Current Protein Identity：P08263
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1GSD GLUTATHIONE TRANSFERASE A1-1 IN UNLIGANDED FORM Deposited 1995-06-09 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–221（221 aa）
Chain B
1–221（221 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.50 Å R-free 0.264 |
| 1GSD GLUTATHIONE TRANSFERASE A1-1 IN UNLIGANDED FORM Deposited 1995-06-09 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–221（221 aa）
Chain D
1–221（221 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.50 Å R-free 0.264 |
| 1GSE GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH AN ETHACRYNIC ACID GLUTATHIONE CONJUGATE (MUTANT R15K) Deposited 1995-06-09 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–221（221 aa）
Chain B
1–221（221 aa）
|
Mutation：R15K Mutation：R15K | GSH Glutathione × 2 EAA ETHACRYNIC ACID × 2 BME BETA-MERCAPTOETHANOL × 4 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.00 Å R-free 0.243 |
| 1GSF GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH ETHACRYNIC ACID Deposited 1995-06-09 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–221（221 aa）
Chain B
1–221（221 aa）
|
Not recorded | EAA ETHACRYNIC ACID × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.70 Å R-free 0.261 |
| 1GSF GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH ETHACRYNIC ACID Deposited 1995-06-09 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–221（221 aa）
Chain D
1–221（221 aa）
|
Not recorded | EAA ETHACRYNIC ACID × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.70 Å R-free 0.261 |
| 1GUH Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the MU and PI class enzymes Deposited 1993-02-24 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–221（221 aa）
Chain B
1–221（221 aa）
|
Not recorded | GSB S-BENZYL-GLUTATHIONE × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.60 Å |
| 1GUH Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the MU and PI class enzymes Deposited 1993-02-24 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–221（221 aa）
Chain D
1–221（221 aa）
|
Not recorded | GSB S-BENZYL-GLUTATHIONE × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.60 Å |
| 1K3L Crystal Structure Analysis of S-hexyl-glutathione Complex of Glutathione Transferase at 1.5 Angstroms Resolution Deposited 2001-10-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–221（221 aa）
Chain B
1–221（221 aa）
|
Not recorded | GTX S-HEXYLGLUTATHIONE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；294 K；18% PEG3350, 0.1 M Tris-Cl pH 7.5, 10mM DTT, VAPOR DIFFUSION, SITTING DROP, temperature 294K
|
Resolution 1.50 Å R-free 0.241 |
| 1K3O Crystal Structure Analysis of apo Glutathione S-Transferase Deposited 2001-10-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–221（221 aa）
Chain B
1–221（221 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；22% PEG3350, 0.1M Tris-Cl 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 100K
|
Resolution 1.80 Å R-free 0.336 |
| 1K3Y Crystal Structure Analysis of human Glutathione S-transferase with S-hexyl glutatione and glycerol at 1.3 Angstrom Deposited 2001-10-04 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–221（221 aa）
Chain B
1–221（221 aa）
|
Not recorded | GTX S-HEXYLGLUTATHIONE × 2 GOL GLYCEROL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；15% PEG2000, 0.1M Tris-Cl 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 100K
|
Resolution 1.30 Å R-free 0.205 |
| 1LBK Crystal structure of a recombinant glutathione transferase, created by replacing the last seven residues of each subunit of the human class pi isoenzyme with the additional C-terminal helix of human class alpha isoenzyme Deposited 2002-04-04 | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
208–213（6 aa）
Chain B
208–213（6 aa）
|
Not recorded | MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 2 GSH Glutathione × 2 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；295 K；PEG 8000, calcium chloride, glutathione, (R,R)-1,4-dithiothreitol, 2-[N-morpholino]ethanesulphonic acid, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 1.86 Å R-free 0.224 |
| 1PKW Crystal structure of human glutathione transferase (GST) A1-1 in complex with glutathione Deposited 2003-06-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | GSH Glutathione × 2 HED 2-HYDROXYETHYL DISULFIDE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.8；293 K；PEG 4000, Tris HCl, 2-mercaptoethanol, pH 7.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.208 |
