Superoxide dismutase [Cu-Zn]
Homo sapiens
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein homooligomer Homooligomer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain A； UniProt 2–154 Chain B； UniProt 2–154 | Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；293 K；Ammonium sulfate, sodium acetate, PVP-K15 | Resolution 2.30 Å R-free 0.210 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 9XJ0 | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1AZV FAMILIAL ALS MUTANT G37R CUZNSOD (HUMAN) Deposited 1997-11-21 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：G37R Mutation：G37R | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.5；20 MG/ML PROTEIN IN 10MM ACETATE PH 5.5 MIXED WITH PRECIPITATING SOLUTION OF 100 MM ACETATE PH 4.6, 2.0 M AMMONIUM SULFATE
|
Resolution 1.90 Å R-free 0.244 |
| 1BA9 THE SOLUTION STRUCTURE OF REDUCED MONOMERIC SUPEROXIDE DISMUTASE, NMR, 36 STRUCTURES Deposited 1998-04-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–153（153 aa）
|
Mutation：C6A, F50E, G51E, C111S, E133Q | ZN ZINC ION × 1 CU1 COPPER (I) ION × 1 |
SOLUTION NMR
NMR measurement conditions
pH 5；298 K；Pressure 1
NMR sample composition
H2O AND D2O
|
Resolution not provided |
| 1DSW THE SOLUTION STRUCTURE OF A MONOMERIC, REDUCED FORM OF HUMAN COPPER, ZINC SUPEROXIDE DISMUTASE BEARING THE SAME CHARGE AS THE NATIVE PROTEIN Deposited 2000-01-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
Fragment：;M4SOD IS A MONOMERIC VARIANT OF HUMAN SOD. THE MUTANT IS STUDIED IN THE REDUCED FORM, EACH MOLECULE CONTAINS A CU(I) AND A ZN(II) IONS.
;
|
Mutation：YES | CU COPPER (II) ION × 1 ZN ZINC ION × 1 |
SOLUTION NMR
NMR measurement conditions
pH 5；298 K；Pressure ATMOSPHERIC
NMR sample composition
2MM M4SOD FULLY ENRICHED IN 15N; 20MM PHOSPHATE BUFFER PH 5.0; 90% H2O, 10% D2O. THE PROTEIN WAS REDUCED WITH SODIUM ISOASCORBATE UNDER UNAEROBIC CONDITIONS.
|
Resolution not provided |
| 1FUN SUPEROXIDE DISMUTASE MUTANT WITH LYS 136 REPLACED BY GLU, CYS 6 REPLACED BY ALA AND CYS 111 REPLACED BY SER (K136E, C6A, C111S) Deposited 1998-07-23 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain F
1–153（153 aa）
|
Mutation：C6A, C111S, K136E Mutation：C6A, C111S, K136E | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；pH 7.0
|
Resolution 2.85 Å |
| 1FUN SUPEROXIDE DISMUTASE MUTANT WITH LYS 136 REPLACED BY GLU, CYS 6 REPLACED BY ALA AND CYS 111 REPLACED BY SER (K136E, C6A, C111S) Deposited 1998-07-23 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
1–153（153 aa）
Chain G
1–153（153 aa）
|
Mutation：C6A, C111S, K136E Mutation：C6A, C111S, K136E | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；pH 7.0
|
Resolution 2.85 Å |
| 1FUN SUPEROXIDE DISMUTASE MUTANT WITH LYS 136 REPLACED BY GLU, CYS 6 REPLACED BY ALA AND CYS 111 REPLACED BY SER (K136E, C6A, C111S) Deposited 1998-07-23 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
Chain H
1–153（153 aa）
|
Mutation：C6A, C111S, K136E Mutation：C6A, C111S, K136E | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；pH 7.0
|
Resolution 2.85 Å |
| 1FUN SUPEROXIDE DISMUTASE MUTANT WITH LYS 136 REPLACED BY GLU, CYS 6 REPLACED BY ALA AND CYS 111 REPLACED BY SER (K136E, C6A, C111S) Deposited 1998-07-23 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–153（153 aa）
Chain I
1–153（153 aa）
|
Mutation：C6A, C111S, K136E Mutation：C6A, C111S, K136E | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；pH 7.0
|
Resolution 2.85 Å |
| 1FUN SUPEROXIDE DISMUTASE MUTANT WITH LYS 136 REPLACED BY GLU, CYS 6 REPLACED BY ALA AND CYS 111 REPLACED BY SER (K136E, C6A, C111S) Deposited 1998-07-23 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–153（153 aa）
Chain J
1–153（153 aa）
|
Mutation：C6A, C111S, K136E Mutation：C6A, C111S, K136E | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；pH 7.0
|
Resolution 2.85 Å |
| 1HL4 The Structure of Apo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2M NH4CL, 20%PEG2000, 10% ETHYLENE GLYCOL, 0.1 M MES PH 5.6
|
Resolution 1.82 Å R-free 0.283 |
| 1HL4 The Structure of Apo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2M NH4CL, 20%PEG2000, 10% ETHYLENE GLYCOL, 0.1 M MES PH 5.6
|
Resolution 1.82 Å R-free 0.283 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain H
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
2–154（153 aa）
Chain I
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain J
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 CA CALCIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
2–154（153 aa）
Chain K
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 CA CALCIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain L
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
2–154（153 aa）
Chain M
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different experimental conditions Different structure-quality metrics | Assembly 7 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
Chain N
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 8 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain O
2–154（153 aa）
Chain Q
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 CA CALCIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different experimental conditions Different structure-quality metrics | Assembly 9 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain P
2–154（153 aa）
Chain S
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1KMG The Solution Structure Of Monomeric Copper-free Superoxide Dismutase Deposited 2001-12-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–153（153 aa）
|
Mutation：C6A, F50E, G51E, C111S, E133Q | ZN ZINC ION × 1 |
SOLUTION NMR
NMR measurement conditions
pH 5；298 K；Ionic strength (raw mmCIF value) 20 mM phosphate；Pressure 1
NMR sample composition
2mM of 15N and 13C enriched superoxide dismutase | 20mM phosphate buffer, 10% D20
NMR sample composition
2mM of 15N and 13C enriched superoxide dismutase | 20mM phosphate buffer, 10% D20
NMR sample composition
2mM unlabelled superoxide dismutase | 20mM phosphate buffer, 10% D20
|
Resolution not provided |
| 1L3N The Solution Structure of Reduced Dimeric Copper Zinc SOD: the Structural Effects of Dimerization Deposited 2002-02-28 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：C6A, C111S Mutation：C6A, C111S | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
SOLUTION NMR
NMR measurement conditions
pH 5；296 K；Pressure 1
NMR measurement conditions
pH 5；286 K；Pressure 1
NMR sample composition
Cu(I),Zn(II) SOD 2mM enriched in 15N | 20mM phosphate buffer pH5.00
10% D2O, 8mM ascorbate reductant
NMR sample composition
Cu(I),Zn(II) SOD 2mM enriched in 15N, 13C | 20mM phosphate buffer pH5.00
10% D2O, 8mM ascorbate reductant
NMR sample composition
Cu(I),Zn(II) SOD 2mM enriched in 15N, 13C and 2H at 70% | 20mM phosphate buffer pH5.00
10% D2O, 8mM ascorbate reductant
NMR sample composition
Cu(I),Zn(II) SOD 2mM enriched in 15N | 20mM phosphate buffer pH5.00
100% D2O, 8mM ascorbate reductant
|
Resolution not provided |
| 1MFM MONOMERIC HUMAN SOD MUTANT F50E/G51E/E133Q AT ATOMIC RESOLUTION Deposited 1999-04-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–153（153 aa）
|
Mutation：C6A,F50E,G51E,C111S,E133Q | ZN ZINC ION × 1 CU COPPER (II) ION × 1 CD CADMIUM ION × 9 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；PEG 6000 15%, CDCL2 200-400 MM, TRIS 100MM, PH=8, pH 8.0
|
Resolution 1.02 Å |
| 1N18 Thermostable mutant of Human Superoxide Dismutase, C6A, C111S Deposited 2002-10-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
0–153（154 aa）
Chain B
0–153（154 aa）
|
Mutation：C6A, C111S Mutation：C6A, C111S | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；Ammonium Sulfate, NaCl, Tris, EDTA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.250 |
| 1N18 Thermostable mutant of Human Superoxide Dismutase, C6A, C111S Deposited 2002-10-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
0–153（154 aa）
Chain D
0–153（154 aa）
|
Mutation：C6A, C111S Mutation：C6A, C111S | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；Ammonium Sulfate, NaCl, Tris, EDTA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.250 |
| 1N18 Thermostable mutant of Human Superoxide Dismutase, C6A, C111S Deposited 2002-10-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
0–153（154 aa）
Chain F
0–153（154 aa）
|
Mutation：C6A, C111S Mutation：C6A, C111S | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；Ammonium Sulfate, NaCl, Tris, EDTA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.250 |
| 1N18 Thermostable mutant of Human Superoxide Dismutase, C6A, C111S Deposited 2002-10-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
0–153（154 aa）
Chain H
0–153（154 aa）
|
Mutation：C6A, C111S Mutation：C6A, C111S | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；Ammonium Sulfate, NaCl, Tris, EDTA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.250 |
| 1N18 Thermostable mutant of Human Superoxide Dismutase, C6A, C111S Deposited 2002-10-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
0–153（154 aa）
Chain J
0–153（154 aa）
|
Mutation：C6A, C111S Mutation：C6A, C111S | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；Ammonium Sulfate, NaCl, Tris, EDTA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.250 |
| 1N19 Structure of the HSOD A4V mutant Deposited 2002-10-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
0–153（154 aa）
Chain B
0–153（154 aa）
|
Mutation：A4V, C6A, C111S Mutation：A4V, C6A, C111S | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；ammonium sulfate, NaCl, Tris, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.86 Å R-free 0.260 |
| 1OEZ Zn His46Arg mutant of Human Cu, Zn Superoxide Dismutase Deposited 2003-04-02 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain Y
1–153（153 aa）
Chain Z
1–153（153 aa）
|
Mutation：YES Mutation：YES | ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2M NA2SO4, 15% PEG 3350, pH 8.00
|
Resolution 2.15 Å R-free 0.234 |
| 1OEZ Zn His46Arg mutant of Human Cu, Zn Superoxide Dismutase Deposited 2003-04-02 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain W
1–153（153 aa）
Chain X
1–153（153 aa）
|
Mutation：YES Mutation：YES | ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2M NA2SO4, 15% PEG 3350, pH 8.00
|
Resolution 2.15 Å R-free 0.234 |
| 1OZT Crystal Structure of apo-H46R Familial ALS Mutant human Cu,Zn Superoxide Dismutase (CuZnSOD) to 2.5A resolution Deposited 2003-04-09 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain M
1–153（153 aa）
Chain N
1–153（153 aa）
|
Mutation：H46R Mutation：H46R | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；magnesium acetate, sodium cacodylate, PEG 8000, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.50 Å R-free 0.270 |
| 1OZT Crystal Structure of apo-H46R Familial ALS Mutant human Cu,Zn Superoxide Dismutase (CuZnSOD) to 2.5A resolution Deposited 2003-04-09 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
1–153（153 aa）
Chain H
1–153（153 aa）
|
Mutation：H46R Mutation：H46R | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；magnesium acetate, sodium cacodylate, PEG 8000, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.50 Å R-free 0.270 |
| 1OZT Crystal Structure of apo-H46R Familial ALS Mutant human Cu,Zn Superoxide Dismutase (CuZnSOD) to 2.5A resolution Deposited 2003-04-09 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain K
1–153（153 aa）
Chain L
1–153（153 aa）
|
Mutation：H46R Mutation：H46R | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；magnesium acetate, sodium cacodylate, PEG 8000, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.50 Å R-free 0.270 |
| 1OZT Crystal Structure of apo-H46R Familial ALS Mutant human Cu,Zn Superoxide Dismutase (CuZnSOD) to 2.5A resolution Deposited 2003-04-09 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–153（153 aa）
Chain J
1–153（153 aa）
|
Mutation：H46R Mutation：H46R | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；magnesium acetate, sodium cacodylate, PEG 8000, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.50 Å R-free 0.270 |
| 1OZU Crystal Structure of Familial ALS Mutant S134N of human Cu,Zn Superoxide Dismutase (CuZnSOD) to 1.3A resolution Deposited 2003-04-09 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：S134N Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：S134N Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 3 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；Ammonium sulfate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 1.30 Å R-free 0.193 |
| 1P1V Crystal Structure of FALS-associated human Copper-Zinc Superoxide Dismutase (CuZnSOD) Mutant D125H to 1.4A Deposited 2003-04-14 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：D125H Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：D125H Non-standard monomer：Yes (specific site not provided by mmCIF) | SO4 SULFATE ION × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；278 K；zinc sulfate, PEG MME 550, MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 278K
|
Resolution 1.40 Å R-free 0.212 |
| 1P1V Crystal Structure of FALS-associated human Copper-Zinc Superoxide Dismutase (CuZnSOD) Mutant D125H to 1.4A Deposited 2003-04-14 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
|
Mutation：D125H Non-standard monomer：Yes (specific site not provided by mmCIF) | SO4 SULFATE ION × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；278 K；zinc sulfate, PEG MME 550, MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 278K
|
Resolution 1.40 Å R-free 0.212 |
| 1PTZ Crystal structure of the human CU, Zn Superoxide Dismutase, Familial Amyotrophic Lateral Sclerosis (FALS) Mutant H43R Deposited 2003-06-23 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：C6A, C111S, H43R Mutation：C6A, C111S, H43R | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；294 K；ammonium sulphate, sodium chloride, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 294K
|
Resolution 1.80 Å R-free 0.215 |
| 1PU0 Structure of Human Cu,Zn Superoxide Dismutase Deposited 2003-06-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Not recorded | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；ammonium sulphate, sodium chloride, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.70 Å R-free 0.243 |
| 1PU0 Structure of Human Cu,Zn Superoxide Dismutase Deposited 2003-06-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
Chain D
1–153（153 aa）
|
Not recorded | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；ammonium sulphate, sodium chloride, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.70 Å R-free 0.243 |
| 1PU0 Structure of Human Cu,Zn Superoxide Dismutase Deposited 2003-06-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–153（153 aa）
Chain F
1–153（153 aa）
|
