Current Protein Identity：P07602
New Search
Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1M12 NMR solution structure of human Saposin C Deposited 2002-06-17 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
311–390（80 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.8；298 K；Ionic strength (raw mmCIF value) ~10-20mM NaCl；Pressure ambient
NMR sample composition
U-15N | 90% H20, 10% D20
NMR sample composition
U-15N, U-13C | 90% H20, 10% D20
NMR sample composition
U-15N, U-13C | 100% D20
|
Resolution not provided |
| 1N69 Crystal structure of human saposin B Deposited 2002-11-08 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
195–273（79 aa）
Chain B
195–273（79 aa）
|
Not recorded | 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.8；295 K；POLYETHYLENE GLYCOL 3350, MAGNESIUM ACETATE,
SODIUM CACODYLATE, PH 5.8, VAPOR DIFFUSION, HANGING DROP,
TEMPERATURE 295K. THE CRYSTAL WAS TREATED WITH A MOTHER
LIQUOR SOLUTION CONTAINING 0.1% HYDROGEN PEROXIDE PRIOR
TO FREEZING.
|
Resolution 2.20 Å R-free 0.262 |
| 1N69 Crystal structure of human saposin B Deposited 2002-11-08 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
195–273（79 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.8；295 K；POLYETHYLENE GLYCOL 3350, MAGNESIUM ACETATE,
SODIUM CACODYLATE, PH 5.8, VAPOR DIFFUSION, HANGING DROP,
TEMPERATURE 295K. THE CRYSTAL WAS TREATED WITH A MOTHER
LIQUOR SOLUTION CONTAINING 0.1% HYDROGEN PEROXIDE PRIOR
TO FREEZING.
|
Resolution 2.20 Å R-free 0.262 |
| 1SN6 NMR solution structure of human Saposin C in SDS micelles Deposited 2004-03-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
311–390（80 aa）
Fragment：Saposin C
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.8；298 K；Ionic strength (raw mmCIF value) 25mM sodium dodecyl sulfate U-2H; 0.01% sodium azide；Pressure ambient
NMR measurement conditions
pH 6.4；298 K；Ionic strength (raw mmCIF value) 25mM sodium dodecyl sulfate U-2H; 0.01% sodium azide；Pressure ambient
NMR sample composition
1mM saposin C U-15N, U-13C;
25mM sodium dodecyl sulfate U-2H;
0.01% sodium azide;
90% H20, 10% D20 | 90% H20, 10% D20
NMR sample composition
1mM saposin C U-15N;
25mM sodium dodecyl sulfate U-2H;
0.01% sodium azide;
90% H20, 10% D20 | 90% H20, 10% D20
NMR sample composition
1mM saposin C U-15N, U-13C;
25mM sodium dodecyl sulfate U-2H;
0.01% sodium azide;
100% D20 | 100% D20
|
Resolution not provided |
| 2DOB Crystal Structure of Human Saposin A Deposited 2006-04-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
60–140（81 aa）
Fragment：Saposin A, residues 60-140
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；PEG 8K, Calcium Acetate, MES buffer, pH 6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.00 Å R-free 0.267 |
| 2DOB Crystal Structure of Human Saposin A Deposited 2006-04-28 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
60–140（81 aa）
Fragment：Saposin A, residues 60-140
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | CA CALCIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；PEG 8K, Calcium Acetate, MES buffer, pH 6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.00 Å R-free 0.267 |
| 2GTG Crystal Structure of Human Saposin C Deposited 2006-04-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
311–391（81 aa）
Fragment：saposin C, residues 311-391
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；PEG400, Calcium Chloride, Sodium Hepes, pH 6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.40 Å R-free 0.283 |
| 2QYP Orthorhombic Crystal Structure of Human Saposin C Dimer in Open Conformation Deposited 2007-08-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
311–392（82 aa）
Fragment：Saposin-C Domain
Chain B
311–392（82 aa）
Fragment：Saposin-C Domain
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；20 mM NaAcetate, 200 mM ammonium sulfate,
30% (v/v) pentaerythriol ethoxylate 15/4, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.45 Å R-free 0.290 |
| 2R0R Crystal Structure of Human Saposin D variant SapD K9E Deposited 2007-08-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
407–484（78 aa）
Chain B
407–484（78 aa）
|
Mutation：K9E Mutation：K9E | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.9；291 K；100 mM BisTris, 2.3 M ammonium sulfate, 100 mM urea, pH 5.9, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.50 Å R-free 0.287 |
