Cryo-EM structure of a tau filament

Method: ELECTRON MICROSCOPY D_max: 88.6 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9tzx
deposition_date	2026-01-25
title	Cryo-EM structure of a tau filament
keywords	tau filament, amyloid fibril, cryo-EM, helical assembly, PROTEIN FIBRIL; PROTEIN FIBRIL
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	27.26 Å
rg_electron	27.34 Å
i0	25018500.00
molecular_weight	38490.0 kDa
excluded_volume	48282 Å³
envelope_volume	67355 Å³
shell_volume	21219 Å³
envelope_diameter	94.4 Å
shell_rg	33.93 Å
envelope_rg	26.89 Å
shape_rg	27.30 Å
total_rg	28.18 Å
total_atoms	2700
n_residues	355
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	88.6 Å
rg_real	27.38 Å
rg_real_error	0.69 Å
i0_real	2.5020e+07
i0_real_error	4.1010e+05
rg_reciprocal	27.34 Å
i0_reciprocal	25020000.0000
total_estimate	0.8720
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	21.4 Å
skewness	0.292
kurtosis	-0.716
angular_range	— – 0.2900 Å⁻¹
current_alpha	0.0000
highest_alpha	3215000.0000
n_real_points	59
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.855; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.811; Smooth: 0.958

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4. Crystallography & Experiment

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5. Entities & Polymer Info (1)

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	2.750 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	2.75 Å
resolution_method	—
num_particles	143765

description	Isoform Tau-F of Microtubule-associated protein tau
formula_weight	45951.9 kDa
src_method	man
entity_count	5

Cryo-EM structure of a tau filament

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D

5. Entities & Polymer Info (1)

Entity 1 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli BL21(DE3)

fit	/app/data/saxs_computation/tz/9tzx/9tzx.fit
pddf	/app/data/pr_computation/tz/9tzx/9tzx.pr.out
profile	/app/data/saxs_computation/tz/9tzx/9tzx.dat

type	polypeptide(L)
strand_id	A,E,B,D,C
atom_count	2700