Not recorded | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；ammonium sulphate, sodium chloride, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.70 Å R-free 0.243 |
| 1PU0 Structure of Human Cu,Zn Superoxide Dismutase Deposited 2003-06-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
1–153（153 aa）
Chain H
1–153（153 aa）
|
Not recorded | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；ammonium sulphate, sodium chloride, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.70 Å R-free 0.243 |
| 1PU0 Structure of Human Cu,Zn Superoxide Dismutase Deposited 2003-06-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–153（153 aa）
Chain J
1–153（153 aa）
|
Not recorded | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；ammonium sulphate, sodium chloride, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.70 Å R-free 0.243 |
| 1RK7 Solution structure of apo Cu,Zn Superoxide Dismutase: role of metal ions in protein folding Deposited 2003-11-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–153（153 aa）
|
Mutation：C6A, F50E, G51E, C111S, E133Q | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 5；298 K；Pressure 1
NMR sample composition
Apo SOD 2mM | 20mM phosphate buffer pH5.0, 10% D2O
NMR sample composition
Apo SOD 2mM enriched in 15N | 20mM phosphate buffer pH5.0, 10% D2O
NMR sample composition
Apo SOD 2mM enriched in 15N and 13C | 20mM phosphate buffer pH5.0, 10% D2O
|
Resolution not provided |
| 1SOS ATOMIC STRUCTURES OF WILD-TYPE AND THERMOSTABLE MUTANT RECOMBINANT HUMAN CU, ZN SUPEROXIDE DISMUTASE Deposited 1992-02-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain F
1–153（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1SOS ATOMIC STRUCTURES OF WILD-TYPE AND THERMOSTABLE MUTANT RECOMBINANT HUMAN CU, ZN SUPEROXIDE DISMUTASE Deposited 1992-02-11 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
1–153（153 aa）
Chain G
1–153（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1SOS ATOMIC STRUCTURES OF WILD-TYPE AND THERMOSTABLE MUTANT RECOMBINANT HUMAN CU, ZN SUPEROXIDE DISMUTASE Deposited 1992-02-11 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
Chain H
1–153（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1SOS ATOMIC STRUCTURES OF WILD-TYPE AND THERMOSTABLE MUTANT RECOMBINANT HUMAN CU, ZN SUPEROXIDE DISMUTASE Deposited 1992-02-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–153（153 aa）
Chain I
1–153（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1SOS ATOMIC STRUCTURES OF WILD-TYPE AND THERMOSTABLE MUTANT RECOMBINANT HUMAN CU, ZN SUPEROXIDE DISMUTASE Deposited 1992-02-11 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–153（153 aa）
Chain J
1–153（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1SPD AMYOTROPHIC LATERAL SCLEROSIS AND STRUCTURAL DEFECTS IN CU,ZN SUPEROXIDE DISMUTASE Deposited 1993-07-21 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.40 Å |
| 1UXL I113T mutant of human SOD1 Deposited 2004-02-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain F
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；100 MM NACL, 2.4M AMMONIUM SULPHATE PH 7.5
|
Resolution 1.60 Å R-free 0.196 |
| 1UXL I113T mutant of human SOD1 Deposited 2004-02-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
1–153（153 aa）
Chain G
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；100 MM NACL, 2.4M AMMONIUM SULPHATE PH 7.5
|
Resolution 1.60 Å R-free 0.196 |
| 1UXL I113T mutant of human SOD1 Deposited 2004-02-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
Chain H
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；100 MM NACL, 2.4M AMMONIUM SULPHATE PH 7.5
|
Resolution 1.60 Å R-free 0.196 |
| 1UXL I113T mutant of human SOD1 Deposited 2004-02-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–153（153 aa）
Chain I
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；100 MM NACL, 2.4M AMMONIUM SULPHATE PH 7.5
|
Resolution 1.60 Å R-free 0.196 |
| 1UXL I113T mutant of human SOD1 Deposited 2004-02-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–153（153 aa）
Chain J
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；100 MM NACL, 2.4M AMMONIUM SULPHATE PH 7.5
|
Resolution 1.60 Å R-free 0.196 |
| 1UXM A4V mutant of human SOD1 Deposited 2004-02-26 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；0.2 M CA ACET, 15% PEG 2000, 0.1 M TRIS PH 8.0
|
Resolution 1.90 Å R-free 0.250 |
| 1UXM A4V mutant of human SOD1 Deposited 2004-02-26 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
Chain D
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；0.2 M CA ACET, 15% PEG 2000, 0.1 M TRIS PH 8.0
|
Resolution 1.90 Å R-free 0.250 |
| 1UXM A4V mutant of human SOD1 Deposited 2004-02-26 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–153（153 aa）
Chain F
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；0.2 M CA ACET, 15% PEG 2000, 0.1 M TRIS PH 8.0
|
Resolution 1.90 Å R-free 0.250 |
| 1UXM A4V mutant of human SOD1 Deposited 2004-02-26 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
1–153（153 aa）
Chain H
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；0.2 M CA ACET, 15% PEG 2000, 0.1 M TRIS PH 8.0
|
Resolution 1.90 Å R-free 0.250 |
| 1UXM A4V mutant of human SOD1 Deposited 2004-02-26 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–153（153 aa）
Chain J
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；0.2 M CA ACET, 15% PEG 2000, 0.1 M TRIS PH 8.0
|
Resolution 1.90 Å R-free 0.250 |
| 1UXM A4V mutant of human SOD1 Deposited 2004-02-26 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain K
1–153（153 aa）
Chain L
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；0.2 M CA ACET, 15% PEG 2000, 0.1 M TRIS PH 8.0
|
Resolution 1.90 Å R-free 0.250 |
| 2AF2 Solution structure of disulfide reduced and copper depleted Human Superoxide Dismutase Deposited 2005-07-25 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：C6A, C111S Mutation：C6A, C111S | ZN ZINC ION × 2 |
SOLUTION NMR
NMR measurement conditions
pH 5；298 K；Ionic strength (raw mmCIF value) 20mM sodium phosphate；Pressure 1
NMR sample composition
1.5mM 15N protein sample | 20mM sodium phosphate, 20mM DTT buffer, pH 5, 90% H2O, 10% D2O
NMR sample composition
1mM 15N;13C protein sample | 20mM sodium phosphate, 20mM DTT buffer, pH 5, 90% H2O, 10% D2O
NMR sample composition
1mM 15N;13C;2H protein sample. The triple labeled dimeric SOD contained about 70% 2H | 20mM sodium phosphate, 20mM DTT, buffer, pH 5, 90% H2O, 10% D2O
|
Resolution not provided |
| 2C9S 1.24 Angstroms resolution structure of Zn-Zn Human Superoxide dismutase Deposited 2005-12-14 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain F
1–153（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 6 ACT ACETATE ION × 3 SO4 SULFATE ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.75；2.5M AMMONIUM SULPHATE,0.1M NACL,50MM ACETATE BUFFER, pH 4.75
|
Resolution 1.24 Å R-free 0.194 |
| 2C9U 1.24 Angstroms resolution structure of as-isolated Cu-Zn Human Superoxide dismutase Deposited 2005-12-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain F
1–153（153 aa）
|
Not recorded | SO4 SULFATE ION × 3 CU COPPER (II) ION × 2 ZN ZINC ION × 4 ACT ACETATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；3.0 M AMMONIUM SULPHATE, 100 MM SODIUM CHLORITE, 50MM SODIUM ACETATE BUFFER, pH 8.00
|
Resolution 1.24 Å R-free 0.176 |
| 2C9V Atomic resolution structure of Cu-Zn Human Superoxide dismutase Deposited 2005-12-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain F
1–153（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 5 NA SODIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.75；3.0M AMMONIUM SULPHATE, 0.1M NACL, 50MM ACETATE BUFFER, pH 4.75
|
Resolution 1.07 Å R-free 0.158 |
| 2GBT C6A/C111A CuZn Superoxide dismutase Deposited 2006-03-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：C6A/C111A Mutation：C6A/C111A | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；18% PEG8000, 50mM TRIS-HCL, 50mM NaAc, 1mM EDTA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 1.70 Å R-free 0.230 |
| 2GBT C6A/C111A CuZn Superoxide dismutase Deposited 2006-03-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
Chain D
1–153（153 aa）
|
Mutation：C6A/C111A Mutation：C6A/C111A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；18% PEG8000, 50mM TRIS-HCL, 50mM NaAc, 1mM EDTA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 1.70 Å R-free 0.230 |
| 2GBU C6A/C111A/C57A/C146A apo CuZn Superoxide dismutase Deposited 2006-03-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：C6A/C111A/C57A/C146A Mutation：C6A/C111A/C57A/C146A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；25% PEG4000, 0.1M Na Cacodylate, 50mM NaAc, 1mM EDTA, 1mM NaN3, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.257 |
| 2GBU C6A/C111A/C57A/C146A apo CuZn Superoxide dismutase Deposited 2006-03-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
Chain D
1–153（153 aa）
|
Mutation：C6A/C111A/C57A/C146A Mutation：C6A/C111A/C57A/C146A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；25% PEG4000, 0.1M Na Cacodylate, 50mM NaAc, 1mM EDTA, 1mM NaN3, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.257 |
| 2GBV C6A/C111A/C57A/C146A holo CuZn Superoxide dismutase Deposited 2006-03-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain F
1–153（153 aa）
|
Mutation：C6A/C111A/C57A/C146A Mutation：C6A/C111A/C57A/C146A | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；2.8M Ammonium Sulphate, 50mM NaAc, 0.1M TRIS-HCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.207 |
| 2GBV C6A/C111A/C57A/C146A holo CuZn Superoxide dismutase Deposited 2006-03-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
1–153（153 aa）
Chain G
1–153（153 aa）
|
Mutation：C6A/C111A/C57A/C146A Mutation：C6A/C111A/C57A/C146A | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；2.8M Ammonium Sulphate, 50mM NaAc, 0.1M TRIS-HCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.207 |
| 2GBV C6A/C111A/C57A/C146A holo CuZn Superoxide dismutase Deposited 2006-03-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
Chain H
1–153（153 aa）
|
Mutation：C6A/C111A/C57A/C146A Mutation：C6A/C111A/C57A/C146A | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；2.8M Ammonium Sulphate, 50mM NaAc, 0.1M TRIS-HCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.207 |
| 2GBV C6A/C111A/C57A/C146A holo CuZn Superoxide dismutase Deposited 2006-03-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–153（153 aa）
Chain I
1–153（153 aa）
|
Mutation：C6A/C111A/C57A/C146A Mutation：C6A/C111A/C57A/C146A | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；2.8M Ammonium Sulphate, 50mM NaAc, 0.1M TRIS-HCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.207 |
| 2GBV C6A/C111A/C57A/C146A holo CuZn Superoxide dismutase Deposited 2006-03-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–153（153 aa）
Chain J
1–153（153 aa）
|
Mutation：C6A/C111A/C57A/C146A Mutation：C6A/C111A/C57A/C146A | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；2.8M Ammonium Sulphate, 50mM NaAc, 0.1M TRIS-HCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.207 |
| 2LU5 Structure and chemical shifts of Cu(I),Zn(II) superoxide dismutase by solid-state NMR Deposited 2012-06-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
|
Mutation：C6A, C111S | CU COPPER (II) ION × 1 |
SOLID-STATE NMR
NMR measurement conditions
pH 5；286 K；Ionic strength (raw mmCIF value) 0.02；Pressure ambient
NMR sample composition
3.5 mg [U-13C; U-15N; U-2H] Superoxide dismutase C6A/C111S thermostable mutant, 20 mM Sodium Citrate, 20% w/v Polyethylene Glycol 6000, 100% H2O | 100% H2O
|
Resolution not provided |
| 2MP3 Truncated L126Z-sod1 in DPC micelle Deposited 2014-05-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–126（125 aa）
Fragment：UNP residues 2-126
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4；313 K；Pressure ambient
NMR sample composition
20 mM dodecylphosphocholine (DPC)-1, 400 uM [U-100% 13C; U-100% 15N] protein-2, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2NAM Full-length WT SOD1 in DPC MICELLE Deposited 2016-01-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4；313 K；Ionic strength (raw mmCIF value) 0；Pressure ambient
NMR sample composition
20 mM DPC-1, 0.4 mM [U-13C; U-15N] entity-2, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2NNX Crystal Structure of the H46R, H48Q double mutant of human [Cu-Zn] Superoxide Dismutase Deposited 2006-10-24 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：H46R, H48Q Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：H46R, H48Q Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.8；298 K；25% PEG 550MME, 0.1M MES, 0.01M zinc sulfate, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.30 Å R-free 0.241 |
| 2NNX Crystal Structure of the H46R, H48Q double mutant of human [Cu-Zn] Superoxide Dismutase Deposited 2006-10-24 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
Chain D
1–153（153 aa）
|
Mutation：H46R, H48Q Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：H46R, H48Q Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 4 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.8；298 K；25% PEG 550MME, 0.1M MES, 0.01M zinc sulfate, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.30 Å R-free 0.241 |
| 2R27 Constitutively zinc-deficient mutant of human superoxide dismutase (SOD), C6A, H80S, H83S, C111S Deposited 2007-08-24 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Mutation：C7A, H81S, D84S, C112S Mutation：C7A, H81S, D84S, C112S | CU COPPER (II) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；2.45 M ammonium sulfate, 200 mM NaCl in 50 mM Tris, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.00 Å R-free 0.246 |
| 2V0A Atomic resolution crystal structure of Human Superoxide Dismutase Deposited 2007-05-11 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain F
1–153（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 3 ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.75；3.5 M AMMONIUM SULPHATE, 100MM NACL, 50MM ACETATE BUFFER PH 4.75
|
Resolution 1.15 Å R-free 0.206 |
| 2VR6 Crystal Structure of G85R ALS mutant of Human Cu,Zn Superoxide Dismutase (CuZnSOD) at 1.3 A resolution Deposited 2008-03-28 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Fragment：RESIDUES 2-154
Chain F
2–154（153 aa）
Fragment：RESIDUES 2-154
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 4 SO4 SULFATE ION × 2 SCN THIOCYANATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；20% P3350 0.2 M NA THYOCYANATE, pH 7.0
|
Resolution 1.30 Å R-free 0.182 |
| 2VR7 Crystal Structure of G85R ALS mutant of Human Cu,Zn Superoxide Dismutase (CuZnSOD) at 1.58 A resolution Deposited 2008-03-28 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Fragment：RESIDUES 2-154
Chain F
2–154（153 aa）
