当前蛋白身份：A0A061IH64
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差异标签只比较当前检索结果；所有PDB和assembly原始记录仍分别保留。
相关结构差异明细
一行代表一个 PDB 条目中的一个 biological assembly；同一蛋白的多个单体会分别列出。
| PDB 条目 | Assembly / 聚集状态 | 构建体 | 突变与修饰 | 配体、离子与非聚合物 | 实验方法 | 实验环境 | 结构质量 |
|---|---|---|---|---|---|---|---|
| 5N1D cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule N-methyl-1-(5-pyridin-3-yloxyfuran-2-yl)methanamine 提交 2017-02-06 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
6–24（19 aa）
|
未记录 | MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 2 8FZ (5-pyridin-3-yloxyfuran-2-yl)methanamine × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 6.9；277 K；MES-BIS-TRIS
Mega8-Solution
DTT
EDTA
LiCl
Methanol
|
分辨率 1.61 Å R-free 0.186 |
| 5N1E cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule N-(1,3-benzodioxol-5-yl)-2-piperidin-1-ylacetamide 提交 2017-02-06 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
12–30（19 aa）
片段：UNP residues 12-30
|
未记录 | MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 9NT ~{N}-(1,3-benzodioxol-5-yl)-2-piperidin-1-ium-1-yl-ethanamide × 1 DMS DIMETHYL SULFOXIDE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 6.9；277 K；MES-BIS-TRIS
Mega8-Solution
DTT
EDTA
LiCl
Methanol
|
分辨率 1.53 Å R-free 0.174 |
| 5N1K cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 2-amino-1-(4-fluorophenyl)ethanol 提交 2017-02-06 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
12–30（19 aa）
|
未记录 | 489 (1S)-2-amino-1-(4-fluorophenyl)ethanol × 3 DMS DIMETHYL SULFOXIDE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 6.9；277 K；MES-BIS-TRIS
Mega8-Solution
DTT
EDTA
LiCl
Methanol
|
分辨率 1.80 Å R-free 0.207 |
| 5N1L cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 2,5-dimethyl-N-pyridin-4-ylfuran-3-carboxamide 提交 2017-02-06 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
12–30（19 aa）
|
未记录 | 47V 2,5-dimethyl-N-(pyridin-4-yl)furan-3-carboxamide × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 2 DMS DIMETHYL SULFOXIDE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 6.9；277 K；MES-BIS-TRIS
Mega8-Solution
DTT
EDTA
LiCl
Methanol
|
分辨率 1.49 Å R-free 0.175 |
| 5N1M cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule (5-chloro-2-methoxyphenyl)methanamine 提交 2017-02-06 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
12–30（19 aa）
|
未记录 | MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 DMS DIMETHYL SULFOXIDE × 1 BJK (4-methoxy-3-oxidanyl-phenyl)methylazanium × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 6.9；277 K；MES-BIS-TRIS
Mega8-Solution
DTT
EDTA
LiCl
Methanol
|
分辨率 1.44 Å R-free 0.170 |
| 5N1N cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 2-chloro-9-propan-2-ylpurine 提交 2017-02-06 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
12–30（19 aa）
|
未记录 | MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 8G8 2-chloranyl-9-methyl-purine × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 6.9；277 K；MES-BIS-TRIS
Mega8-Solution
DTT
EDTA
LiCl
Methanol
|
分辨率 1.41 Å R-free 0.179 |
| 5N1O cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 2-chloro-4-(chloromethyl)-5-hydroxyphenyl)ethan-1-one 提交 2017-02-06 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
12–30（19 aa）
片段：UNP residues 12-30
|
未记录 | MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 8GB 1-[5-chloranyl-3-(chloromethyl)-2-oxidanyl-phenyl]ethanone × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 6.9；277 K；MES-BIS-TRIS
Mega8-Solution
DTT
EDTA
LiCl
Methanol
|
分辨率 1.80 Å R-free 0.191 |
| 5N32 cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 4-chlorobenzyl carbamimidothioate 提交 2017-02-08 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
12–30（19 aa）
片段：UNP residues 12-30
|
未记录 | 8K5 [azanyl-[(4-chlorophenyl)methylsulfanyl]methylidene]azanium × 2 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 6.9；277 K；MES-BIS-TRIS
Mega8-Solution
DTT
EDTA
LiCl
Methanol
|
分辨率 1.83 Å R-free 0.214 |
| 5N33 cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 3-amino-5-(trifluoromethyl)-1H-pyridin-2-one 提交 2017-02-08 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
12–30（19 aa）
片段：UNP residues 12-30
|
未记录 | 8JW 3-azanyl-5-(trifluoromethyl)-1~{H}-pyridin-2-one × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 DMS DIMETHYL SULFOXIDE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 6.9；277 K；MES-BIS-TRIS
