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9v0t

Cryo-EM structure of hMPV pre-F in complex with antibody CNR2047

Method: ELECTRON MICROSCOPY D_max: 100.9 Å Quality: EXCELLENT

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9v0t
deposition_date	2025-05-18
title	Cryo-EM structure of hMPV pre-F in complex with antibody CNR2047
keywords	hMPV, Fusion Protein, Antibody, VIRAL PROTEIN; VIRAL PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	31.75 Å
rg_electron	31.30 Å
i0	86671500.00
molecular_weight	72539.0 kDa
excluded_volume	90489 Å³
envelope_volume	119330 Å³
shell_volume	33290 Å³
envelope_diameter	107.7 Å
shell_rg	36.50 Å
envelope_rg	31.36 Å
shape_rg	31.27 Å
total_rg	31.89 Å
total_atoms	5090
n_residues	673
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	100.9 Å
rg_real	31.73 Å
rg_real_error	0.71 Å
i0_real	8.6670e+07
i0_real_error	1.3110e+06
rg_reciprocal	31.74 Å
i0_reciprocal	86670000.0000
total_estimate	0.9039
solution_quality	EXCELLENT a EXCELLENT solution
n_peaks	1
r_peak_primary	32.3 Å
skewness	0.218
kurtosis	-0.691
angular_range	— – 0.2500 Å⁻¹
current_alpha	0.0000
highest_alpha	17200000.0000
n_real_points	51
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.949; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.978; Smooth: 0.920

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	CNR2047 heavy chain
formula_weight	12947.6 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	D
atom_count	5090

VQLVESGGGLVKPGESLRLSCAVSGSMFSSYVMHWVRQAPGKGLDWVSSITGGGNYISYADSVKGRFIISRDNGRNSLSLQMSSLRVDDTAVYYCVRGLSGVMGVTWFDSWGQGTLVTVSS

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 polymer

description	CNR2047 light chain
formula_weight	11717.9 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	E

QSVLTQPPSVSGAPGQRVTISCTGSSSNIGAGFDVHWYQHLPGKAPKVIIYENSHRPSGVPDRFFGSKSGTSASLSISGLQPEDEADYYCQSYDRGLDWVFGGGTKLTVL

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 3 polymer

description	hMPV fusion protein
formula_weight	59332.3 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	F

MSWKVVIIFSLLITPQHGLKESYLEESCSTITEGYLSVLRTGWYTNVFTLEVGDVENLTCADGPSLIKTELDLTKSALRELRTVSADQLAREEQIENPRRRRFVLGAIALGVATAAAVTAGVAIAKTIRLESEVTAIKNALKKTNEAVSTLGNGVRVLATAVRELKDFVSKNLTRAINKNKCDIPDLKMAVSFSQFNRRFLNVVRQFSDNAGITPAISLDLMTDAELARAVSNMPTSAGQIKLMLENRAMVRRKGFGILIGVYGSSVIYMVQLPIFGVIDTPCWIVKAAPSCSEKKGNYACLLREDQGWYCQNAGSTVYYPNEKDCETRGDHVFCDTAAGINVAEQSKECNINISTTNYPCKVSTGRHPISMVALSPLGALVACYKGVSCSIGSNRVGIIKQLNKGCSYITNQDADTVTIDNTVYQLSKVEGEQHVIKGRPVSSSFDPVKFPEDQFNVALDQVFESIENSQALVDQSNRILSSAEKGNTSGRENLYFQGGGGSGYIPEAPRDGQAYVRKDGEWVLLSTFLGGIEGRHHHHHH

Source

organism	Human metapneumovirus A
ncbi_taxonomy_id	3037664
host_organism	Homo sapiens

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	4.120 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	4.12 Å
resolution_method	—
num_particles	49711

fit	/app/data/saxs_computation/v0/9v0t/9v0t.fit
pddf	/app/data/pr_computation/v0/9v0t/9v0t.pr.out
profile	/app/data/saxs_computation/v0/9v0t/9v0t.dat

Cryo-EM structure of hMPV pre-F in complex with antibody CNR2047

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D

5. Entities & Polymer Info (3)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)