Fragment：RESIDUES 2-154
|
Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 6 SO4 SULFATE ION × 2 SCN THIOCYANATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；20% PEG3350, 0.2M SODIUM THIOCYANATE, pH 7.0
|
Resolution 1.58 Å R-free 0.175 |
| 2VR8 Crystal Structure of G85R ALS mutant of Human Cu,Zn Superoxide Dismutase (CuZnSOD) at 1.36 A resolution Deposited 2008-03-28 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Fragment：RESIDUES 2-154
Chain F
2–154（153 aa）
Fragment：RESIDUES 2-154
|
Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 6 SO4 SULFATE ION × 2 SCN THIOCYANATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；20% PEG3350, 0.2M SODIUM THIOCYANATE, pH 7.0
|
Resolution 1.36 Å R-free 0.153 |
| 2WKO Structure of metal loaded Pathogenic SOD1 Mutant G93A. Deposited 2009-06-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Fragment：RESIDUES 2-154
Chain F
2–154（153 aa）
Fragment：RESIDUES 2-154
|
Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 IOD IODIDE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；20% P3350, 0.2 M AMMONIUM IODIDE, pH 6.5
|
Resolution 1.97 Å R-free 0.231 |
| 2WYT 1.0 A resolution structure of L38V SOD1 mutant Deposited 2009-11-20 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 4 SO4 SULFATE ION × 6 ACT ACETATE ION × 1 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.75；150 MM NACL, 2-3M AMMONIUM SULPHATE, 100 MM NA ACETATE BUFFER PH 4.75
|
Resolution 1.00 Å R-free 0.147 |
| 2WYZ L38V SOD1 mutant complexed with UMP Deposited 2009-11-20 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 4 CU COPPER (II) ION × 2 SO4 SULFATE ION × 4 U5P URIDINE-5'-MONOPHOSPHATE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；150 MM NACL, 3.0 M AMMONIUM SULPHATE, 100 MM TRIS PH 7.5
|
Resolution 1.70 Å R-free 0.239 |
| 2WZ0 L38V SOD1 mutant complexed with aniline. Deposited 2009-11-20 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 3 SO4 SULFATE ION × 2 ZZT 2-METHOXY-5-METHYLANILINE × 2 DMS DIMETHYL SULFOXIDE × 1 DSN D-SERINE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；150 MM NACL,3.0 M AMMONIUM SULPHATE, 100 MM TRIS-HCL PH 7.5
|
Resolution 1.72 Å R-free 0.260 |
| 2WZ5 L38V SOD1 mutant complexed with L-methionine. Deposited 2009-11-23 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | ZN ZINC ION × 3 CU COPPER (II) ION × 2 SO4 SULFATE ION × 3 MET METHIONINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.75；150 MM NACL, 2.0-3.0 M AMMONIUM SULPHATE, 100 MM ACETATE BUFFER PH 4.75
|
Resolution 1.50 Å R-free 0.255 |
| 2WZ6 G93A SOD1 mutant complexed with Quinazoline. Deposited 2009-11-23 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | ZN ZINC ION × 4 CU COPPER (II) ION × 2 ZO0 4-(4-METHYL-1,4-DIAZEPAN-1-YL)-2-(TRIFLUOROMETHYL)QUINAZOLINE × 2 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.75；150 MM NACL, 2.0-3.0 M AMMONIUM SULPHATE, 100 MM ACETATE BUFFER PH 4.75
|
Resolution 1.55 Å R-free 0.248 |
| 2XJK Monomeric Human Cu,Zn Superoxide dismutase Deposited 2010-07-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
|
Mutation：YES | CU COPPER (II) ION × 1 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；25% PEG 6000, 0.1M MES (PH 6.0), 0.01M ZNCL2
|
Resolution 1.45 Å R-free 0.199 |
| 2XJL Monomeric Human Cu,Zn Superoxide dismutase without Cu ligands Deposited 2010-07-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
|
Mutation：YES | ZN ZINC ION × 4 PEG DI(HYDROXYETHYL)ETHER × 1 NA SODIUM ION × 2 ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；25% PEG 6000, 0.1M SODIUM ACETATE (PH 5.0), 0.01M ZNCL2
|
Resolution 1.55 Å R-free 0.183 |
| 2ZKW Crystal structure of human Cu-Zn superoxide dismutase mutant G85R in space group P21 Deposited 2008-03-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Mutation：G85R Mutation：G85R | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.2；293 K；0.2M Ammonium iodide, 20%(w/v) PEG3350, pH 6.2, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 1.90 Å R-free 0.252 |
| 2ZKX Crystal structure of human Cu-Zn superoxide dismutase mutant G85R in space group I212121 Deposited 2008-03-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Mutation：G85R Mutation：G85R | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.6；293 K；0.1M Sodium Acetate(pH 4.6), 1.5M Ammonium Sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.72 Å R-free 0.246 |
| 2ZKX Crystal structure of human Cu-Zn superoxide dismutase mutant G85R in space group I212121 Deposited 2008-03-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
|
Mutation：G85R Mutation：G85R | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.6；293 K；0.1M Sodium Acetate(pH 4.6), 1.5M Ammonium Sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.72 Å R-free 0.246 |
| 2ZKY Crystal structure of human Cu-Zn superoxide dismutase mutant G93A Deposited 2008-03-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1M Cacodylate(pH 6.5), 0.2M NaCl, 2.0M Ammonium sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.40 Å R-free 0.235 |
| 2ZKY Crystal structure of human Cu-Zn superoxide dismutase mutant G93A Deposited 2008-03-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1M Cacodylate(pH 6.5), 0.2M NaCl, 2.0M Ammonium sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.40 Å R-free 0.235 |
| 2ZKY Crystal structure of human Cu-Zn superoxide dismutase mutant G93A Deposited 2008-03-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–154（154 aa）
Chain F
1–154（154 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1M Cacodylate(pH 6.5), 0.2M NaCl, 2.0M Ammonium sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.40 Å R-free 0.235 |
| 2ZKY Crystal structure of human Cu-Zn superoxide dismutase mutant G93A Deposited 2008-03-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
1–154（154 aa）
Chain H
1–154（154 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1M Cacodylate(pH 6.5), 0.2M NaCl, 2.0M Ammonium sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.40 Å R-free 0.235 |
| 2ZKY Crystal structure of human Cu-Zn superoxide dismutase mutant G93A Deposited 2008-03-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1M Cacodylate(pH 6.5), 0.2M NaCl, 2.0M Ammonium sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.40 Å R-free 0.235 |
| 3CQP Human SOD1 G85R Variant, Structure I Deposited 2008-04-03 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4 M sodium malonate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.95 Å R-free 0.223 |
| 3CQP Human SOD1 G85R Variant, Structure I Deposited 2008-04-03 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 MLI MALONATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4 M sodium malonate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.95 Å R-free 0.223 |
| 3CQQ Human SOD1 G85R Variant, Structure II Deposited 2008-04-03 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 3 ACE ACETYL GROUP × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4 M sodium malonate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.90 Å R-free 0.240 |
| 3ECU Crystal structure of human apo Cu,Zn Superoxide Dismutase (SOD1) Deposited 2008-09-02 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；289.1 K；0.1 M MES
20% PEG 3350, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 289.1K
|
Resolution 1.90 Å R-free 0.279 |
| 3ECU Crystal structure of human apo Cu,Zn Superoxide Dismutase (SOD1) Deposited 2008-09-02 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；289.1 K；0.1 M MES
20% PEG 3350, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 289.1K
|
Resolution 1.90 Å R-free 0.279 |
| 3ECV Crystal structure of the ALS-related pathological mutant I113T of human apo Cu,Zn Superoxide Dismutase (SOD1) Deposited 2008-09-02 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；289.1 K；0.1 M MES
20% PEG 3350 , pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 289.1K
|
Resolution 1.90 Å R-free 0.277 |
| 3ECV Crystal structure of the ALS-related pathological mutant I113T of human apo Cu,Zn Superoxide Dismutase (SOD1) Deposited 2008-09-02 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；289.1 K；0.1 M MES
20% PEG 3350 , pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 289.1K
|
Resolution 1.90 Å R-free 0.277 |
| 3ECW Crystal structure of the ALS-related pathological mutant T54R of human apo Cu,Zn Superoxide Dismutase (SOD1) Deposited 2008-09-02 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；289.1 K；0.1 M HEPES
20% PEG 3350, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 289.1K
|
Resolution 2.15 Å R-free 0.297 |
| 3ECW Crystal structure of the ALS-related pathological mutant T54R of human apo Cu,Zn Superoxide Dismutase (SOD1) Deposited 2008-09-02 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；289.1 K；0.1 M HEPES
20% PEG 3350, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 289.1K
|
Resolution 2.15 Å R-free 0.297 |
| 3GQF Structural and Biophysical Properties of the Pathogenic SOD1 Variant H46R/H48Q Deposited 2009-03-24 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：H46R, H48Q Mutation：H46R, H48Q | ZN ZINC ION × 2 CA CALCIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；297 K；20% polyethylene glycol 1000, imidazole pH 8.0, calcium acetate, VAPOR DIFFUSION, HANGING DROP, temperature 297K
|
Resolution 2.20 Å R-free 0.242 |
| 3GQF Structural and Biophysical Properties of the Pathogenic SOD1 Variant H46R/H48Q Deposited 2009-03-24 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Mutation：H46R, H48Q Mutation：H46R, H48Q | ZN ZINC ION × 2 CA CALCIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；297 K；20% polyethylene glycol 1000, imidazole pH 8.0, calcium acetate, VAPOR DIFFUSION, HANGING DROP, temperature 297K
|
Resolution 2.20 Å R-free 0.242 |
| 3GQF Structural and Biophysical Properties of the Pathogenic SOD1 Variant H46R/H48Q Deposited 2009-03-24 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：H46R, H48Q Mutation：H46R, H48Q | ZN ZINC ION × 2 CA CALCIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；297 K；20% polyethylene glycol 1000, imidazole pH 8.0, calcium acetate, VAPOR DIFFUSION, HANGING DROP, temperature 297K
|
Resolution 2.20 Å R-free 0.242 |
| 3GTV Human-mouse SOD1 chimera Deposited 2009-03-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
Chain B
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；298 K；0.1 m HEPES, 25% PEG 8000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.231 |
| 3GTV Human-mouse SOD1 chimera Deposited 2009-03-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
Chain D
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；298 K；0.1 m HEPES, 25% PEG 8000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.231 |
| 3GTV Human-mouse SOD1 chimera Deposited 2009-03-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
Chain F
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；298 K；0.1 m HEPES, 25% PEG 8000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.231 |
| 3GTV Human-mouse SOD1 chimera Deposited 2009-03-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
Chain H
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；298 K；0.1 m HEPES, 25% PEG 8000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.231 |
| 3GTV Human-mouse SOD1 chimera Deposited 2009-03-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
Chain J
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；298 K；0.1 m HEPES, 25% PEG 8000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.231 |
| 3GTV Human-mouse SOD1 chimera Deposited 2009-03-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain K
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
Chain L
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；298 K；0.1 m HEPES, 25% PEG 8000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.231 |
| 3GZO HUMAN SOD1 G93A Variant Deposited 2009-04-07 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；2.4 M sodium malonate, pH 6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.214 |
| 3GZO HUMAN SOD1 G93A Variant Deposited 2009-04-07 | Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；2.4 M sodium malonate, pH 6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.214 |
| 3GZO HUMAN SOD1 G93A Variant Deposited 2009-04-07 | Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；2.4 M sodium malonate, pH 6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.214 |
| 3GZO HUMAN SOD1 G93A Variant Deposited 2009-04-07 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
Chain H
2–154（153 aa）
|
Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 MLI MALONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；2.4 M sodium malonate, pH 6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.214 |
| 3GZO HUMAN SOD1 G93A Variant Deposited 2009-04-07 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
Chain J
2–154（153 aa）
|
Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；2.4 M sodium malonate, pH 6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.214 |
| 3GZP HUMAN SOD1 G93A Metal-free Variant Deposited 2009-04-07 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：G93A Mutation：G93A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4 M ammonium sulfate, 0.1 M HEPES, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.10 Å R-free 0.248 |
| 3GZP HUMAN SOD1 G93A Metal-free Variant Deposited 2009-04-07 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Mutation：G93A Mutation：G93A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4 M ammonium sulfate, 0.1 M HEPES, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.10 Å R-free 0.248 |
| 3GZQ HUMAN SOD1 A4V Metal-free Variant Deposited 2009-04-07 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：A4V Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：A4V Non-standard monomer：Yes (specific site not provided by mmCIF) | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；1.6 M ammonium sulfate, 0.1 M MES, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.40 Å R-free 0.193 |
| 3H2P Human SOD1 D124V Variant Deposited 2009-04-14 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：D124V Mutation：D124V | ZN ZINC ION × 3 MLI MALONATE ION × 2 ACE ACETYL GROUP × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4 M sodium malonate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.55 Å R-free 0.202 |
| 3H2Q Human SOD1 H80R variant, P21 crystal form Deposited 2009-04-14 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：H80R Mutation：H80R | ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；2.3 M AMMONIUM SULFATE, 0.1 M Tris, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.85 Å R-free 0.222 |
