Cryo-EM structure of BA1-1-bound alpha-synuclein fibril polymorph 6A6B

Method: ELECTRON MICROSCOPY D_max: 104.8 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9uf6
deposition_date	2025-04-10
title	Cryo-EM structure of BA1-1-bound alpha-synuclein fibril polymorph 6A6B
keywords	amyloid fibril, complex, PROTEIN FIBRIL; PROTEIN FIBRIL
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	30.16 Å
rg_electron	30.68 Å
i0	190529000.00
molecular_weight	77040.0 kDa
excluded_volume	76339 Å³
envelope_volume	129730 Å³
shell_volume	36193 Å³
envelope_diameter	110.1 Å
shell_rg	36.97 Å
envelope_rg	30.84 Å
shape_rg	30.77 Å
total_rg	30.90 Å
total_atoms	5904
n_residues	756
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	104.8 Å
rg_real	30.25 Å
rg_real_error	1.09 Å
i0_real	1.9050e+08
i0_real_error	3.2250e+06
rg_reciprocal	30.21 Å
i0_reciprocal	190500000.0000
total_estimate	0.8646
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	29.7 Å
skewness	0.437
kurtosis	-0.241
angular_range	— – 0.2650 Å⁻¹
current_alpha	0.0000
highest_alpha	38400000.0000
n_real_points	54
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.779; Stabil: 0.998; Sysdev: 1.000; Positv: 1.000; Valcen: 0.922; Smooth: 0.983

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4. Crystallography & Experiment

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5. Entities & Polymer Info (2)

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	2.90 Å
resolution_method	—
num_particles	326123

description	Alpha-synuclein
formula_weight	14476.1 kDa
src_method	man
entity_count	12

type	polypeptide(L)
strand_id	E,F,G,H,I,J,K,L,M,N,O,P
atom_count	5904

Cryo-EM structure of BA1-1-bound alpha-synuclein fibril polymorph 6A6B

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

EM 3D

5. Entities & Polymer Info (2)

Entity 1 polymer

Polymer

Source

Entity 2 non-polymer

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

description	(2~{E})-1-ethyl-2-[(~{E})-3-(1-ethylquinolin-1-ium-2-yl)prop-2-enylidene]quinoline
formula_weight	353.5 kDa
src_method	syn
entity_count	24

fit	/app/data/saxs_computation/uf/9uf6/9uf6.fit
pddf	/app/data/pr_computation/uf/9uf6/9uf6.pr.out
profile	/app/data/saxs_computation/uf/9uf6/9uf6.dat