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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：O60895 New Search
10PDB entries
24Biological assembly
32chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2XVT Structure of the extracellular domain of human RAMP2 Deposited 2010-10-31 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain D 48–139（92 aa） Fragment：EXTRACELLULAR DOMAIN, RESIDUES 48-139
Chain E 48–139（92 aa） Fragment：EXTRACELLULAR DOMAIN, RESIDUES 48-139
Chain F 48–139（92 aa） Fragment：EXTRACELLULAR DOMAIN, RESIDUES 48-139
Not recorded CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；0.1M CALCIUM CHLORIDE, 26% PEG MONOMETHYLETHER 350, 0.1M HEPES PH 7.5
Resolution 2.05 Å R-free 0.246
2XVT Structure of the extracellular domain of human RAMP2 Deposited 2010-10-31 Assembly 2 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 48–139（92 aa） Fragment：EXTRACELLULAR DOMAIN, RESIDUES 48-139
Chain B 48–139（92 aa） Fragment：EXTRACELLULAR DOMAIN, RESIDUES 48-139
Chain C 48–139（92 aa） Fragment：EXTRACELLULAR DOMAIN, RESIDUES 48-139
Not recorded CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；0.1M CALCIUM CHLORIDE, 26% PEG MONOMETHYLETHER 350, 0.1M HEPES PH 7.5
Resolution 2.05 Å R-free 0.246
2XVT Structure of the extracellular domain of human RAMP2 Deposited 2010-10-31 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 48–139（92 aa） Fragment：EXTRACELLULAR DOMAIN, RESIDUES 48-139
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；0.1M CALCIUM CHLORIDE, 26% PEG MONOMETHYLETHER 350, 0.1M HEPES PH 7.5
Resolution 2.05 Å R-free 0.246
2XVT Structure of the extracellular domain of human RAMP2 Deposited 2010-10-31 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 48–139（92 aa） Fragment：EXTRACELLULAR DOMAIN, RESIDUES 48-139
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；0.1M CALCIUM CHLORIDE, 26% PEG MONOMETHYLETHER 350, 0.1M HEPES PH 7.5
Resolution 2.05 Å R-free 0.246
2XVT Structure of the extracellular domain of human RAMP2 Deposited 2010-10-31 Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 48–139（92 aa） Fragment：EXTRACELLULAR DOMAIN, RESIDUES 48-139
Not recorded CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；0.1M CALCIUM CHLORIDE, 26% PEG MONOMETHYLETHER 350, 0.1M HEPES PH 7.5
Resolution 2.05 Å R-free 0.246
2XVT Structure of the extracellular domain of human RAMP2 Deposited 2010-10-31 Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 48–139（92 aa） Fragment：EXTRACELLULAR DOMAIN, RESIDUES 48-139
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；0.1M CALCIUM CHLORIDE, 26% PEG MONOMETHYLETHER 350, 0.1M HEPES PH 7.5
Resolution 2.05 Å R-free 0.246
2XVT Structure of the extracellular domain of human RAMP2 Deposited 2010-10-31 Assembly 7 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain E 48–139（92 aa） Fragment：EXTRACELLULAR DOMAIN, RESIDUES 48-139
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；0.1M CALCIUM CHLORIDE, 26% PEG MONOMETHYLETHER 350, 0.1M HEPES PH 7.5
Resolution 2.05 Å R-free 0.246
2XVT Structure of the extracellular domain of human RAMP2 Deposited 2010-10-31 Assembly 8 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain F 48–139（92 aa） Fragment：EXTRACELLULAR DOMAIN, RESIDUES 48-139
Not recorded CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；0.1M CALCIUM CHLORIDE, 26% PEG MONOMETHYLETHER 350, 0.1M HEPES PH 7.5
Resolution 2.05 Å R-free 0.246
3AQE Crystal structure of the extracellular domain of human RAMP2 Deposited 2010-10-29 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 56–139（84 aa） Fragment：extracellular Domain, UNP residues 56-139
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1M Sodium-HEPES, 25% (v/v) PEG 400, 0.2M Calcium chloride di-hydrate, 0.15% Agarose , pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.00 Å R-free 0.276
3AQE Crystal structure of the extracellular domain of human RAMP2 Deposited 2010-10-29 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 56–139（84 aa） Fragment：extracellular Domain, UNP residues 56-139
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1M Sodium-HEPES, 25% (v/v) PEG 400, 0.2M Calcium chloride di-hydrate, 0.15% Agarose , pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.00 Å R-free 0.276
3AQE Crystal structure of the extracellular domain of human RAMP2 Deposited 2010-10-29 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 56–139（84 aa） Fragment：extracellular Domain, UNP residues 56-139
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1M Sodium-HEPES, 25% (v/v) PEG 400, 0.2M Calcium chloride di-hydrate, 0.15% Agarose , pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.00 Å R-free 0.276
3AQE Crystal structure of the extracellular domain of human RAMP2 Deposited 2010-10-29 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 56–139（84 aa） Fragment：extracellular Domain, UNP residues 56-139