| 3H2Q Human SOD1 H80R variant, P21 crystal form Deposited 2009-04-14 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Mutation：H80R Mutation：H80R | ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；2.3 M AMMONIUM SULFATE, 0.1 M Tris, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.85 Å R-free 0.222 |
| 3HFF Monomeric human Cu,Zn Superoxide dismutase without Zn ligands Deposited 2009-05-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
|
Mutation：C6A, C111A, F50E, G51E, H63S, H71S, H80S, D83S | ZN ZINC ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；16% PEG 6000, 10% Jeffamine M-600 (pH 7.0), 0.1M Tris-HCl (pH 8.0), 0.1M ZnCl2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.20 Å R-free 0.281 |
| 3HFF Monomeric human Cu,Zn Superoxide dismutase without Zn ligands Deposited 2009-05-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
|
Mutation：C6A, C111A, F50E, G51E, H63S, H71S, H80S, D83S | ZN ZINC ION × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；16% PEG 6000, 10% Jeffamine M-600 (pH 7.0), 0.1M Tris-HCl (pH 8.0), 0.1M ZnCl2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.20 Å R-free 0.281 |
| 3K91 Polysulfane Bridge in Cu-Zn Superoxide Dismutase Deposited 2009-10-15 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：H46R, H48Q Mutation：H46R, H48Q | PS5 PENTASULFIDE-SULFUR × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.6；298 K；0.17 M ammonium sulfate, 0.085 M sodium acetate, 25.5% PEG 4000, 15% glycerol, pH 4.6, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 1.75 Å R-free 0.218 |
| 3KH3 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P212121 crystal form containing 12 chains in the asymmetric unit Deposited 2009-10-30 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.277 |
| 3KH3 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P212121 crystal form containing 12 chains in the asymmetric unit Deposited 2009-10-30 | Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.277 |
| 3KH3 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P212121 crystal form containing 12 chains in the asymmetric unit Deposited 2009-10-30 | Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain F
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.277 |
| 3KH3 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P212121 crystal form containing 12 chains in the asymmetric unit Deposited 2009-10-30 | Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
Chain H
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.277 |
| 3KH3 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P212121 crystal form containing 12 chains in the asymmetric unit Deposited 2009-10-30 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
Chain J
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.277 |
| 3KH3 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P212121 crystal form containing 12 chains in the asymmetric unit Deposited 2009-10-30 | Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain K
2–154（153 aa）
Chain L
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.277 |
| 3KH4 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P6522 crystal form containing 6 chains in the asymmetric unit Deposited 2009-10-30 | Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.208 |
| 3KH4 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P6522 crystal form containing 6 chains in the asymmetric unit Deposited 2009-10-30 | Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.208 |
| 3KH4 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P6522 crystal form containing 6 chains in the asymmetric unit Deposited 2009-10-30 | Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain F
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.208 |
| 3LTV Mouse-human sod1 chimera Deposited 2010-02-16 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
82–154（73 aa）
Fragment：;RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN,RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN
;
Chain B
82–154（73 aa）
Fragment：;RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN,RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN
;
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；0.1 M SODIUM ACETATE, 25% PEG 4000, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.45 Å R-free 0.265 |
| 3LTV Mouse-human sod1 chimera Deposited 2010-02-16 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
82–154（73 aa）
Fragment：;RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN,RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN
;
Chain D
82–154（73 aa）
Fragment：;RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN,RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN
;
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；0.1 M SODIUM ACETATE, 25% PEG 4000, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.45 Å R-free 0.265 |
| 3LTV Mouse-human sod1 chimera Deposited 2010-02-16 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
82–154（73 aa）
Fragment：;RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN,RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN
;
Chain F
82–154（73 aa）
Fragment：;RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN,RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN
;
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；0.1 M SODIUM ACETATE, 25% PEG 4000, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.45 Å R-free 0.265 |
| 3QQD Human SOD1 H80R variant, P212121 crystal form Deposited 2011-02-15 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；2.3 M AMMONIUM SULFATE, 0.1 M TRIS, TEMPERATURE 298K, pH 8.0, VAPOR DIFFUSION, HANGING DROP
|
Resolution 1.65 Å R-free 0.183 |
| 3RE0 Crystal structure of human apo Cu,Zn superoxide dismutase (SOD1) complexed with cisplatin Deposited 2011-04-02 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | CPT Cisplatin × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；20% PEG 3350, 0.1M HEPES, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.28 Å R-free 0.290 |
| 3RE0 Crystal structure of human apo Cu,Zn superoxide dismutase (SOD1) complexed with cisplatin Deposited 2011-04-02 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Not recorded | CPT Cisplatin × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；20% PEG 3350, 0.1M HEPES, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.28 Å R-free 0.290 |
| 3T5W 2ME modified human SOD1 Deposited 2011-07-28 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；15% PEG 3350, 300mM (NH4)2SO4, pH6.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 1.80 Å R-free 0.241 |
| 3T5W 2ME modified human SOD1 Deposited 2011-07-28 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
2–154（153 aa）
Chain E
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；15% PEG 3350, 300mM (NH4)2SO4, pH6.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 1.80 Å R-free 0.241 |
| 3T5W 2ME modified human SOD1 Deposited 2011-07-28 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
2–154（153 aa）
Chain G
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；15% PEG 3350, 300mM (NH4)2SO4, pH6.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 1.80 Å R-free 0.241 |
| 3T5W 2ME modified human SOD1 Deposited 2011-07-28 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain H
2–154（153 aa）
Chain I
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；15% PEG 3350, 300mM (NH4)2SO4, pH6.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 1.80 Å R-free 0.241 |
| 3T5W 2ME modified human SOD1 Deposited 2011-07-28 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain J
2–154（153 aa）
Chain K
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；15% PEG 3350, 300mM (NH4)2SO4, pH6.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 1.80 Å R-free 0.241 |
| 3T5W 2ME modified human SOD1 Deposited 2011-07-28 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain L
2–154（153 aa）
Chain M
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；15% PEG 3350, 300mM (NH4)2SO4, pH6.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 1.80 Å R-free 0.241 |
| 4A7G Structure of human I113T SOD1 mutant complexed with 4-methylpiperazin- 1-yl)quinazoline in the p21 space group. Deposited 2011-11-14 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | SO4 SULFATE ION × 5 12I 4-(4-METHYLPIPERAZIN-1-YL)QUINAZOLINE × 3 CU COPPER (II) ION × 2 ZN ZINC ION × 2 ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；100MM SODIUM ACETATE PH 5, 150 MM SODIUM CHLORIDE, 2.5 M AMMONIUM SULPHATE
|
Resolution 1.24 Å R-free 0.175 |
| 4A7Q Structure of human I113T SOD1 mutant complexed with 4-(4-methyl-1,4- diazepan-1-yl)quinazoline in the p21 space group. Deposited 2011-11-14 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | 4MQ 4-(4-METHYL-1,4-DIAZEPAN-1-YL)QUINAZOLINE × 2 SO4 SULFATE ION × 6 CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；100 MM SODIUM ACETATE PH 5, 150 MM SODIUM CHLORIDE, 2.5 AMMONIUM SULPHATE
|
Resolution 1.22 Å R-free 0.159 |
| 4A7S Structure of human I113T SOD1 mutant complexed with 5-Fluorouridine in the p21 space group Deposited 2011-11-14 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 5 ACT ACETATE ION × 2 5UD 5-FLUOROURIDINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；100 MM SODIUM ACETATE, 150 MM SODIUM CHLORIDE, 2.5 AMMONIUM SULPHATE PH 5
|
Resolution 1.06 Å R-free 0.200 |
| 4A7T Structure of human I113T SOD1 mutant complexed with isoproteranol in the p21 space group Deposited 2011-11-14 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | 5FW ISOPRENALINE × 5 SO4 SULFATE ION × 4 ACT ACETATE ION × 2 CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；100 MM SODIUM ACETATE PH 5, 150 MM SODIUM CHLORIDE, 2.5 AMMONIUM SULPHATE
|
Resolution 1.45 Å R-free 0.188 |
| 4A7U Structure of human I113T SOD1 complexed with adrenaline in the p21 space group. Deposited 2011-11-14 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | ALE L-EPINEPHRINE × 2 SO4 SULFATE ION × 4 CU COPPER (II) ION × 2 ZN ZINC ION × 2 ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；100 MM SODIUM ACETATE, 150 MM SODIUM CHLORIDE, 2.5 AMMONIUM SULPHATE PH 5
|
Resolution 0.98 Å R-free 0.153 |
| 4A7V Structure of human I113T SOD1 mutant complexed with dopamine in the p21 space group Deposited 2011-11-14 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | LDP L-DOPAMINE × 1 SO4 SULFATE ION × 4 CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；100 MM SODIUM ACETATE, 150 MM SODIUM CHLORIDE, 2.5 M AMMONIUM SULPHATE PH 5
|
Resolution 1.00 Å R-free 0.181 |
| 4B3E Structure of copper-zinc superoxide dismutase complexed with bicarbonate. Deposited 2012-07-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain F
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 CO3 CARBONATE ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1 M AMMONIUM SULPHATE, 50 MM TRIS PH 8.0 AND 50 MM NACL
|
Resolution 2.15 Å R-free 0.215 |
| 4B3E Structure of copper-zinc superoxide dismutase complexed with bicarbonate. Deposited 2012-07-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
1–154（154 aa）
Chain G
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 CO3 CARBONATE ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1 M AMMONIUM SULPHATE, 50 MM TRIS PH 8.0 AND 50 MM NACL
|
Resolution 2.15 Å R-free 0.215 |
| 4B3E Structure of copper-zinc superoxide dismutase complexed with bicarbonate. Deposited 2012-07-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain H
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 CO3 CARBONATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1 M AMMONIUM SULPHATE, 50 MM TRIS PH 8.0 AND 50 MM NACL
|
Resolution 2.15 Å R-free 0.215 |
| 4B3E Structure of copper-zinc superoxide dismutase complexed with bicarbonate. Deposited 2012-07-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–154（154 aa）
Chain I
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 CO3 CARBONATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1 M AMMONIUM SULPHATE, 50 MM TRIS PH 8.0 AND 50 MM NACL
|
Resolution 2.15 Å R-free 0.215 |
| 4B3E Structure of copper-zinc superoxide dismutase complexed with bicarbonate. Deposited 2012-07-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 CO3 CARBONATE ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1 M AMMONIUM SULPHATE, 50 MM TRIS PH 8.0 AND 50 MM NACL
|
Resolution 2.15 Å R-free 0.215 |
| 4BCY Monomeric Human Cu,Zn Superoxide dismutase, mutation H43F Deposited 2012-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
|
Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 1 CD CADMIUM ION × 6 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
293 K；25% PEG 400, 0.1M NA ACETATE PH 4.6, 0.1 M CDCL2, 20 C
|
Resolution 1.27 Å R-free 0.203 |
| 4BCZ Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form. Deposited 2012-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–49（48 aa）
Fragment：RESIDUES 2049,83-124,141-154
Chain A
83–124（42 aa）
Fragment：RESIDUES 2049,83-124,141-154
Chain A
141–154（14 aa）
Fragment：RESIDUES 2049,83-124,141-154
|
Mutation：YES Mutation：YES Mutation：YES | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
293 K；30% PEG 1500, 0.1M MIB BUFFER, PH 4.0, 20 C
|
Resolution 1.93 Å R-free 0.220 |
| 4BCZ Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form. Deposited 2012-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
2–49（48 aa）
Fragment：RESIDUES 2049,83-124,141-154
Chain B
83–124（42 aa）
Fragment：RESIDUES 2049,83-124,141-154
Chain B
141–154（14 aa）
Fragment：RESIDUES 2049,83-124,141-154
|
Mutation：YES Mutation：YES Mutation：YES | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
293 K；30% PEG 1500, 0.1M MIB BUFFER, PH 4.0, 20 C
|
Resolution 1.93 Å R-free 0.220 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–49（48 aa）
Chain A
83–124（42 aa）
Chain A
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
2–49（48 aa）
Chain B
83–124（42 aa）
Chain B
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
2–49（48 aa）
Chain C
83–124（42 aa）
Chain C
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
2–49（48 aa）
Chain D
83–124（42 aa）
Chain D
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain E
2–49（48 aa）
Chain E
83–124（42 aa）
Chain E
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain F
2–49（48 aa）
Chain F
83–124（42 aa）
Chain F
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 7 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain G
2–49（48 aa）
Chain G
83–124（42 aa）
Chain G
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 8 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain H
2–49（48 aa）
Chain H
83–124（42 aa）
Chain H
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 9 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain I
2–49（48 aa）
Chain I
83–124（42 aa）
Chain I
