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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P01344 New Search
16PDB entries
18Biological assembly
29chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1IGL SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR II RELATIONSHIP TO RECEPTOR AND BINDING PROTEIN INTERACTIONS Deposited 1994-12-29 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 25–91（67 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR mmCIF provides none of the parsed conditions Resolution not provided
2L29 Complex structure of E4 mutant human IGF2R domain 11 bound to IGF-II Deposited 2010-08-13 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 25–91（67 aa） Fragment：residues 25-91
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 4.2；310 K；Ionic strength (raw mmCIF value) 0；Pressure ambient
NMR sample composition 0.5-1 mM [U-98% 13C; U-98% 15N] IGF2R, 1.-1.5 mM IGF2, 5 % D2O, 100 uM sodium azide, 5 mM sodium acetate, 0.1 mM EDTA, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.5-1 mM [U-98% 13C; U-98% 15N] IGF2, 1.-1.5 mM IGF2R, 5 % D2O, 100 uM sodium azide, 5 mM sodium acetate, 0.1 mM EDTA, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.5-1 mM [U-98% 15N; U-95% 2H] IGF2, 1.-1.5 mM IGF2R, 5 % D2O, 100 uM sodium azide, 5 mM sodium acetate, 0.1 mM EDTA, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
2V5P COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II Deposited 2007-07-06 Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 25–91（67 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；0.1 M TRIS-HCL PH 9.0, 15% (V/V) MPD
Resolution 4.10 Å R-free 0.327
2V5P COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II Deposited 2007-07-06 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 25–91（67 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；0.1 M TRIS-HCL PH 9.0, 15% (V/V) MPD
Resolution 4.10 Å R-free 0.327
3E4Z Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II Deposited 2008-08-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 25–91（67 aa） Fragment：UNP residues 25-91
Not recorded ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；10-13% PEG MME 5000, 100 mM HEPES pH 7.0, 4-14% Tacsimate, 10% dioxane, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.28 Å R-free 0.230
3E4Z Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II Deposited 2008-08-12 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 25–91（67 aa） Fragment：UNP residues 25-91
Not recorded ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；10-13% PEG MME 5000, 100 mM HEPES pH 7.0, 4-14% Tacsimate, 10% dioxane, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.28 Å R-free 0.230
3KR3 Crystal structure of IGF-II antibody complex Deposited 2009-11-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain D 25–91（67 aa）
Not recorded EDO 1,2-ETHANEDIOL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 5.3；293 K；18.5% PEG 6000, 118mM CaCl2, 10% (v/v) PCB buffer (propionate-cacodylate-bis-tris propane buffer), pH 5.3, vapor diffusion, temperature 293K
Resolution 2.20 Å R-free 0.251
5L3L D11 bound IGF-II Deposited 2016-05-23 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 25–91（67 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 4.2；308 K；Ionic strength (raw mmCIF value) 0；Pressure 1
NMR sample composition 20 uM d4 acetic acid, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
5L3M D11 bound [S39_PQ]-IGF-II Deposited 2016-05-23 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 25–91（67 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 4.2；308 K；Ionic strength (raw mmCIF value) 0；Pressure 1
NMR sample composition 20 mM d4 acetic acid, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
5L3N D11 bound [N29, S39_PQ]-IGF-II Deposited 2016-05-23 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 25–91（67 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 4.2；308 K；Ionic strength (raw mmCIF value) 0；Pressure 1
NMR sample composition 20 mM d4 acetic acid, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
6UM2 Structure of M-6-P/IGFII Receptor and IGFII complex Deposited 2019-10-08 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 25–91（67 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.32 Å
6VWG Head region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II. Deposited 2020-02-19 Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain I 25–91（67 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.21 Å
6VWI Head region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II. Deposited 2020-02-19 Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain I 25–91（67 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
8U4C Cryo-EM structure of long form insulin receptor (IR-B) with four IGF2 bound, symmetric conformation. Deposited 2023-09-10 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain C 1–180（180 aa）
Chain D 1–180（180 aa）
Chain E 1–180（180 aa）
Chain F 1–180（180 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
8U4E Cryo-EM structure of long form insulin receptor (IR-B) with three IGF2 bound, asymmetric conformation. Deposited 2023-09-10 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain C 1–180（180 aa）
Chain D 1–180（180 aa）
Chain E 1–180（180 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.20 Å
8VJB Cryo-EM structure of short form insulin receptor (IR-A) with four IGF2 bound, symmetric conformation. Deposited 2024-01-06 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain C 1–180（180 aa）
Chain D 1–180（180 aa）
Chain E 1–180（180 aa）
Chain F 1–180（180 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
8VJC Cryo-EM structure of short form insulin receptor (IR-A) with three IGF2 bound, asymmetric conformation. Deposited 2024-01-06 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain C 1–180（180 aa）
Chain D 1–180（180 aa）
Chain E 1–180（180 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
8YSZ Cryo-EM structure of the complex IR with three IGF-II Deposited 2024-03-24 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 1–180（180 aa）
Chain D 1–180（180 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.38 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.