Current Protein Identity：P05546
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1JMJ Crystal Structure of Native Heparin Cofactor II Deposited 2001-07-18 | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
20–499（480 aa）
Chain B
20–499（480 aa）
|
Not recorded | CA CALCIUM ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；MgCl2, Tris, PEG 4000, glycerol, pH 8.5, VAPOR DIFFUSION, HANGING DROP at 298K
|
Resolution 2.35 Å R-free 0.255 |
| 1JMO Crystal Structure of the Heparin Cofactor II-S195A Thrombin Complex Deposited 2001-07-19 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
20–499（480 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | NA SODIUM ION × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；298 K；NH4Cl, PEG 3350, pH 7.4, VAPOR DIFFUSION, HANGING DROP at 298K
|
Resolution 2.20 Å R-free 0.211 |
| 2NAT Structural insights into interaction of KYE28 and lipopolysachharide Deposited 2016-01-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
192–219（28 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 4.5；298 K；Ionic strength (raw mmCIF value) 0；Pressure ambient
NMR sample composition
1 mM entity-1, 1 mM TSP-2, 55.5 mM H2O-3, 61.3 mM D2O-4, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2NCU NMR structure of KYE21 in LPS micelles Deposited 2016-04-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
192–212（21 aa）
Fragment：Glycosaminoglycan-binding site residues 192-212
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 4.5；298 K；Ionic strength (raw mmCIF value) 0.01；Pressure ambient
NMR sample composition
1 mM protein, 1 mM DSS, 10 mM sodium phosphate, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2NCV NMR structure of RWS21 structure in LPS micelles Deposited 2016-04-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
192–212（21 aa）
Fragment：Glycosaminoglycan-binding site residues 192-212
|
Mutation：L192R, Y193W, E194S | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 4.5；298 K；Ionic strength (raw mmCIF value) 0.01；Pressure ambient
NMR sample composition
1 mM protein, 1 mM DSS, 10 mM sodium phosphate, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2NCW NMR structure of WWWKYE21 structure in LPS micelles Deposited 2016-04-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
189–212（24 aa）
Fragment：Glycosaminoglycan-binding site residues 189-212
|
Mutation：L192R, Y193W, E194S | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 4.5；298 K；Ionic strength (raw mmCIF value) 0.01；Pressure ambient
NMR sample composition
1 mM protein, 1 mM DSS, 10 mM sodium phosphate, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 6J12 Three-dimensional Solution NMR Structure of KYE28-PEG48 in Microgel Deposited 2018-12-27 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
192–219（28 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 4.52；298 K；Ionic strength (raw mmCIF value) 1；Pressure 9.8
NMR sample composition
1 mM KYE28-PEG48, 55.5 M Water, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 6KBO Three-dimensional LPS bound structure of VG16KRKP-KYE28. Deposited 2019-06-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
192–219（28 aa）
Fragment：Helix-D
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 4.5；298 K；Ionic strength (raw mmCIF value) 0.6；Pressure 1
NMR sample composition
0.3 mM 1H, Natural Abundance VG16KRKP, 0.3 mM 1H, Natural Abundance KYE28, 55.55 M 1H, Natural Abundance Water, 10 uM 1H, Natural Abundance Lipopolysaccharide, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 6KBV Three-dimensional cytoplasmic membrane-bound structure of VG16KRKP-KYE28 Deposited 2019-06-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
192–219（28 aa）
Fragment：helix D
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 4.5；298 K；Ionic strength (raw mmCIF value) 0.6；Pressure 1
NMR sample composition
0.3 uM 1H, natural abundance VG16KRKP, 0.3 uM 1H, natural abundance KYE28, 12 uM 1H, natural abundance 3:1 POPE/POPG vesicles, 55.55 M 1H, natural abundance water, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |