrofuran-2-yl]-7-methyl-6-oxo-6,9-dihydro-3H-purin-7-ium ; × 1 water × 2 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 A0A2V2XI07_TRYCR
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–200; UniProt 1–200 作者链 C; PDB构建体 1–200; UniProt 1–200 作者链 E; PDB构建体 1–200; UniProt 1–200

Eukaryotic translation initiation factor 4 gamma 1

Trypanosoma cruzi Dm28c

UniProt A0A2V2UXK5

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 2 Putative Eukaryotic translation initiation factor 4E type 5 × 1 (A0A2V2XI07) SULFATE ION × 3 water × 2 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 2 Putative Eukaryotic translation initiation factor 4E type 5 × 1 (A0A2V2XI07) SULFATE ION × 1 ;2-amino-9-[(2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(S)-({(2R,3R,4R,5R)-3-{[(R)-{[(2R,3R,4R,5R)-3-{[(S)-{[(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-{[(S)-hydroxy{[(2R,3R,4R,5R)-3-hydroxy-4-methoxy-5-(3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methoxy}phosphoryl]oxy}-4-methoxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}-5-(6-amino-9H-purin-9-yl)-4-methoxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}-5-[6-(dimethylamino)-9H-purin-9-yl]-4-methoxytetrahydrofuran-2-yl}methoxy)(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxytetrahydrofuran-2-yl]-7-methyl-6-oxo-6,9-dihydro-3H-purin-7-ium ; × 1 water × 2 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 2 Putative Eukaryotic translation initiation factor 4E type 5 × 1 (A0A2V2XI07) SULFATE ION × 1 ;2-amino-9-[(2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(S)-({(2R,3R,4R,5R)-3-{[(R)-{[(2R,3R,4R,5R)-3-{[(S)-{[(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-{[(S)-hydroxy{[(2R,3R,4R,5R)-3-hydroxy-4-methoxy-5-(3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methoxy}phosphoryl]oxy}-4-methoxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}-5-(6-amino-9H-purin-9-yl)-4-methoxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}-5-[6-(dimethylamino)-9H-purin-9-yl]-4-methoxytetrahydrofuran-2-yl}methoxy)(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxytetrahydrofuran-2-yl]-7-methyl-6-oxo-6,9-dihydro-3H-purin-7-ium ; × 1 water × 2 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 A0A2V2UXK5_TRYCR
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 3–42; UniProt 108–147 作者链 D; PDB构建体 3–42; UniProt 108–147 作者链 F; PDB构建体 3–42; UniProt 108–147

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id9q75
沉积日期 deposition_date2025-08-22
最后修订 last_revision2026-01-21
结构标题 titleCrystal structure of T. cruzi EIF4E5 in complex with EIF4G1 peptide and cap-4.
关键词 keywordsTRANSLATION INITIATION FACTOR, EIF4E FAMILY, EIF4E5, EIF4G1, CAP-4, TRANSLATION; TRANSLATION
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

9q75__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

9q75__assembly_2__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

9q75__assembly_2__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)18.62 Å
Rg(电子密度)17.40 Å
总 Rg18.42 Å
原子数1959
残基数227
排除体积34493 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 9q75__assembly_1__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 9q75__assembly_2__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
3 1 9q75__assembly_3__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (5)

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7. 引用文献 (1)