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4FF9 Crystal Structure of cysteinylated WT SOD1. Deposited 2012-05-31 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | CYS CYSTEINE × 1 ZN ZINC ION × 2 CU COPPER (II) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.25；298 K；0.1M MES, pH 6.25, 20% PEG3350, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.50 Å R-free 0.335 |
| 4MCM Human SOD1 C57S Mutant, As-isolated Deposited 2013-08-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Fragment：UNP residues 2-154
Chain B
2–154（153 aa）
Fragment：UNP residues 2-154
|
Mutation：C57S Mutation：C57S | ZN ZINC ION × 4 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；295 K；0.2 M ammonium sulfate, 0.1 M bis-tris, 25% PEG 3350, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.20 Å R-free 0.262 |
| 4MCM Human SOD1 C57S Mutant, As-isolated Deposited 2013-08-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Fragment：UNP residues 2-154
Chain D
2–154（153 aa）
Fragment：UNP residues 2-154
|
Mutation：C57S Mutation：C57S | ZN ZINC ION × 4 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；295 K；0.2 M ammonium sulfate, 0.1 M bis-tris, 25% PEG 3350, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.20 Å R-free 0.262 |
| 4MCM Human SOD1 C57S Mutant, As-isolated Deposited 2013-08-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Fragment：UNP residues 2-154
Chain F
2–154（153 aa）
Fragment：UNP residues 2-154
|
Mutation：C57S Mutation：C57S | ZN ZINC ION × 4 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；295 K；0.2 M ammonium sulfate, 0.1 M bis-tris, 25% PEG 3350, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.20 Å R-free 0.262 |
| 4MCM Human SOD1 C57S Mutant, As-isolated Deposited 2013-08-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
Fragment：UNP residues 2-154
Chain H
2–154（153 aa）
Fragment：UNP residues 2-154
|
Mutation：C57S Mutation：C57S | ZN ZINC ION × 4 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；295 K；0.2 M ammonium sulfate, 0.1 M bis-tris, 25% PEG 3350, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.20 Å R-free 0.262 |
| 4MCM Human SOD1 C57S Mutant, As-isolated Deposited 2013-08-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
Fragment：UNP residues 2-154
Chain J
2–154（153 aa）
Fragment：UNP residues 2-154
|
Mutation：C57S Mutation：C57S | ZN ZINC ION × 4 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；295 K；0.2 M ammonium sulfate, 0.1 M bis-tris, 25% PEG 3350, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.20 Å R-free 0.262 |
| 4MCM Human SOD1 C57S Mutant, As-isolated Deposited 2013-08-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain K
2–154（153 aa）
Fragment：UNP residues 2-154
Chain L
2–154（153 aa）
Fragment：UNP residues 2-154
|
Mutation：C57S Mutation：C57S | ZN ZINC ION × 4 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；295 K；0.2 M ammonium sulfate, 0.1 M bis-tris, 25% PEG 3350, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.20 Å R-free 0.262 |
| 4MCN Human SOD1 C57S Mutant, Metal-free Deposited 2013-08-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Fragment：UNP residues 2-154
Chain B
2–154（153 aa）
Fragment：UNP residues 2-154
|
Mutation：C57S Mutation：C57S | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；295 K；3.2 M ammonium sulfate, 0.1 M MES, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.60 Å R-free 0.245 |
| 4NIN DSVISLS segment 101-107 from Human Superoxide Dismutase Deposited 2013-11-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
102–108（7 aa）
Fragment：UNP residues 102-108
|
Not recorded | ZN ZINC ION × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；0.1 M MES pH 6.0, 20% PEG 6000, and 5 mM ZnCl2, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.40 Å R-free 0.228 |
| 4NIO GVTGIAQ segment 147-153 from Human Superoxide Dismutase with I149T mutation associated with a familial form of amyotrophic lateral sclerosis Deposited 2013-11-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
148–154（7 aa）
Fragment：UNP Residues 148-154
|
Mutation：I149T | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；298 K；0.1 M sodium acetate pH 4.5, 0.7 M hexanediol, vapor diffusion, hanging drop, temperature 298K
|
Resolution 1.30 Å R-free 0.233 |
| 4NIP GVIGIAQ segment 147-153 from Human Superoxide Dismutase Deposited 2013-11-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
148–154（7 aa）
Fragment：UNP Residues 148-154
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；298 K；1 M sodium acetate pH 4.5, 1.75 M ammonium sulfate, vapor diffusion, hanging drop, temperature 298K
|
Resolution 1.90 Å R-free 0.248 |
| 4OH2 Crystal Structure of Cu/Zn Superoxide Dismutase I149T Deposited 2014-01-16 | Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：C6A, C111S, L149T Mutation：C6A, C111S, L149T | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；298 K；100mM NaCl, 100mM Tris-HCl pH 7.6, 2.8M (NH4)2SO4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.38 Å R-free 0.216 |
| 4OH2 Crystal Structure of Cu/Zn Superoxide Dismutase I149T Deposited 2014-01-16 | Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Mutation：C6A, C111S, L149T Mutation：C6A, C111S, L149T | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；298 K；100mM NaCl, 100mM Tris-HCl pH 7.6, 2.8M (NH4)2SO4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.38 Å R-free 0.216 |
| 4OH2 Crystal Structure of Cu/Zn Superoxide Dismutase I149T Deposited 2014-01-16 | Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：C6A, C111S, L149T Mutation：C6A, C111S, L149T | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；298 K；100mM NaCl, 100mM Tris-HCl pH 7.6, 2.8M (NH4)2SO4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.38 Å R-free 0.216 |
| 4OH2 Crystal Structure of Cu/Zn Superoxide Dismutase I149T Deposited 2014-01-16 | Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
Chain H
2–154（153 aa）
|
Mutation：C6A, C111S, L149T Mutation：C6A, C111S, L149T | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；298 K；100mM NaCl, 100mM Tris-HCl pH 7.6, 2.8M (NH4)2SO4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.38 Å R-free 0.216 |
| 4OH2 Crystal Structure of Cu/Zn Superoxide Dismutase I149T Deposited 2014-01-16 | Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
Chain J
2–154（153 aa）
|
Mutation：C6A, C111S, L149T Mutation：C6A, C111S, L149T | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；298 K；100mM NaCl, 100mM Tris-HCl pH 7.6, 2.8M (NH4)2SO4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.38 Å R-free 0.216 |
| 4XCR Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant I35A Deposited 2014-12-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
|
Mutation：I45A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 5.5；293 K；0.1 M Bis Tris and 2.0 M ammonium sulfate
|
Resolution 3.60 Å R-free 0.239 |
| 4XCR Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant I35A Deposited 2014-12-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
2–154（153 aa）
|
Mutation：I45A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 5.5；293 K；0.1 M Bis Tris and 2.0 M ammonium sulfate
|
Resolution 3.60 Å R-free 0.239 |
| 5DLI Corkscrew assembly of SOD1 residues 28-38 Deposited 2015-09-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric |
Chain A
29–39（11 aa）
Fragment：Residues 29-39
Chain B
29–39（11 aa）
Fragment：Residues 29-39
Chain C
29–39（11 aa）
Fragment：Residues 29-39
Chain D
29–39（11 aa）
Fragment：Residues 29-39
Chain E
29–39（11 aa）
Fragment：Residues 29-39
Chain F
29–39（11 aa）
Fragment：Residues 29-39
Chain G
29–39（11 aa）
Fragment：Residues 29-39
Chain H
29–39（11 aa）
Fragment：Residues 29-39
|
Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K | GOL GLYCEROL × 1 IOD IODIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；reservoir contained 13% PEG 6000, 0.2M Sodium Citrate
|
Resolution 2.10 Å R-free 0.262 |
| 5IIW Corkscrew assembly of SOD1 residues 28-38 without potassium iodide Deposited 2016-03-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric |
Chain A
29–39（11 aa）
Fragment：UNP Residues 29-39
Chain B
29–39（11 aa）
Fragment：UNP Residues 29-39
Chain C
29–39（11 aa）
Fragment：UNP Residues 29-39
Chain D
29–39（11 aa）
Fragment：UNP Residues 29-39
Chain E
29–39（11 aa）
Fragment：UNP Residues 29-39
Chain F
29–39（11 aa）
Fragment：UNP Residues 29-39
Chain G
29–39（11 aa）
Fragment：UNP Residues 29-39
Chain H
29–39（11 aa）
Fragment：UNP Residues 29-39
|
Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；reservoir contained 13% PEG 6000, 0.2M Sodium Citrate
|
Resolution 2.00 Å R-free 0.252 |
| 5J07 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P1/2 Deposited 2016-03-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
14–49（36 aa）
Chain A
84–124（41 aa）
Chain A
141–154（14 aa）
Chain A
2–13（12 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 5；293 K；0.1 M MIB buffer
pH 5.0
25 % w/v PEG 1500
|
Resolution 2.00 Å R-free 0.231 |
| 5J07 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P1/2 Deposited 2016-03-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
14–49（36 aa）
Chain B
84–124（41 aa）
Chain B
141–154（14 aa）
Chain B
2–13（12 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 5；293 K；0.1 M MIB buffer
pH 5.0
25 % w/v PEG 1500
|
Resolution 2.00 Å R-free 0.231 |
| 5J0C Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P2/3 Deposited 2016-03-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
29–49（21 aa）
Chain A
84–124（41 aa）
Chain A
2–26（25 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 5；293 K；0.1 M MIB buffer
pH 5.0
25 % w/v PEG 1500
|
Resolution 1.60 Å R-free 0.186 |
| 5J0C Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P2/3 Deposited 2016-03-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
29–49（21 aa）
Chain B
84–124（41 aa）
Chain B
2–26（25 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 5；293 K；0.1 M MIB buffer
pH 5.0
25 % w/v PEG 1500
|
Resolution 1.60 Å R-free 0.186 |
| 5J0F Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P4/5 Deposited 2016-03-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
83–124（42 aa）
Chain A
2–49（48 aa）
|
Not recorded | GOL GLYCEROL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；0.17 M ammonium sulfate, 25.5 % w/v PEG 4K, 15 % v/v Glycerol
|
Resolution 1.25 Å R-free 0.170 |
| 5J0F Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P4/5 Deposited 2016-03-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
83–124（42 aa）
Chain B
2–49（48 aa）
|
Not recorded | GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；0.17 M ammonium sulfate, 25.5 % w/v PEG 4K, 15 % v/v Glycerol
|
Resolution 1.25 Å R-free 0.170 |
| 5J0G Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P7/8 Deposited 2016-03-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–124（123 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M di-ammonium hydrogen citrate,
20 % w/v PEG 3350
|
Resolution 2.50 Å R-free 0.235 |
| 5J0G Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P7/8 Deposited 2016-03-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
2–124（123 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M di-ammonium hydrogen citrate,
20 % w/v PEG 3350
|
Resolution 2.50 Å R-free 0.235 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different experimental conditions Different structure-quality metrics | Assembly 10 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain Q
2–154（153 aa）
Chain V
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different experimental conditions Different structure-quality metrics | Assembly 11 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain R
2–154（153 aa）
Chain U
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different experimental conditions Different structure-quality metrics | Assembly 12 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain S
2–154（153 aa）
Chain T
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain L
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
2–154（153 aa）
Chain K
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain J
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
2–154（153 aa）
Chain I
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
Chain H
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different experimental conditions Different structure-quality metrics | Assembly 7 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain M
2–154（153 aa）
Chain N
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different experimental conditions Different structure-quality metrics | Assembly 8 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain O
2–154（153 aa）
Chain X
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different experimental conditions Different structure-quality metrics | Assembly 9 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain P
2–154（153 aa）
Chain W
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5O3Y SOD1 bound to Ebsulfur Deposited 2017-05-25 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 4 9JK ~{N}-phenyl-2-sulfanyl-benzamide × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 3.75；293 K；100 mM NaAct pH 3.75, 100 mM NaCl, 2.8 M AmSO4
|
Resolution 1.30 Å R-free 0.186 |
| 5O40 SOD1 bound to Ebselen Deposited 2017-05-25 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 4 9JT N-phenyl-2-selanylbenzamide × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；100 mM NaACT pH 4, 2.4 M AMSO4, 150 mM NaCl
|
Resolution 1.50 Å R-free 0.215 |
| 5U9M Copper-Zinc Superoxide Dismutase is Activated through a Sulfenic Acid Intermediate at a Copper-ion Entry Site Deposited 2016-12-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
|
Mutation：H46R,H48Q | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；25 % PEG 3350, 0.2 M ammonium sulfate, 0.1 M bis-tris pH 6.5
|
Resolution 2.35 Å R-free 0.235 |
| 5U9M Copper-Zinc Superoxide Dismutase is Activated through a Sulfenic Acid Intermediate at a Copper-ion Entry Site Deposited 2016-12-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
|
Mutation：H46R,H48Q | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；25 % PEG 3350, 0.2 M ammonium sulfate, 0.1 M bis-tris pH 6.5
|
Resolution 2.35 Å R-free 0.235 |
| 5WMJ KVWGSI segment from Superoxide Dismutase 1,residues 30-35 Deposited 2017-07-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric |
Chain A
31–36（6 aa）
Fragment：UNP residues 31-36
Chain B
31–36（6 aa）
Fragment：UNP residues 31-36
|
Not recorded | TFA trifluoroacetic acid × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；Reservoir solution contained 4M Sodium Formate
|
Resolution 1.40 Å R-free 0.170 |
| 5WOR Corkscrew assembly of SOD1 residues 28-38 with familial mutation G37R Deposited 2017-08-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 20 PDB declaration: eicosameric |
