Current Protein Identity：P04278
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1D2S CRYSTAL STRUCTURE OF THE N-TERMINAL LAMININ G-LIKE DOMAIN OF SHBG IN COMPLEX WITH DIHYDROTESTOSTERONE Deposited 1999-09-28 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
30–211（182 aa）
Fragment：RESIDUES 1 TO 205
|
Not recorded | CA CALCIUM ION × 4 DHT 5-ALPHA-DIHYDROTESTOSTERONE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；PEG400, HEPES, CALCIUM CHLORIDE, DIHYDROTESTOSTERONE, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 20K
|
Resolution 1.55 Å R-free 0.251 |
| 1F5F CRYSTAL STRUCTURE OF THE N-TERMINAL G-DOMAIN OF SHBG IN COMPLEX WITH ZINC Deposited 2000-06-14 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
30–234（205 aa）
Fragment：N-TERMINAL FRAGMENT OF SHBG (RESIDUES 1 TO 205)
|
Not recorded | CA CALCIUM ION × 2 ZN ZINC ION × 4 DHT 5-ALPHA-DIHYDROTESTOSTERONE × 2 IPA ISOPROPYL ALCOHOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293.15 K；Crystal growth: ISOPROPANOL, PEG400, HEPES-buffer, CaCl2, DHT
Crystals were soaked with 2.5 mM ZnCl2 for three days, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293.15K
|
Resolution 1.70 Å R-free 0.259 |
| 1KDK THE STRUCTURE OF THE N-TERMINAL LG DOMAIN OF SHBG IN CRYSTALS SOAKED WITH EDTA Deposited 2001-11-13 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–170（170 aa）
Fragment：N-terminal LG-domain
|
Not recorded | DHT 5-ALPHA-DIHYDROTESTOSTERONE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；PEG400, Isopropanol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.70 Å R-free 0.245 |
| 1KDM THE CRYSTAL STRUCTURE OF THE HUMAN SEX HORMONE-BINDING GLOBULIN (TETRAGONAL CRYSTAL FORM) Deposited 2001-11-13 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–170（170 aa）
Fragment：N-terminal LG-domain
|
Not recorded | CA CALCIUM ION × 2 DHT 5-ALPHA-DIHYDROTESTOSTERONE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；PEG4000, isopropanol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.35 Å R-free 0.264 |
| 1LHN CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 5ALPHA-ANDROSTANE-3BETA,17ALPHA-DIOL Deposited 2002-04-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
30–218（189 aa）
Fragment：LG-like 1 domain, Residues 30-218
|
Not recorded | CA CALCIUM ION × 2 ZN ZINC ION × 2 AON 5-ALPHA-ANDROSTANE-3-BETA,17-ALPHA-DIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；Hepes, Calcium chloride, 17a-DHA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.239 |
| 1LHO CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 5ALPHA-ANDROSTANE-3BETA,17BETA-DIOL Deposited 2002-04-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
30–218（189 aa）
Fragment：LG-like 1 domain, Residues 30-218
|
Not recorded | CA CALCIUM ION × 2 AOM 5-ALPHA-ANDROSTANE-3-BETA,17BETA-DIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；HEPES, Calcium chloride, 17b-DHA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.223 |
| 1LHU CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH ESTRADIOL Deposited 2002-04-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
30–218（189 aa）
Fragment：LG-like 1 domain, Residues 43-218
|
Not recorded | CA CALCIUM ION × 2 EST ESTRADIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；HEPES, Calcium chloride, estradiol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.80 Å R-free 0.237 |
| 1LHV CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH NORGESTREL Deposited 2002-04-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
30–218（189 aa）
Fragment：LG-like 1 domain, Residues 30-218
|
Not recorded | CA CALCIUM ION × 2 ZN ZINC ION × 2 NOG 13-BETA-ETHYL-17-ALPHA-ETHYNYL-17-BETA-HYDROXYGON-4-EN-3-ONE × 2 IPA ISOPROPYL ALCOHOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；HEPES, Calcium chloride, norgestrel, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.264 |
| 1LHW CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 2-METHOXYESTRADIOL Deposited 2002-04-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
30–218（189 aa）
Fragment：LG-like 1 domain, Residues 30-218
|
Not recorded | CA CALCIUM ION × 2 ESM 1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-METHYL ETHER × 2 IPA ISOPROPYL ALCOHOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；HEPES, Calcium chloride, 2-methoxyestradiol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.75 Å R-free 0.238 |
| 6PYA Sex Hormone-binding globulin mutant E176K in complex with IPI Deposited 2019-07-29 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
30–234（205 aa）
|
Mutation：E176K | P57 3-[(1H-imidazol-1-yl)methyl]-2-phenyl-1H-indole × 2 CA CALCIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；20% Peg 3350, 0.2 M potassium thiocyanate, HEPES pH 7.5, 2.5 mM Calcium Chloride
|
Resolution 1.71 Å R-free 0.216 |
| 6PYB Sex Hormone-binding globulin mutant E176K in complex with DVT Deposited 2019-07-29 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
30–234（205 aa）
|
Mutation：E176K | P5G 4,4'-[(3R,4R)-oxolane-3,4-diylbis(methylene)]bis(2-methoxyphenol) × 2 CA CALCIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；PEG 3350, Potassium thiocyanate
|
Resolution 1.80 Å R-free 0.231 |
| 6PYF Sex Hormone-binding globulin mutant E176K in complex with Estradiol Deposited 2019-07-29 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
30–234（205 aa）
|
Mutation：E176K | CA CALCIUM ION × 2 EST ESTRADIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；PEG 3350, potassium thiocyanate
|
Resolution 1.73 Å R-free 0.220 |
| 6ULB Sex Hormone-binding globulin mutant E176K in complex with Danazol Deposited 2019-10-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
30–234（205 aa）
|
Mutation：E176K | CA CALCIUM ION × 2 QA1 Danazol × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；20% PEG 3350, 0.2M potassium thiocyanate
|
Resolution 1.75 Å R-free 0.225 |