| 1PKZ Crystal structure of human glutathione transferase (GST) A1-1 Deposited 2003-06-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | HED 2-HYDROXYETHYL DISULFIDE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；MethylPEG2000, Tris-HCl, NaAc, 2-mercaptoethanol, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.10 Å R-free 0.230 |
| 1PL1 Crystal structure of human glutathione transferase (GST) A1-1 in complex with a decarboxy-glutathione Deposited 2003-06-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CL CHLORIDE ION × 2 ABY N-(4-AMINOBUTANOYL)-S-(4-METHOXYBENZYL)-L-CYSTEINYLGLYCINE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.8；293 K；PEG 4000, Tris-HCl, DTT, pH 7.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.75 Å R-free 0.189 |
| 1PL2 Crystal structure of human glutathione transferase (GST) A1-1 T68E mutant in complex with decarboxy-glutathione Deposited 2003-06-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Mutation：T68E Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：T68E Non-standard monomer：Yes (specific site not provided by mmCIF) | CL CHLORIDE ION × 2 ABY N-(4-AMINOBUTANOYL)-S-(4-METHOXYBENZYL)-L-CYSTEINYLGLYCINE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.8；293 K；PEG 4000, Tris-HCl, DTT, pH 7.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.80 Å R-free 0.200 |
| 1USB Rational design of a novel enzyme - efficient thioester hydrolysis enabled by the incorporation of a single His residue into human glutathione transferase A1-1 Deposited 2003-11-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–221（221 aa）
Chain B
1–221（221 aa）
|
Mutation：YES Mutation：YES | GSH Glutathione × 2 CL CHLORIDE ION × 2 K POTASSIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.8；0.1 M TRISHCL PH 7.8, 26 % PEG4000, 2 MM DITHIOTHREITOL
|
Resolution 2.07 Å R-free 0.245 |
| 1XWG Human GST A1-1 T68E mutant Deposited 2004-11-01 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
2–222（221 aa）
Chain B
2–222（221 aa）
|
Mutation：T68E Mutation：T68E | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.8；293 K；PEG4 000, DTT, Tris-HCl, MPD, pH 7.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.85 Å R-free 0.218 |
| 1YDK Crystal structure of the I219A mutant of human glutathione transferase A1-1 with S-hexylglutathione Deposited 2004-12-24 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–221（221 aa）
Chain B
1–221（221 aa）
|
Mutation：I219A Mutation：I219A | GTX S-HEXYLGLUTATHIONE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；PEG 2000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.95 Å R-free 0.253 |
| 2R3X Crystal structure of an R15L hGSTA1-1 mutant complexed with S-hexyl-glutathione Deposited 2007-08-30 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Mutation：R15L Mutation：R15L | GTX S-HEXYLGLUTATHIONE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；A 4uL hanging drop comprising: 2uL 14 mg/mL R15L hGSTA1-1 solution added to 2uL reservoir buffer (5mM S-hexyl-glutathione, 0.1M TrisHCl, pH 7.5, 10 mM DTT, 15% PEG 4000) was left to equilibrate in a sealed 24 plate well with 1 mL of reservoir buffer. Crystals were grown for 3 days before harvesting, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.259 |
| 2R6K Crystal structure of an I71V hGSTA1-1 mutant in complex with S-hexylglutathione Deposited 2007-09-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Mutation：I71V Mutation：I71V | GTX S-HEXYLGLUTATHIONE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；297 K；14 mg protein per ml, 0.1M Tris-HCl, 10 mM DTT, 19% PEG4000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 297K
|
Resolution 2.51 Å R-free 0.298 |
| 3I69 Apo Glutathione Transferase A1-1 GIMF-helix mutant Deposited 2009-07-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Mutation：A12G, L107I, L108M, V111F, M208P, K211I, S212Y, L213V, E214R, E215T, A216V, R217Y, K218N, F222P Mutation：A12G, L107I, L108M, V111F, M208P, K211I, S212Y, L213V, E214R, E215T, A216V, R217Y, K218N, F222P | GSH Glutathione × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；18% PEG 4000, 0.1 M Tric-Cl, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.38 Å R-free 0.289 |
