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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：O43516 New Search
6PDB entries
6Biological assembly
6chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1MKE Structure of the N-WASP EVH1 Domain-WIP complex Deposited 2002-08-29 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 461–485（25 aa） Fragment：WIP peptide and N-WASP EVH1 domain
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；303 K；Ionic strength (raw mmCIF value) 20 mM NaCl；Pressure ambient
NMR sample composition U-15N protein 20 mM PO4 buffer 1 mM dithiothreitol | 90% H2O/10% D2O
NMR sample composition U-13C/15N protein 20 mM PO4 buffer 1 mM dithiothreitol | 90% H2O/10% D2O
Resolution not provided
2A41 Ternary complex of the WH2 Domain of WIP with Actin-DNAse I Deposited 2005-06-27 Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 29–60（32 aa） Fragment：first WH2 domain
Not recorded CA CALCIUM ION × 2 ATP ADENOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FMT FORMIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；sodium formate, PEG3350, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.60 Å R-free 0.219
2IFS Structure of the N-WASP EVH1 domain in complex with an extended WIP peptide Deposited 2006-09-21 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 451–485（35 aa） Fragment：WIP peptide (residues 451-485) and N-WASP EVH1 domain (Residues 26-147)
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；303 K；Ionic strength (raw mmCIF value) 0.044 mM；Pressure 1
NMR sample composition 1.0 mM U-15N/13C protein, 20 mM sodium phosphate, 1 mM Dithiothreitol, 90% H2O, 10% D2O | 90% H2O/10% D2O
Resolution not provided
9EZN Canonical class 1 structure of the human cortactin SH3 domain in complex with WIP-derived peptide Deposited 2024-04-13 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 165–183（19 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.6；298 K；Ionic strength (raw mmCIF value) 0.055；Pressure 1
NMR sample composition 0.7 mM Human WIP (165-183), 20 mM potassium phosphate, 20 mM sodium chloride, 0.02 % sodium azide, 93% H2O/7% D2O | 93% H2O/7% D2O
NMR sample composition 0.7 mM Human WIP (165-183), 20 mM potassium phosphate, 20 mM sodium chloride, 0.02 % sodium azide, 100% D2O | 100% D2O
NMR sample composition 1.1 mM Human WIP (165-183), 0.22 mM [U-99% 15N; U-80% 2H] Human cortactin SH3 domain (494-550), 20 mM potassium phosphate, 20 mM sodium chloride, 1 mM dithiothreitol, 0.02 % sodium azide, 93% H2O/7% D2O | 93% H2O/7% D2O
NMR sample composition 1.1 mM Human WIP (165-183), 0.22 mM [U-99% 15N; U-80% 2H] Human cortactin SH3 domain (494-550), 20 mM potassium phosphate, 20 mM sodium chloride, 1 mM dithiothreitol, 0.02 % sodium azide, 100% D2O | 100% D2O
NMR sample composition 1.1 mM Human WIP (165-183), 0.22 mM [U-99% 13C; U-99% 15N] Human cortactin SH3 domain (494-550), 20 mM potassium phosphate, 20 mM sodium chloride, 1 mM dithiothreitol, 0.02 % sodium azide, 100% D2O | 100% D2O
Resolution not provided
9EZO Canonical class 2 structure of the human cortactin SH3 domain in complex with WIP-derived peptide Deposited 2024-04-13 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 165–183（19 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.6；298 K；Ionic strength (raw mmCIF value) 0.055；Pressure 1
NMR sample composition 0.7 mM Human WIP (165-183), 20 mM potassium phosphate, 20 mM sodium chloride, 0.02 % sodium azide, 93% H2O/7% D2O | 93% H2O/7% D2O
NMR sample composition 0.7 mM Human WIP (165-183), 20 mM potassium phosphate, 20 mM sodium chloride, 0.02 % sodium azide, 100% D2O | 100% D2O
NMR sample composition 0.22 mM [U-99% 15N; U-80% 2H] Human cortactin SH3 domain (494-550), 1.1 mM Human WIP (165-183), 20 mM potassium phosphate, 20 mM sodium chloride, 0.02 % sodium azide, 1 mM dithiothreitol, 93% H2O/7% D2O | 93% H2O/7% D2O
NMR sample composition 0.22 mM [U-99% 15N; U-80% 2H] Human cortactin SH3 domain (494-550), 1.1 mM Human WIP (165-183), 20 mM potassium phosphate, 20 mM sodium chloride, 0.02 % sodium azide, 1 mM dithiothreitol, 100% D2O | 100% D2O
NMR sample composition 0.22 mM [U-99% 13C; U-99% 15N] Human cortactin SH3 domain (494-550), 1.1 mM Human WIP (165-183), 20 mM potassium phosphate, 20 mM sodium chloride, 0.02 % sodium azide, 1 mM dithiothreitol, 100% D2O | 100% D2O
Resolution not provided
9EZP Non-canonical structure of the human cortactin SH3 domain in complex with WIP-derived peptide Deposited 2024-04-13 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 165–183（19 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.6；298 K；Ionic strength (raw mmCIF value) 0.055；Pressure 1
NMR sample composition 0.7 mM Human WIP (165-183), 20 mM potassium phosphate, 20 mM sodium chloride, 0.02 % sodium azide, 93% H2O/7% D2O | 93% H2O/7% D2O
NMR sample composition 0.7 mM Human WIP (165-183), 20 mM potassium phosphate, 20 mM sodium chloride, 0.02 % sodium azide, 100% D2O | 100% D2O
NMR sample composition 1.1 mM Human WIP (165-183), 0.22 mM [U-99% 15N; U-80% 2H] Human cortactin SH3 domain (494-550), 20 mM potassium phosphate, 20 mM sodium chloride, 1 mM dithiothreitol, 0.02 % sodium azide, 93% H2O/7% D2O | 93% H2O/7% D2O
NMR sample composition 1.1 mM Human WIP (165-183), 0.22 mM [U-99% 15N; U-80% 2H] Human cortactin SH3 domain (494-550), 20 mM potassium phosphate, 20 mM sodium chloride, 1 mM dithiothreitol, 0.02 % sodium azide, 100% D2O | 100% D2O
NMR sample composition 1.1 mM Human WIP (165-183), 0.22 mM [U-99% 13C; U-99% 15N] Human cortactin SH3 domain (494-550), 20 mM potassium phosphate, 20 mM sodium chloride, 1 mM dithiothreitol, 0.02 % sodium azide, 100% D2O | 100% D2O
Resolution not provided

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.