Current Protein Identity：P03950
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1A4Y RIBONUCLEASE INHIBITOR-ANGIOGENIN COMPLEX Deposited 1998-02-08 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain B
25–147（123 aa）
Chain E
25–147（123 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 4.2；THE COMPLEX WAS CRYSTALLIZED FROM 10% PEG4000, 20MM SODIUM CITRATE (PH 4.2), 0.1 AMMONIUM SULPHATE AND 25 MM DTT.
|
Resolution 2.00 Å R-free 0.286 |
| 1ANG CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN REVEALS THE STRUCTURAL BASIS FOR ITS FUNCTIONAL DIVERGENCE FROM RIBONUCLEASE Deposited 1994-01-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
25–147（123 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.40 Å |
| 1AWZ 3D SOLUTION STRUCTURE OF HUMAN ANGIOGENIN DETERMINED BY 1H, 15N NMR SPECTROSCOPY, 30 STRUCTURES Deposited 1997-10-07 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 5；313 K；Ionic strength (raw mmCIF value) 150 mM；Pressure 1
|
Resolution not provided |
| 1B1E CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN VARIANT K40Q Deposited 1998-11-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–123（123 aa）
|
Mutation：K40Q | CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.2；289 K；pH 5.2, temperature 289K
|
Resolution 2.00 Å R-free 0.287 |
| 1B1I CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN Deposited 1998-11-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–123（123 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.6；pH 5.6
|
Resolution 1.80 Å R-free 0.273 |
| 1B1J CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN VARIANT H13A. Deposited 1998-11-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–123（123 aa）
|
Mutation：H13A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.5；pH 7.5
|
Resolution 2.00 Å R-free 0.319 |
| 1GV7 ARH-I, an angiogenin/RNase A chimera Deposited 2002-02-06 | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–81（57 aa）
Chain A
95–147（53 aa）
|
Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) | CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 5.8；289 K；VAPOUR DIFFUSION, 16 C 10 MG/ML PROTEIN, 15 % PEG 4000, 8 % TERT-BUTANOL, 0.3 M AMMONIUM ACETATE, 0.1 M SODIUM CITRATE BUFFER, PH 5.8
|
Resolution 2.10 Å R-free 0.274 |
| 1H0D Crystal structure of Human Angiogenin in complex with Fab fragment of its monoclonal antibody mAb 26-2F Deposited 2002-06-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain C
25–147（123 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | SO4 SULFATE ION × 8 GOL GLYCEROL × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6；30% PEG 3350 AND 0.2M LITHIUM SULPHATE PH 6.0-7.5
|
Resolution 2.00 Å R-free 0.272 |
| 1H52 Binding of Phosphate and Pyrophosphate ions at the active site of human Angiogenin as revealed by X-ray Crystallography Deposited 2001-05-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | POP PYROPHOSPHATE 2- × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.2；20MM SODIUM CITRATE, 0.2M SODIUM POTASSIUM TARTARATE, 10% PEG 6000 PH 5.2
|
Resolution 2.00 Å R-free 0.287 |
| 1H53 Binding of Phosphate and Pyrophosphate ions at the active site of human Angiogenin as revealed by X-ray Crystallography Deposited 2001-05-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
26–147（122 aa）
|
Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) | CIT CITRIC ACID × 1 PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.2；20MM SODIUM CITRATE, 0.2M SODIUM POTASSIUM TARTARATE, 10% PEG 6000 PH 5.2
|
Resolution 2.00 Å R-free 0.260 |
| 1HBY Binding of Phosphate and Pyrophosphate ions at the active site of human angiogenin as revealed by X-ray Crystallography Deposited 2001-04-21 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6；25% PEG 6000, 0.1M MES, PH 6.0, 0.1M NACL
|
Resolution 2.00 Å R-free 0.230 |
| 1K58 Crystal Structure of Human Angiogenin Variant D116H Deposited 2001-10-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：D116H Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；289 K；sodium citrate, 2-propanol, PEG 4000, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 2.70 Å R-free 0.360 |