| 2R1Q Crystal Structure of Iodinated Human Saposin D in Space Group C2221 Deposited 2007-08-23 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
407–484（78 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.9；291 K；100 mM BisTris, 2.3 M ammonium sulfate, 100 mM urea, pH 5.9, vapor diffusion, hanging drop, temperature 291K
|
Resolution 2.50 Å R-free 0.278 |
| 2RB3 Crystal Structure of Human Saposin D Deposited 2007-09-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
407–484（78 aa）
Chain D
407–484（78 aa）
|
Not recorded | SO4 SULFATE ION × 2 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.9；291 K；100 mM BisTris, 2.3 M ammonium sulfate, 100 mM urea, pH 5.9, vapor diffusion, hanging drop, temperature 291K
|
Resolution 2.10 Å R-free 0.274 |
| 2RB3 Crystal Structure of Human Saposin D Deposited 2007-09-18 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
407–484（78 aa）
Chain C
407–484（78 aa）
|
Not recorded | SO4 SULFATE ION × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.9；291 K；100 mM BisTris, 2.3 M ammonium sulfate, 100 mM urea, pH 5.9, vapor diffusion, hanging drop, temperature 291K
|
Resolution 2.10 Å R-free 0.274 |
| 2Z9A Crystal Structure of Human Saposin C Dimer in Open Conformation Deposited 2007-09-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
311–389（79 aa）
Chain B
311–389（79 aa）
|
Not recorded | GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；291 K；20 mM NaAcetate, 240 mM magnesium sulfate, 41% (v/v) pentaerythriol ethoxylate 15/4, pH 4.0, vapor diffusion, sitting drop, temperature 291K
|
Resolution 2.50 Å R-free 0.271 |
| 3BQP Crystal Structure of Human Saposin D (orthorhombic) Deposited 2007-12-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
405–484（80 aa）
Fragment：SAPOSIN D, RESIDUES 405-484
|
Not recorded | MG MAGNESIUM ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；PEG 8K, MAGNESIUM CHLORIDE, TRIS.HCL BUFFER, PH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 1.30 Å R-free 0.234 |
| 3BQP Crystal Structure of Human Saposin D (orthorhombic) Deposited 2007-12-20 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
405–484（80 aa）
Fragment：SAPOSIN D, RESIDUES 405-484
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；PEG 8K, MAGNESIUM CHLORIDE, TRIS.HCL BUFFER, PH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 1.30 Å R-free 0.234 |
| 3BQQ Crystal Structure of Human Saposin D (triclinic) Deposited 2007-12-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
405–484（80 aa）
Fragment：SAPOSIN D, RESIDUES 405-484
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；PEG 4K, ZINC SULFATE, SODIUM ACETATE BUFFER, PH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 2.00 Å R-free 0.242 |
| 3BQQ Crystal Structure of Human Saposin D (triclinic) Deposited 2007-12-20 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
405–484（80 aa）
Fragment：SAPOSIN D, RESIDUES 405-484
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；PEG 4K, ZINC SULFATE, SODIUM ACETATE BUFFER, PH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 2.00 Å R-free 0.242 |
| 3BQQ Crystal Structure of Human Saposin D (triclinic) Deposited 2007-12-20 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
405–484（80 aa）
Fragment：SAPOSIN D, RESIDUES 405-484
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；PEG 4K, ZINC SULFATE, SODIUM ACETATE BUFFER, PH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 2.00 Å R-free 0.242 |
| 3BQQ Crystal Structure of Human Saposin D (triclinic) Deposited 2007-12-20 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
405–484（80 aa）
Fragment：SAPOSIN D, RESIDUES 405-484
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；PEG 4K, ZINC SULFATE, SODIUM ACETATE BUFFER, PH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 2.00 Å R-free 0.242 |
| 4DDJ Crystal structure of saposin A in complex with lauryldimethylamine-N-oxide (LDAO) Deposited 2012-01-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
60–140（81 aa）
Fragment：UNP residues 60-140
|
Not recorded | LDA LAURYL DIMETHYLAMINE-N-OXIDE × 40 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；300 K；1.6 M trisodium citrate, pH 6.5, VAPOR DIFFUSION, temperature 300K
|
Resolution 1.90 Å R-free 0.280 |
| 4UEX Structure of human Saposin A at lysosomal pH Deposited 2014-12-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
60–142（83 aa）
Fragment：RESIDUES 60-142
