Current Protein Identity：O74036
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1PZN Rad51 (RadA) Deposited 2003-07-12 | Assembly 1 Protein homooligomer Homooligomer；Protein × 14 PDB declaration: tetradecameric（14） Consistent with protein count |
Chain A
1–349（349 aa）
Chain B
1–349（349 aa）
Chain C
1–349（349 aa）
Chain D
1–349（349 aa）
Chain E
1–349（349 aa）
Chain F
1–349（349 aa）
Chain G
1–349（349 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | SO4 SULFATE ION × 14 IMD IMIDAZOLE × 18 GOL GLYCEROL × 18 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 8 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.85 Å R-free 0.307 |
| 1PZN Rad51 (RadA) Deposited 2003-07-12 | Assembly 2 Protein homooligomer Homooligomer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain A
1–349（349 aa）
Chain B
1–349（349 aa）
Chain C
1–349（349 aa）
Chain D
1–349（349 aa）
Chain E
1–349（349 aa）
Chain F
1–349（349 aa）
Chain G
1–349（349 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | SO4 SULFATE ION × 7 IMD IMIDAZOLE × 9 GOL GLYCEROL × 9 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 4 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.85 Å R-free 0.307 |
| 4A6P RadA C-terminal ATPase domain from Pyrococcus furiosus Deposited 2011-11-08 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：C-TERMINAL ATPASE DOMAIN, RESIDUES 108-288 AND 301-349
|
Not recorded | PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.8；60 MM NA2HPO4 PH 6.0; 15% PEG 1000
|
Resolution 1.50 Å R-free 0.214 |
| 4A6X RadA C-terminal ATPase domain from Pyrococcus furiosus bound to ATP Deposited 2011-11-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：RADA C-TERMINAL ATPASE DOMAIN, RESIDUES 108-349
|
Not recorded | MG MAGNESIUM ION × 1 ATP ADENOSINE-5'-TRIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.8；60MM NA2HPO4 PH 6.0; 15% PEG1000
|
Resolution 1.55 Å R-free 0.235 |
| 4A6X RadA C-terminal ATPase domain from Pyrococcus furiosus bound to ATP Deposited 2011-11-10 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
108–349（242 aa）
Fragment：RADA C-TERMINAL ATPASE DOMAIN, RESIDUES 108-349
|
Not recorded | MG MAGNESIUM ION × 1 ATP ADENOSINE-5'-TRIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.8；60MM NA2HPO4 PH 6.0; 15% PEG1000
|
Resolution 1.55 Å R-free 0.235 |
| 4B2I Humanised monomeric RadA in complex with indazole Deposited 2012-07-16 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：ATPASE, RESIDUES 108-349
|
Mutation：YES | PO4 PHOSPHATE ION × 1 LZ1 1H-indazole × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；10-15% PEG-1000, 50 MM NAKPHOSPHATE, PH 6.2
|
Resolution 1.30 Å R-free 0.223 |
| 4B2L Humanised monomeric RadA in complex with L-methylester tryptophan Deposited 2012-07-16 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：ATPASE, RESIDUES 108-349
|
Mutation：YES | PO4 PHOSPHATE ION × 1 TR7 methyl L-tryptophanate × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；10-15% PEG-1000, 50 MM NAKPHOSPHATE PH 6.2
|
Resolution 1.50 Å R-free 0.223 |
| 4B2P RadA C-terminal ATPase domain from Pyrococcus furiosus bound to GTP Deposited 2012-07-17 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：C-TERMINAL ATPASE DOMAIN, RESIDUES 108-349
|
Mutation：YES | GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；pH 6.2
|
Resolution 1.60 Å R-free 0.220 |
| 4B32 Humanised monomeric RadA in complex with napht-1-ol Deposited 2012-07-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：ATPASE, RESIDUES 108-349
|
