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9v0s

Cryo-EM structure of RSV pre-F in complex with antibody CNR2047

Method: ELECTRON MICROSCOPY D_max: 127.6 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9v0s
deposition_date	2025-05-18
title	Cryo-EM structure of RSV pre-F in complex with antibody CNR2047
keywords	RSV, Fusion Protein, Antibody, VIRAL PROTEIN; VIRAL PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	39.93 Å
rg_electron	39.25 Å
i0	740963000.00
molecular_weight	223120.0 kDa
excluded_volume	279600 Å³
envelope_volume	365950 Å³
shell_volume	75181 Å³
envelope_diameter	140.3 Å
shell_rg	46.58 Å
envelope_rg	39.18 Å
shape_rg	39.26 Å
total_rg	39.62 Å
total_atoms	15651
n_residues	2040
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	127.6 Å
rg_real	39.67 Å
rg_real_error	0.95 Å
i0_real	7.4100e+08
i0_real_error	1.2320e+07
rg_reciprocal	39.83 Å
i0_reciprocal	741100000.0000
total_estimate	0.8187
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	51.1 Å
skewness	0.169
kurtosis	-0.415
angular_range	— – 0.2000 Å⁻¹
current_alpha	0.0000
highest_alpha	114800000.0000
n_real_points	41
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.885; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.985; Smooth: 0.000

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	RSV Pre-fusion Protein
formula_weight	61626.5 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	B,A,C
atom_count	15651

MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGHHHHHHHH

Source

organism	Respiratory syncytial virus A2
ncbi_taxonomy_id	1972429
host_organism	Homo sapiens

Entity 2 polymer

description	CNR2047 Heavy Chain
formula_weight	12947.6 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	D,F,G

VQLVESGGGLVKPGESLRLSCAVSGSMFSSYVMHWVRQAPGKGLDWVSSITGGGNYISYADSVKGRFIISRDNGRNSLSLQMSSLRVDDTAVYYCVRGLSGVMGVTWFDSWGQGTLVTVSS

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 3 polymer

description	CNR2047 Light Chain
formula_weight	11717.9 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	E,H,I

QSVLTQPPSVSGAPGQRVTISCTGSSSNIGAGFDVHWYQHLPGKAPKVIIYENSHRPSGVPDRFFGSKSGTSASLSISGLQPEDEADYYCQSYDRGLDWVFGGGTKLTVL

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

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6. Citations (1)

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resolution	3.780 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	3.78 Å
resolution_method	—
num_particles	39908

fit	/app/data/saxs_computation/v0/9v0s/9v0s.fit
pddf	/app/data/pr_computation/v0/9v0s/9v0s.pr.out
profile	/app/data/saxs_computation/v0/9v0s/9v0s.dat

Cryo-EM structure of RSV pre-F in complex with antibody CNR2047

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Refinement

EM 3D

5. Entities & Polymer Info (3)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)