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.8；SITTING-DROP VAPOUR DIFFUSION: 400 NL DROP (200 NL PROTEIN AT 19.6 MG/ML IN 150 MM NACL, 50 MM TRIS PH 7.4 MIXED WITH 200 NL RESERVOIR SOLUTION) WAS EQUILIBRATED AGAINST A 80 UL RESERVOIR OF 0.2 M LITHIUM SULPHATE, 0.1 M SODIUM ACETATE PH 4.8 AND 25% W/V POLYETHYLENE GLYCOL 4000
|
Resolution 1.80 Å R-free 0.210 |
| 4UEX Structure of human Saposin A at lysosomal pH Deposited 2014-12-20 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
60–142（83 aa）
Fragment：RESIDUES 60-142
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.8；SITTING-DROP VAPOUR DIFFUSION: 400 NL DROP (200 NL PROTEIN AT 19.6 MG/ML IN 150 MM NACL, 50 MM TRIS PH 7.4 MIXED WITH 200 NL RESERVOIR SOLUTION) WAS EQUILIBRATED AGAINST A 80 UL RESERVOIR OF 0.2 M LITHIUM SULPHATE, 0.1 M SODIUM ACETATE PH 4.8 AND 25% W/V POLYETHYLENE GLYCOL 4000
|
Resolution 1.80 Å R-free 0.210 |
| 4V2O Structure of saposin B in complex with chloroquine Deposited 2014-10-13 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
195–273（79 aa）
Chain C
195–273（79 aa）
|
Not recorded | CLQ N4-(7-CHLORO-QUINOLIN-4-YL)-N1,N1-DIETHYL-PENTANE-1,4-DIAMINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.5；0.1M MES, PH 6.0, 30% PEG6000
|
Resolution 2.13 Å R-free 0.254 |
| 4V2O Structure of saposin B in complex with chloroquine Deposited 2014-10-13 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
195–273（79 aa）
|
Not recorded | CLQ N4-(7-CHLORO-QUINOLIN-4-YL)-N1,N1-DIETHYL-PENTANE-1,4-DIAMINE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.5；0.1M MES, PH 6.0, 30% PEG6000
|
Resolution 2.13 Å R-free 0.254 |
| 6SLR Structure of saposin B in complex with atovaquone Deposited 2019-08-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
195–272（78 aa）
Chain C
195–272（78 aa）
|
Not recorded | GOL GLYCEROL × 1 AOQ 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxynaphthalene-1,4-dione × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M MES, 30% PEG6000
|
Resolution 2.38 Å R-free 0.278 |
| 6SLR Structure of saposin B in complex with atovaquone Deposited 2019-08-20 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
195–272（78 aa）
|
Not recorded | GOL GLYCEROL × 4 AOQ 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxynaphthalene-1,4-dione × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M MES, 30% PEG6000
|
Resolution 2.38 Å R-free 0.278 |
| 8EQU Structure of SARS-CoV-2 Orf3a in late endosome/lysosome-like environment, Saposin A nanodisc Deposited 2022-10-09 | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain C
60–140（81 aa）
Chain F
60–140（81 aa）
|
Not recorded | PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |
| 9AVS Human alpha-galactosidase A in complex with saposin B Deposited 2024-03-04 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain C
195–273（79 aa）
|
Not recorded | SO4 SULFATE ION × 8 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；500 nL of protein (0.1 mM GLA plus 0.22 mM SapB) was mixed with 500 nL of reservoir solution (0.1 M Tris pH 8.0, 1 M Ammonium sulfate) and equilibrated against 70 uL reservoirs at 20 C.
|
Resolution 3.53 Å R-free 0.265 |
| 9AXG Human saposin B in the presence of globotriaosylceramide-NBD Deposited 2024-03-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
195–273（79 aa）
Chain B
195–273（79 aa）
|
Not recorded | MLI MALONATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；500 nL of protein-lipid complex (0.82 mM SapB plus 0.87 mM Gb3-NBD) was mixed with 250 nL of reservoir solution (3.1-3.3 M malonate pH 5) and equilibrated against 70 uL reservoirs at 20 C.
|
Resolution 2.68 Å R-free 0.287 |
| 9EKO A chimeric hybrid protein fused with the FGFR3 Transmembrane Domain Deposited 2024-12-03 | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
79–139（61 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.90 Å R-free 0.287 |
| 9I63 Synthetic Human Saposin D glycoprotein Deposited 2025-01-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
405–486（82 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；2.4 M (NH4)2SO4, 0.2 M NH4OAc, 20 mM Tris pH 7.5
|
Resolution 1.65 Å R-free 0.201 |
| 9I63 Synthetic Human Saposin D glycoprotein Deposited 2025-01-29 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
405–486（82 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；2.4 M (NH4)2SO4, 0.2 M NH4OAc, 20 mM Tris pH 7.5
|
Resolution 1.65 Å R-free 0.201 |