Mutation：YES | PO4 PHOSPHATE ION × 1 03V naphthalen-2-ol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；8% PEG-1000, 100 MM NAK PHOSPHATE, PH 6.2
|
Resolution 1.50 Å R-free 0.228 |
| 4B33 Humanised monomeric RadA in complex with napht-2-ol Deposited 2012-07-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：ATPASE, RESIDUES 108-349
|
Mutation：YES | PO4 PHOSPHATE ION × 1 1NP 1-NAPHTHOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；8% PEG-1000, 100 MM NAK PHOSPHATE, PH 6.2
|
Resolution 1.50 Å R-free 0.227 |
| 4B34 Humanised monomeric RadA in complex with 2-amino benzothiazole Deposited 2012-07-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：ATPASE, RESIDUES 108-349
|
Mutation：YES | PO4 PHOSPHATE ION × 1 ABV 1,3-benzothiazol-2-amine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；8% PEG-1000, 50 MM NAKPHOSPHATE, PH 6.2
|
Resolution 1.55 Å R-free 0.224 |
| 4B35 Humanised monomeric RadA in complex with 4-methylester indole Deposited 2012-07-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：ATPASE, RESIDUES 108-349
|
Mutation：YES | PO4 PHOSPHATE ION × 1 4ME methyl 1H-indole-4-carboxylate × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；8% PEG-1000, 100 MM NAK PHOSPHATE, PH 6.2
|
Resolution 1.40 Å R-free 0.223 |
| 4B3B Humanised monomeric RadA in complex with FHTA tetrapeptide Deposited 2012-07-23 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
108–287（180 aa）
Fragment：ATPASE, RESIDUES 108-287,300-349
Chain A
300–349（50 aa）
Fragment：ATPASE, RESIDUES 108-287,300-349
|
Mutation：YES Mutation：YES | PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；pH 6.2
|
Resolution 1.19 Å R-free 0.167 |
| 4B3C Humanised monomeric RadA in complex with 5-hydroxy indole Deposited 2012-07-23 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–287（180 aa）
Fragment：ATPASE, RESIDUES 108-287,300-349
Chain A
300–349（50 aa）
Fragment：ATPASE, RESIDUES 108-287,300-349
|
Mutation：YES Mutation：YES | PO4 PHOSPHATE ION × 1 5H1 1H-indol-5-ol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；8% PEG1000, 100MM NA/K PHOSPHATE PH 6.2
|
Resolution 1.90 Å R-free 0.261 |
| 4B3D Humanised monomeric RadA in complex with 5-methyl indole Deposited 2012-07-23 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–287（180 aa）
Fragment：ATPASE
Chain A
300–349（50 aa）
Fragment：ATPASE
|
Mutation：YES Mutation：YES | PO4 PHOSPHATE ION × 1 5MI 5-METHYL INDOLE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；8% PEG-1000, 100 MM NAK PHOSPHATE, PH 6.2
|
Resolution 1.59 Å R-free 0.212 |
| 4B3D Humanised monomeric RadA in complex with 5-methyl indole Deposited 2012-07-23 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
108–287（180 aa）
Fragment：ATPASE
Chain C
300–349（50 aa）
Fragment：ATPASE
|
Mutation：YES Mutation：YES | PO4 PHOSPHATE ION × 1 5MI 5-METHYL INDOLE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；8% PEG-1000, 100 MM NAK PHOSPHATE, PH 6.2
|
Resolution 1.59 Å R-free 0.212 |
| 4D6P RADA C-TERMINAL ATPASE DOMAIN FROM PYROCOCCUS FURIOSUS BOUND TO AMPPNP Deposited 2014-11-13 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：C-TERMINAL ATPASE DOMAIN, UNP RESIDUES 108-349
|
Mutation：YES | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 GOL GLYCEROL × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.8；60 MM NA2HPO4 PH 6.0, 15% PEG 1000
|
Resolution 1.48 Å R-free 0.239 |
| 4D6P RADA C-TERMINAL ATPASE DOMAIN FROM PYROCOCCUS FURIOSUS BOUND TO AMPPNP Deposited 2014-11-13 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
