当前蛋白身份:D0VWZ0 重新检索
本组结构的主要差异维度
构建体不同 突变/修饰不同 组装状态不同 配体/离子不同 实验环境不同 结构质量指标不同

差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。

相关结构差异明细

一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。

PDB 条目 Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法 实验环境 结构质量
3N2G TUBULIN-NSC 613863: RB3 Stathmin-like domain complex 提交 2010-05-18 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–451(451 aa)
链 C 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 3 GDP GUANOSINE-5'-DIPHOSPHATE × 2 G2N ethyl [(2R)-5-amino-2-methyl-3-phenyl-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 7;PEG, PIPES BUFFER, PH 7.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K
分辨率 4.00 Å R-free 0.241
3N2K TUBULIN-NSC 613862: RB3 Stathmin-like domain complex 提交 2010-05-18 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–451(451 aa)
链 C 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 3 GDP GUANOSINE-5'-DIPHOSPHATE × 2 K2N ethyl [(2S)-5-amino-2-methyl-3-phenyl-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7;PEG, PIPES BUFFER, PH 7.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K
分辨率 4.00 Å R-free 0.250
3RYC Tubulin: RB3 stathmin-like domain complex 提交 2011-05-11 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–451(451 aa)
链 C 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 3 MG MAGNESIUM ION × 3 SO4 SULFATE ION × 11 GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.8;293 K;PEG, LISO4, PIPES BUFFER, pH 6.80, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.10 Å R-free 0.201
3RYF GTP-Tubulin: RB3 Stathmin-like domain complex 提交 2011-05-11 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–451(451 aa)
链 C 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 4 MG MAGNESIUM ION × 4 SO4 SULFATE ION × 11 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.8;293 K;PEG, LISO4, PIPES BUFFER, pH 6.80, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.52 Å R-free 0.208
3RYH GMPCPP-Tubulin: RB3 Stathmin-like domain complex 提交 2011-05-11 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–451(451 aa)
链 C 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 4 SO4 SULFATE ION × 8 G2P PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.8;293 K;PEG, LISO4, PIPES BUFFER, pH 6.80, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.80 Å R-free 0.217
3RYI GDP-Tubulin: rb3 stathmin-like domain complex 提交 2011-05-11 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–451(451 aa)
链 C 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 SO4 SULFATE ION × 12 GDP GUANOSINE-5'-DIPHOSPHATE × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8;293 K;PEG, LISO4, PIPES BUFFER, pH 6.80, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.40 Å R-free 0.201
3UT5 Tubulin-Colchicine-Ustiloxin: Stathmin-like domain complex 提交 2011-11-25 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 A 1–451(451 aa)
链 C 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 SO4 SULFATE ION × 5 GDP GUANOSINE-5'-DIPHOSPHATE × 2 LOC N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8;293 K;PEG, LISO4, PIPES BUFFER, PH 6.80, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.73 Å R-free 0.222
4DRX GTP-Tubulin in complex with a DARPIN 提交 2012-02-17 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 1–437(437 aa) 片段:UNP residues 1-437
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 7;292 K;PEG 6K, 0.05M KCl, 0.01 M MGCL2, 0.2M LiCl, 0.01 M HEPES pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 292K
分辨率 2.22 Å R-free 0.194
4DRX GTP-Tubulin in complex with a DARPIN 提交 2012-02-17 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 C 1–437(437 aa) 片段:UNP residues 1-437
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 7;292 K;PEG 6K, 0.05M KCl, 0.01 M MGCL2, 0.2M LiCl, 0.01 M HEPES pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 292K
分辨率 2.22 Å R-free 0.194
4EB6 Tubulin-Vinblastine: Stathmin-like complex 提交 2012-03-23 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–451(451 aa)
链 C 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 SO4 SULFATE ION × 5 GDP GUANOSINE-5'-DIPHOSPHATE × 2 VLB (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8;293 K;PEG, Li2SO4, PIPES, pH 6.80, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 3.47 Å R-free 0.253
4F61 Tubulin:Stathmin-like domain complex 提交 2012-05-14 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 9 PDB 声明:nonameric(9) 与蛋白数一致
链 A 1–451(451 aa)
链 C 1–451(451 aa)
链 E 1–451(451 aa)
链 G 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 4 MG MAGNESIUM ION × 4 GDP GUANOSINE-5'-DIPHOSPHATE × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.8;293 K;PEG, NACL, PIPES BUFFER, PH 6.80, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K
分辨率 4.17 Å R-free 0.261
4F6R Tubulin:Stathmin-like domain complex 提交 2012-05-15 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SO4 SULFATE ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;293 K;PEG, MES BUFFER, PH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.64 Å R-free 0.201
