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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：O00418 New Search
10PDB entries
11Biological assembly
19chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
5J8H Structure of calmodulin in a complex with a peptide derived from a calmodulin-dependent kinase Deposited 2016-04-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 74–100（27 aa） Fragment：residues 74-100
Not recorded CA CALCIUM ION × 2 SOLUTION NMR
NMR measurement conditions pH 6.8；308.15 K；Ionic strength (raw mmCIF value) 20 mM BisTris 150 mM Potassium Chloride 10 mM Calcium Chloride；Pressure 1
NMR measurement conditions pH 6.8；308.15 K；Ionic strength (raw mmCIF value) 20 mM BisTris 150 mM Potassium Chloride 10 mM Calcium Chloride；Pressure 1
NMR measurement conditions pH 6.8；308.15 K；Ionic strength (raw mmCIF value) 20 mM BisTris 150 mM Potassium Chloride 10 mM Calcium Chloride；Pressure 1
NMR measurement conditions pH 6.8；308.15 K；Ionic strength (raw mmCIF value) 20 mM BisTris 150 mM Potassium Chloride 10 mM Calcium Chloride；Pressure 1
NMR sample composition 320 uM [U-99% 13C; U-99% 15N] Calmodulin, 320 uM eEF2K_74-100, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 595 uM [U-99% 13C; U-99% 15N] eEF2K_74-100, 595 uM Calmodulin, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 320 uM [U-99% 13C; U-99% 15N] Calmodulin, 320 uM eEF2K_74-100, 100% D2O | 100% D2O
NMR sample composition 320 uM [U-99% 13C; U-99% 15N] eEF2K_74-100, 320 uM Calmodulin, 100% D2O | 100% D2O
Resolution not provided
5KS5 Structure of the C-terminal Helical Repeat Domain of Elongation Factor 2 Kinase Deposited 2016-07-07 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 627–725（99 aa） Fragment：UNP residues 627-725
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；298.15 K；Ionic strength (raw mmCIF value) 50 mM Sodium Phosphate；Pressure 1
NMR measurement conditions pH 6.5；298.15 K；Ionic strength (raw mmCIF value) 50 mM Sodium Phosphate；Pressure 1
NMR sample composition 600 uM [U-99% 13C; U-99% 15N] eEF2K_627-725, 50 mM sodium phosphate, 4 mM DTT, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 300 uM [U-99% 13C; U-99% 15N] eEF2K_627-725, 50 mM sodium phosphate, 4 mM DTT, 100% D2O | 100% D2O
NMR sample composition 300 uM [U-99% 13C; U-99% 1 eEF2K_627-725, 15 mg/mL Pf1 phage (ASLA Ltd), 50 mM sodium phosphate, 4 mM DTT, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
6NX4 Structure of the C-terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase (eEF-2K) Deposited 2019-02-08 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 562–725（164 aa） Fragment：562-725 C-terminal fragment
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；298.15 K；Ionic strength (raw mmCIF value) 20 mM Phosphate 100 mM NaCl；Pressure 1
NMR sample composition 200 uM [U-99% 13C; U-99% 15N] eEF2K (562-725), 20 mM sodium phosphate, 100 mM sodium chloride, 4 mM DTT, 0.2 mM EDTA, 2 mM AEBSF protease inhibitor, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 400 uM [U-99% 13C; U-99% 15N] eEF2K (562-725), 20 mM sodium phosphate, 100 mM sodium chloride, 4 mM DTT, 0.2 mM EDTA, 2 mM AEBSF protease inhibitor, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 340 uM [U-99% 13C; U-99% 15N] eEF2K (562-725), 14 mg/mL Pf1 phage, 14 mM sodium phosphate, 100 mM sodium chloride, 4 mM DTT, 0.2 mM EDTA, 2 mM AEBSF protease inhibitor, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 360 uM [U-99% 13C; U-99% 15N] eEF2K (562-725), 20 mM sodium phosphate, 100 mM sodium chloride, 4 mM DTT, 0.2 mM EDTA, 2 mM AEBSF protease inhibitor, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
7SHQ Structure of a functional construct of eukaryotic elongation factor 2 kinase in complex with calmodulin. Deposited 2021-10-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 70–358（289 aa）
Chain A 490–725（236 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) ZN ZINC ION × 1 MG MAGNESIUM ION × 5 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.9；298.15 K；Cocktail solution: Peg3350: 24% MgCl2: 300 mM BisTris pH 6.9: 100 mM Protein Solution: 11 mg/mL CaM-eEF2Kp1/1 Tris pH 7.5: 20 mM NaCl: 0.1 M CaCl2: 3mM TCEP: 1mM MgCl2: 1.5 mM AMPPNP: 1.0 mM Crystallization conditions: 1/1 Protein/Cocktail under Paraffin Oil in a Greiner 72-Well microbatch plate