108–349（242 aa）
Fragment：C-TERMINAL ATPASE DOMAIN, UNP RESIDUES 108-349
|
Mutation：YES | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 GOL GLYCEROL × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.8；60 MM NA2HPO4 PH 6.0, 15% PEG 1000
|
Resolution 1.48 Å R-free 0.239 |
| 4UQO RADA C-TERMINAL ATPASE DOMAIN FROM PYROCOCCUS FURIOSUS BOUND TO ADP Deposited 2014-06-24 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：C-TERMINAL ATPASE DOMAIN, RESIDUES 108-349
|
Mutation：YES | ADP ADENOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.8；60 MM NAPHOSPHATE PH 5.8, 15% PEG1000
|
Resolution 1.88 Å R-free 0.231 |
| 4UQO RADA C-TERMINAL ATPASE DOMAIN FROM PYROCOCCUS FURIOSUS BOUND TO ADP Deposited 2014-06-24 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
108–349（242 aa）
Fragment：C-TERMINAL ATPASE DOMAIN, RESIDUES 108-349
|
Mutation：YES | ADP ADENOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.8；60 MM NAPHOSPHATE PH 5.8, 15% PEG1000
|
Resolution 1.88 Å R-free 0.231 |
| 5FOS HUMANISED MONOMERIC RADA IN COMPLEX WITH OLIGOMERISATION PEPTIDE Deposited 2015-11-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：ATPASE, UNP RESIDUES 108-349
Chain C
93–108（16 aa）
Fragment：OLIGOMERISATION PEPTIDE, UNP RESIDUES 93-108
|
Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) | PO4 PHOSPHATE ION × 1 GOL GLYCEROL × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；8% PEG-1000, 100 MM NAK PHOSPHATE, PH 6.2
|
Resolution 1.35 Å R-free 0.181 |
| 5FOT HUMANISED MONOMERIC RADA IN COMPLEX WITH FHTU TETRAPEPTIDE Deposited 2015-11-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：ATPASE, UNP RESIDUES 108-349
|
Mutation：YES | PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；8% PEG-1000, 100 MM NAK PHOSPHATE, PH 6.2
|
Resolution 1.19 Å R-free 0.157 |
| 5FOU HUMANISED MONOMERIC RADA IN COMPLEX WITH FHPA TETRAPEPTIDE Deposited 2015-11-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：ATPASE, UNP RESIDUES 108-349
|
Mutation：YES | PO4 PHOSPHATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；8% PEG-1000, 100 MM NAK PHOSPHATE, PH 6.2
|
Resolution 1.50 Å R-free 0.192 |
| 5FOV HUMANISED MONOMERIC RADA IN COMPLEX WITH FHTG TETRAPEPTIDE Deposited 2015-11-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：ATPASE, UNP RESIDUES 108-349
|
Mutation：YES | PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；8% PEG-1000, 100 MM NAK PHOSPHATE, PH 6.2
|
Resolution 1.74 Å R-free 0.216 |
| 5FOV HUMANISED MONOMERIC RADA IN COMPLEX WITH FHTG TETRAPEPTIDE Deposited 2015-11-26 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
108–349（242 aa）
Fragment：ATPASE, UNP RESIDUES 108-349
|
Mutation：YES | PO4 PHOSPHATE ION × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；8% PEG-1000, 100 MM NAK PHOSPHATE, PH 6.2
|
Resolution 1.74 Å R-free 0.216 |
| 5FOW HUMANISED MONOMERIC RADA IN COMPLEX WITH WHTA TETRAPEPTIDE Deposited 2015-11-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：ATPASE, UNP RESIDUES 108-349
|
Mutation：YES | PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；8% PEG-1000, 100 MM NAK PHOSPHATE, PH 6.2
|
Resolution 1.80 Å R-free 0.218 |
| 5FOW HUMANISED MONOMERIC RADA IN COMPLEX WITH WHTA TETRAPEPTIDE Deposited 2015-11-26 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
108–349（242 aa）
Fragment：ATPASE, UNP RESIDUES 108-349
|
Mutation：YES | PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；8% PEG-1000, 100 MM NAK PHOSPHATE, PH 6.2
|
Resolution 1.80 Å R-free 0.218 |