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1M Sodium-HEPES, 25% (v/v) PEG 400, 0.2M Calcium chloride di-hydrate, 0.15% Agarose , pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.00 Å R-free 0.276
3AQE Crystal structure of the extracellular domain of human RAMP2 Deposited 2010-10-29 Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain E 56–139（84 aa） Fragment：extracellular Domain, UNP residues 56-139
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1M Sodium-HEPES, 25% (v/v) PEG 400, 0.2M Calcium chloride di-hydrate, 0.15% Agarose , pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.00 Å R-free 0.276
3AQE Crystal structure of the extracellular domain of human RAMP2 Deposited 2010-10-29 Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain F 56–139（84 aa） Fragment：extracellular Domain, UNP residues 56-139
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1M Sodium-HEPES, 25% (v/v) PEG 400, 0.2M Calcium chloride di-hydrate, 0.15% Agarose , pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.00 Å R-free 0.276
3AQE Crystal structure of the extracellular domain of human RAMP2 Deposited 2010-10-29 Assembly 7 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 56–139（84 aa） Fragment：extracellular Domain, UNP residues 56-139
Chain B 56–139（84 aa） Fragment：extracellular Domain, UNP residues 56-139
Chain C 56–139（84 aa） Fragment：extracellular Domain, UNP residues 56-139
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1M Sodium-HEPES, 25% (v/v) PEG 400, 0.2M Calcium chloride di-hydrate, 0.15% Agarose , pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.00 Å R-free 0.276
3AQE Crystal structure of the extracellular domain of human RAMP2 Deposited 2010-10-29 Assembly 8 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain D 56–139（84 aa） Fragment：extracellular Domain, UNP residues 56-139
Chain E 56–139（84 aa） Fragment：extracellular Domain, UNP residues 56-139
Chain F 56–139（84 aa） Fragment：extracellular Domain, UNP residues 56-139
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1M Sodium-HEPES, 25% (v/v) PEG 400, 0.2M Calcium chloride di-hydrate, 0.15% Agarose , pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.00 Å R-free 0.276
3AQF Crystal structure of the human CRLR/RAMP2 extracellular complex Deposited 2010-10-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 56–139（84 aa） Fragment：Extracellular Domain, UNP residues 39-139
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1M bis-Tris, 30 % (v/v) PEG MME 550, 0.05M Calcium Chloride, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.60 Å R-free 0.282
4RWF Crystal structure of the CLR:RAMP2 extracellular domain heterodimer with bound adrenomedullin Deposited 2014-12-03 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 55–138（84 aa）
Not recorded EDO 1,2-ETHANEDIOL × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.3；293 K；19% PEG3350 0.1 M Tris-HCl, pH 8.3 225 mM Sodium Acetate 20% ethylene glycol, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.76 Å R-free 0.200
6UUN CryoEM Structure of the active Adrenomedullin 1 receptor G protein complex with adrenomedullin peptide Deposited 2019-10-30 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain E 44–175（132 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
6V2E Crystal structure of the human CLR:RAMP2 extracellular domain heterodimer with bound high-affinity adrenomedullin S45R/K46L/S48G/Q50W variant Deposited 2019-11-22 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 55–140（86 aa）
Mutation：L106R,RAMP2 L106R FMT FORMIC ACID × 3 NH2 AMINO GROUP × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.3；293 K；20% PEG MME 5000, 0.1 M sodium HEPEs pH 8.2, 150 mM sodium formate, 3% (v/v) dimethyl sulfoxide
Resolution 1.83 Å R-free 0.190
7TYH Human Amylin2 Receptor in complex with Gs and human calcitonin peptide Deposited 2022-02-13 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain E 44–175（132 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
7TYX Human Amylin2 Receptor in complex with Gs and rat amylin peptide Deposited 2022-02-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain E 44–175（132 aa）
Not recorded PLM PALMITIC ACID × 8 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 Y01 CHOLESTEROL HEMISUCCINATE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.55 Å
7TYY Human Amylin2 Receptor in complex with Gs and salmon calcitonin peptide Deposited 2022-02-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain E 44–175（132 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 PLM PALMITIC ACID × 5 Y01 CHOLESTEROL HEMISUCCINATE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9BQ3 Human Amylin2 Receptor in Complex with Gs and Cagrilintide Deposited 2024-05-08 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain E 44–175（132 aa）
Not recorded A1B90 icosanedioic acid × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.