Current Protein Identity:A0A160JCU6
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 5MFX Zika NS3 helicase:RNA complex Deposited 2016-11-18 | Assembly 1 Protein–RNA Monomer;Protein × 1 PDB declaration: dimeric(2) Consistent with all polymers |
Chain A
1685–2125(441 aa)
Fragment:UNP residues 1685-2125
|
Not recorded | ACT ACETATE ION × 1 FLC CITRATE ANION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP;pH 6.5;293 K;20% (w/v) ethylene glycol, 10% (w/v) polyethylene glycol 8000, 0.1 M MES/Imidazole pH 6.5, 20mM sodium formate, 20mM ammonium acetate, 20mM tri-sodium citrate, 20mM sodium potassium L-tartrate.
|
Resolution 1.60 Å R-free 0.191 |
| 5TFN CRYSTAL STRUCTURE OF THE ZIKA VIRUS NS2B-NS3 PROTEASE in super-open conformation Deposited 2016-09-26 | Assembly 1 Insufficient information Monomer;Protein × 1 PDB declaration: monomeric(1) Consistent with protein count |
Chain A
1420–1466(47 aa)
|
Mutation:S135A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP;pH 6.5;293 K;0.6 mM protein, in 100 mM NaCl, 1.0 mM TCEP, 20 mM Tris-Cl buffer (pH 8.0) was mixed with the well solution (25% PEG3330, 200 mM NaCl and 100 mM BisTris pH 6.5)
|
Resolution 3.00 Å R-free 0.259 |
| 5TFN CRYSTAL STRUCTURE OF THE ZIKA VIRUS NS2B-NS3 PROTEASE in super-open conformation Deposited 2016-09-26 | Assembly 2 Insufficient information Monomer;Protein × 1 PDB declaration: monomeric(1) Consistent with protein count |
Chain B
1420–1466(47 aa)
|
Mutation:S135A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP;pH 6.5;293 K;0.6 mM protein, in 100 mM NaCl, 1.0 mM TCEP, 20 mM Tris-Cl buffer (pH 8.0) was mixed with the well solution (25% PEG3330, 200 mM NaCl and 100 mM BisTris pH 6.5)
|
Resolution 3.00 Å R-free 0.259 |
| 5TFN CRYSTAL STRUCTURE OF THE ZIKA VIRUS NS2B-NS3 PROTEASE in super-open conformation Deposited 2016-09-26 | Assembly 3 Insufficient information Homooligomer;Protein × 2 PDB declaration: dimeric(2) Consistent with protein count |
Chain A
1420–1466(47 aa)
Chain B
1420–1466(47 aa)
|
Mutation:S135A Mutation:S135A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP;pH 6.5;293 K;0.6 mM protein, in 100 mM NaCl, 1.0 mM TCEP, 20 mM Tris-Cl buffer (pH 8.0) was mixed with the well solution (25% PEG3330, 200 mM NaCl and 100 mM BisTris pH 6.5)
|
Resolution 3.00 Å R-free 0.259 |
| 6RWZ Structure of Zika virus NS3 helicase in complex with ADP-BeF3 Deposited 2019-06-07 | Assembly 1 Protein monomer Monomer;Protein × 1 PDB declaration: monomeric(1) Consistent with protein count |
Chain A
1685–2125(441 aa)
|
Not recorded | MN MANGANESE (II) ION × 1 BEF BERYLLIUM TRIFLUORIDE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION;293.15 K;20% w/v glycerol, 10% w/v polyethylene glycol 4000, 0.1 M MES/imidazole pH 6.5, 20 mM sodium formate, 20 mM ammonium acetate, 20 mM trisodium citrate, and 20 mM sodium potassium L-tartrate.
|
Resolution 1.70 Å R-free 0.206 |
| 6S0J Structure of Zika virus NS3 helicase in complex with ADP-MgF3(H2O)- Deposited 2019-06-16 | Assembly 1 Protein monomer Monomer;Protein × 1 PDB declaration: monomeric(1) Consistent with protein count |
Chain A
1685–2125(441 aa)
|
Not recorded | KQB trifluoromagnesate monohydrate × 1 MG MAGNESIUM ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION;293 K;15% PEG3350, 0.16 M sodium citrate and 9% ethylene glycol
|
Resolution 1.50 Å R-free 0.189 |