| 1K59 Crystal Structure of Human Angiogenin Variant Q117G Deposited 2001-10-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：Q117G Non-standard monomer：Yes (specific site not provided by mmCIF) | CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.2；289 K；sodium citrate, PEG 6000, pH 5.2, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 1.80 Å R-free 0.241 |
| 1K5A Crystal structure of human angiogenin double variant I119A/F120A Deposited 2001-10-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：I119A,F120A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；289 K；ammonium actate, sodium citrate, PEG 4000, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 2.33 Å R-free 0.281 |
| 1K5B Crystal Structure of Human Angiogenin Variant des(121-123) Deposited 2001-10-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：DEL(121-123) Non-standard monomer：Yes (specific site not provided by mmCIF) | CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.2；289 K；sodium citrate, sodium potassium tartrate, PEG 6000, pH 5.2, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 1.80 Å R-free 0.275 |
| 1UN3 CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN VARIANT T44D Deposited 2003-09-04 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.2；15% PEG 4000, 0.02% DIOXANE, 0.2M SODIUM POTASSIUM TARTRATE, 0.02M SODIUM CITRATE BUFFER, PH 5.2
|
Resolution 1.70 Å R-free 0.223 |
| 1UN4 CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN VARIANT T80A Deposited 2003-09-04 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) | CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.2；15% PEG 4000, 0.02% DIOXANE, 0.2M SODIUM POTASSIUM TARTRATE, 0.02M SODIUM CITRATE BUFFER, PH 5.2
|
Resolution 2.10 Å R-free 0.232 |
| 1UN5 ARH-II, AN ANGIOGENIN/RNASE A CHIMERA Deposited 2003-09-04 | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–61（37 aa）
Chain A
66–147（82 aa）
|
Mutation：YES Mutation：YES | CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.4；10% PEG 6000, PH 5.4 0.2M SODIUM POTASSIUM TARTRATE, 0.02M SODIUM CITRATE BUFFER
|
Resolution 2.60 Å R-free 0.237 |
| 2ANG CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN OF THE MET(-1) FORM Deposited 1998-11-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Not recorded | CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.2；pH 5.2
|
Resolution 2.00 Å R-free 0.286 |
| 4AHD Q12L - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis Deposited 2012-02-06 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：YES | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
20 % PEG 4K, 0.05 M NA/K TARTRATE, 0.1 M NACL, 0.1 M HEPES PH 7.0
|
Resolution 2.47 Å R-free 0.249 |
| 4AHD Q12L - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis Deposited 2012-02-06 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
25–147（123 aa）
|
Mutation：YES | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
20 % PEG 4K, 0.05 M NA/K TARTRATE, 0.1 M NACL, 0.1 M HEPES PH 7.0
|
Resolution 2.47 Å R-free 0.249 |
| 4AHE K17I - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis Deposited 2012-02-06 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：YES | TLA L(+)-TARTARIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
20 % PEG 4K, 0.4 M NA/K TARTRATE, 0.1 M NA CITRATE PH 5.5
|
Resolution 2.08 Å R-free 0.300 |
| 4AHF K17E - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis Deposited 2012-02-06 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：YES | SO4 SULFATE ION × 3 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
20 % PEG 4K, 0.05 M NA/K TARTRATE, 0.1 M NACL, 0.1 M HEPES PH 7.0
|
Resolution 2.12 Å R-free 0.285 |
| 4AHG S28N - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis Deposited 2012-02-06 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：YES | TAR D(-)-TARTARIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
20 % PEG 4K, 0.4 M NA/K TARTRATE, 0.1 M NA CITRATE PH 5.5
|
Resolution 2.45 Å R-free 0.275 |