Chain A
29–39（11 aa）
Fragment：UNP residues 29-39
Chain B
29–39（11 aa）
Fragment：UNP residues 29-39
Chain C
29–39（11 aa）
Fragment：UNP residues 29-39
Chain D
29–39（11 aa）
Fragment：UNP residues 29-39
Chain E
29–39（11 aa）
Fragment：UNP residues 29-39
Chain F
29–39（11 aa）
Fragment：UNP residues 29-39
Chain G
29–39（11 aa）
Fragment：UNP residues 29-39
Chain H
29–39（11 aa）
Fragment：UNP residues 29-39
Chain I
29–39（11 aa）
Fragment：UNP residues 29-39
Chain J
29–39（11 aa）
Fragment：UNP residues 29-39
|
Mutation：P29K,G38R Mutation：P29K,G38R Mutation：P29K,G38R Mutation：P29K,G38R Mutation：P29K,G38R Mutation：P29K,G38R Mutation：P29K,G38R Mutation：P29K,G38R Mutation：P29K,G38R Mutation：P29K,G38R | MLI MALONATE ION × 6 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；reservoir contained 15% PEG 3350, 0.3M Sodium Malonate
|
Resolution 2.77 Å R-free 0.247 |
| 5YTO Crystal Structure of human Superoxide Dismutase I (hSOD1) in complex with a napthalene-catechol linked compound. Deposited 2017-11-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 2 946 4-[(1~{R})-2-(naphthalen-2-ylmethylamino)-1-oxidanyl-ethyl]benzene-1,2-diol × 1 PS5 PENTASULFIDE-SULFUR × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；sodium citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.215 |
| 5YTO Crystal Structure of human Superoxide Dismutase I (hSOD1) in complex with a napthalene-catechol linked compound. Deposited 2017-11-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 1 946 4-[(1~{R})-2-(naphthalen-2-ylmethylamino)-1-oxidanyl-ethyl]benzene-1,2-diol × 1 PS5 PENTASULFIDE-SULFUR × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；sodium citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.215 |
| 5YTO Crystal Structure of human Superoxide Dismutase I (hSOD1) in complex with a napthalene-catechol linked compound. Deposited 2017-11-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–154（154 aa）
Chain F
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 PS5 PENTASULFIDE-SULFUR × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；sodium citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.215 |
| 5YTO Crystal Structure of human Superoxide Dismutase I (hSOD1) in complex with a napthalene-catechol linked compound. Deposited 2017-11-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
1–154（154 aa）
Chain H
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 946 4-[(1~{R})-2-(naphthalen-2-ylmethylamino)-1-oxidanyl-ethyl]benzene-1,2-diol × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；sodium citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.215 |
| 5YTO Crystal Structure of human Superoxide Dismutase I (hSOD1) in complex with a napthalene-catechol linked compound. Deposited 2017-11-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；sodium citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.215 |
| 5YTU Structure of human SOD1 complexed with isoproteranol in C2221 space group Deposited 2017-11-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain H
1–154（154 aa）
|
Not recorded | 5FW ISOPRENALINE × 1 ZN ZINC ION × 2 TAM TRIS(HYDROXYETHYL)AMINOMETHANE × 1 S4P Dihydrogen tetrasulfide × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.221 |
| 5YTU Structure of human SOD1 complexed with isoproteranol in C2221 space group Deposited 2017-11-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 S4P Dihydrogen tetrasulfide × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.221 |
| 5YTU Structure of human SOD1 complexed with isoproteranol in C2221 space group Deposited 2017-11-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–154（154 aa）
Chain E
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 S4P Dihydrogen tetrasulfide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.221 |
| 5YTU Structure of human SOD1 complexed with isoproteranol in C2221 space group Deposited 2017-11-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
1–154（154 aa）
Chain G
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.221 |
| 5YTU Structure of human SOD1 complexed with isoproteranol in C2221 space group Deposited 2017-11-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.221 |
| 5YUL Native Structure of hSOD1 in P6322 space group Deposited 2017-11-22 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain H
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 S4P Dihydrogen tetrasulfide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate pH 6.0
|
Resolution 1.90 Å R-free 0.227 |
| 5YUL Native Structure of hSOD1 in P6322 space group Deposited 2017-11-22 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 S4P Dihydrogen tetrasulfide × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate pH 6.0
|
Resolution 1.90 Å R-free 0.227 |
| 5YUL Native Structure of hSOD1 in P6322 space group Deposited 2017-11-22 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–154（154 aa）
Chain E
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 S4P Dihydrogen tetrasulfide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate pH 6.0
|
Resolution 1.90 Å R-free 0.227 |
| 5YUL Native Structure of hSOD1 in P6322 space group Deposited 2017-11-22 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
1–154（154 aa）
Chain G
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate pH 6.0
|
Resolution 1.90 Å R-free 0.227 |
| 5YUL Native Structure of hSOD1 in P6322 space group Deposited 2017-11-22 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 1 S4P Dihydrogen tetrasulfide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate pH 6.0
|
Resolution 1.90 Å R-free 0.227 |
| 6A9O Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis Deposited 2018-07-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 DMS DIMETHYL SULFOXIDE × 1 GOL GLYCEROL × 2 S4P Dihydrogen tetrasulfide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.5M Sodium Citrate, pH 6.0
|
Resolution 2.50 Å R-free 0.237 |
| 6A9O Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis Deposited 2018-07-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 DMS DIMETHYL SULFOXIDE × 1 GOL GLYCEROL × 2 S4P Dihydrogen tetrasulfide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.5M Sodium Citrate, pH 6.0
|
Resolution 2.50 Å R-free 0.237 |
| 6A9O Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis Deposited 2018-07-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–154（154 aa）
Chain F
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 S4P Dihydrogen tetrasulfide × 1 6B3 2'-[(6-oxo-5,6-dihydrophenanthridin-3-yl)carbamoyl][1,1'-biphenyl]-2-carboxylic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.5M Sodium Citrate, pH 6.0
|
Resolution 2.50 Å R-free 0.237 |
| 6A9O Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis Deposited 2018-07-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
1–154（154 aa）
Chain H
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.5M Sodium Citrate, pH 6.0
|
Resolution 2.50 Å R-free 0.237 |
| 6A9O Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis Deposited 2018-07-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.5M Sodium Citrate, pH 6.0
|
Resolution 2.50 Å R-free 0.237 |
| 6B79 Curved pair of sheets formed from SOD1 residues 28-38 with familial mutation G37R. Deposited 2017-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric |
Chain A
29–39（11 aa）
Chain B
29–39（11 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | ORA 7-hydroxy-8-[(E)-phenyldiazenyl]naphthalene-1,3-disulfonic acid × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；HEPES pH 7.5, Sodium citrate, 2-Methyl-2,4-pentanediol
|
Resolution 1.80 Å R-free 0.267 |
| 6DTK Heterodimers of FALS mutant SOD enzyme Deposited 2018-06-17 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–154（154 aa）
Chain A
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；2-3 M Ammonium sulfate or Sodium malonate
|
Resolution 2.00 Å R-free 0.190 |
| 6DTK Heterodimers of FALS mutant SOD enzyme Deposited 2018-06-17 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
1–154（154 aa）
Chain C
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；2-3 M Ammonium sulfate or Sodium malonate
|
Resolution 2.00 Å R-free 0.190 |
| 6DTK Heterodimers of FALS mutant SOD enzyme Deposited 2018-06-17 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain E
1–154（154 aa）
Chain E
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 2 MLI MALONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；2-3 M Ammonium sulfate or Sodium malonate
|
Resolution 2.00 Å R-free 0.190 |
| 6DTK Heterodimers of FALS mutant SOD enzyme Deposited 2018-06-17 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain G
1–154（154 aa）
Chain G
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；2-3 M Ammonium sulfate or Sodium malonate
|
Resolution 2.00 Å R-free 0.190 |
| 6DTK Heterodimers of FALS mutant SOD enzyme Deposited 2018-06-17 | Different construct Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain I
1–154（154 aa）
Chain I
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；2-3 M Ammonium sulfate or Sodium malonate
|
Resolution 2.00 Å R-free 0.190 |
| 6FFK Human apo-SOD1 bound to PtCl2(1R,2R-1,4-DACH Deposited 2018-01-08 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | D7Z PtCl2(1(R),2(R)-DACH) × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M HEPES, 20% PEG 3350
|
Resolution 1.94 Å R-free 0.256 |
| 6FFK Human apo-SOD1 bound to PtCl2(1R,2R-1,4-DACH Deposited 2018-01-08 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
2–154（153 aa）
Chain F
2–154（153 aa）
|
Not recorded | D7Z PtCl2(1(R),2(R)-DACH) × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M HEPES, 20% PEG 3350
|
Resolution 1.94 Å R-free 0.256 |
| 6FLH Monomeric Human Cu,Zn Superoxide dismutase, SOD1 7+7, apo form Deposited 2018-01-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
|
Not recorded | SO4 SULFATE ION × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M sodium acetate pH 4.6 and 2 M ammonium sulfate
|
Resolution 1.79 Å R-free 0.197 |
| 6FOI Human Cys57/156Ala superoxide dismutase-1 (SOD1), as isolated. Deposited 2018-02-07 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.2 M Lithium sulphate
24% w/v PEG 4000
0.1 M Tris-HCl pH 8.0
|
Resolution 2.00 Å R-free 0.259 |
| 6FOI Human Cys57/156Ala superoxide dismutase-1 (SOD1), as isolated. Deposited 2018-02-07 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
2–154（153 aa）
Chain G
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.2 M Lithium sulphate
24% w/v PEG 4000
0.1 M Tris-HCl pH 8.0
|
Resolution 2.00 Å R-free 0.259 |
| 6FOI Human Cys57/156Ala superoxide dismutase-1 (SOD1), as isolated. Deposited 2018-02-07 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
Chain K
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.2 M Lithium sulphate
24% w/v PEG 4000
0.1 M Tris-HCl pH 8.0
|
Resolution 2.00 Å R-free 0.259 |
| 6FOI Human Cys57/156Ala superoxide dismutase-1 (SOD1), as isolated. Deposited 2018-02-07 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain M
2–154（153 aa）
Chain O
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.2 M Lithium sulphate
24% w/v PEG 4000
0.1 M Tris-HCl pH 8.0
|
Resolution 2.00 Å R-free 0.259 |
| 6FOI Human Cys57/156Ala superoxide dismutase-1 (SOD1), as isolated. Deposited 2018-02-07 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain Q
2–154（153 aa）
Chain S
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.2 M Lithium sulphate
24% w/v PEG 4000
0.1 M Tris-HCl pH 8.0
|
Resolution 2.00 Å R-free 0.259 |
| 6FOI Human Cys57/156Ala superoxide dismutase-1 (SOD1), as isolated. Deposited 2018-02-07 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain U
2–154（153 aa）
Chain W
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.2 M Lithium sulphate
24% w/v PEG 4000
0.1 M Tris-HCl pH 8.0
|
Resolution 2.00 Å R-free 0.259 |
| 6FOL Domain II of the human copper chaperone in complex with human Cu,Zn superoxide dismutase Deposited 2018-02-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；25% (w/v) PEG 1500 and 0.1 M PCTP buffer pH 7.0 (sodium propionate, sodium cacodylate, and BIS-TRIS propane in the molar ratios 2:1:2, respectively)
|
Resolution 2.55 Å R-free 0.248 |
| 6FOL Domain II of the human copper chaperone in complex with human Cu,Zn superoxide dismutase Deposited 2018-02-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 PE8 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；25% (w/v) PEG 1500 and 0.1 M PCTP buffer pH 7.0 (sodium propionate, sodium cacodylate, and BIS-TRIS propane in the molar ratios 2:1:2, respectively)
|
Resolution 2.55 Å R-free 0.248 |
| 6FOL Domain II of the human copper chaperone in complex with human Cu,Zn superoxide dismutase Deposited 2018-02-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain F
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；25% (w/v) PEG 1500 and 0.1 M PCTP buffer pH 7.0 (sodium propionate, sodium cacodylate, and BIS-TRIS propane in the molar ratios 2:1:2, respectively)
|
Resolution 2.55 Å R-free 0.248 |
| 6FOL Domain II of the human copper chaperone in complex with human Cu,Zn superoxide dismutase Deposited 2018-02-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；25% (w/v) PEG 1500 and 0.1 M PCTP buffer pH 7.0 (sodium propionate, sodium cacodylate, and BIS-TRIS propane in the molar ratios 2:1:2, respectively)
|
Resolution 2.55 Å R-free 0.248 |
| 6FON Elongated conformer of the human copper chaperone for SOD1 complexed with human SOD1 Deposited 2018-02-07 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain B
2–154（153 aa）
Chain D
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；0.1 M MES pH 6.0
0.2 M Magnesium chloride
20 % (w/v) PEG 6000
|
Resolution 3.05 Å R-free 0.246 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 PPI PROPANOIC ACID × 2 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 10 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain S
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 11 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain U
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 12 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain W
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 PPI PROPANOIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain K
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 PPI PROPANOIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 7 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain M
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 8 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain O
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 9 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain Q