| 3I69 Apo Glutathione Transferase A1-1 GIMF-helix mutant Deposited 2009-07-06 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–222（222 aa）
Chain D
1–222（222 aa）
|
Mutation：A12G, L107I, L108M, V111F, M208P, K211I, S212Y, L213V, E214R, E215T, A216V, R217Y, K218N, F222P Mutation：A12G, L107I, L108M, V111F, M208P, K211I, S212Y, L213V, E214R, E215T, A216V, R217Y, K218N, F222P | GSH Glutathione × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；18% PEG 4000, 0.1 M Tric-Cl, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.38 Å R-free 0.289 |
| 3I69 Apo Glutathione Transferase A1-1 GIMF-helix mutant Deposited 2009-07-06 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain E
1–222（222 aa）
Chain F
1–222（222 aa）
|
Mutation：A12G, L107I, L108M, V111F, M208P, K211I, S212Y, L213V, E214R, E215T, A216V, R217Y, K218N, F222P Mutation：A12G, L107I, L108M, V111F, M208P, K211I, S212Y, L213V, E214R, E215T, A216V, R217Y, K218N, F222P | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；18% PEG 4000, 0.1 M Tric-Cl, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.38 Å R-free 0.289 |
| 3I69 Apo Glutathione Transferase A1-1 GIMF-helix mutant Deposited 2009-07-06 | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain G
1–222（222 aa）
Chain H
1–222（222 aa）
|
Mutation：A12G, L107I, L108M, V111F, M208P, K211I, S212Y, L213V, E214R, E215T, A216V, R217Y, K218N, F222P Mutation：A12G, L107I, L108M, V111F, M208P, K211I, S212Y, L213V, E214R, E215T, A216V, R217Y, K218N, F222P | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；18% PEG 4000, 0.1 M Tric-Cl, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.38 Å R-free 0.289 |
| 3I6A Human GST A1-1 GIMF mutant with Glutathione Deposited 2009-07-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Mutation：A12G, L107I, L108M, V111F, M208P, K211I, S212Y, L213V, E214R, E215T, A216V, R217Y, K218N, F222P Mutation：A12G, L107I, L108M, V111F, M208P, K211I, S212Y, L213V, E214R, E215T, A216V, R217Y, K218N, F222P | GSH Glutathione × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；18% PEG 4000, 0.1 M Tric-Cl, 10 mM DTT, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 1.98 Å R-free 0.244 |
| 3I6A Human GST A1-1 GIMF mutant with Glutathione Deposited 2009-07-06 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–222（222 aa）
Chain D
1–222（222 aa）
|
Mutation：A12G, L107I, L108M, V111F, M208P, K211I, S212Y, L213V, E214R, E215T, A216V, R217Y, K218N, F222P Mutation：A12G, L107I, L108M, V111F, M208P, K211I, S212Y, L213V, E214R, E215T, A216V, R217Y, K218N, F222P | GSH Glutathione × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；18% PEG 4000, 0.1 M Tric-Cl, 10 mM DTT, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 1.98 Å R-free 0.244 |
| 3I6A Human GST A1-1 GIMF mutant with Glutathione Deposited 2009-07-06 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain E
1–222（222 aa）
Chain F
1–222（222 aa）
|
Mutation：A12G, L107I, L108M, V111F, M208P, K211I, S212Y, L213V, E214R, E215T, A216V, R217Y, K218N, F222P Mutation：A12G, L107I, L108M, V111F, M208P, K211I, S212Y, L213V, E214R, E215T, A216V, R217Y, K218N, F222P | GSH Glutathione × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；18% PEG 4000, 0.1 M Tric-Cl, 10 mM DTT, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 1.98 Å R-free 0.244 |
| 3I6A Human GST A1-1 GIMF mutant with Glutathione Deposited 2009-07-06 | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain G
1–222（222 aa）
Chain H
1–222（222 aa）
|
Mutation：A12G, L107I, L108M, V111F, M208P, K211I, S212Y, L213V, E214R, E215T, A216V, R217Y, K218N, F222P Mutation：A12G, L107I, L108M, V111F, M208P, K211I, S212Y, L213V, E214R, E215T, A216V, R217Y, K218N, F222P | GSH Glutathione × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；18% PEG 4000, 0.1 M Tric-Cl, 10 mM DTT, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 1.98 Å R-free 0.244 |
| 3IK9 Human GST A1-1-GIMF with GSDHN Deposited 2009-08-05 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Not recorded | BOB (S)-2-amino-5-((R)-1-(carboxymethylamino)-3-((3S,4R)-1,4-dihydroxynonan-3-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；16% PEG mme 5000, 0.1 M HEPES, pH 7.5, and 10% isopropanol, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.279 |
| 3IK9 Human GST A1-1-GIMF with GSDHN Deposited 2009-08-05 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–222（222 aa）
Chain D
1–222（222 aa）
|
