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9v0p

Cryo-EM structure of RSV pre-F in complex with antibody CNR2053

Method: ELECTRON MICROSCOPY D_max: 153.9 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9v0p
deposition_date	2025-05-18
title	Cryo-EM structure of RSV pre-F in complex with antibody CNR2053
keywords	RSV, Fusion Protein, Antibody, VIRAL PROTEIN; VIRAL PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	46.24 Å
rg_electron	46.02 Å
i0	754542000.00
molecular_weight	226540.0 kDa
excluded_volume	283760 Å³
envelope_volume	410040 Å³
shell_volume	75218 Å³
envelope_diameter	160.8 Å
shell_rg	49.41 Å
envelope_rg	45.40 Å
shape_rg	46.03 Å
total_rg	46.13 Å
total_atoms	15885
n_residues	2055
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	153.9 Å
rg_real	46.28 Å
rg_real_error	1.15 Å
i0_real	7.5450e+08
i0_real_error	1.5310e+07
rg_reciprocal	46.25 Å
i0_reciprocal	754500000.0000
total_estimate	0.8767
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	49.8 Å
skewness	0.345
kurtosis	-0.456
angular_range	— – 0.1700 Å⁻¹
current_alpha	0.0001
highest_alpha	71840000.0000
n_real_points	35
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.860; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.999; Smooth: 0.815

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	CNR2053 Heavy Chain
formula_weight	13585.1 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	H,D,E
atom_count	15885

QEQSVQSGAEVKKPGASVKVSCRASEFTFSSDFIHWVRQVPGQGLEWMGRITPSDGTTTYAQKFQGRVTMTRDPSTGTVYIELRRLKSEDTAVYYCVAYDRVTTSAGTGATDIWGQGTMVTVSS

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 polymer

description	CNR2053 Light Chain
formula_weight	12225.7 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	L,F,G

DIVMTQSPLSLPVTPGEPASISCRSSQSLLHGDGYNYLDWYLQKPGRSPQLLIYLGSHRASGVPDRFSGSGSGTDFTLRISRVEAEDVGIYYCMQGLQTPFTFGPGTRVDLK

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 3 polymer

description	RSV Pre-fusion Protein
formula_weight	61626.5 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	A,B,C

MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGHHHHHHHH

Source

organism	Respiratory syncytial virus A2
ncbi_taxonomy_id	1972429
host_organism	Homo sapiens

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.87 Å
resolution_method	—
num_particles	139169

fit	/app/data/saxs_computation/v0/9v0p/9v0p.fit
pddf	/app/data/pr_computation/v0/9v0p/9v0p.pr.out
profile	/app/data/saxs_computation/v0/9v0p/9v0p.dat

Cryo-EM structure of RSV pre-F in complex with antibody CNR2053

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

EM 3D

5. Entities & Polymer Info (3)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)