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9t9m

Tilvestamab Fab bound to the anti-Fab nanobody

Method: ELECTRON MICROSCOPY D_max: 85.0 Å Quality: EXCELLENT

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9t9m
deposition_date	2025-11-16
title	Tilvestamab Fab bound to the anti-Fab nanobody
keywords	anti-AXL, monoclonal antibody, cancer, AXL is a receptor tyrosine kinase, ANTITUMOR PROTEIN; ANTITUMOR PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	27.42 Å
rg_electron	26.49 Å
i0	59639300.00
molecular_weight	59090.0 kDa
excluded_volume	73471 Å³
envelope_volume	92421 Å³
shell_volume	29208 Å³
envelope_diameter	90.6 Å
shell_rg	33.64 Å
envelope_rg	26.14 Å
shape_rg	26.48 Å
total_rg	27.30 Å
total_atoms	4165
n_residues	544
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	85.0 Å
rg_real	27.31 Å
rg_real_error	0.53 Å
i0_real	5.9640e+07
i0_real_error	9.0120e+05
rg_reciprocal	27.35 Å
i0_reciprocal	59640000.0000
total_estimate	0.9125
solution_quality	EXCELLENT a EXCELLENT solution
n_peaks	2
r_peak_primary	36.6 Å
skewness	0.153
kurtosis	-0.587
angular_range	— – 0.2900 Å⁻¹
current_alpha	0.0000
highest_alpha	13570000.0000
n_real_points	59
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.962; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 1.000; Smooth: 0.973

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	Light chain of BGB149 antibody
formula_weight	23872.5 kDa
src_method	nat
entity_count	1

Polymer

type	polypeptide(L)
strand_id	L
atom_count	4165

DIQMTQSPSSLSASVGDRVTITCRSSQSLVHSNGIPYLHWYQQKPGKAPKLLIYRVSNRFSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCSQGTHVPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE

Entity 2 polymer

description	Anti Nab-Fab nanobody
formula_weight	13390.6 kDa
src_method	nat
entity_count	1

Polymer

type	polypeptide(L)
strand_id	K

GSQVQLQESGGGLVQPGGSLRLSCAASGRTISRYAMSWFRQAPGKEREFVAVARRSGDGAFYADSVQGRFTVSRDDAKNTVYLQMNSLKPEDTAVYYCAIDSDTFYSGSYDYWGQGTQVTVSS

Entity 3 polymer

description	Heavy chain of BGB149 antibody
formula_weight	23531.3 kDa
src_method	nat
entity_count	1

Polymer

type	polypeptide(L)
strand_id	H

EVQLVESGGGLVQPGGSLRLSCAASGYSFTDFYINWVRQAPGKGLEWVARIFPGGDNTYYNEKFKGRFTLSADTSKSTAYLQMNSLRAEDTAVYYCARRGLYYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKS

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.09 Å
resolution_method	—
num_particles	1316916

fit	/app/data/saxs_computation/t9/9t9m/9t9m.fit
pddf	/app/data/pr_computation/t9/9t9m/9t9m.pr.out
profile	/app/data/saxs_computation/t9/9t9m/9t9m.dat

Tilvestamab Fab bound to the anti-Fab nanobody

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

EM 3D

5. Entities & Polymer Info (3)

Entity 1 polymer

Polymer

Entity 2 polymer

Polymer

Entity 3 polymer

Polymer

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)