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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：O14842 New Search
9PDB entries
9Biological assembly
13chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
4PHU Crystal structure of Human GPR40 bound to allosteric agonist TAK-875 Deposited 2014-05-07 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–211（211 aa） Fragment：UNP O14842 residues 2-213, UNP P00720 residues 2-161, UNP O14842 residues 214-300
Chain A 214–300（87 aa） Fragment：UNP O14842 residues 2-213, UNP P00720 residues 2-161, UNP O14842 residues 214-300
Mutation：L42A,F88A,G103A,Y202F,S211G,G212S,C1154T,C1197A Mutation：L42A,F88A,G103A,Y202F,S211G,G212S,C1154T,C1197A 2YB [(3S)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid × 1 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 5 1PE PENTAETHYLENE GLYCOL × 1 DMS DIMETHYL SULFOXIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIPIDIC CUBIC PHASE；pH 8；294 K；29-31% Peg 400,100 mM Tris pH 8.0. 0.2 M Na Malonate,200 uM TAK-875
X-ray crystallization conditions LIPIDIC CUBIC PHASE；pH 7.2；294 K；39.8 % Peg 400, 100 mM Bis-Tris-Propane pH 7.2, 0.1 Ammonium Phosphate (monobasic), 200 uM TAK-875
Resolution 2.33 Å R-free 0.233
5KW2 The extra-helical binding site of GPR40 and the structural basis for allosteric agonism and incretin stimulation Deposited 2016-07-15 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–211（211 aa）
Chain A 214–300（87 aa）
Not recorded 6XQ (3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIPIDIC CUBIC PHASE；298 K；0.1 M Tris HCl, pH 8.5, 30% PEG 400, 0.2 M ammonium formate.
Resolution 2.76 Å R-free 0.273
5TZR GPR40 in complex with partial agonist MK-8666 Deposited 2016-11-22 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–211（211 aa）
Chain A 214–300（87 aa）
Mutation：L42A, F88A, G103A, Y202F, R1012G, C1054T, C1097A, I1137R Mutation：L42A, F88A, G103A, Y202F, R1012G, C1054T, C1097A, I1137R NA SODIUM ION × 1 MK6 (5aR,6S,6aS)-3-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl}methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid × 1 MLI MALONATE ION × 1 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 8 1PE PENTAETHYLENE GLYCOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIPIDIC CUBIC PHASE；pH 7.7；293 K；25-28%PEG 400, 0.2M sodium malonate, 0.1M Tris pH7.7
Resolution 2.20 Å R-free 0.228
5TZY GPR40 in complex with AgoPAM AP8 and partial agonist MK-8666 Deposited 2016-11-22 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–211（211 aa）
Chain A 214–300（87 aa）
Mutation：;L42A, G103A, Y202F, R1012G, C1054T, C1097A, I1137R,L42A, G103A, Y202F, R1012G, C1054T, C1097A, I1137R,L42A, G103A, Y202F, R1012G, C1054T, C1097A, I1137R ; Mutation：;L42A, G103A, Y202F, R1012G, C1054T, C1097A, I1137R,L42A, G103A, Y202F, R1012G, C1054T, C1097A, I1137R,L42A, G103A, Y202F, R1012G, C1054T, C1097A, I1137R ; OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 1 MK6 (5aR,6S,6aS)-3-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl}methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid × 1 7OS (2S,3R)-3-cyclopropyl-3-[(2R)-2-(1-{(1S)-1-[5-fluoro-2-(trifluoromethoxy)phenyl]ethyl}piperidin-4-yl)-3,4-dihydro-2H-1-benzopyran-7-yl]-2-methylpropanoic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIPIDIC CUBIC PHASE；pH 6.5；293 K；22% PEG 400, 0.37M potassium nitrate, 0.1M MES pH6.5
Resolution 3.22 Å R-free 0.287
8EIT Structure of FFAR1-Gq complex bound to DHA Deposited 2022-09-15 Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain R 2–300（299 aa）
Not recorded HXA DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
8EJC Structure of FFAR1-Gq complex bound to TAK-875 Deposited 2022-09-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain R 2–300（299 aa）
Not recorded 2YB [(3S)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
8EJK Structure of FFAR1-Gq complex bound to TAK-875 in a lipid nanodisc Deposited 2022-09-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain R 2–300（299 aa）
Not recorded 2YB [(3S)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8T3V Cryo-EM structure of the DHA bound FFA1-Gq complex Deposited 2023-06-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain R 1–279（279 aa）
Not recorded CLR CHOLESTEROL × 1 HXA DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.39 Å
9K1C Cryo-EM structure of the DHA bound FFA1-Gi complex Deposited 2024-10-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain R 1–300（300 aa）
Not recorded HXA DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.