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9tm2

Plasmodium falciparum dihydroorotate dehydrogenase in complex with 3-hydroxy-1-methyl pyrazole derivatives

Method: X-RAY DIFFRACTION Dmax: 103.5 Å Quality: GOOD

SAXS Profile

SAXS profile for 9tm2

P(r) Distribution

P(r) distribution for 9tm2
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1. Structure Basics

entry_id9tm2
deposition_date2025-12-11
last_revision2026-04-01
titlePlasmodium falciparum dihydroorotate dehydrogenase in complex with 3-hydroxy-1-methyl pyrazole derivatives
keywords;Malaria, Plasmodium falciparum, Pyrimidine biosynthesis, dihydroorotate dehydrogenase, structure-based drug design, inhibitors, OXIDOREDUCTASE ;; OXIDOREDUCTASE
methodX-RAY DIFFRACTION
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Download Data

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2. SAXS Parameters (CRYSOL)

rg_guinier30.19 Å
rg_electron30.03 Å
i0227707000.00
molecular_weight81107.0 kDa
excluded_volume78774 ų
envelope_volume130900 ų
shell_volume36512 ų
envelope_diameter112.0 Å
shell_rg36.86 Å
envelope_rg30.10 Å
shape_rg30.08 Å
total_rg30.38 Å
total_atoms6176
n_residues758
n_harmonics20
q_range— – 0.5000 Å−1
n_points101
shell_typedirectional
solvent_density0.3340 e/ų
contrast_shell0.0300 e/ų
crysol_version4.1.3
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3. P(r) Analysis (GNOM)

dmax103.5 Å
rg_real30.28 Å
rg_real_error0.81 Å
i0_real2.2770e+08
i0_real_error3.3080e+06
rg_reciprocal30.24 Å
i0_reciprocal227700000.0000
total_estimate0.8584
solution_quality GOOD a GOOD solution
n_peaks2
r_peak_primary29.9 Å
skewness0.429
kurtosis-0.407
angular_range— – 0.2600 Å−1
current_alpha0.0000
highest_alpha45900000.0000
n_real_points53
gnom_version4.1.3
quality_criteria AN1: 0.000; Oscil: 0.762; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.903; Smooth: 0.967
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4. Crystallography & Experiment

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5. Entities & Polymer Info (5)

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6. Citations (1)

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7. Files & Curves (10)