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9v0q

Cryo-EM structure of RSV pre-F in complex with antibody CNR2056

Method: ELECTRON MICROSCOPY D_max: 141.5 Å Quality: REASONABLE

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9v0q
deposition_date	2025-05-18
title	Cryo-EM structure of RSV pre-F in complex with antibody CNR2056
keywords	RSV, Fusion Protein, Antibody, VIRAL PROTEIN; VIRAL PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	44.03 Å
rg_electron	43.46 Å
i0	746810000.00
molecular_weight	225830.0 kDa
excluded_volume	283090 Å³
envelope_volume	384610 Å³
shell_volume	73890 Å³
envelope_diameter	147.9 Å
shell_rg	47.99 Å
envelope_rg	43.29 Å
shape_rg	43.49 Å
total_rg	43.59 Å
total_atoms	15855
n_residues	2055
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	141.5 Å
rg_real	43.89 Å
rg_real_error	0.98 Å
i0_real	7.4680e+08
i0_real_error	1.2910e+07
rg_reciprocal	44.03 Å
i0_reciprocal	746900000.0000
total_estimate	0.6752
solution_quality	REASONABLE a REASONABLE solution
n_peaks	1
r_peak_primary	55.0 Å
skewness	0.189
kurtosis	-0.527
angular_range	— – 0.1800 Å⁻¹
current_alpha	0.0001
highest_alpha	68750000.0000
n_real_points	37
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.931; Stabil: 1.000; Sysdev: 0.032; Positv: 1.000; Valcen: 0.997; Smooth: 0.885

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	RSV Pre-fusion Protein
formula_weight	61626.5 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	B,F,G
atom_count	15855

MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGHHHHHHHH

Source

organism	Respiratory syncytial virus A2
ncbi_taxonomy_id	1972429
host_organism	Homo sapiens

Entity 2 polymer

description	CNR2056 Heavy Chain
formula_weight	13949.5 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	A,D,E

QVQLVESGGGVVQPGTSLTLSCAASGFTFRTYAFHWVRQAPGKGLEWLALVTYDGTTQYYADSVKGRLTIYRDNSKNTLFLHLNSLRRDDTAIYFCARGGEGSFSWLGYLQYMDVWGQGTTVTVSS

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 3 polymer

description	CNR2056 Light Chain
formula_weight	11619.6 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	C,H,I

QSALTQPASVSGSPGQSITLSCTGTSSDIGDYDYVSWYQKYPDTAPKLVIYDVSERPSGVSTRFSGSKSGNTASLTISGLQPEDEADYYCNSYSSTNTLKFGGGTKLTVL

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.850 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	3.85 Å
resolution_method	—
num_particles	31556

fit	/app/data/saxs_computation/v0/9v0q/9v0q.fit
pddf	/app/data/pr_computation/v0/9v0q/9v0q.pr.out
profile	/app/data/saxs_computation/v0/9v0q/9v0q.dat

Cryo-EM structure of RSV pre-F in complex with antibody CNR2056

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D

5. Entities & Polymer Info (3)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)