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9wni

Wild-type Menin complexed with KO-539

Method: X-RAY DIFFRACTION D_max: 98.4 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9wni
deposition_date	2025-09-04
last_revision	2026-04-29
title	Wild-type Menin complexed with KO-539
keywords	HUMAN MENIN, TRANSCRIPTION, M322I MUTANT INHIBITOR COMPLEX, DS1594; TRANSCRIPTION
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	31.74 Å
rg_electron	30.89 Å
i0	319978000.00
molecular_weight	96111.0 kDa
excluded_volume	93253 Å³
envelope_volume	166610 Å³
shell_volume	43976 Å³
envelope_diameter	106.6 Å
shell_rg	38.90 Å
envelope_rg	30.24 Å
shape_rg	30.89 Å
total_rg	31.40 Å
total_atoms	7293
n_residues	906
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	98.4 Å
rg_real	31.55 Å
rg_real_error	0.67 Å
i0_real	3.2000e+08
i0_real_error	4.5930e+06
rg_reciprocal	31.63 Å
i0_reciprocal	320000000.0000
total_estimate	0.8985
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	43.3 Å
skewness	0.108
kurtosis	-0.524
angular_range	— – 0.2500 Å⁻¹
current_alpha	0.0000
highest_alpha	59890000.0000
n_real_points	51
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.927; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.991; Smooth: 0.906

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4. Crystallography & Experiment

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5. Entities & Polymer Info (4)

Entity 1 polymer

description	Menin
formula_weight	54723.1 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	A,B
atom_count	7723

GLKTAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRITFQSEKMKGMKELLVATKINSSAIKLQLTAQS

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 2 non-polymer

description	Ziftomenib
formula_weight	717.9 kDa
src_method	syn
entity_count	2

Entity 3 non-polymer

description	MAGNESIUM ION
formula_weight	24.3 kDa
src_method	nat
entity_count	2

Entity 4 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	425

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6. Citations (1)

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length_a	70.089 Å
length_b	78.852 Å
length_c	93.340 Å
angle_alpha	90.00 °
angle_beta	101.54 °
angle_gamma	90.00 °
z_pdb	4

space_group	P 1 21 1
int_tables_number	4
crystal_system	—

resolution	2.400 Å
resolution_low	48.340 Å
r_factor	0.2112
r_work	0.2079
r_free	0.2747

fit	/app/data/saxs_computation/wn/9wni/9wni.fit
pddf	/app/data/pr_computation/wn/9wni/9wni.pr.out
profile	/app/data/saxs_computation/wn/9wni/9wni.dat

Wild-type Menin complexed with KO-539

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction