Current Protein Identity：O43278
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1YC0 short form HGFA with first Kunitz domain from HAI-1 Deposited 2004-12-21 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain I
245–303（59 aa）
Fragment：sequence database residues 245-303
|
Not recorded | PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；292 K；50% MPD, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 292K
|
Resolution 2.60 Å R-free 0.218 |
| 2MSX The solution structure of the MANEC-type domain from Hepatocyte Growth Factor Inhibitor 1 reveals an unexpected PAN/apple domain-type fold Deposited 2014-08-09 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
47–152（106 aa）
Fragment：UNP residues 47-152
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.5；310 K；Ionic strength (raw mmCIF value) 100；Pressure ambient
NMR measurement conditions
pH 6.5；298 K；Ionic strength (raw mmCIF value) 100；Pressure ambient
NMR sample composition
1 mM [U-99% 13C; U-99% 15N] protein_1, 93% H2O/7% D2O | 93% H2O/7% D2O
|
Resolution not provided |
| 4ISL Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1 Deposited 2013-01-16 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
245–304（60 aa）
Fragment：Kunitz domain I (unp residues 245-304)
|
Not recorded | PG4 TETRAETHYLENE GLYCOL × 1 GOL GLYCEROL × 3 PGE TRIETHYLENE GLYCOL × 1 GSH Glutathione × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；295 K；0.1 M Tris-HCl, 20% (w/v) polyethylene glycol 8000, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
Resolution 2.29 Å R-free 0.232 |
| 4ISO Crystal Structure of Matriptase in complex with its inhibitor HAI-1 Deposited 2013-01-16 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
245–304（60 aa）
Fragment：Kunitz domain I (UNP RESISDUES 245-304)
|
Not recorded | GSH Glutathione × 1 GOL GLYCEROL × 2 PEG DI(HYDROXYETHYL)ETHER × 4 PGE TRIETHYLENE GLYCOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；295 K；0.1 M Tris-HCl, 20% (w/v) polyethylene glycol 8000 , pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
Resolution 2.01 Å R-free 0.219 |
| 5EZD Crystal structure of a Hepatocyte growth factor activator inhibitor-1 (HAI-1) fragment covering the PKD-like 'internal' domain and Kunitz domain 1 Deposited 2015-11-26 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
168–303（136 aa）
Fragment：UNP residues 168-303
|
Not recorded | K POTASSIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；28% w/v PEG 2000 MME, 0.1 M sodium acetate pH 5.5, 0.2 M potassium bromide
|
Resolution 2.10 Å R-free 0.257 |
| 5EZD Crystal structure of a Hepatocyte growth factor activator inhibitor-1 (HAI-1) fragment covering the PKD-like 'internal' domain and Kunitz domain 1 Deposited 2015-11-26 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
168–303（136 aa）
Fragment：UNP residues 168-303
|
Not recorded | K POTASSIUM ION × 1 ACT ACETATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；28% w/v PEG 2000 MME, 0.1 M sodium acetate pH 5.5, 0.2 M potassium bromide
|
Resolution 2.10 Å R-free 0.257 |
| 5H7V Structure of full-length extracellular domain of HAI-1 at pH 4.6 Deposited 2016-11-21 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
36–441（406 aa）
Fragment：ligand binding region, UNP residues 36-441
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.6；293 K；1.6M ammonium sulfate, 20% (v/v) glycerol, 0.08M sodium acetate, pH 4.6
|
Resolution 3.82 Å R-free 0.328 |