| 4AHH R31K - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis Deposited 2012-02-06 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：YES | TLA L(+)-TARTARIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
20 % PEG 4K, 0.05 M NA/K TARTRATE, 0.1 M NACL, 0.1 M HEPES PH 7.0
|
Resolution 2.50 Å R-free 0.242 |
| 4AHI K40I - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis Deposited 2012-02-06 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：YES | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
20 % PEG 4K, 0.05 M NA/K TARTRATE, 0.1 M NACL, 0.1 M HEPES PH 7.0
|
Resolution 2.80 Å R-free 0.278 |
| 4AHJ I46V - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis Deposited 2012-02-06 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：YES | TAR D(-)-TARTARIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
20 % PEG 4K, 0.05 M NA/K TARTRATE, 0.1 M NACL, 0.1 M HEPES PH 7.0
|
Resolution 2.03 Å R-free 0.280 |
| 4AHK K54E - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis Deposited 2012-02-06 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：YES | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
20 % PEG 4K, 0.4 M NA/K TARTRATE, 0.1 M NA CITRATE PH 5.5
|
Resolution 1.97 Å R-free 0.279 |
| 4AHK K54E - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis Deposited 2012-02-06 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
25–147（123 aa）
|
Mutation：YES | TAR D(-)-TARTARIC ACID × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
20 % PEG 4K, 0.4 M NA/K TARTRATE, 0.1 M NA CITRATE PH 5.5
|
Resolution 1.97 Å R-free 0.279 |
| 4AHL P112L - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis Deposited 2012-02-06 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：YES | TLA L(+)-TARTARIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
20 % PEG 4K, 0.4 M NA/K TARTRATE, 0.1 M NA CITRATE PH 5.5
|
Resolution 2.05 Å R-free 0.303 |
| 4AHM V113I - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis Deposited 2012-02-06 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：YES | TLA L(+)-TARTARIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
20 % PEG 4K, 0.4 M NA/K TARTRATE, 0.1 M NA CITRATE PH 5.5
|
Resolution 1.96 Å R-free 0.221 |
| 4AHN R121H - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis Deposited 2012-02-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：YES | CL CHLORIDE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
20 % PEG 4K, 0.05 M NA/K TARTRATE, 0.1 M NACL, 0.1 M HEPES PH 7.0
|
Resolution 2.98 Å R-free 0.283 |
| 4AOH Structural snapshots and functional analysis of human angiogenin variants associated with Amyotrophic Lateral Sclerosis (ALS) Deposited 2012-03-27 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
24–147（124 aa）
Fragment：RESIDUES 24-147
|
Not recorded | TAR D(-)-TARTARIC ACID × 1 TLA L(+)-TARTARIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7；20 % PEG 4K, 0.05 M NA/K TARTRATE, 0.1 M NACL, 0.1 M HEPES PH 7.0
|
Resolution 1.04 Å R-free 0.188 |
| 4B36 Crystal Structure of Human Angiogenin with an Engineered Loop Exhibits Conformational Flexibility at the Functional Regions of the Molecule Deposited 2012-07-20 | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–107（83 aa）
Fragment：RESIDUES 25-107,111-120,116-147
Chain A
116–147（32 aa）
Fragment：RESIDUES 25-107,111-120,116-147
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
1.75-2.5 M NACL
|
Resolution 1.76 Å R-free 0.285 |
| 4B36 Crystal Structure of Human Angiogenin with an Engineered Loop Exhibits Conformational Flexibility at the Functional Regions of the Molecule Deposited 2012-07-20 | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
25–107（83 aa）
Fragment：RESIDUES 25-107,111-120,116-147
Chain B
116–147（32 aa）
Fragment：RESIDUES 25-107,111-120,116-147
|
Not recorded | CL CHLORIDE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
1.75-2.5 M NACL
|
Resolution 1.76 Å R-free 0.285 |
| 5EOP Crystal structure of human Angiogenin at 1.35 Angstroms resolution Deposited 2015-11-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
26–146（121 aa）
Fragment：UNP residues 26-166
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7；289 K；Malic acid/NaOH pH 7.0
PEG 3350
|
