← Back to search

9xqb

Cryo-EM structure of the human A2A adenosine receptor in complex with a Fab antibody fragment

Method: ELECTRON MICROSCOPY D_max: 100.2 Å Quality: GOOD

SAXS Profile

P(r) Distribution

▼

1. Structure Basics

entry_id	9xqb
deposition_date	2025-11-18
title	Cryo-EM structure of the human A2A adenosine receptor in complex with a Fab antibody fragment
keywords	Cryo-EM Lip-MS, MEMBRANE PROTEIN; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

▼

Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

▼

2. SAXS Parameters (CRYSOL)

rg_guinier	29.49 Å
rg_electron	29.73 Å
i0	31936900.00
molecular_weight	41251.0 kDa
excluded_volume	50456 Å³
envelope_volume	73748 Å³
shell_volume	22917 Å³
envelope_diameter	107.5 Å
shell_rg	32.91 Å
envelope_rg	29.78 Å
shape_rg	29.66 Å
total_rg	30.28 Å
total_atoms	2932
n_residues	453
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

▼

3. P(r) Analysis (GNOM)

dmax	100.2 Å
rg_real	29.80 Å
rg_real_error	0.99 Å
i0_real	3.1940e+07
i0_real_error	5.3860e+05
rg_reciprocal	29.67 Å
i0_reciprocal	31930000.0000
total_estimate	0.8129
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	24.1 Å
skewness	0.541
kurtosis	-0.426
angular_range	— – 0.2700 Å⁻¹
current_alpha	0.0000
highest_alpha	11500000.0000
n_real_points	55
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.692; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.662; Smooth: 0.827

▶

4. Crystallography & Experiment

▶

5. Entities & Polymer Info (3)

Entity 1 polymer

description	Fab Light chain
formula_weight	13761.1 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	B
atom_count	2932

DIQLTQSPAVLSVSPGERVSFSCRASQTIGTSIHWYQQRTNGSPRLLVKFASESISGIPSRFSGSGSGTDFTLTINSVESEDIADYYCQQSNSWPYTFGGGTKLEIKRADAAPTVSKGEFQHTGGRY

Source

organism	Mus musculus
ncbi_taxonomy_id	10090
host_organism	Mus musculus

Entity 2 polymer

description	A2A receptor-BRIL
formula_weight	47924.8 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	C

DYKDDDDKPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLEQSRIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKQHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAGGSGSGLEVLFQ

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 3 polymer

description	Fab Heavy chain
formula_weight	15465.1 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A

EVKLVESGPELKKPGETVKISCKASGYSFTNYGINWMKQAPGEGLEWMGWINTYTGEATYDDDFKGRFAFSLETSASTAYLQIINLKNEDMATYFCSRRGAYYRYDGYFYTMDFWGQGTSVTVSSKGEFQHTGGRY

Source

organism	Mus musculus
ncbi_taxonomy_id	10090
host_organism	Mus musculus

▶

6. Citations (1)

▶

length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.450 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	3.45 Å
resolution_method	—
num_particles	172394

fit	/app/data/saxs_computation/xq/9xqb/9xqb.fit
pddf	/app/data/pr_computation/xq/9xqb/9xqb.pr.out
profile	/app/data/saxs_computation/xq/9xqb/9xqb.dat

Cryo-EM structure of the human A2A adenosine receptor in complex with a Fab antibody fragment

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D

5. Entities & Polymer Info (3)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)