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9v11

The Fab fragment of Osemitamab (TST001), a therapeutic antibody targeting claudin 18.2

Method: X-RAY DIFFRACTION D_max: 82.2 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9v11
deposition_date	2025-05-19
last_revision	2026-05-27
title	The Fab fragment of Osemitamab (TST001), a therapeutic antibody targeting claudin 18.2
keywords	CLDN18.2, gastric cancer, antibody, crystal, ANTITUMOR PROTEIN; ANTITUMOR PROTEIN
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	24.76 Å
rg_electron	23.94 Å
i0	41526400.00
molecular_weight	47870.0 kDa
excluded_volume	58958 Å³
envelope_volume	72119 Å³
shell_volume	25246 Å³
envelope_diameter	84.4 Å
shell_rg	30.88 Å
envelope_rg	23.83 Å
shape_rg	23.92 Å
total_rg	24.75 Å
total_atoms	3348
n_residues	430
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	82.2 Å
rg_real	24.73 Å
rg_real_error	0.44 Å
i0_real	4.1530e+07
i0_real_error	5.6680e+05
rg_reciprocal	24.74 Å
i0_reciprocal	41530000.0000
total_estimate	0.8929
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	28.7 Å
skewness	0.302
kurtosis	-0.417
angular_range	— – 0.3200 Å⁻¹
current_alpha	0.0002
highest_alpha	10830000.0000
n_real_points	64
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.882; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.963; Smooth: 0.993

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4. Crystallography & Experiment

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5. Entities & Polymer Info (4)

Entity 1 polymer

description	Fab of Osemitamab (TST001), Heavy chain
formula_weight	27096.1 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	H
atom_count	3636

QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYNMNWVRQAPGQGLEWMGNIDPYYGGTSYNQKFKGRVTMTIDKSTSTVYMELSSLRSEDTAVYYCARMYHGNAFDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCAAAENLYFQGDYKDDDDKHHHHHHHHHH

Source

organism	Mus musculus
ncbi_taxonomy_id	10090
host_organism	Escherichia coli

Entity 2 polymer

description	Fab of Osemitamab (TST001), Light chain
formula_weight	24122.8 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	L

DIVMTQSPDSLAVSLGERATINCKSSQSLLNSGNLKNYLTWYQQKPGQPPKLLIYWASTRKSGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQNDYSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Source

organism	Mus musculus
ncbi_taxonomy_id	10090
host_organism	Escherichia coli

Entity 3 non-polymer

description	SULFATE ION
formula_weight	96.1 kDa
src_method	syn
entity_count	12

Entity 4 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	261

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6. Citations (1)

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length_a	36.512 Å
length_b	106.144 Å
length_c	112.148 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	4

space_group	P 21 21 21
int_tables_number	19
crystal_system	—

resolution	1.728 Å
resolution_low	47.972 Å
r_factor	0.2008
r_work	0.1995
r_free	0.2286

fit	/app/data/saxs_computation/v1/9v11/9v11.fit
pddf	/app/data/pr_computation/v1/9v11/9v11.pr.out
profile	/app/data/saxs_computation/v1/9v11/9v11.dat

The Fab fragment of Osemitamab (TST001), a therapeutic antibody targeting claudin 18.2

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction

5. Entities & Polymer Info (4)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 non-polymer

Entity 4 water

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)