4HNA Kinesin motor domain in the ADP-MG-ALFX state in complex with tubulin and a DARPIN 提交 2012-10-19 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 3 GDP GUANOSINE-5'-DIPHOSPHATE × 1 ALF TETRAFLUOROALUMINATE ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.8;293 K;PEG, PIPES BUFFER, PH 6.8, 0.8 MM ALCL3, 4 MM NAF, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 3.19 Å R-free 0.211
4X1I Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications 提交 2014-11-24 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–451(451 aa)
链 C 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 2 LOC N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide × 2 3WD 2-methyl-L-alanyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.8;291 K;5% PEG 400, 0.1M LiSO4, 5-7% PEG 20K, 50 mM K-PIPES
分辨率 3.11 Å R-free 0.253
4X1K Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications 提交 2014-11-24 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–451(451 aa)
链 C 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 2 LOC N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide × 2 3WZ 2-methyl-L-alanyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;290 K;5% PEG 400, 0.1M LiSO4, 5-7% PEG 20K, 50 mM K-PIPES, pH 6.8 at 19oC
分辨率 3.50 Å R-free 0.263
4X1Y Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications 提交 2014-11-25 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–451(451 aa)
链 C 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 2 LOC N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide × 2 3WV N,2-dimethyl-L-alanyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.8;291 K;5% PEG 400, 0.1M LiSO4, 5-7% PEG 20K, 50 mM K-PIPES
分辨率 3.19 Å R-free 0.273
4X20 Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications 提交 2014-11-25 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–451(451 aa)
链 C 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 2 LOC N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide × 2 3WY 2-methyl-L-prolyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.8;291 K;5% PEG 400, 0.1M LiSO4, 5-7% PEG 20K, 50 mM K-PIPES
分辨率 3.50 Å R-free 0.252
5EYP TUBULIN-DARPIN COMPLEX 提交 2015-11-25 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SO4 SULFATE ION × 3 GOL GLYCEROL × 8 GDP GUANOSINE-5'-DIPHOSPHATE × 1 LOC N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5.6;293 K;PEG 4000, tri-sodium citrate, ammonium sulfate
分辨率 1.90 Å R-free 0.208
5KX5 Crystal structure of tubulin-stathmin-TTL-Compound 11 complex 提交 2016-07-20 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 A 1–451(451 aa)
链 C 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 6 CA CALCIUM ION × 4 GDP GUANOSINE-5'-DIPHOSPHATE × 2 6YK (2~{S},4~{R})-4-[[2-[(1~{R},3~{R})-1-acetyloxy-3-[[(2~{S},3~{S})-2-[[(2~{R})-1,2-dimethylpyrrolidin-2-yl]carbonylamino]-3-methyl-pentanoyl]-methyl-amino]-4-methyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]-5-(4-aminophenyl)-2-methyl-pentanoic acid × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.7;293 K;precipitant solution: 3% PEG 4K, 4-6% glycerol, 30 mM MgCl2, 30 mM CaCl2, 100 mM MES/Imidazole pH 6.7
分辨率 2.50 Å R-free 0.251
6GVM Tubulin:F3II DARPin complex 提交 2018-06-21 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;293 K;PEG5000MME, Mes pH 6.0, 150 mM AMMONIUM SULFATE, 50 mM KCl
分辨率 3.50 Å R-free 0.270
6GVN Tubulin:TM-3 DARPin complex 提交 2018-06-21 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;293 K;PEG5000 MME, 0.1 M Mes pH 6.0, 150 mM AMMONIUM SULFATE
分辨率 2.69 Å R-free 0.216
6GX7 Tubulin-CopN-alphaRep complex 提交 2018-06-26 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 SO4 SULFATE ION × 1 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 2 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;293 K;polyethylene glycol 400, 0.1 M Mes
分辨率 3.19 Å R-free 0.210
6GX7 Tubulin-CopN-alphaRep complex 提交 2018-06-26 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 C 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 SO4 SULFATE ION × 1 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 2 GOL GLYCEROL × 2 PGE TRIETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;293 K;polyethylene glycol 400, 0.1 M Mes
分辨率 3.19 Å R-free 0.210
8CGZ tubulin-AB8939 complex 提交 2023-02-06 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–451(451 aa)
链 C 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 2 UIY AB-8939 × 2 SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;293 K;PEG, LiSO4, PIPES BUFFER, pH 6.80
分辨率 2.53 Å R-free 0.235
9F07 TUBULIN:STATHMIN:DARPIN:TAU MTBR3 COMPLEX 提交 2024-04-15 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 A 1–451(451 aa)
链 E 1–451(451 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 2 GOL GLYCEROL × 7 PEG DI(HYDROXYETHYL)ETHER × 2 1PE PENTAETHYLENE GLYCOL × 1 P6G HEXAETHYLENE GLYCOL × 1 PGE TRIETHYLENE GLYCOL × 5 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.8;293 K;20 to 25% (w/v) polyethylene glycol 3350 0.2 M K/Na tartrate
分辨率 2.21 Å R-free 0.234