Current Protein Identity：O15527
New Search
Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1EBM CRYSTAL STRUCTURE OF THE HUMAN 8-OXOGUANINE GLYCOSYLASE (HOGG1) BOUND TO A SUBSTRATE OLIGONUCLEOTIDE Deposited 2000-01-24 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–325（314 aa）
Fragment：CORE FRAGMENT (RESIDUES 12 TO 325)
|
Mutation：K249Q | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG 8000, sodium cacodylate, calcium acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.10 Å R-free 0.263 |
| 1FN7 COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN Deposited 2000-08-21 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–325（314 aa）
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；100 mM sodium cacodylate pH 6.5, 200 mM calcium acetate, 16-18% PEG, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.60 Å R-free 0.270 |
| 1HU0 CRYSTAL STRUCTURE OF AN HOGG1-DNA BOROHYDRIDE TRAPPED INTERMEDIATE COMPLEX Deposited 2001-01-03 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–327（316 aa）
Fragment：CORE FRAGMENT (RESIDUES 12 TO 327)
|
Not recorded | CA CALCIUM ION × 1 OXG 8-OXOGUANINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG 8000, calcium acetate, sodium cacodylate, pH 6.50, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.35 Å R-free 0.245 |
| 1KO9 Native Structure of the Human 8-oxoguanine DNA Glycosylase hOGG1 Deposited 2001-12-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–345（345 aa）
|
Not recorded | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
MICROBATCH；pH 4.6；277 K；PEG 4000, Ammonium Sulphate, Sodium citrate, pH 4.6, Microbatch, temperature 277K
|
Resolution 2.15 Å R-free 0.252 |
| 1LWV Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-aminoguanine Deposited 2002-06-03 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–327（316 aa）
Fragment：CORE FRAGMENT (RESIDUES 12-327)
|
Not recorded | CA CALCIUM ION × 1 ANG 8-AMINOGUANINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.3；277 K；sodium cacodylate, calcium acetate, PEG 8000, pH 6.3, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.30 Å R-free 0.269 |
| 1LWW Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine Deposited 2002-06-03 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–327（316 aa）
Fragment：CORE FRAGMENT (RESIDUES 12 TO 327)
|
Not recorded | CA CALCIUM ION × 1 BRG 8-BROMOGUANINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.3；277 K；sodium cacodylate, calcium acetate, PEG 8000, pH 6.3, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.10 Å R-free 0.257 |
| 1LWY hOgg1 Borohydride-Trapped Intermediate without 8-oxoguanine Deposited 2002-06-03 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–327（316 aa）
Fragment：CORE FRAGMENT (RESIDUES 12 TO 327)
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.3；277 K；sodium cacodylate, calcium acetate, PEG 8000, pH 6.3, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.01 Å R-free 0.258 |
| 1M3H Crystal Structure of Hogg1 D268E Mutant with Product Oligonucleotide Deposited 2002-06-27 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain A
12–325（314 aa）
Fragment：core fragment (residues 12-325)
|
Mutation：D268E | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG 8000, cacodylate, Calcium Acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.05 Å R-free 0.282 |
| 1M3Q Crystal Structure of hogg1 D268E Mutant with Base-Excised DNA and 8-aminoguanine Deposited 2002-06-28 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–325（314 aa）
Fragment：core fragment (residues 12-325)
|
Mutation：d268e | CA CALCIUM ION × 1 ANG 8-AMINOGUANINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG 8000, calcium acetate, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.268 |
| 1N39 Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase Deposited 2002-10-25 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–325（314 aa）
|
Mutation：D268E | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18% PEG 8000, 200mM Ca(OAC)2, 100mM sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.20 Å R-free 0.273 |
| 1N3A Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase Deposited 2002-10-25 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–325（314 aa）
|
Mutation：D268Q | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；cacodylate, calcium acetate, 16-18% PEG 8000, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.20 Å R-free 0.262 |
| 1N3C Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase Deposited 2002-10-25 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–325（314 aa）
Fragment：3.2.2.-, 4.2.99.18
|
Mutation：D268N | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；sodium cacodylate, calcium acetate, PEG 8000 (16-18%), pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.70 Å R-free 0.273 |
| 1YQK Human 8-oxoguanine glycosylase crosslinked with guanine containing DNA Deposited 2005-02-01 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–327（316 aa）
Fragment：8-oxoguanine DNA glycosylase
|
Mutation：N149C | CA CALCIUM ION × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.50 Å R-free 0.270 |
| 1YQL Catalytically inactive hOGG1 crosslinked with 7-deaza-8-azaguanine containing DNA Deposited 2005-02-02 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–327（316 aa）
Fragment：8-oxoguanine DNA glycosylase
|
Mutation：N149C,K249Q | CA CALCIUM ION × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.60 Å R-free 0.260 |
| 1YQM Catalytically inactive human 8-oxoguanine glycosylase crosslinked to 7-deazaguanine containing DNA Deposited 2005-02-02 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–327（316 aa）
Fragment：8-oxoguanine DNA glycosylase
|
Mutation：N149C,K249Q | CA CALCIUM ION × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.50 Å R-free 0.261 |
| 1YQR Catalytically inactive human 8-oxoguanine glycosylase crosslinked to oxoG containing DNA Deposited 2005-02-02 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–327（316 aa）
Fragment：8-OXOGUANINE DNA GLYCOSYLASE
|
Mutation：N149C,K249Q | CA CALCIUM ION × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.43 Å R-free 0.251 |
| 2I5W Structure of hOGG1 crosslinked to DNA sampling a normal G adjacent to an oxoG Deposited 2006-08-26 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–323（312 aa）
Fragment：8-oxoguanine DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase, AP lyase
|
Mutation：N149C | CA CALCIUM ION × 2 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；16-18% PEG 8000, 150 mM CaCl2, 100 mM sod. cacodylate pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.60 Å R-free 0.266 |
| 2NOB Structure of catalytically inactive H270A human 8-oxoguanine glycosylase crosslinked to 8-oxoguanine DNA Deposited 2006-10-25 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–327（316 aa）
Fragment：8-oxoguanine DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase
|
Mutation：N149C,K249Q,H270A | CA CALCIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG 8000, Ca(OAc)2, Na cacodylate, pH 6.5, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.10 Å R-free 0.258 |
| 2NOE Structure of catalytically inactive G42A human 8-oxoguanine glycosylase complexed to 8-oxoguanine DNA Deposited 2006-10-25 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–327（316 aa）
Fragment：8-oxoguanine DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase
|
Mutation：G42A,K249Q | CA CALCIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG 8000, Ca(OAc)2, Na cacodylate, pH 6.5, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.20 Å R-free 0.269 |
| 2NOF Structure of Q315F human 8-oxoguanine glycosylase proximal crosslink to 8-oxoguanine DNA Deposited 2006-10-25 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–327（316 aa）
Fragment：8-oxoguanine DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase
|
Mutation：N149C,Q315F | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；PEG 8000, CaCl2, Na cacodylate, pH 6.0, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.35 Å R-free 0.270 |
| 2NOH Structure of catalytically inactive Q315A human 8-oxoguanine glycosylase complexed to 8-oxoguanine DNA Deposited 2006-10-25 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–327（316 aa）
Fragment：8-oxoguanine DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase
|
Mutation：K249Q,Q315A | CA CALCIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG 8000, Ca(OAc)2, Na cacodylate, pH 6.5, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.01 Å R-free 0.242 |
| 2NOI Structure of G42A human 8-oxoguanine glycosylase crosslinked to undamaged G-containing DNA Deposited 2006-10-25 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–327（316 aa）
Fragment：8-oxoguanine DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase
|
Mutation：G42A,N149C,K249Q | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；PEG 8000, CaCl2, Na cacodylate, pH 6.0, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.35 Å R-free 0.259 |
| 2NOL Structure of catalytically inactive human 8-oxoguanine glycosylase distal crosslink to oxoG DNA Deposited 2006-10-25 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–327（316 aa）
Fragment：8-oxoguanine DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase
|
Mutation：K249Q,S292C | CA CALCIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；PEG 8000, CaCl2, Na cacodylate, pH 6.0, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.57 Å R-free 0.250 |
| 2NOZ Structure of Q315F human 8-oxoguanine glycosylase distal crosslink to 8-oxoguanine DNA Deposited 2006-10-26 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–327（316 aa）
Fragment：8-oxoguanine DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase
|
Mutation：S292C,Q315F | CA CALCIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；PEG 8000, CaCl2, Na cacodylate, pH 6.0, vapor diffusion, hanging drop, temperature 277K, VAPOR DIFFUSION, HANGING DROP
|
Resolution 2.43 Å R-free 0.275 |
| 2XHI Separation-of-function mutants unravel the dual reaction mode of human 8-oxoguanine DNA glycosylase Deposited 2010-06-16 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
1–345（345 aa）
|
Mutation：YES | CA CALCIUM ION × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.55 Å R-free 0.265 |
| 3IH7 Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to guanine-containing DNA Deposited 2009-07-29 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–325（314 aa）
Fragment：UNP residues 12-325
|
Mutation：S292C | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；63 mM Magnesium acetate, 12.6% PEG 8000, 90 mM Sodium cacodylate, 10 mM Sodium acetate pH 4.6, 60 mM Sodium fluoride, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 3.10 Å R-free 0.267 |
| 3KTU Structure of human 8-oxoGuanine Glycosylase 1 bound to fluorninated oxoG-containing DNA Deposited 2009-11-26 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–325（314 aa）
Fragment：sequence database residues 12-325
|
Not recorded | CA CALCIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6；277 K；Calcium Chloride, Sodium Cacodylate, pH 6.0, PEG 8000, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.30 Å R-free 0.257 |
| 5AN4 Crystal structure of the human 8-oxoguanine glycosylase (OGG1) processed with the CrystalDirect automated mounting and cryo-cooling technology Deposited 2015-09-04 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
12–323（312 aa）
Fragment：UNP RESIDUES 12-323
|
Not recorded | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
0.1 M SODIUM CITRATE, PH=5.5, 0.2 M AMMONIUM SULFATE, 24 % PEG 3350
|
Resolution 1.60 Å R-free 0.214 |
| 6RLW Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with inhibitor TH5487 Deposited 2019-05-03 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain AAA
11–327（317 aa）
|
Not recorded | K8Q 4-(4-bromanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(4-iodophenyl)piperidine-1-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；294 K；0.12 M Alcohols, 0.1 M Buffer System 2 pH 7.5, 48 % v/v Precipitant Mix from 4 Morpheus screen (Molecular Dimensions)
|
Resolution 2.00 Å R-free 0.274 |
| 6RLW Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with inhibitor TH5487 Deposited 2019-05-03 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain BBB
11–327（317 aa）
|
Not recorded | K8Q 4-(4-bromanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(4-iodophenyl)piperidine-1-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；294 K；0.12 M Alcohols, 0.1 M Buffer System 2 pH 7.5, 48 % v/v Precipitant Mix from 4 Morpheus screen (Molecular Dimensions)
|
Resolution 2.00 Å R-free 0.274 |
| 6RLW Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with inhibitor TH5487 Deposited 2019-05-03 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain CCC
11–327（317 aa）
|
Not recorded | K8Q 4-(4-bromanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(4-iodophenyl)piperidine-1-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；294 K；0.12 M Alcohols, 0.1 M Buffer System 2 pH 7.5, 48 % v/v Precipitant Mix from 4 Morpheus screen (Molecular Dimensions)
|
Resolution 2.00 Å R-free 0.274 |
| 6RLW Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with inhibitor TH5487 Deposited 2019-05-03 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain DDD
11–327（317 aa）
|
Not recorded | K8Q 4-(4-bromanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(4-iodophenyl)piperidine-1-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；294 K；0.12 M Alcohols, 0.1 M Buffer System 2 pH 7.5, 48 % v/v Precipitant Mix from 4 Morpheus screen (Molecular Dimensions)
|
Resolution 2.00 Å R-free 0.274 |
| 6RLW Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with inhibitor TH5487 Deposited 2019-05-03 | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain EEE
11–327（317 aa）
|
Not recorded | K8Q 4-(4-bromanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(4-iodophenyl)piperidine-1-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；294 K；0.12 M Alcohols, 0.1 M Buffer System 2 pH 7.5, 48 % v/v Precipitant Mix from 4 Morpheus screen (Molecular Dimensions)
|
Resolution 2.00 Å R-free 0.274 |
| 6W0M Human 8-oxoguanine glycosylase crosslinked with oxoG lesion containing DNA Deposited 2020-03-02 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–325（314 aa）
|
Mutation：E122Q, Y207C, K249Q | MG MAGNESIUM ION × 2 S5Y 2-(2-ethoxyethoxy)ethanethiol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；100 mM sodium cacodylate, pH 6.5, 200 mM MgCl2, and 18 % polyethylene glycol 8000.
|
Resolution 2.37 Å R-free 0.266 |
| 6W0R Human 8-oxoguanine glycosylase interrogating fully intrahelical undamaged DNA Deposited 2020-03-02 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–323（312 aa）
|
Mutation：E122Q, Y207C | NA SODIUM ION × 1 NO3 NITRATE ION × 3 S5Y 2-(2-ethoxyethoxy)ethanethiol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；200 mM NH4NO3, and 20 % polyethylene glycol 3350
|
Resolution 2.35 Å R-free 0.249 |
| 6W13 Human 8-oxoguanine glycosylase interrogating fully intrahelical oxoG lesion DNA Deposited 2020-03-03 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–325（314 aa）
|
Mutation：E122Q, Y207C, C253W | MG MAGNESIUM ION × 4 ACT ACETATE ION × 2 S5Y 2-(2-ethoxyethoxy)ethanethiol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM sodium cacodylate, pH 6.1, 200 mM MgOAc, and 17 % polyethylene glycol 8000
|
Resolution 2.38 Å R-free 0.271 |
| 7AYY Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator TH10785 Deposited 2020-11-13 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain AAA
11–327（317 aa）
|
Not recorded | SEQ ~{N}-cyclohexyl-2-cyclopropyl-quinazolin-4-amine × 1 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293.15 K；0.12 M Alcohols, 0.1 M Buffer System 2 pH 7.5 and 48 % v/v Precipitant Mix 4 (Morpheus screen, Molecular Dimensions)
|
Resolution 2.00 Å R-free 0.250 |
| 7AYY Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator TH10785 Deposited 2020-11-13 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain BBB
11–327（317 aa）
|
Not recorded | SEQ ~{N}-cyclohexyl-2-cyclopropyl-quinazolin-4-amine × 1 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293.15 K；0.12 M Alcohols, 0.1 M Buffer System 2 pH 7.5 and 48 % v/v Precipitant Mix 4 (Morpheus screen, Molecular Dimensions)
|
Resolution 2.00 Å R-free 0.250 |
| 7AYY Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator TH10785 Deposited 2020-11-13 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain CCC
11–327（317 aa）
|
Not recorded | SEQ ~{N}-cyclohexyl-2-cyclopropyl-quinazolin-4-amine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293.15 K；0.12 M Alcohols, 0.1 M Buffer System 2 pH 7.5 and 48 % v/v Precipitant Mix 4 (Morpheus screen, Molecular Dimensions)
|
Resolution 2.00 Å R-free 0.250 |
| 7AYY Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator TH10785 Deposited 2020-11-13 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain DDD
11–327（317 aa）
|
Not recorded | SEQ ~{N}-cyclohexyl-2-cyclopropyl-quinazolin-4-amine × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293.15 K；0.12 M Alcohols, 0.1 M Buffer System 2 pH 7.5 and 48 % v/v Precipitant Mix 4 (Morpheus screen, Molecular Dimensions)
|
Resolution 2.00 Å R-free 0.250 |
| 7AYY Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator TH10785 Deposited 2020-11-13 | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain EEE
11–327（317 aa）
|
Not recorded | SEQ ~{N}-cyclohexyl-2-cyclopropyl-quinazolin-4-amine × 1 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293.15 K；0.12 M Alcohols, 0.1 M Buffer System 2 pH 7.5 and 48 % v/v Precipitant Mix 4 (Morpheus screen, Molecular Dimensions)
|
Resolution 2.00 Å R-free 0.250 |
| 8VWT OGG1 bound to a nucleosome containing 8oxoG at SHL-6 (composite map) Deposited 2024-02-02 | Assembly 1 Protein–DNA Heteromer；Protein × 9 PDB declaration: 11-meric（11） Consistent with all polymers |
Chain K
1–345（345 aa）
|
Mutation：Q249K | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.1；50 mM HEPES (pH-7.1), 100 mM NaCl, 1 mM TCEP, and
1 mM EDTA
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 8VWV OGG1 bound to a nucleosome containing 8oxoG at SHL4 (composite map) Deposited 2024-02-02 | Assembly 1 Protein–DNA Heteromer；Protein × 9 PDB declaration: 11-meric（11） Consistent with all polymers |
Chain K
1–345（345 aa）
|
Mutation：Q249K | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.1；50 mM HEPES (pH-7.1), 100 mM NaCl, 1 mM TCEP, and
1 mM EDTA
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.60 Å |
| 8VX4 Human OGG1 bound to a 35-bp DNA with an 8-oxoG in the middle Deposited 2024-02-03 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
2–345（344 aa）
|
Mutation：K249Q | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.70 Å |
| 8VX6 Human OGG1 bound at the nucleosomal DNA entry site Deposited 2024-02-03 | Assembly 1 Protein–DNA Heteromer；Protein × 9 PDB declaration: undecameric（11） Consistent with all polymers |
Chain K