| 5FOX HUMANISED MONOMERIC RADA IN COMPLEX WITH FHAA TETRAPEPTIDE Deposited 2015-11-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：ATPASE, UNP RESIDUES 108-349
|
Mutation：YES | PO4 PHOSPHATE ION × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6；8% PEG-1000, 100 MM NAK PHOSPHATE, PH 6.2
|
Resolution 1.30 Å R-free 0.182 |
| 5FPK MONOMERIC RADA IN COMPLEX WITH FATA TETRAPEPTIDE Deposited 2015-12-01 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：ATPASE, UNP RESIDUES 108-349
|
Mutation：YES | PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；8% PEG-1000, 100 MM NAK PHOSPHATE, PH 6.2
|
Resolution 1.34 Å R-free 0.164 |
| 5J4H Structure of humanised RadA-mutant humRadA22F in complex with indole-6-carboxylic acid Deposited 2016-04-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
|
Mutation：V168A, I169M, W170Y, I182L, K198D, H199N, I200V, Y201A, V202Y, K221M | 1F1 1H-indole-6-carboxylic acid × 1 NA SODIUM ION × 2 CA CALCIUM ION × 1 DMS DIMETHYL SULFOXIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；0.08M NaCacodylate pH=6.5, 0.16M CaAcetate, 18% PEG 8000, 20% glycerol
soaking: 10% DMSO, 5mM compound
|
Resolution 1.37 Å R-free 0.170 |
| 5J4K Structure of humanised RadA-mutant humRadA22F in complex with 1-Indane-6-carboxylic acid Deposited 2016-04-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
|
Mutation：V168A, I169M, W170Y, I182L, K198D, H199N, I200V, Y201A, V202Y, K221M | NA SODIUM ION × 2 CA CALCIUM ION × 1 6FZ 2,3-dihydro-1H-indene-2-carboxylic acid × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；0.08M NaCacodylate pH=6.5, 0.16M CaAcetate, 18% PEG8000, 20%glycerol
soaking: 10% DMSO, 5mM compound
|
Resolution 1.35 Å R-free 0.164 |
| 5J4L Apo-structure of humanised RadA-mutant humRadA22F Deposited 2016-04-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
|
Mutation：V168A, I169M, W170Y, I182L, K198D, H199N, I200V, Y201A, V202Y, K221M | CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；0.08M NaCacodylate, pH=6.5, 0.16M CaAcetate, 18% PEG8000, 20% glycerol
|
Resolution 1.13 Å R-free 0.145 |
| 5JEC Apo-structure of humanised RadA-mutant humRadA33F Deposited 2016-04-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
|
Mutation：;S167K, V168A, I169M, W170Y, N175G, I182L, R183L, D192S, P193G D194S, E195D, K198D, H199N, I200V, Y201A, V202Y, E219S, K221M, I222M, K223V, V232Y ; | CL CHLORIDE ION × 2 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；22% PEG3350, 0.1M BisTris pH=5.0, 0.2M Li2SO4
|
Resolution 2.34 Å R-free 0.239 |
| 5JEC Apo-structure of humanised RadA-mutant humRadA33F Deposited 2016-04-18 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
108–349（242 aa）
|
Mutation：;S167K, V168A, I169M, W170Y, N175G, I182L, R183L, D192S, P193G D194S, E195D, K198D, H199N, I200V, Y201A, V202Y, E219S, K221M, I222M, K223V, V232Y ; | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；22% PEG3350, 0.1M BisTris pH=5.0, 0.2M Li2SO4
|
Resolution 2.34 Å R-free 0.239 |
| 5JED Apo-structure of humanised RadA-mutant humRadA28 Deposited 2016-04-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
|
Mutation：;S167K, V168A, I169M, W170Y, I182L, K198D, H199N, I200V, Y201A, V202Y, L213Q, V215L, Q216Y, E219S, K221M, I222M, K223V, L225S, V232Y, K263R, H264F, A266R, D267M, L274E, Y275F ; | SO4 SULFATE ION × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；0.1M NaCacodylate pH=6.5, 5% PEG8000, 40% MPD
|
Resolution 1.33 Å R-free 0.171 |
| 5JEE Apo-structure of humanised RadA-mutant humRadA26F Deposited 2016-04-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
