Current Protein Identity：A0A142IX72
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 5GJ4 Structure of NS2B-NS3 Protease from Zika Virus caught after self-cleavage Deposited 2016-06-27 | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
1411–1462（52 aa）
Fragment：UNP residues 1411-1462,UNP residues 1492-1496
Chain A
1492–1496（5 aa）
Fragment：UNP residues 1411-1462,UNP residues 1492-1496
Chain B
1497–1673（177 aa）
Fragment：UNP residues 1497-1673
Chain E
1411–1462（52 aa）
Fragment：UNP residues 1411-1462,UNP residues 1492-1496
Chain E
1492–1496（5 aa）
Fragment：UNP residues 1411-1462,UNP residues 1492-1496
Chain F
1497–1673（177 aa）
Fragment：UNP residues 1497-1673
|
Not recorded | CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291.15 K；0.2 M Sodium Malonate, pH 4.0, 10% PEG 3350
|
Resolution 1.84 Å R-free 0.195 |
| 5GJ4 Structure of NS2B-NS3 Protease from Zika Virus caught after self-cleavage Deposited 2016-06-27 | Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain C
1411–1462（52 aa）
Fragment：UNP residues 1411-1462,UNP residues 1492-1496
Chain C
1492–1496（5 aa）
Fragment：UNP residues 1411-1462,UNP residues 1492-1496
Chain D
1497–1673（177 aa）
Fragment：UNP residues 1497-1673
Chain G
1411–1462（52 aa）
Fragment：UNP residues 1411-1462,UNP residues 1492-1496
Chain G
1492–1496（5 aa）
Fragment：UNP residues 1411-1462,UNP residues 1492-1496
Chain H
1497–1673（177 aa）
Fragment：UNP residues 1497-1673
|
Not recorded | CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291.15 K；0.2 M Sodium Malonate, pH 4.0, 10% PEG 3350
|
Resolution 1.84 Å R-free 0.195 |
| 5ZOB Crystal structure of Zika NS3 protease with 4-guanidinomethyl-phenylacetyl-Arg-Arg-Arg-4-amidinobenzylamide Deposited 2018-04-12 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
1497–1673（177 aa）
Chain H
1497–1673（177 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293.15 K；2 M ammonium sulfate, 0.1 M sodium acetate trihydrate pH 4.6
|
Resolution 2.00 Å R-free 0.279 |
| 5ZOB Crystal structure of Zika NS3 protease with 4-guanidinomethyl-phenylacetyl-Arg-Arg-Arg-4-amidinobenzylamide Deposited 2018-04-12 | Assembly 2 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain D
1497–1673（177 aa）
Chain F
1497–1673（177 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293.15 K；2 M ammonium sulfate, 0.1 M sodium acetate trihydrate pH 4.6
|
Resolution 2.00 Å R-free 0.279 |
| 6JPW Crystal structure of Zika NS2B-NS3 protease with compound 1C Deposited 2019-03-28 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1497–1673（177 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291.15 K；0.2M Ammonium Sulfate, 0.1M Sodium Acetate Trihydrate pH 4.6, 25% Peg 4000
|
Resolution 1.95 Å R-free 0.205 |
| 6JPW Crystal structure of Zika NS2B-NS3 protease with compound 1C Deposited 2019-03-28 | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain D
1497–1673（177 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291.15 K；0.2M Ammonium Sulfate, 0.1M Sodium Acetate Trihydrate pH 4.6, 25% Peg 4000
|
Resolution 1.95 Å R-free 0.205 |
| 6JPW Crystal structure of Zika NS2B-NS3 protease with compound 1C Deposited 2019-03-28 | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain F
1497–1673（177 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291.15 K；0.2M Ammonium Sulfate, 0.1M Sodium Acetate Trihydrate pH 4.6, 25% Peg 4000
|
Resolution 1.95 Å R-free 0.205 |
| 6JPW Crystal structure of Zika NS2B-NS3 protease with compound 1C Deposited 2019-03-28 | Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain H
1497–1673（177 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291.15 K；0.2M Ammonium Sulfate, 0.1M Sodium Acetate Trihydrate pH 4.6, 25% Peg 4000
|
Resolution 1.95 Å R-free 0.205 |
| 6KK2 Crystal structure of Zika NS2B-NS3 protease with compound 2 Deposited 2019-07-23 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1497–1673（177 aa）
|
Not recorded | D9U 1-[(10~{S},17~{S},20~{S})-17,20-bis(4-azanylbutyl)-4,9,16,19,22-pentakis(oxidanylidene)-3,8,15,18,21-pentazabicyclo[22.2.2]octacosa-1(27),24(28),25-trien-10-yl]guanidine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291.15 K；0.2M Ammonium Sulfate, 0.1M Sodium acetate trihydrate 4.6, 25% PEG 4000
|
Resolution 2.02 Å R-free 0.256 |
| 6KK3 Crystal structure of Zika NS2B-NS3 protease with compound 4 Deposited 2019-07-23 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1513–1666（154 aa）
|
Not recorded | DUU 1-[(10~{R},17~{S},20~{S})-17,20-bis(4-azanylbutyl)-4,9,16,19,22-pentakis(oxidanylidene)-3,8,15,18,21-pentazabicyclo[22.2.2]octacosa-1(26),24,27-trien-10-yl]guanidine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.2M Ammonium Sulfate, 0.1M Sodium Acetate Trihydrate pH 4.6, 30% Peg 2000
|
Resolution 2.05 Å R-free 0.217 |