Mega8-Solution
DTT
EDTA
LiCl
Methanol
|
分辨率 1.43 Å R-free 0.174 |
| 5N37 cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule N-(1,3-benzodioxol-5-ylmethyl)cyclopentanamine 提交 2017-02-08 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
12–30（19 aa）
片段：UNP residues 12-30
|
未记录 | MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 8JT 1,3-benzodioxol-5-ylmethyl(cyclopentyl)azanium × 2 DMS DIMETHYL SULFOXIDE × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 6.9；277 K；MES-BIS-TRIS
Mega8-Solution
DTT
EDTA
LiCl
Methanol
|
分辨率 1.59 Å R-free 0.167 |
| 5N39 cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)pyrrolidine 提交 2017-02-08 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
12–30（19 aa）
|
未记录 | 8LZ (2~{S})-2-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrrolidin-1-ium × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 2 DMS DIMETHYL SULFOXIDE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 6.9；277 K；MES-BIS-TRIS
Mega8-Solution
DTT
EDTA
LiCl
Methanol
|
分辨率 1.45 Å R-free 0.169 |
| 5N3D cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 4-(trifluoromethyl)benzenecarboximidamide 提交 2017-02-08 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
12–30（19 aa）
|
未记录 | 8NE [azanyl-[4-(trifluoromethyl)phenyl]methylidene]azanium × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 6.9；277 K；MES-BIS-TRIS
Mega8-Solution
DTT
EDTA
LiCl
Methanol
|
分辨率 1.77 Å R-free 0.193 |
| 5N3E cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 6-dimethylaminopyridine-3-carboxylic acid 提交 2017-02-08 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
12–30（19 aa）
|
未记录 | 46L 6-(dimethylamino)pyridine-3-carboxylic acid × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 DMS DIMETHYL SULFOXIDE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 6.9；277 K；MES-BIS-TRIS
Mega8-Solution
DTT
EDTA
LiCl
Methanol
|
分辨率 1.53 Å R-free 0.185 |
| 5N7U cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 4-Bromo-3,5-dimethyl-1H-pyrazole 提交 2017-02-21 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
12–30（19 aa）
|
未记录 | MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 8PQ 4-bromanyl-3,5-dimethyl-1~{H}-pyrazole × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 6.9；277 K；MES-BIS-TRIS
Mega8-Solution
DTT
EDTA
LiCl
Methanol
|
分辨率 1.37 Å R-free 0.177 |
| 5NTJ Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compound RKp032 提交 2017-04-28 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
6–23（18 aa）
|
未记录 | MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 RIP beta-D-ribopyranose × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.9；277.15 K；5 mM Mes-Bis-Tris, 75 mM lithium chloride, 1 mM DTT, 0.1 mM sodium EDTA, 0.25 mM Mega 8, 0.7 mM peptidic ligand, 16 % v/v methanol/water in reservoir
|
分辨率 1.56 Å R-free 0.177 |
| 5OT3 Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp191 and RKp117 提交 2017-08-19 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 D
6–23（18 aa）
片段：UNP Residues 6-23
|
未记录 | 9LQ [2-[(4-isoquinolin-5-ylsulfonyl-1,4-diazepan-1-yl)methyl]phenyl]boronic acid × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 RIP beta-D-ribopyranose × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 6.9；277.15 K；100 mM Mes-Bis-Tris, 75 mM lithium chloride, 1 mM DTT, 0.1 mM sodium EDTA, 0.25 mM Mega 8, 0.7 mM peptidic ligand, 5 mM RKp117, 20 % v/v methanol/water in reservoir
|
分辨率 2.04 Å R-free 0.228 |
| 6ERT Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp193 and RKp117 提交 2017-10-19 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 D
6–23（18 aa）
|
未记录 | BVZ [2-[(4-isoquinolin-5-ylsulfonyl-1,4-diazepan-1-yl)methyl]phenyl]-tris(oxidanyl)boranuide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 6.9；277.15 K；100 mM Mes-Bis-Tris, 75 mM lithium chloride, 1 mM DTT, 0.1 mM sodium EDTA, 0.25 mM Mega 8, 0.7 mM peptidic ligand, 5 mM RKp117, 17% v/v methanol/water in reservoir
|
分辨率 1.80 Å R-free 0.218 |
| 6ERV Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp013 提交 2017-10-19 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
6–23（18 aa）
|
未记录 | MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 6.9；277.15 K；100 mM Mes-Bis-Tris, 75 mM lithium chloride, 1 mM DTT, 0.1 mM sodium EDTA, 0.25 mM Mega 8, 0.7 mM peptidic ligand, 20% v/v methanol/water in reservoir
|
分辨率 2.06 Å R-free 0.217 |