|
Mutation：S167K, V168A, I169M, W170Y, I182L, R183L, K198D, H199N, I200V, Y201A, V202Y, E219S, K221M, I222M | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；292 K；0.1M NaAcetate pH=4.6, 15% PEG20K
|
Resolution 1.49 Å R-free 0.218 |
| 5JFG Structure of humanised RadA-mutant humRadA22F in complex with peptide FHTA Deposited 2016-04-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：UNP residues 108-349
|
Mutation：YES | DMS DIMETHYL SULFOXIDE × 3 CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；0.08M NaCacodylate pH=6.5, 0.16M CaAcetate, 18% PEG8000, 20% glycerol
soaking: 5mM FHTA, 10% DMSO
|
Resolution 1.77 Å R-free 0.192 |
| 5KDD Apo-structure of humanised RadA-mutant humRadA22 Deposited 2016-06-08 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
|
Mutation：;V168A, I169M, W170Y, I182L, K198D, H199N, I200V, Y201A, V202Y, L213Q, V215L, Q216Y, E219S, D220A, K221M, I222M, K223V, L225S, V232Y, K263R, H264F, A266R, D267M, L274E, Y275F ; | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；297 K；20% PEG3350, 0.2M MgSO4
|
Resolution 1.99 Å R-free 0.250 |
| 5KDD Apo-structure of humanised RadA-mutant humRadA22 Deposited 2016-06-08 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
108–349（242 aa）
|
Mutation：;V168A, I169M, W170Y, I182L, K198D, H199N, I200V, Y201A, V202Y, L213Q, V215L, Q216Y, E219S, D220A, K221M, I222M, K223V, L225S, V232Y, K263R, H264F, A266R, D267M, L274E, Y275F ; | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；297 K；20% PEG3350, 0.2M MgSO4
|
Resolution 1.99 Å R-free 0.250 |
| 5L8V Apo-structure of humanised RadA-mutant humRadA4 Deposited 2016-06-08 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
|
Not recorded | PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；12% PEG20K, 0.1 M MES pH 6.5
|
Resolution 1.50 Å R-free 0.193 |
| 5LB2 Apo-structure of humanised RadA-mutant humRadA2 Deposited 2016-06-15 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；25% PEG6000, 100 mM MES pH 7.0
|
Resolution 2.10 Å R-free 0.252 |
| 5LB4 Apo-structure of humanised RadA-mutant humRadA14 Deposited 2016-06-15 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
|
Mutation：;V168A, I169M, W170Y, Y201A, V202Y, L213Q, V215L, Q216Y, E219S, D220A, K221M, I222M, K223V, L225S, V232Y, H264F, D267M, L274E, Y275F ; | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；292 K；25% PEG4000, 0.1 M Tris pH 8.5
|
Resolution 1.98 Å R-free 0.260 |
| 5LBI Apo-structure of humanised RadA-mutant humRadA3 Deposited 2016-06-16 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；4-8% PEG1000, 100 mM Na/KPO4, pH 5.6
|
Resolution 1.43 Å R-free 0.193 |
| 6TUU Leishmania infantum Rad51 surrogate LiRadA10 in complex with 5,6,7,8-tetrahydro-2-naphthoic acid Deposited 2020-01-08 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
|
Not recorded | PO4 PHOSPHATE ION × 1 NY5 5,6,7,8-tetrahydronaphthalene-2-carboxylic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；292 K；20 %w/v PEG 1K (Precipitant), 0.1 M Na K Phos 6.2 pH (Buffer), 0.2 M NaCl (Salt)
|
Resolution 1.74 Å R-free 0.230 |
| 6TUU Leishmania infantum Rad51 surrogate LiRadA10 in complex with 5,6,7,8-tetrahydro-2-naphthoic acid Deposited 2020-01-08 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
108–349（242 aa）
|
Not recorded | PO4 PHOSPHATE ION × 1 NY5 5,6,7,8-tetrahydronaphthalene-2-carboxylic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；292 K；20 %w/v PEG 1K (Precipitant), 0.1 M Na K Phos 6.2 pH (Buffer), 0.2 M NaCl (Salt)