| 6KK4 Crystal structure of Zika NS2B-NS3 protease with compound 9 Deposited 2019-07-23 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1497–1673（177 aa）
|
Not recorded | DE0 1-[(9~{R},16~{S},19~{S})-16,19-bis(4-azanylbutyl)-4,8,15,18,21-pentakis(oxidanylidene)-3,7,14,17,20-pentazabicyclo[21.3.1]heptacosa-1(26),23(27),24-trien-9-yl]guanidine × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.2M Ammonium Sulfate, 0.1M Sodium Acetate Trihydrate pH 4.6, 25% Peg 4000
|
Resolution 1.74 Å R-free 0.184 |
| 6KK5 Crystal structure of Zika NS2B-NS3 protease with compound 15 Deposited 2019-07-23 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1497–1673（177 aa）
|
Not recorded | DE6 1-[(5~{S},8~{R},15~{S},18~{S})-15,18-bis(4-azanylbutyl)-5-methyl-4,7,14,17,20-pentakis(oxidanylidene)-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(25),22(26),23-trien-8-yl]guanidine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291.15 K；2M Ammonium Sulfate, 0.1M Sodium Acetate Trihydrate pH 4.6
|
Resolution 2.03 Å R-free 0.231 |
| 6KK6 Crystal structure of Zika NS2B-NS3 protease with compound 16 Deposited 2019-07-23 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1497–1673（177 aa）
|
Not recorded | SO4 SULFATE ION × 1 GOL GLYCEROL × 1 DV0 1-[(5~{R},8~{R},15~{S},18~{S})-15,18-bis(4-azanylbutyl)-5-methyl-4,7,14,17,20-pentakis(oxidanylidene)-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(25),22(26),23-trien-8-yl]guanidine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291.15 K；2M Ammonium Sulfate, 5% Propanol
|
Resolution 1.74 Å R-free 0.181 |
| 6KPQ Crystal structure of Zika NS2B-NS3 protease with compound 8 Deposited 2019-08-15 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1497–1673（177 aa）
|
Not recorded | DT0 1-[(10~{R},17~{S},20~{S})-17,20-bis(4-azanylbutyl)-4,9,16,19,22-pentakis(oxidanylidene)-3,8,15,18,21-pentazabicyclo[22.3.1]octacosa-1(27),24(28),25-trien-10-yl]guanidine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291.15 K；0.2M Ammonium Sulfate, 0.1M Sodium Acetate Trihydrate pH 4.6, 30% Peg 2000
|
Resolution 2.62 Å R-free 0.246 |
| 6L50 Crystal structure of Zika NS2B-NS3 protease with compound 16 Deposited 2019-10-21 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1497–1673（177 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.2 M Ammonium sulfate, 0.1 M Sodium acetate trihydrate pH 4.6, 30% PEG2000
|
Resolution 1.95 Å R-free 0.235 |
| 6L50 Crystal structure of Zika NS2B-NS3 protease with compound 16 Deposited 2019-10-21 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
1497–1673（177 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.2 M Ammonium sulfate, 0.1 M Sodium acetate trihydrate pH 4.6, 30% PEG2000
|
Resolution 1.95 Å R-free 0.235 |
| 6L50 Crystal structure of Zika NS2B-NS3 protease with compound 16 Deposited 2019-10-21 | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain F
1497–1673（177 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.2 M Ammonium sulfate, 0.1 M Sodium acetate trihydrate pH 4.6, 30% PEG2000
|
Resolution 1.95 Å R-free 0.235 |
| 6L50 Crystal structure of Zika NS2B-NS3 protease with compound 16 Deposited 2019-10-21 | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain H
1497–1673（177 aa）
|
Not recorded | E60 2-sulfanylidene-1,3-thiazolidin-4-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.2 M Ammonium sulfate, 0.1 M Sodium acetate trihydrate pH 4.6, 30% PEG2000
|
Resolution 1.95 Å R-free 0.235 |
| 7DOC Crystal structure of Zika NS2B-NS3 protease with compound 5 Deposited 2020-12-14 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1513–1665（153 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291.15 K；0.2M Ammonium Sulfate, 0.1M Sodium Acetate Trihydrate pH 4.6, 30% Peg 2000
|
Resolution 1.90 Å R-free 0.229 |
| 7DOC Crystal structure of Zika NS2B-NS3 protease with compound 5 Deposited 2020-12-14 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
1514–1665（152 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291.15 K；0.2M Ammonium Sulfate, 0.1M Sodium Acetate Trihydrate pH 4.6, 30% Peg 2000
|
Resolution 1.90 Å R-free 0.229 |
| 7DOC Crystal structure of Zika NS2B-NS3 protease with compound 5 Deposited 2020-12-14 | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain F
1510–1667（158 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291.15 K；0.2M Ammonium Sulfate, 0.1M Sodium Acetate Trihydrate pH 4.6, 30% Peg 2000
|
Resolution 1.90 Å R-free 0.229 |
| 7IAQ Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102809 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.83 Å R-free 0.213 |
| 7IAQ Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102809 from ECBL-96 Deposited 2025-05-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1411–1462（52 aa）
Chain D
1498–1673（176 aa）
|
Mutation：C143S | A1CD2 (1S,3S)-3-ethoxy-7-azaspiro[3.5]nonan-1-ol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.83 Å R-free 0.213 |
