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9v6u

The cryo-EM structure of FD4 bound Lewy fold fibril.

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Alpha-synuclein

OrganismNot specified

UniProt P37840

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 15 (2~{R})-1-fluoranyl-3-[[2-[(~{E})-2-[5-[6-(methylamino)pyridin-3-yl]pyridin-2-yl]ethenyl]-1,3-benzothiazol-6-yl]oxy]propan-2-ol × 18 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1xq8 2jn5 2kkw 9hgs

4 assemblies

Homodimer
9cx6 9hgr 9hxa

3 assemblies

Homotetramer

None

Other homooligomers
10xu 2n0a 4r0u 4r0w 4rik 4ril 4znn 6a6b 6cu7 6cu8 6h6b 6l1t

196 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
2m55 2x6m 3q25 3q25 3q26 3q27 3q28 3q29 3q29 4bxl 6i42 7stx

32 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name SYUA_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain c； PDBConstruct 1–139； UniProt 1–140 Author chain d； PDBConstruct 1–139； UniProt 1–140 Author chain e； PDBConstruct 1–139； UniProt 1–140 Author chain f； PDBConstruct 1–139； UniProt 1–140 Author chain g； PDBConstruct 1–139； UniProt 1–140 Author chain h； PDBConstruct 1–139； UniProt 1–140 Author chain i； PDBConstruct 1–139； UniProt 1–140 Author chain j； PDBConstruct 1–139； UniProt 1–140 Author chain k； PDBConstruct 1–139； UniProt 1–140 Author chain o； PDBConstruct 1–139； UniProt 1–140 Author chain p； PDBConstruct 1–139； UniProt 1–140 Author chain q； PDBConstruct 1–139； UniProt 1–140 Author chain r； PDBConstruct 1–139； UniProt 1–140 Author chain s； PDBConstruct 1–139； UniProt 1–140 Author chain t； PDBConstruct 1–139； UniProt 1–140

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9v6u
Deposition date deposition_date2025-05-27
Structure title titleThe cryo-EM structure of FD4 bound Lewy fold fibril.
Keywords keywordsamyloid, PROTEIN FIBRIL; PROTEIN FIBRIL
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9v6u__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9v6u__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9v6u__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）30.49 Å
Rg (electron density)29.29 Å
Total Rg29.99 Å
Atom count7758
Residues1035
Excluded volume137240 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9v6u__assembly_1__model_1 pentadecameric （15） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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7. Citations (1)