|
Resolution 1.74 Å R-free 0.230 |
| 6TUU Leishmania infantum Rad51 surrogate LiRadA10 in complex with 5,6,7,8-tetrahydro-2-naphthoic acid Deposited 2020-01-08 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
108–349（242 aa）
|
Not recorded | NY5 5,6,7,8-tetrahydronaphthalene-2-carboxylic acid × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；292 K；20 %w/v PEG 1K (Precipitant), 0.1 M Na K Phos 6.2 pH (Buffer), 0.2 M NaCl (Salt)
|
Resolution 1.74 Å R-free 0.230 |
| 6TUU Leishmania infantum Rad51 surrogate LiRadA10 in complex with 5,6,7,8-tetrahydro-2-naphthoic acid Deposited 2020-01-08 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
108–349（242 aa）
|
Not recorded | NY5 5,6,7,8-tetrahydronaphthalene-2-carboxylic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；292 K；20 %w/v PEG 1K (Precipitant), 0.1 M Na K Phos 6.2 pH (Buffer), 0.2 M NaCl (Salt)
|
Resolution 1.74 Å R-free 0.230 |
| 6TV3 HumRadA1 in complex with 3-amino-2-naphthoic acid Deposited 2020-01-08 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
|
Not recorded | NYE 3-azanylnaphthalene-2-carboxylic acid × 1 PO4 PHOSPHATE ION × 1 GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；293 K；8% PEG-1000, 100 MM NA/K PHOSPHATE
|
Resolution 1.50 Å R-free 0.217 |
| 6TW3 HumRadA2 in complex with Naphthyl-HPA fragment-peptide chimera Deposited 2020-01-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 O0E (2~{S})-1-[(2~{S})-2-[(3-azanylnaphthalen-2-yl)carbonylamino]-3-(1~{H}-imidazol-4-yl)propanoyl]-~{N}-[(2~{S})-1-azanyl-1-oxidanylidene-propan-2-yl]pyrrolidine-2-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；100 mM Na/K phosphate, 6 % PEG1000
|
Resolution 1.35 Å R-free 0.210 |
| 6TW4 HumRadA22F in complex with compound 6 Deposited 2020-01-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：humRadA22F
|
Mutation：;S167K, V168A, I169M, W170Y, N175G, I182L, R183L, D192S, P193G D194S, E195D, K198D, H199N, I200V, Y201A, V202Y, L213Q, V215L, Q216Y, E219S, D220A, K221M, I222M, K223V, L225S, V232Y, K263R, H264F, A266R, D267M, L274E, Y275F ; | NZW ~{N}-[2-[(2~{S})-2-[[(1~{S})-1-(4-methoxyphenyl)ethyl]carbamoyl]pyrrolidin-1-yl]-2-oxidanylidene-ethyl]quinoline-2-carboxamide × 1 CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；20% PEG8000, 0.08 M Na Cacodylate pH 6.5, 0.16M Ca acetate, 18% glycerol
|
Resolution 1.73 Å R-free 0.210 |
| 6TW9 HumRadA22F in complex with CAM833 Deposited 2020-01-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：humRadA22F
|
Mutation：;S167K, V168A, I169M, W170Y, N175G, I182L, R183L, D192S, P193G D194S, E195D, K198D, H199N, I200V, Y201A, V202Y, L213Q, V215L, Q216Y, E219S, D220A, K221M, I222M, K223V, L225S, V232Y, K263R, H264F, A266R, D267M, L274E, Y275F ; | O08 ~{N}-[2-[(2~{S},4~{R})-2-[[(1~{S})-1-(2-chloranyl-4-methoxy-phenyl)ethyl]carbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-2-oxidanylidene-ethyl]-6-fluoranyl-quinoline-2-carboxamide × 1 CA CALCIUM ION × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；20% PEG8000, 0.08 M Na Cacodylate pH 6.5, 0.16M Ca acetate, 18% glycerol
|
Resolution 1.52 Å R-free 0.172 |
| 6XTW HumRadA33F in complex with peptidic inhibitor 6 Deposited 2020-01-16 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
Fragment：humRadA22F
|