| 7IAR Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102546 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.70 Å R-free 0.227 |
| 7IAR Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102546 from ECBL-96 Deposited 2025-05-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1411–1462（52 aa）
Chain D
1498–1673（176 aa）
|
Mutation：C143S | A1CD1 2-(5-methylthiophen-2-yl)ethan-1-amine × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.70 Å R-free 0.227 |
| 7IAS Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102659 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.54 Å R-free 0.210 |
| 7IAS Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102659 from ECBL-96 Deposited 2025-05-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1411–1462（52 aa）
Chain D
1498–1673（176 aa）
|
Mutation：C143S | A1CD0 5-methylfuran-2-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.54 Å R-free 0.210 |
| 7IAT Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102811 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.53 Å R-free 0.205 |
| 7IAT Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102811 from ECBL-96 Deposited 2025-05-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1411–1462（52 aa）
Chain D
1498–1673（176 aa）
|
Mutation：C143S | A1CDM 2,3-dihydro-1H-1lambda~6~,2-benzothiazole-1,1-dione × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.53 Å R-free 0.205 |
| 7IAU Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102654 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.70 Å R-free 0.236 |
| 7IAU Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102654 from ECBL-96 Deposited 2025-05-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1411–1462（52 aa）
Chain D
1498–1673（176 aa）
|
Mutation：C143S | A1CDZ 4-[2-(methylamino)ethyl]benzonitrile × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.70 Å R-free 0.236 |
| 7IAV Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102592 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.53 Å R-free 0.220 |
| 7IAV Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102592 from ECBL-96 Deposited 2025-05-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1411–1462（52 aa）
Chain D
1498–1673（176 aa）
|
Mutation：C143S | A1CDY N,5-dimethyl-1,3,4-thiadiazol-2-amine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.53 Å R-free 0.220 |
| 7IAW Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102818 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.45 Å R-free 0.193 |
| 7IAW Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102818 from ECBL-96 Deposited 2025-05-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1411–1462（52 aa）
Chain D
1498–1673（176 aa）
|
Mutation：C143S | WQY 1-(quinolin-3-yl)methanamine × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.45 Å R-free 0.193 |
| 7IAX Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS103099 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | A1CDX 2-[(1S)-2,2-difluorocyclopentyl]ethan-1-amine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.60 Å R-free 0.203 |
| 7IAX Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS103099 from ECBL-96 Deposited 2025-05-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1411–1462（52 aa）
Chain D
1498–1673（176 aa）
|
Mutation：C143S | A1CDX 2-[(1S)-2,2-difluorocyclopentyl]ethan-1-amine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.60 Å R-free 0.203 |
| 7IAY Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS103107 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.57 Å R-free 0.299 |
| 7IAY Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS103107 from ECBL-96 Deposited 2025-05-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1411–1462（52 aa）
Chain D
1498–1673（176 aa）
|
Mutation：C143S | A1EHQ 2-phenoxyethanamine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.57 Å R-free 0.299 |
| 7IAZ Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS103092 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.63 Å R-free 0.247 |
| 7IAZ Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS103092 from ECBL-96 Deposited 2025-05-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1411–1462（52 aa）
Chain D
1498–1673（176 aa）
|
Mutation：C143S | A1CDV 2-amino-5-bromopyridine-3-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.63 Å R-free 0.247 |
| 7IB0 Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102853 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | A1CDU (2S)-2-hydroxy-3-phenylpropanamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.60 Å R-free 0.209 |
| 7IB0 Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102853 from ECBL-96 Deposited 2025-05-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1411–1462（52 aa）
Chain D
1498–1673（176 aa）
|