Resolution 2.34 Å R-free 0.252
8FNY Nucleotide-bound structure of a functional construct of eukaryotic elongation factor 2 kinase. Deposited 2022-12-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 70–358（289 aa）
Chain A 490–725（236 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) ATP ADENOSINE-5'-TRIPHOSPHATE × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ZN ZINC ION × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；293 K；100 mM Bis-trispropane, 100 mM NaF, 20.5 % w/v PEG-3350 (2protein/1solution)
Resolution 2.22 Å R-free 0.229
8FNY Nucleotide-bound structure of a functional construct of eukaryotic elongation factor 2 kinase. Deposited 2022-12-28 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 70–358（289 aa）
Chain C 490–725（236 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) ATP ADENOSINE-5'-TRIPHOSPHATE × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ZN ZINC ION × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；293 K；100 mM Bis-trispropane, 100 mM NaF, 20.5 % w/v PEG-3350 (2protein/1solution)
Resolution 2.22 Å R-free 0.229
8FO6 Nucleotide-free structure of a functional construct of eukaryotic elongation factor 2 kinase. Deposited 2022-12-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 70–358（289 aa）
Chain A 490–725（236 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) ZN ZINC ION × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 5.9；293 K；100 mM Bis-trispropane, 200 mM NaF, 17.6% PEG-3350 (2protein 1solution)
Resolution 2.55 Å R-free 0.231
8GM4 Functional construct of the Eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor Deposited 2023-03-24 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 70–358（289 aa）
Chain A 490–725（236 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) ADP ADENOSINE-5'-DIPHOSPHATE × 1 EKI 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide × 1 ZN ZINC ION × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6.2；295.15 K；Cocktail:16.55% PEG-3350, 200 mM NaF, 100 mM BisTris-Propane Protein sol: 10.3 mg/mL 20 mM Tris pH 7.5, 100 mM NaCl, 3 mM CaCl2, 1mM TCEP, 0.3 mM ADP, 0.3 m Inhibitor , 0.7 % DMSO 2protein/1cocktail (0.2 ul total)
Resolution 2.12 Å R-free 0.238
8GM5 Functional construct of the Eukaryotic elongation factor 2 kinase bound to Calmodulin, ADP and to the A-484954 inhibitor and showing two conformations for the 498-520 loop Deposited 2023-03-24 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 70–358（289 aa）
Chain A 490–725（236 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) ADP ADENOSINE-5'-DIPHOSPHATE × 1 EKI 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide × 1 ZN ZINC ION × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6.5；295.15 K；Cocktail:16.55% PEG-3350, 0.2 M NaF, 100 mM BisTris-Propane Protein solution: 10.3 mg/mL 20 mM Tris pH 7.5, 100 mM NaCl, 3 mM CaCl2, 1mM TCEP, 1.5 m Inhibitor , 3.1 % DMSO 2protein/1cocktail (0.2 ul total)
Resolution 2.12 Å R-free 0.225
9OCW A constitutively active construct of eukaryotic elongation factor 2 kinase Deposited 2025-04-25 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 71–358（288 aa）
Chain A 490–725（236 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) ADP ADENOSINE-5'-DIPHOSPHATE × 2 ZN ZINC ION × 1 CA CALCIUM ION × 2 MG MAGNESIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298.15 K；2 ul of protein were mixed with 1 ul of a 18.8% PEG3350 (Hampton Research) and 314 mM magnesium acetate (pH not adjusted) solution in a 24 wells plate at room temperature
Resolution 2.27 Å R-free 0.257
9PCQ Phosphorylation of a Conserved Aspartate at the Eukaryotic Elongation Factor 2 Kinase Catalytic Site Deposited 2025-06-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 70–358（289 aa）
Chain A 490–725（236 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) ADP ADENOSINE-5'-DIPHOSPHATE × 2 MN MANGANESE (II) ION × 2 ZN ZINC ION × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；298.15 K；Protein was mixed 1/1 with 100 mM BisTrisPropane, 80 mM NaF, 20% w/v PEG3350
Resolution 2.30 Å R-free 0.243

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.