Mutation：;S167K, V168A, I169M, W170Y, N175G, I182L, R183L, D192S, P193G D194S, E195D, K198D, H199N, I200V, Y201A, V202Y, L213Q, V215L, Q216Y, E219S, D220A, K221M, I222M, K223V, L225S, V232Y, K263R, H264F, A266R, D267M, L274E, Y275F ; | NZW ~{N}-[2-[(2~{S})-2-[[(1~{S})-1-(4-methoxyphenyl)ethyl]carbamoyl]pyrrolidin-1-yl]-2-oxidanylidene-ethyl]quinoline-2-carboxamide × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；22% PEG3350, 0.1 M BisTris pH5.0, 0.2 M LiSO4
|
Resolution 2.31 Å R-free 0.229 |
| 6XTW HumRadA33F in complex with peptidic inhibitor 6 Deposited 2020-01-16 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
108–349（242 aa）
Fragment：humRadA22F
|
Mutation：;S167K, V168A, I169M, W170Y, N175G, I182L, R183L, D192S, P193G D194S, E195D, K198D, H199N, I200V, Y201A, V202Y, L213Q, V215L, Q216Y, E219S, D220A, K221M, I222M, K223V, L225S, V232Y, K263R, H264F, A266R, D267M, L274E, Y275F ; | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；22% PEG3350, 0.1 M BisTris pH5.0, 0.2 M LiSO4
|
Resolution 2.31 Å R-free 0.229 |
| 6XUF HumRadA1 in complex with 5-Ethyl-N-(1H-indol-5-ylmethyl)-1,3,4-thiadiazol-2-amine in P21 Deposited 2020-01-19 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
|
Not recorded | PO4 PHOSPHATE ION × 1 O1E 5-Ethyl-N-(1H-indol-5-ylmethyl)-1,3,4-thiadiazol-2-amine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；293 K；50 mM Na/K PHOSPHATE, 5% PEG1000
|
Resolution 1.24 Å R-free 0.186 |
| 6XUJ HumRadA1 in complex with 5-Ethyl-N-(1H-indol-5-ylmethyl)-1,3,4-thiadiazol-2-amine in P21212 Deposited 2020-01-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
108–349（242 aa）
|
Not recorded | PO4 PHOSPHATE ION × 1 O1E 5-Ethyl-N-(1H-indol-5-ylmethyl)-1,3,4-thiadiazol-2-amine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；293 K；50 mM Na/K Phosphate, 5% PEG1000
|
Resolution 1.54 Å R-free 0.205 |
| 8BR9 Stapled peptide SP24 in complex with humanised RadA mutant HumRadA22 Deposited 2022-11-22 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
107–349（243 aa）
|
Not recorded | ADP ADENOSINE-5'-DIPHOSPHATE × 1 RF6 4,6-diethylpyrimidin-2-amine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291.15 K；0.1 M Na 3 Cit 4.2 pH (Buffer)
20 %w/v PEG 1K
(Precipitant)
0.2 M Li 2 SO4 (Salt)
|
Resolution 1.63 Å R-free 0.282 |
| 8C3J Stapled peptide SP2 in complex with humanised RadA mutant HumRadA22 Deposited 2022-12-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
107–349（243 aa）
|
Not recorded | TKI 2-[(4,6-diethyl-1,3,5-triazin-2-yl)-methyl-amino]ethanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Protein in 20 mM CHES pH 9.5, 100
mM NaCl.
Condition: 8 % w/v PEG 8000
(precipitant) 0.08 M
Potassium phosphate pH
5.6 (buffer)
200:200 uL drop
|
Resolution 3.02 Å R-free 0.281 |
| 8C3J Stapled peptide SP2 in complex with humanised RadA mutant HumRadA22 Deposited 2022-12-26 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
107–349（243 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Protein in 20 mM CHES pH 9.5, 100
mM NaCl.
Condition: 8 % w/v PEG 8000
(precipitant) 0.08 M
Potassium phosphate pH
5.6 (buffer)
200:200 uL drop
|
Resolution 3.02 Å R-free 0.281 |
| 8C3N Stapled peptide SP30 in complex with humanised RadA mutant HumRadA22 Deposited 2022-12-27 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
107–349（243 aa）
|
Not recorded | ADP ADENOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 RF6 4,6-diethylpyrimidin-2-amine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Protein: 0.5 mM SP30:HumRadA22 in 20 mM CHES pH 9.5, 100 mM NaCl, 20 mM ADP/MgCl 2
Condition:
14% w/v PEG 4000
(precipitant), 6% v/v MPD
(precipitant), 0.1M Na K
Phos pH 6.2 (buffer)
|
Resolution 1.21 Å R-free 0.218 |