Resolution 1.35 Å R-free 0.192 |
| 5EPZ Human Angiogenin in complex with sulphate anions at a basic solution Deposited 2015-11-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
26–145（120 aa）
Fragment：UNP residues 26-145
|
Not recorded | SO4 SULFATE ION × 4 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8；289 K；0.1 M Tris/HCl buffer pH 8.0, 2.4 M ammonium sulphate
|
Resolution 1.85 Å R-free 0.217 |
| 5EQO Human Angiogenin in complex with sulphate anions at an acidic solution Deposited 2015-11-13 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–145（121 aa）
|
Not recorded | SO4 SULFATE ION × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6；289 K；0.1 M sodium cacodylate pH 6.0
2.0 M ammonium sulphate
|
Resolution 2.40 Å R-free 0.250 |
| 5M9A Human angiogenin PD variant H13R Deposited 2016-11-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：H13R | TAR D(-)-TARTARIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；289 K；0.2 M Na/K tartrate
20% PEG 3350
|
Resolution 1.95 Å R-free 0.297 |
| 5M9C Human angiogenin ALS variant K40R Deposited 2016-11-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：K40R | TAR D(-)-TARTARIC ACID × 1 PEG DI(HYDROXYETHYL)ETHER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；0.4 M Na/K tartrate
0.1 M Na citrate
20 % PEG 4000
|
Resolution 2.05 Å R-free 0.231 |
| 5M9G Human angiogenin PD variant K54R Deposited 2016-11-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Mutation：K54R | TAR D(-)-TARTARIC ACID × 1 PEG DI(HYDROXYETHYL)ETHER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；289 K；0.2 M Na/K tartrate
0.1 M HEPES
3% propanol
20% PEG 8000
|
Resolution 2.28 Å R-free 0.271 |
| 5M9J Human angiogenin PD variant K60E Deposited 2016-11-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Not recorded | TLA L(+)-TARTARIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；289 K；0.2 M Na/K tartrate
0.1 M Na cacodylate
25% PEG 4000
|
Resolution 1.90 Å R-free 0.216 |
| 5M9M Human angiogenin PD variant Q77P Deposited 2016-11-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Not recorded | SO4 SULFATE ION × 2 PGE TRIETHYLENE GLYCOL × 1 EDO 1,2-ETHANEDIOL × 2 BTB 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；289 K；0.2 M ammonium sulphate
0.1 M bis-tris methane
25% PEG 3350
|
Resolution 1.65 Å R-free 0.270 |
| 5M9M Human angiogenin PD variant Q77P Deposited 2016-11-01 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
25–147（123 aa）
|
Not recorded | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；289 K；0.2 M ammonium sulphate
0.1 M bis-tris methane
25% PEG 3350
|
Resolution 1.65 Å R-free 0.270 |
| 5M9M Human angiogenin PD variant Q77P Deposited 2016-11-01 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
25–147（123 aa）
|
Not recorded | SO4 SULFATE ION × 4 EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；289 K；0.2 M ammonium sulphate
0.1 M bis-tris methane
25% PEG 3350
|
Resolution 1.65 Å R-free 0.270 |
| 5M9M Human angiogenin PD variant Q77P Deposited 2016-11-01 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
25–147（123 aa）
|
Not recorded | SO4 SULFATE ION × 4 PGE TRIETHYLENE GLYCOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；289 K；0.2 M ammonium sulphate
0.1 M bis-tris methane
25% PEG 3350
|
Resolution 1.65 Å R-free 0.270 |
| 5M9P Human angiogenin ALS variant T80S Deposited 2016-11-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Not recorded | SO4 SULFATE ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；0.2 M ammonium sulphate
0.1 M bis-tris propane
25% PEG 3350
|
Resolution 1.80 Å R-free 0.285 |
| 5M9Q Human angiogenin PD variant R95Q Deposited 2016-11-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Not recorded | SO4 SULFATE ION × 4 PEG DI(HYDROXYETHYL)ETHER × 3 PGE TRIETHYLENE GLYCOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；289 K；0.2 M ammonium sulphate
0.1 M Na cacodylate
30% PEG 8000
|
Resolution 1.35 Å R-free 0.179 |
| 5M9R Human angiogenin ALS variant F100I Deposited 2016-11-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Not recorded | TAR D(-)-TARTARIC ACID × 1 TLA L(+)-TARTARIC ACID × 1 PEG DI(HYDROXYETHYL)ETHER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；289 K；0.2 M Na/K tartrate
