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9v0n

Cryo-EM structure of RSV pre-F in complex with antibody CNR2042

Method: ELECTRON MICROSCOPY D_max: 130.3 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9v0n
deposition_date	2025-05-18
title	Cryo-EM structure of RSV pre-F in complex with antibody CNR2042
keywords	RSV, Fusion Protein, Antibody, VIRAL PROTEIN; VIRAL PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	40.08 Å
rg_electron	39.53 Å
i0	706856000.00
molecular_weight	216970.0 kDa
excluded_volume	271510 Å³
envelope_volume	360850 Å³
shell_volume	74294 Å³
envelope_diameter	141.7 Å
shell_rg	46.46 Å
envelope_rg	39.16 Å
shape_rg	39.53 Å
total_rg	39.90 Å
total_atoms	15225
n_residues	1983
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	130.3 Å
rg_real	39.90 Å
rg_real_error	0.83 Å
i0_real	7.0690e+08
i0_real_error	1.1070e+07
rg_reciprocal	40.08 Å
i0_reciprocal	707000000.0000
total_estimate	0.8882
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	50.1 Å
skewness	0.151
kurtosis	-0.424
angular_range	— – 0.1950 Å⁻¹
current_alpha	0.0000
highest_alpha	98230000.0000
n_real_points	40
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.866; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.993; Smooth: 0.951

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	RSV Pre-fusion Protein
formula_weight	61626.5 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	A,D,E
atom_count	15225

MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGHHHHHHHH

Source

organism	Respiratory syncytial virus A2
ncbi_taxonomy_id	1972429
host_organism	Homo sapiens

Entity 2 polymer

description	CNR2042 Heavy Chain
formula_weight	13505.9 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	C,H,I

EVQLVESGGGLVKPGGSLRLSCAASGFSFSSYNMNWVRQAPGKGLEWVSSITGGSNFIDYPDSLKGRFTISRDNSRNSLYLQMNSLRAEDTGLYYCVRESYFGSGGSLNWFDPWGQGTLVIVSS

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 3 polymer

description	CNR2042 Light Chain
formula_weight	11630.8 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	B,F,G

QSVLTQPPSVSGAPGQRVTISCTGSSSSIGRGYDVHWYQQVPGTAPRLLIYANTNRPSGIPDRFSGSKSATSASLAITGLQAEDEADYYCQSYDSSMLWVFGGGTKLTVL

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

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6. Citations (1)

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resolution	3.750 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	3.75 Å
resolution_method	—
num_particles	42798

fit	/app/data/saxs_computation/v0/9v0n/9v0n.fit
pddf	/app/data/pr_computation/v0/9v0n/9v0n.pr.out
profile	/app/data/saxs_computation/v0/9v0n/9v0n.dat

Cryo-EM structure of RSV pre-F in complex with antibody CNR2042

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Refinement

EM 3D

5. Entities & Polymer Info (3)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)