← Back to search

Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：A0A8F2ZG71 New Search
4PDB entries
12Biological assembly
24chain/assembly records
Main Difference Dimensions in This Set
Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
9IR8 CCoV-HuPn-2018 3CL protease (3CLpro) in complex with compound 6 Deposited 2024-07-15 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2881–3182（302 aa）
Chain D 2881–3182（302 aa）
Not recorded A1D7M (2~{S})-~{N}-[(2~{S})-1-azanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[(2~{S})-3,3-dimethyl-2-(methylsulfonylamino)butanoyl]amino]-4-methyl-pentanamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；12% PEG3350, 100 mM sodium malonate, pH 5.0
Resolution 2.12 Å R-free 0.273
9IR8 CCoV-HuPn-2018 3CL protease (3CLpro) in complex with compound 6 Deposited 2024-07-15 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 2881–3182（302 aa）
Chain C 2881–3182（302 aa）
Not recorded A1D7M (2~{S})-~{N}-[(2~{S})-1-azanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[(2~{S})-3,3-dimethyl-2-(methylsulfonylamino)butanoyl]amino]-4-methyl-pentanamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；12% PEG3350, 100 mM sodium malonate, pH 5.0
Resolution 2.12 Å R-free 0.273
9UOP Crystal structure of CCoV-HuPn-2018 3CL protease (3CLpro) in complex with compound 8 Deposited 2025-04-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2881–3182（302 aa）
Chain C 2881–3182（302 aa）
Not recorded A1EPZ (2~{S})-2-[[(2~{S})-3,3-dimethyl-2-[2,2,2-tris(fluoranyl)ethanoylamino]butanoyl]amino]-4-methyl-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]pentanamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；20% (w/v) PEG3350, 200 mM Lithium citrate tribasic tetrahydrate, pH8.4
Resolution 1.61 Å R-free 0.230
9UOP Crystal structure of CCoV-HuPn-2018 3CL protease (3CLpro) in complex with compound 8 Deposited 2025-04-26 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 2881–3182（302 aa）
Chain D 2881–3182（302 aa）
Not recorded A1EPZ (2~{S})-2-[[(2~{S})-3,3-dimethyl-2-[2,2,2-tris(fluoranyl)ethanoylamino]butanoyl]amino]-4-methyl-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]pentanamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；20% (w/v) PEG3350, 200 mM Lithium citrate tribasic tetrahydrate, pH8.4
Resolution 1.61 Å R-free 0.230
9X7E Crystal of CCoV-HuPn-2018 3CL protease (3CLpro) in complex with nirmatrelvir Deposited 2025-10-16 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2881–3182（302 aa）
Chain C 2881–3182（302 aa）
Not recorded 4WI (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；12% PEG3350, 100 mM sodium malonate, pH 5.0
Resolution 2.37 Å R-free 0.300
9X7E Crystal of CCoV-HuPn-2018 3CL protease (3CLpro) in complex with nirmatrelvir Deposited 2025-10-16 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 2881–3182（302 aa）
Chain F 2881–3182（302 aa）
Not recorded 4WI (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；12% PEG3350, 100 mM sodium malonate, pH 5.0
Resolution 2.37 Å R-free 0.300
9X7E Crystal of CCoV-HuPn-2018 3CL protease (3CLpro) in complex with nirmatrelvir Deposited 2025-10-16 Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 2881–3182（302 aa）
Chain G 2881–3182（302 aa）
Not recorded 4WI (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；12% PEG3350, 100 mM sodium malonate, pH 5.0
Resolution 2.37 Å R-free 0.300
9X7E Crystal of CCoV-HuPn-2018 3CL protease (3CLpro) in complex with nirmatrelvir Deposited 2025-10-16 Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 2881–3182（302 aa）
Chain H 2881–3182（302 aa）
Not recorded 4WI (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；12% PEG3350, 100 mM sodium malonate, pH 5.0
Resolution 2.37 Å R-free 0.300
9X7I Crystal of CCoV-HuPn-2018 3CL protease (3CLpro) in complex with compound 3 Deposited 2025-10-16 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2881–3182（302 aa）
Chain C 2881–3182（302 aa）
Not recorded A1D7N (1~{R},2~{S},5~{S})-~{N}-[(2~{S})-1-azanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-3-[(2~{S})-3,3-dimethyl-2-(methylsulfonylamino)butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；12% PEG3350, 100 mM sodium malonate, pH 5.0
Resolution 2.23 Å R-free 0.280
9X7I Crystal of CCoV-HuPn-2018 3CL protease (3CLpro) in complex with compound 3 Deposited 2025-10-16 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 2881–3182（302 aa）
Chain D 2881–3182（302 aa）
Not recorded A1D7N (1~{R},2~{S},5~{S})-~{N}-[(2~{S})-1-azanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-3-[(2~{S})-3,3-dimethyl-2-(methylsulfonylamino)butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；12% PEG3350, 100 mM sodium malonate, pH 5.0
Resolution 2.23 Å R-free 0.280
9X7I Crystal of CCoV-HuPn-2018 3CL protease (3CLpro) in complex with compound 3 Deposited 2025-10-16 Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 2881–3182（302 aa）
Chain H 2881–3182（302 aa）
Not recorded A1D7N (1~{R},2~{S},5~{S})-~{N}-[(2~{S})-1-azanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-3-[(2~{S})-3,3-dimethyl-2-(methylsulfonylamino)butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；12% PEG3350, 100 mM sodium malonate, pH 5.0
Resolution 2.23 Å R-free 0.280
9X7I Crystal of CCoV-HuPn-2018 3CL protease (3CLpro) in complex with compound 3 Deposited 2025-10-16 Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain F 2881–3182（302 aa）
Chain G 2881–3182（302 aa）
Not recorded A1D7N (1~{R},2~{S},5~{S})-~{N}-[(2~{S})-1-azanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-3-[(2~{S})-3,3-dimethyl-2-(methylsulfonylamino)butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；12% PEG3350, 100 mM sodium malonate, pH 5.0
Resolution 2.23 Å R-free 0.280

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.