0.1 M Na cacodylate
20% PEG 4000
|
Resolution 1.44 Å R-free 0.195 |
| 5M9R Human angiogenin ALS variant F100I Deposited 2016-11-02 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
25–147（123 aa）
|
Not recorded | TAR D(-)-TARTARIC ACID × 1 TLA L(+)-TARTARIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；289 K；0.2 M Na/K tartrate
0.1 M Na cacodylate
20% PEG 4000
|
Resolution 1.44 Å R-free 0.195 |
| 5M9S Human angiogenin ALS variant V103I Deposited 2016-11-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Not recorded | TAR D(-)-TARTARIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；289 K；0.2 M Na/K tartrate
0.1 M MES
20% PEG 4000
|
Resolution 1.85 Å R-free 0.264 |
| 5M9T Human angiogenin ALS variant H114R Deposited 2016-11-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Not recorded | GOL GLYCEROL × 1 BO4 BORATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；289 K；0.01 M Na borate
1.1 M Na citrate
|
Resolution 2.20 Å R-free 0.236 |
| 5M9T Human angiogenin ALS variant H114R Deposited 2016-11-02 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
25–147（123 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；289 K；0.01 M Na borate
1.1 M Na citrate
|
Resolution 2.20 Å R-free 0.236 |
| 5M9V Human angiogenin PD/ALS variant R121C Deposited 2016-11-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Not recorded | TLA L(+)-TARTARIC ACID × 1 GSH Glutathione × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；289 K；0.2 M Na/K tartrate
0.1 M bis-tris propane
16% PEG 4000
|
Resolution 1.70 Å R-free 0.239 |
| 7NPM X-ray structure of the adduct formed upon reaction of oxaliplatin with human angiogenin Deposited 2021-02-27 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain AAA
26–146（121 aa）
Fragment：UNP residues 26-166
|
Not recorded | PT PLATINUM (II) ION × 3 TAR D(-)-TARTARIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；10 % PEG6K, 20 mM sodium citrate pH 5.1, 0.2 M sodium/potassium tartrate
|
Resolution 1.86 Å R-free 0.254 |
| 7PNJ Human Angiogenin quardruple mutant-S28AT36AS37AS87A Deposited 2021-09-07 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–145（121 aa）
|
Not recorded | CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；289 K；100 mM SODIUM CITRATE PH 5.6, 25% (w/v) PEG 4000
|
Resolution 3.10 Å R-free 0.276 |
| 7PNP Human Angiogenin mutant-S28A Deposited 2021-09-07 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–147（123 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；289 K；Malic acid/NaOH pH 7.0, PEG 3350
|
Resolution 1.80 Å R-free 0.254 |
| 7PNR Human Angiogenin mutant-S28AT36AS37A Deposited 2021-09-07 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
25–145（121 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；289 K；Malic acid/NaOH pH 7.0, PEG 3350
|
Resolution 1.60 Å R-free 0.201 |
| 8AF0 Crystal structure of human angiogenin and RNA duplex Deposited 2022-07-15 | Assembly 1 Protein–RNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain A
25–147（123 aa）
Chain B
25–147（123 aa）
|
Mutation：H114A Mutation：H114A | GOL GLYCEROL × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277.15 K；200 mM NaCl, 20 % (w/v) PEG6000, 100 mM Hepes pH 7.0
|
Resolution 2.43 Å R-free 0.268 |
| 9BDL 80S ribosome with angiogenin Deposited 2024-04-12 | Assembly 1 Protein–RNA Heteromer；Protein × 75 PDB declaration: 82-meric（82） Consistent with all polymers |
Chain ANG
1–147（147 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |
| 9BDN 80S ribosome with angiogenin and tRNAAla Deposited 2024-04-12 | Assembly 1 Protein–RNA Heteromer；Protein × 77 PDB declaration: 85-meric（85） Consistent with all polymers |
Chain ANG
1–147（147 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9BDP 80S ribosome bound with angiogenin and complex of eEF1A and Ala-tRNAAla Deposited 2024-04-12 | Assembly 1 Protein–RNA Heteromer；Protein × 78 PDB declaration: 86-meric（86） Consistent with all polymers |
Chain ANG
1–147（147 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.70 Å |