Mutation：C143S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.60 Å R-free 0.209 |
| 7IB1 Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102869 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.65 Å R-free 0.207 |
| 7IB1 Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102869 from ECBL-96 Deposited 2025-05-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1411–1462（52 aa）
Chain D
1498–1673（176 aa）
|
Mutation：C143S | A1CDT N-(2-aminoethyl)thiophene-2-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.65 Å R-free 0.207 |
| 7IB2 Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS103118 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.51 Å R-free 0.206 |
| 7IB2 Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS103118 from ECBL-96 Deposited 2025-05-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1411–1462（52 aa）
Chain D
1498–1673（176 aa）
|
Mutation：C143S | A1CDS 2-(5-amino-3-phenyl-1H-pyrazol-1-yl)ethan-1-ol × 1 DMS DIMETHYL SULFOXIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.51 Å R-free 0.206 |
| 7IB3 Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS103134 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.61 Å R-free 0.201 |
| 7IB3 Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS103134 from ECBL-96 Deposited 2025-05-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1411–1462（52 aa）
Chain D
1498–1673（176 aa）
|
Mutation：C143S | A1CDR 1-(1-ethyl-1H-pyrrol-3-yl)methanamine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.61 Å R-free 0.201 |
| 7IB4 Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS103292 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.62 Å R-free 0.197 |
| 7IB4 Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS103292 from ECBL-96 Deposited 2025-05-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1411–1462（52 aa）
Chain D
1498–1673（176 aa）
|
Mutation：C143S | A1CDQ (3R,4S)-4-phenoxypyrrolidin-3-ol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.62 Å R-free 0.197 |
| 7IB5 Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS103238 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.52 Å R-free 0.222 |
| 7IB5 Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS103238 from ECBL-96 Deposited 2025-05-21 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1411–1462（52 aa）
Chain D
1498–1673（176 aa）
|
Mutation：C143S | A1CDP N-(2-fluorophenyl)piperidin-4-amine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.52 Å R-free 0.222 |
| 7IB6 Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102680 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | A1CDO N-methyl-2,3-dihydro-1H-inden-2-amine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.60 Å R-free 0.234 |
| 7IB7 Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS103119 from ECBL-96 Deposited 2025-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1411–1462（52 aa）
Chain B
1498–1673（176 aa）
|
Mutation：C143S | A1CDN 4-methoxy-2,3-dihydro-1H-isoindole × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1 M sodium acetate pH 4.6, 0.2 M ammonium sulfate, 24 % (w/v) PEG 2000
|
Resolution 1.55 Å R-free 0.210 |
| 7VLG Crystal structure of Zika NS2B-NS3 protease with compound MI2201 Deposited 2021-10-02 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1497–1673（177 aa）
|
Not recorded | SO4 SULFATE ION × 1 7PZ 1-[(5~{R},8~{R},15~{S},18~{S})-15,18-bis(4-azanylbutyl)-4,7,14,17,20-pentakis(oxidanylidene)-5-propan-2-yl-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(25),22(26),23-trien-8-yl]guanidine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291.15 K；2M Ammonium Sulfate
|
Resolution 1.77 Å R-free 0.197 |
| 7VLH Crystal structure of Zika NS2B-NS3 protease with compound MI2219 Deposited 2021-10-02 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1497–1673（177 aa）
|
Not recorded | 7Q3 1-[(3~{S},6~{R},18~{R})-3,6-bis(4-azanylbutyl)-2,5,8,11,14,17-hexakis(oxidanylidene)-1,4,7,10,13,16-hexazacyclodocos-18-yl]guanidine × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291.15 K；2M Ammonium Sulfate
|
Resolution 2.62 Å R-free 0.289 |
| 7VLI Crystal structure of Zika NS2B-NS3 protease with compound MI2220 Deposited 2021-10-02 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1497–1673（177 aa）
|
Not recorded | 7QG 1-[(3~{S},6~{S},19~{R})-3,6-bis(4-azanylbutyl)-2,5,8,12,15,18-hexakis(oxidanylidene)-1,4,7,11,14,17-hexazacyclotricos-19-yl]guanidine × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291.15 K；2M Ammonium Sulfate
|
Resolution 2.38 Å R-free 0.288 |
| 8PN6 Crystal Structure of co-expressed NS2B-NS3 Protease from Zika Virus Deposited 2023-06-29 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1507–1673（167 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；30% w/v PEG 2000, 0.2M Ammonium sulfate, 0.1M acetate (pH 4.8)
|
Resolution 1.61 Å R-free 0.258 |