2–345（344 aa）
|
Mutation：K249Q | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 8XWC Crystal structure of human 8-oxoguanine glycosylase K249H mutant bound to the substrate 8-oxoguanine DNA at pH 8.0 under 277 K Deposited 2024-01-16 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
12–345（334 aa）
|
Mutation：K249H | PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；277 K；Sodium cacodylate, MgCl2, PEG 4000, glycerol
|
Resolution 1.45 Å R-free 0.179 |
| 8XWU Crystal structure of human 8-oxoguanine glycosylase K249H mutant bound to the reaction intermediate derived from the crystal soaked into the solution at pH 4.0 under 277 K for 24 hourss Deposited 2024-01-16 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain A
12–345（334 aa）
|
Not recorded | A1LXK [(2~{R},3~{S},5~{S})-5-[2-azanyl-6,8-bis(oxidanylidene)-1,7-dihydropurin-9-yl]-2,3,5-tris(oxidanyl)pentyl] dihydrogen phosphate × 1 MG MAGNESIUM ION × 2 GOL GLYCEROL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；277 K；sodium cacodylate, PEG 4000, MgCl2
|
Resolution 1.68 Å R-free 0.213 |
| 8XXG Crystal structure of human 8-oxoguanine glycosylase K249H mutant bound to the reaction intermediate derived from the crystal soaked into the solution at pH 4.0 under 277 K for 2.5 hours Deposited 2024-01-18 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain A
12–345（334 aa）
|
Mutation：K249H | A1LXK [(2~{R},3~{S},5~{S})-5-[2-azanyl-6,8-bis(oxidanylidene)-1,7-dihydropurin-9-yl]-2,3,5-tris(oxidanyl)pentyl] dihydrogen phosphate × 1 MG MAGNESIUM ION × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；277 K；PEG 4000, MgCl2, Sodium cacodylate, glycerol
|
Resolution 1.82 Å R-free 0.194 |
| 8XXK Crystal structure of human 8-oxoguanine glycosylase K249H mutant bound to the reaction intermediate derived from the crystal soaked into the solution at pH 4.0 under 298 K for 3 weeks Deposited 2024-01-18 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain A
12–345（334 aa）
|
Not recorded | A1LXK [(2~{R},3~{S},5~{S})-5-[2-azanyl-6,8-bis(oxidanylidene)-1,7-dihydropurin-9-yl]-2,3,5-tris(oxidanyl)pentyl] dihydrogen phosphate × 1 GOL GLYCEROL × 4 MG MAGNESIUM ION × 2 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；277 K；MgCl2, PEG 4000, Sodium Cacodylate, glycerol
|
Resolution 1.70 Å R-free 0.213 |
| 9EOZ Human OGG1 bound to a nucleosome core particle with 8-oxodGuo lesion at SHL6.0 Deposited 2024-03-16 | Assembly 1 Protein–DNA Heteromer；Protein × 9 PDB declaration: 11-meric（11） Consistent with all polymers |
Chain A
2–345（344 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9KKY Co-crystal structure of human 8-oxoguanine glycosylase N149C mutant with DNA containing photocaged 8-oxoguanine Deposited 2024-11-14 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
11–327（317 aa）
|
Not recorded | CA CALCIUM ION × 4 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；PEG 6000, calcium chloride, sodium cacodylate
|
Resolution 2.81 Å R-free 0.262 |
| 9KL8 Co-crystal structure of human 8-oxoguanine glycosylase N149C mutant with DNA containing photocaged 8-oxoguanine after deprotection Deposited 2024-11-14 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain A
11–327（317 aa）
|
Mutation：N149C | CA CALCIUM ION × 9 GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；PEG 6000, calcium chloride, sodium cacodylate
|
Resolution 2.48 Å R-free 0.251 |
| 9NZ8 Crystal structure of human OGG1 in a DNA-free state Deposited 2025-03-31 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
12–327（316 aa）
|
Not recorded | SO4 SULFATE ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；288 K；100 mM sodium citrate, pH 5.0, 22% PEG6000, 5% ammonium sulfate (saturated)
|
Resolution 1.85 Å R-free 0.199 |
| 9NZ9 Crystal structure of product-bound human OGG1(WT) Deposited 2025-03-31 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain A
12–327（316 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；288 K；50 mM MES, pH 6.0, 16-23% PEG6000, cryoprotectant: 25% ethylene glycol
|
Resolution 2.00 Å R-free 0.242 |
| 9NZA Crystal structure of human OGG1 (WT) in a product bound state in the presence of the agonist F01 Deposited 2025-03-31 | Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain A
12–327（316 aa）
|
Not recorded | OXG 8-OXOGUANINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；288 K；50 mM MES, pH 6.0, 16-23% PEG6000, 4.5 mM F01, cryoprotectant: 25% ethylene glycol
|
Resolution 2.50 Å R-free 0.246 |