Not recorded | BOB (S)-2-amino-5-((R)-1-(carboxymethylamino)-3-((3S,4R)-1,4-dihydroxynonan-3-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；16% PEG mme 5000, 0.1 M HEPES, pH 7.5, and 10% isopropanol, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.279 |
| 3IK9 Human GST A1-1-GIMF with GSDHN Deposited 2009-08-05 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain E
1–222（222 aa）
Chain F
1–222（222 aa）
|
Not recorded | BOB (S)-2-amino-5-((R)-1-(carboxymethylamino)-3-((3S,4R)-1,4-dihydroxynonan-3-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；16% PEG mme 5000, 0.1 M HEPES, pH 7.5, and 10% isopropanol, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.279 |
| 3IK9 Human GST A1-1-GIMF with GSDHN Deposited 2009-08-05 | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain G
1–222（222 aa）
Chain H
1–222（222 aa）
|
Not recorded | BOB (S)-2-amino-5-((R)-1-(carboxymethylamino)-3-((3S,4R)-1,4-dihydroxynonan-3-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；16% PEG mme 5000, 0.1 M HEPES, pH 7.5, and 10% isopropanol, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.279 |
| 3KTL Crystal Structure of an I71A human GSTA1-1 mutant in complex with S-hexylglutathione Deposited 2009-11-25 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
2–222（221 aa）
Chain B
2–222（221 aa）
|
Mutation：I71A Mutation：I71A | GTX S-HEXYLGLUTATHIONE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；20% PEG 4000, 0.1M Tris-Cl PH 7.5, 0.02% NaN3, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.75 Å R-free 0.281 |
| 3L0H Crystal Structure Analysis of W21A mutant of human GSTA1-1 in complex with S-hexylglutathione Deposited 2009-12-10 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Mutation：W21A Mutation：W21A | GTX S-HEXYLGLUTATHIONE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；1.4M Sodium citrate in 0.1M HEPES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.13 Å R-free 0.233 |
| 3Q74 Crystal Structure Analysis of the L7A Mutant of the Apo Form of Human Alpha Class Glutathione Transferase Deposited 2011-01-04 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
2–222（221 aa）
Chain B
2–222（221 aa）
|
Mutation：L7A Mutation：L7A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
hanging drop；pH 7.5；293 K；0.1 M Tris, 20% PEG 3350, 2 mM DTT, 0.02% azide, pH 7.5, hanging drop, temperature 293K
|
Resolution 1.79 Å R-free 0.271 |
| 3U6V Crystal Structure Analysis of L23A mutant of human GST A1-1 Deposited 2011-10-13 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Mutation：L23A Mutation：L23A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.1 M Tris, 20% PEG 3350, 2 mM DTT, 0.02% azide, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.20 Å R-free 0.288 |
| 3ZFB Crystal structure of the I75A mutant of human class alpha glutathione transferase in the apo form Deposited 2012-12-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Mutation：YES Mutation：YES | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.1 M TRIS, 17% PEG 4000, 2 MM DTT, 0.02% AZIDE, PH 7.5, VAPOUR DIFFUSION, HANGING DROP, TEMPERATURE 293K
|
Resolution 1.86 Å R-free 0.285 |
| 3ZFL Crystal structure of the V58A mutant of human class alpha glutathione transferase in the apo form Deposited 2012-12-12 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Mutation：YES Mutation：YES | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.1 M TRIS, 19% PEG 3350, 2 MM DTT, 0.02% AZIDE, PH 7.5, VAPOUR DIFFUSION, HANGING DROP, TEMPERATURE 293K
|
Resolution 1.88 Å R-free 0.289 |
| 4HJ2 Crystal Structure Analysis of GSTA1-1 in complex with chlorambucil Deposited 2012-10-12 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
4–220（217 aa）
Chain B
4–220（217 aa）
|
Not recorded | LZ6 L-gamma-glutamyl-S-(2-{[4-(3-carboxypropyl)phenyl](2-chloroethyl)amino}ethyl)-L-cysteinylglycine × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.10 Å R-free 0.258 |
| 5JCU Crystal Structure of hGSTA1-1 with Glutathione Adduct of Phenethyl Isothiocyanate and Cystein Adduct of Phenethyl Isothiocyanate Deposited 2016-04-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
2–222（221 aa）
Chain B
2–222（221 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | GVX L-gamma-glutamyl-S-[(2-phenylethyl)carbamothioyl]-L-cysteinylglycine × 2 EDO 1,2-ETHANEDIOL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.4；293 K；PEG 3350 20% (w/v), Sodium acetate 0.2 M