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 PPI PROPANOIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6SPA A4V MUTANT OF HUMAN SUPEROXIDE DISMUTASE 1 IN C2 SPACE GROUP Deposited 2019-08-31 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain C
2–154（153 aa）
|
Mutation：Ala4Val Mutation：Ala4Val | ZN ZINC ION × 2 GOL GLYCEROL × 4 DMS DIMETHYL SULFOXIDE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Tris-HCl pH 7.4-8.0, 2.4-2.6 M ammonium sulphate, 150 mM NaCl
|
Resolution 1.65 Å R-free 0.196 |
| 6SPA A4V MUTANT OF HUMAN SUPEROXIDE DISMUTASE 1 IN C2 SPACE GROUP Deposited 2019-08-31 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain G
2–154（153 aa）
|
Mutation：Ala4Val Mutation：Ala4Val | ZN ZINC ION × 2 GOL GLYCEROL × 6 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Tris-HCl pH 7.4-8.0, 2.4-2.6 M ammonium sulphate, 150 mM NaCl
|
Resolution 1.65 Å R-free 0.196 |
| 6SPA A4V MUTANT OF HUMAN SUPEROXIDE DISMUTASE 1 IN C2 SPACE GROUP Deposited 2019-08-31 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain J
2–154（153 aa）
Chain L
2–154（153 aa）
|
Mutation：Ala4Val Mutation：Ala4Val | ZN ZINC ION × 2 GOL GLYCEROL × 2 DMS DIMETHYL SULFOXIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Tris-HCl pH 7.4-8.0, 2.4-2.6 M ammonium sulphate, 150 mM NaCl
|
Resolution 1.65 Å R-free 0.196 |
| 6SPH A4V MUTANT OF HUMAN SUPEROXIDE DISMUTASE 1 WITH EBSELEN BOND IN C2 SPACE GROUP Deposited 2019-09-01 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain C
2–154（153 aa）
|
Mutation：Ala4Val Mutation：Ala4Val | ZN ZINC ION × 2 9JT N-phenyl-2-selanylbenzamide × 2 GOL GLYCEROL × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Tris-HCl pH 7.4-8.0, 2.4-2.6 M ammonium sulphate, 150 mM NaCl
|
Resolution 2.25 Å R-free 0.222 |
| 6SPH A4V MUTANT OF HUMAN SUPEROXIDE DISMUTASE 1 WITH EBSELEN BOND IN C2 SPACE GROUP Deposited 2019-09-01 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain G
2–154（153 aa）
|
Mutation：Ala4Val Mutation：Ala4Val | ZN ZINC ION × 2 9JT N-phenyl-2-selanylbenzamide × 2 GOL GLYCEROL × 3 SO4 SULFATE ION × 1 DMS DIMETHYL SULFOXIDE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Tris-HCl pH 7.4-8.0, 2.4-2.6 M ammonium sulphate, 150 mM NaCl
|
Resolution 2.25 Å R-free 0.222 |
| 6SPH A4V MUTANT OF HUMAN SUPEROXIDE DISMUTASE 1 WITH EBSELEN BOND IN C2 SPACE GROUP Deposited 2019-09-01 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain J
2–154（153 aa）
Chain L
2–154（153 aa）
|
Mutation：Ala4Val Mutation：Ala4Val | ZN ZINC ION × 2 9JT N-phenyl-2-selanylbenzamide × 2 GOL GLYCEROL × 2 SO4 SULFATE ION × 1 DMS DIMETHYL SULFOXIDE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Tris-HCl pH 7.4-8.0, 2.4-2.6 M ammonium sulphate, 150 mM NaCl
|
Resolution 2.25 Å R-free 0.222 |
| 6SPI A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 4 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain J
1–154（154 aa）
|
Mutation：A4V Mutation：A4V | LQW ~{N}-[(4-chlorophenyl)methyl]-2-selanyl-benzamide × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；100mM Tris-HCl pH 7.8, 2.6 M ammonium sulphate
|
Resolution 2.80 Å R-free 0.241 |
| 6SPI A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 4 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
1–154（154 aa）
Chain K
1–154（154 aa）
|
Mutation：A4V Mutation：A4V | LQW ~{N}-[(4-chlorophenyl)methyl]-2-selanyl-benzamide × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；100mM Tris-HCl pH 7.8, 2.6 M ammonium sulphate
|
Resolution 2.80 Å R-free 0.241 |
| 6SPI A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 4 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain I
1–154（154 aa）
|
Mutation：A4V Mutation：A4V | LQW ~{N}-[(4-chlorophenyl)methyl]-2-selanyl-benzamide × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；100mM Tris-HCl pH 7.8, 2.6 M ammonium sulphate
|
Resolution 2.80 Å R-free 0.241 |
| 6SPI A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 4 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–154（154 aa）
Chain L
1–154（154 aa）
|
Mutation：A4V Mutation：A4V | LQW ~{N}-[(4-chlorophenyl)methyl]-2-selanyl-benzamide × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；100mM Tris-HCl pH 7.8, 2.6 M ammonium sulphate
|
Resolution 2.80 Å R-free 0.241 |
| 6SPI A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 4 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–154（154 aa）
Chain G
1–154（154 aa）
|
Mutation：A4V Mutation：A4V | LQW ~{N}-[(4-chlorophenyl)methyl]-2-selanyl-benzamide × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；100mM Tris-HCl pH 7.8, 2.6 M ammonium sulphate
|
Resolution 2.80 Å R-free 0.241 |
| 6SPI A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 4 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
1–154（154 aa）
Chain H
1–154（154 aa）
|
Mutation：A4V Mutation：A4V | LQW ~{N}-[(4-chlorophenyl)methyl]-2-selanyl-benzamide × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；100mM Tris-HCl pH 7.8, 2.6 M ammonium sulphate
|
Resolution 2.80 Å R-free 0.241 |
| 6SPJ A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 1 Deposited 2019-09-01 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 LR2 ~{N}-pyridin-2-yl-2-selanyl-benzamide × 2 SO4 SULFATE ION × 13 GOL GLYCEROL × 2 DMS DIMETHYL SULFOXIDE × 3 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；2.6 M Ammonium sulphate, 100 mM Tris-HCl pH 7.6, 150 mM NaCl
|
Resolution 1.97 Å R-free 0.225 |
| 6SPJ A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 1 Deposited 2019-09-01 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 LR2 ~{N}-pyridin-2-yl-2-selanyl-benzamide × 2 SO4 SULFATE ION × 7 GOL GLYCEROL × 2 DMS DIMETHYL SULFOXIDE × 4 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；2.6 M Ammonium sulphate, 100 mM Tris-HCl pH 7.6, 150 mM NaCl
|
Resolution 1.97 Å R-free 0.225 |
| 6SPJ A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 1 Deposited 2019-09-01 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
Chain J
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 LR2 ~{N}-pyridin-2-yl-2-selanyl-benzamide × 2 SO4 SULFATE ION × 10 GOL GLYCEROL × 2 DMS DIMETHYL SULFOXIDE × 2 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；2.6 M Ammonium sulphate, 100 mM Tris-HCl pH 7.6, 150 mM NaCl
|
Resolution 1.97 Å R-free 0.225 |
| 6SPK A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 6 Deposited 2019-09-01 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 2 LQN 2-selanyl-~{N}-[3-[4-(trifluoromethyl)phenyl]phenyl]benzamide × 2 SO4 SULFATE ION × 8 GOL GLYCEROL × 1 CL CHLORIDE ION × 3 DMS DIMETHYL SULFOXIDE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；2.6 M Ammonium sulphate, 100 mM Tris-HCl pH 7.6, 150 mM NaCl
|
Resolution 2.77 Å R-free 0.229 |
| 6SPK A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 6 Deposited 2019-09-01 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 2 LQN 2-selanyl-~{N}-[3-[4-(trifluoromethyl)phenyl]phenyl]benzamide × 2 SO4 SULFATE ION × 10 CL CHLORIDE ION × 3 DMS DIMETHYL SULFOXIDE × 2 NA SODIUM ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；2.6 M Ammonium sulphate, 100 mM Tris-HCl pH 7.6, 150 mM NaCl
|
Resolution 2.77 Å R-free 0.229 |
| 6SPK A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 6 Deposited 2019-09-01 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
Chain J
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 3 LQN 2-selanyl-~{N}-[3-[4-(trifluoromethyl)phenyl]phenyl]benzamide × 2 SO4 SULFATE ION × 8 CL CHLORIDE ION × 3 NA SODIUM ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；2.6 M Ammonium sulphate, 100 mM Tris-HCl pH 7.6, 150 mM NaCl
|
Resolution 2.77 Å R-free 0.229 |
| 6Z3V A4V mutant of human SOD1 bound with N-aryl benzoisoselenazolone derivative 13 in P21 space group Deposited 2020-05-22 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain BBB
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 Q6H 5-fluoranyl-~{N}-(3-morpholin-4-ylcarbonylphenyl)-2-selanyl-benzamide × 2 SO4 SULFATE ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.25 Å R-free 0.191 |
| 6Z4G A4V mutant of human SOD1 bound with ebselen in P21 space group Deposited 2020-05-25 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain BBB
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 ACT ACETATE ION × 2 9JT N-phenyl-2-selanylbenzamide × 2 SO4 SULFATE ION × 4 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.45 Å R-free 0.193 |
| 6Z4H A4V mutant of human SOD1 bound with benzyl benzoisoselenazolone derivative 2 in P21 space group Deposited 2020-05-25 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain BBB
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 LQW ~{N}-[(4-chlorophenyl)methyl]-2-selanyl-benzamide × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.6M ammonium sulphate
|
Resolution 1.95 Å R-free 0.242 |
| 6Z4I A4V mutant of human SOD1 bound with benzyl benzoisoselenazolone derivative 3 in P21 space group Deposited 2020-05-25 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain FFF
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 ACT ACETATE ION × 2 SO4 SULFATE ION × 2 Q85 ~{N}-[(4-methoxyphenyl)methyl]-2-selanyl-benzamide × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.60 Å R-free 0.217 |
| 6Z4J A4V mutant of human SOD1 bound with benzyl benzoisoselenazolone derivative 5 in P21 space group Deposited 2020-05-25 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain BBB
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 Q7W ~{N}-[(3-chlorophenyl)methyl]-2-selanyl-benzamide × 2 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.5M ammonium sulphate
|
Resolution 1.55 Å R-free 0.208 |
| 6Z4K A4V mutant of human SOD1 bound with benzyl benzoisoselenazolone derivative 6 in P21 space group Deposited 2020-05-25 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain BBB
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | Q7N ~{N}-[(3-methoxyphenyl)methyl]-2-selanyl-benzamide × 2 ZN ZINC ION × 4 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.45 Å R-free 0.209 |
| 6Z4L A4V mutant of human SOD1 bound with 2-(pyridin-3-ylmethyl)benzoisoselenazolone derivative 9 in P21 space group Deposited 2020-05-25 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain BBB
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | Q8H ~{N}-(pyridin-3-ylmethyl)-2-selanyl-benzamide × 2 ZN ZINC ION × 4 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.60 Å R-free 0.208 |
| 6Z4M A4V mutant of human SOD1 bound with 2-(pyridin-3-ylmethyl)benzoisoselenazolone derivative 10 in P21 space group Deposited 2020-05-25 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain BBB
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | Q8E ~{N}-[(6-methoxypyridin-3-yl)methyl]-2-selanyl-benzamide × 2 ZN ZINC ION × 4 CL CHLORIDE ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.55 Å R-free 0.208 |
| 6Z4O A4V mutant of human SOD1 bound with benzyl benzoisoselenazolone derivative 1 in P21 space group Deposited 2020-05-25 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain BBB
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 Q7T ~{N}-(phenylmethyl)-2-selanyl-benzamide × 2 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.40 Å R-free 0.232 |
| 7FB6 C57D/C146D mutant of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–154（154 aa）
|
Mutation：C57D/C146D Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 1 CU COPPER (II) ION × 1 CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.2M MgCl2, 22% (w/v) PEG 3350
|
Resolution 1.80 Å R-free 0.213 |
| 7FB6 C57D/C146D mutant of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
1–154（154 aa）
|
Mutation：C57D/C146D Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 1 CU COPPER (II) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.2M MgCl2, 22% (w/v) PEG 3350
|
Resolution 1.80 Å R-free 0.213 |
| 7FB9 Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.1M sodium acetate-HCl (pH 4.5), 21% (w/v) PEG 3350
|
Resolution 2.70 Å R-free 0.247 |
| 7FB9 Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain I
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.1M sodium acetate-HCl (pH 4.5), 21% (w/v) PEG 3350
|
Resolution 2.70 Å R-free 0.247 |
| 7FB9 Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–154（154 aa）
Chain E
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.1M sodium acetate-HCl (pH 4.5), 21% (w/v) PEG 3350
|
Resolution 2.70 Å R-free 0.247 |
| 7FB9 Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
1–154（154 aa）
Chain G
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.1M sodium acetate-HCl (pH 4.5), 21% (w/v) PEG 3350
|
Resolution 2.70 Å R-free 0.247 |
| 7FB9 Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain H
1–154（154 aa）
Chain L
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.1M sodium acetate-HCl (pH 4.5), 21% (w/v) PEG 3350
|
Resolution 2.70 Å R-free 0.247 |
| 7FB9 Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain J
1–154（154 aa）
Chain K
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.1M sodium acetate-HCl (pH 4.5), 21% (w/v) PEG 3350
|
Resolution 2.70 Å R-free 0.247 |
| 7FB9 Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 7 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain M
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.1M sodium acetate-HCl (pH 4.5), 21% (w/v) PEG 3350
|
Resolution 2.70 Å R-free 0.247 |
| 7FB9 Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 8 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain N
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.1M sodium acetate-HCl (pH 4.5), 21% (w/v) PEG 3350
|
Resolution 2.70 Å R-free 0.247 |
| 7NXX Structure of Superoxide Dismutase 1 (SOD1) in complex with nanobody 2 (Nb2). Deposited 2021-03-19 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；273 K；0.1 M Hepes,1.5 M Lithium sulphate, pH 7.5
|
Resolution 2.19 Å R-free 0.245 |
| 7T8E G93A mutant of human SOD1 in P21 space group Deposited 2021-12-16 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 4 ACT ACETATE ION × 1 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.40 Å R-free 0.229 |
| 7T8F G93A mutant of human SOD1 bound with Ebselen in P21 space group Deposited 2021-12-16 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 4 ACT ACETATE ION × 1 9JT N-phenyl-2-selanylbenzamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.40 Å R-free 0.225 |
| 7T8G G93A mutant of human SOD1 bound with MR6-8-2 in P21 space group Deposited 2021-12-16 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 4 Q8H ~{N}-(pyridin-3-ylmethyl)-2-selanyl-benzamide × 2 ACT ACETATE ION × 1 SO4 SULFATE ION × 2 SE SELENIUM ATOM × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.35 Å R-free 0.202 |
| 7T8H G93A mutant of human SOD1 bound with MR6-26-2 in P21 space group Deposited 2021-12-16 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 4 ACT ACETATE ION × 1 Q8E ~{N}-[(6-methoxypyridin-3-yl)methyl]-2-selanyl-benzamide × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.50 Å R-free 0.224 |
| 7VZF Cryo-EM structure of amyloid fibril formed by full-length human SOD1 Deposited 2021-11-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.95 Å |
| 7XX3 Crystal structure of human Superoxide Dismutase (SOD1) in complex with a fungal metabolite molecule, Phialomustin B (PB) Deposited 2022-05-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 4 I2G (2~{E},4~{E},6~{S})-4,6-dimethyldeca-2,4-dienoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate (pH = 6.5)
|
Resolution 1.90 Å R-free 0.230 |
| 7XX3 Crystal structure of human Superoxide Dismutase (SOD1) in complex with a fungal metabolite molecule, Phialomustin B (PB) Deposited 2022-05-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 1 I2G (2~{E},4~{E},6~{S})-4,6-dimethyldeca-2,4-dienoic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate (pH = 6.5)
|
Resolution 1.90 Å R-free 0.230 |
| 7XX3 Crystal structure of human Superoxide Dismutase (SOD1) in complex with a fungal metabolite molecule, Phialomustin B (PB) Deposited 2022-05-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–154（154 aa）
Chain H
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 DMS DIMETHYL SULFOXIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate (pH = 6.5)
|
Resolution 1.90 Å R-free 0.230 |
| 7XX3 Crystal structure of human Superoxide Dismutase (SOD1) in complex with a fungal metabolite molecule, Phialomustin B (PB) Deposited 2022-05-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
1–154（154 aa）
Chain G
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate (pH = 6.5)
|
Resolution 1.90 Å R-free 0.230 |
| 7XX3 Crystal structure of human Superoxide Dismutase (SOD1) in complex with a fungal metabolite molecule, Phialomustin B (PB) Deposited 2022-05-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 1 I2G (2~{E},4~{E},6~{S})-4,6-dimethyldeca-2,4-dienoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate (pH = 6.5)
|
Resolution 1.90 Å R-free 0.230 |
| 8CCX Human SOD1 in complex with S-XL6 cross-linker Deposited 2023-01-27 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain F
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 4 SO4 SULFATE ION × 2 UDI butane-1,4-dithiol × 1 DMS DIMETHYL SULFOXIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.75；293 K；2.5M ammonium sulphate, 150mM NaCl, sodium acetate pH 4.75
|
Resolution 1.67 Å R-free 0.233 |
| 8GSQ Structure based studies reveal an atypical antipsychotic drug candidate - Paliperidone as a potent hSOD1 modulator with implications in ALS treatment. Deposited 2022-09-06 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；Sodium Citrate
|
Resolution 2.10 Å R-free 0.208 |
| 8GSQ Structure based studies reveal an atypical antipsychotic drug candidate - Paliperidone as a potent hSOD1 modulator with implications in ALS treatment. Deposited 2022-09-06 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；Sodium Citrate
|
Resolution 2.10 Å R-free 0.208 |
| 8GSQ Structure based studies reveal an atypical antipsychotic drug candidate - Paliperidone as a potent hSOD1 modulator with implications in ALS treatment. Deposited 2022-09-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain F
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；Sodium Citrate
|
Resolution 2.10 Å R-free 0.208 |
| 8GSQ Structure based studies reveal an atypical antipsychotic drug candidate - Paliperidone as a potent hSOD1 modulator with implications in ALS treatment. Deposited 2022-09-06 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；Sodium Citrate
|
Resolution 2.10 Å R-free 0.208 |
| 8IHU Cryo-EM structure of an amyloid fibril formed by ALS-causing SOD1 mutation G85R Deposited 2023-02-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.97 Å |
| 8IHV Cryo-EM structure of an amyloid fibril formed by ALS-causing SOD1 mutation H46R Deposited 2023-02-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.11 Å |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 10 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain Y
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 11 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain U
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 12 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain W
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain K
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 7 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain L
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 8 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain N
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 9 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain P
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K3A SOD1 and Nanobody2 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Magnesium chloride, 0.1 M Sodium, citrate pH 5, 15%(w/v) PEG 4000
|
Resolution 2.74 Å R-free 0.256 |
| 8K3L SOD1 and Nanobody3 complex Deposited 2023-07-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 1 ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.2 M Ammonium acetate, 0.1 M Sodium acetate trihydrate pH 4.6, 30% w/v
Polyethylene, glycol monomethyl ether 2,000
|
Resolution 2.30 Å R-free 0.235 |
| 8K3L SOD1 and Nanobody3 complex Deposited 2023-07-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 1 ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.2 M Ammonium acetate, 0.1 M Sodium acetate trihydrate pH 4.6, 30% w/v
Polyethylene, glycol monomethyl ether 2,000
|
Resolution 2.30 Å R-free 0.235 |
| 8K3L SOD1 and Nanobody3 complex Deposited 2023-07-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 1 ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.2 M Ammonium acetate, 0.1 M Sodium acetate trihydrate pH 4.6, 30% w/v
Polyethylene, glycol monomethyl ether 2,000
|
Resolution 2.30 Å R-free 0.235 |
| 8K3L SOD1 and Nanobody3 complex Deposited 2023-07-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 1 ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.2 M Ammonium acetate, 0.1 M Sodium acetate trihydrate pH 4.6, 30% w/v
Polyethylene, glycol monomethyl ether 2,000
|
Resolution 2.30 Å R-free 0.235 |
| 8Q6M Human SOD1 low dose data collecton Deposited 2023-08-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Not recorded | ACT ACETATE ION × 1 ZN ZINC ION × 2 CU COPPER (II) ION × 2 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.75；293 K；2.5 M Ammonium sulphate, Acetate buffer pH 4.75
|
Resolution 1.77 Å R-free 0.251 |
| 8YAF SOD1, Nanobody1 and Nanobody2 complex Deposited 2024-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；5% (v/v) Isopropanol, 2.0 M Ammonium sulfate
|
Resolution 3.28 Å R-free 0.249 |
| 8YAF SOD1, Nanobody1 and Nanobody2 complex Deposited 2024-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain D
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；5% (v/v) Isopropanol, 2.0 M Ammonium sulfate
|
Resolution 3.28 Å R-free 0.249 |
| 8YAF SOD1, Nanobody1 and Nanobody2 complex Deposited 2024-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain H
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；5% (v/v) Isopropanol, 2.0 M Ammonium sulfate
|
Resolution 3.28 Å R-free 0.249 |
| 8YAF SOD1, Nanobody1 and Nanobody2 complex Deposited 2024-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain L
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；5% (v/v) Isopropanol, 2.0 M Ammonium sulfate
|
Resolution 3.28 Å R-free 0.249 |
| 8YAF SOD1, Nanobody1 and Nanobody2 complex Deposited 2024-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain P
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；5% (v/v) Isopropanol, 2.0 M Ammonium sulfate
|
Resolution 3.28 Å R-free 0.249 |
| 8YAF SOD1, Nanobody1 and Nanobody2 complex Deposited 2024-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain T
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；5% (v/v) Isopropanol, 2.0 M Ammonium sulfate
|
Resolution 3.28 Å R-free 0.249 |
| 8YAT SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Deposited 2024-02-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.2M Ammonium sulfate, 0.1M HEPES pH8.0, 20%w/v Polyethylene glycol 3350
|
Resolution 3.94 Å R-free 0.368 |
| 8YAT SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Deposited 2024-02-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.2M Ammonium sulfate, 0.1M HEPES pH8.0, 20%w/v Polyethylene glycol 3350
|
Resolution 3.94 Å R-free 0.368 |
| 8YAT SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Deposited 2024-02-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain I
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.2M Ammonium sulfate, 0.1M HEPES pH8.0, 20%w/v Polyethylene glycol 3350
|
Resolution 3.94 Å R-free 0.368 |
| 8YAT SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Deposited 2024-02-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain M
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.2M Ammonium sulfate, 0.1M HEPES pH8.0, 20%w/v Polyethylene glycol 3350
|
Resolution 3.94 Å R-free 0.368 |
| 8YD3 Crystal structure of human Cu-Zn Superoxide Dismutase 1 in complex with 1,2,10-Decanetriol Deposited 2024-02-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 2 A1LYN (2S)-decane-1,2,10-triol × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate
|
Resolution 1.96 Å R-free 0.211 |
| 8YD3 Crystal structure of human Cu-Zn Superoxide Dismutase 1 in complex with 1,2,10-Decanetriol Deposited 2024-02-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 2 A1LYN (2S)-decane-1,2,10-triol × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate
|
Resolution 1.96 Å R-free 0.211 |
| 8YD3 Crystal structure of human Cu-Zn Superoxide Dismutase 1 in complex with 1,2,10-Decanetriol Deposited 2024-02-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–154（154 aa）
Chain F
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 1 A1LYN (2S)-decane-1,2,10-triol × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate
|
Resolution 1.96 Å R-free 0.211 |
| 8YD3 Crystal structure of human Cu-Zn Superoxide Dismutase 1 in complex with 1,2,10-Decanetriol Deposited 2024-02-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
1–154（154 aa）
Chain H
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 1 A1LYN (2S)-decane-1,2,10-triol × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate
|
Resolution 1.96 Å R-free 0.211 |
| 8YD3 Crystal structure of human Cu-Zn Superoxide Dismutase 1 in complex with 1,2,10-Decanetriol Deposited 2024-02-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 A1LYN (2S)-decane-1,2,10-triol × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate
|
Resolution 1.96 Å R-free 0.211 |
| 9IYD Cryo-EM structure of an amyloid fibril formed by SOD1 mutant - G93A Deposited 2024-07-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
|
Mutation：G94A Mutation：G94A Mutation：G94A | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.09 Å |
| 9IYJ Cryo-EM structure of an amyloid fibril formed by SOD1 mutant - D101N Deposited 2024-07-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
Chain C
2–154（153 aa）
|
Mutation：D102N Mutation：D102N Mutation：D102N | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.92 Å |
| 9IYK Crystal structure of hSOD1 in C121 space group Deposited 2024-07-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 3 ACT ACETATE ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Ammonium sulfate, sodium acetate
|
Resolution 2.34 Å R-free 0.263 |
| 9IYK Crystal structure of hSOD1 in C121 space group Deposited 2024-07-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 ACT ACETATE ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Ammonium sulfate, sodium acetate
|
Resolution 2.34 Å R-free 0.263 |
| 9IYK Crystal structure of hSOD1 in C121 space group Deposited 2024-07-30 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain K
1–154（154 aa）
Chain L
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Ammonium sulfate, sodium acetate
|
Resolution 2.34 Å R-free 0.263 |
| 9IYK Crystal structure of hSOD1 in C121 space group Deposited 2024-07-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–154（154 aa）
Chain F
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Ammonium sulfate, sodium acetate
|
Resolution 2.34 Å R-free 0.263 |
| 9IYK Crystal structure of hSOD1 in C121 space group Deposited 2024-07-30 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
1–154（154 aa）
Chain H
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Ammonium sulfate, sodium acetate
|
Resolution 2.34 Å R-free 0.263 |
| 9IYK Crystal structure of hSOD1 in C121 space group Deposited 2024-07-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Ammonium sulfate, sodium acetate
|
Resolution 2.34 Å R-free 0.263 |
| 9JBO Cryo-EM structure of human SOD1 (WT) amyloid filament Deposited 2024-08-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.39 Å |
| 9JBP Cryo-EM structure of human SOD1 (C6A/C111A) amyloid filament Deposited 2024-08-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
Chain E
1–154（154 aa）
Chain F
1–154（154 aa）
|
Mutation：C6A,C111A Mutation：C6A,C111A Mutation：C6A,C111A Mutation：C6A,C111A Mutation：C6A,C111A Mutation：C6A,C111A | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.18 Å |
| 9LI1 Cryo-EM structure of human SOD1 (G93A) amyloid filament Deposited 2025-01-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.74 Å |
| 9MIL Superoxide dismutase residues 28-39 with G37R mutation Deposited 2024-12-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
29–40（12 aa）
Chain B
29–40（12 aa）
Chain C
29–40（12 aa）
Chain D
29–40（12 aa）
Chain E
29–40（12 aa）
Chain F
29–40（12 aa）
Chain G
29–40（12 aa）
Chain H
29–40（12 aa）
Chain I
29–40（12 aa）
Chain J
29–40（12 aa）
|
Not recorded | SO4 SULFATE ION × 5 PG4 TETRAETHYLENE GLYCOL × 2 PEG DI(HYDROXYETHYL)ETHER × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；1.0 M Ammonium sulfate, 0.1 M BIS-TRIS pH 5.5, 1% w/v Polyethylene glycol 3,350
|
Resolution 2.50 Å R-free 0.263 |
| 9XJI Cryogenic structure of SOD1, determined as the SSX counterpart Deposited 2025-11-04 | Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Ammonium sulfate, sodium acetate, PVP-K15
|
Resolution 2.37 Å R-free 0.231 |
153 other PDB entries and 375 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | SODC_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–153； UniProt 2–154 Author chain B； PDBConstruct 1–153； UniProt 2–154 |