|
Resolution 1.93 Å R-free 0.240 |
| 5JCU Crystal Structure of hGSTA1-1 with Glutathione Adduct of Phenethyl Isothiocyanate and Cystein Adduct of Phenethyl Isothiocyanate Deposited 2016-04-15 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
2–222（221 aa）
Chain D
2–222（221 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | GVX L-gamma-glutamyl-S-[(2-phenylethyl)carbamothioyl]-L-cysteinylglycine × 2 EDO 1,2-ETHANEDIOL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.4；293 K；PEG 3350 20% (w/v), Sodium acetate 0.2 M
|
Resolution 1.93 Å R-free 0.240 |
| 5LCZ Chimeric GST Deposited 2016-06-23 | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–53（53 aa）
Fragment：UNP residues 1-54,UNP residues 54-65,UNP residues 66-85,UNP residues 86-213,UNP residues 214-222
Chain A
66–85（20 aa）
Fragment：UNP residues 1-54,UNP residues 54-65,UNP residues 66-85,UNP residues 86-213,UNP residues 214-222
Chain A
214–222（9 aa）
Fragment：UNP residues 1-54,UNP residues 54-65,UNP residues 66-85,UNP residues 86-213,UNP residues 214-222
Chain B
1–53（53 aa）
Fragment：UNP residues 1-54,UNP residues 54-65,UNP residues 66-85,UNP residues 86-213,UNP residues 214-222
Chain B
66–85（20 aa）
Fragment：UNP residues 1-54,UNP residues 54-65,UNP residues 66-85,UNP residues 86-213,UNP residues 214-222
Chain B
214–222（9 aa）
Fragment：UNP residues 1-54,UNP residues 54-65,UNP residues 66-85,UNP residues 86-213,UNP residues 214-222
|
Not recorded | GSH Glutathione × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.4；289 K；PEG 4000 20% (w/v), ammonium citrate 0.2 M, pH 6.4
|
Resolution 2.33 Å R-free 0.268 |
| 5LD0 Chimeric GST Deposited 2016-06-23 | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–85（85 aa）
Fragment：UNP residues 1-85,UNP residues 86-213,UNP residues 214-222
Chain A
214–222（9 aa）
Fragment：UNP residues 1-85,UNP residues 86-213,UNP residues 214-222
|
Not recorded | CL CHLORIDE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；289 K；Sodium formate 0.15 M, PEG 4000 15% (w/v)
|
Resolution 1.60 Å R-free 0.201 |
| 6ATO Crystal structure of hGSTA1-1 complexed with GSH and MPD in each subunit Deposited 2017-08-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–222（221 aa）
|
Not recorded | GSH Glutathione × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；PEG 200 MME, 25% (w/v), 0.1 M Tris HCl, pH 8.5
|
Resolution 1.55 Å R-free 0.208 |
| 6ATO Crystal structure of hGSTA1-1 complexed with GSH and MPD in each subunit Deposited 2017-08-29 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
2–222（221 aa）
|
Not recorded | GSH Glutathione × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；PEG 200 MME, 25% (w/v), 0.1 M Tris HCl, pH 8.5
|
Resolution 1.55 Å R-free 0.208 |
| 6ATP Crystal structure of apo-hGSTA1-1 exhibiting a new conformation of C-terminal helix Deposited 2017-08-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–222（221 aa）
|
Not recorded | MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；PEG 2000 MME, 20% (w/v), 0.05 M Tris HCl, pH 8.5
|
Resolution 1.70 Å R-free 0.201 |
| 6ATP Crystal structure of apo-hGSTA1-1 exhibiting a new conformation of C-terminal helix Deposited 2017-08-29 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
2–222（221 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；PEG 2000 MME, 20% (w/v), 0.05 M Tris HCl, pH 8.5
|
Resolution 1.70 Å R-free 0.201 |
| 6ATQ Crystal structure of apo-hGSTA1-1 exhibiting a new conformation of C-terminal helix Deposited 2017-08-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–222（221 aa）
|
Not recorded | MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 3 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；PEG 2000 MME, 25% (w/v), 0.1 M MES, 6.5
|
Resolution 2.00 Å R-free 0.235 |
| 6ATQ Crystal structure of apo-hGSTA1-1 exhibiting a new conformation of C-terminal helix Deposited 2017-08-29 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
2–222（221 aa）
|
Not recorded | MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；PEG 2000 MME, 25% (w/v), 0.1 M MES, 6.5
|
Resolution 2.00 Å R-free 0.235 |
| 6ATR Crystal structure of hGSTA1-1 complexed with two GSH analogues in each subunit Deposited 2017-08-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–222（221 aa）
|
Not recorded | BWS L-gamma-glutamyl-L-alanylglycine × 1 GSN 2-AMINO-5-[1-(CARBOXYLATOMETHYLCARBAMOYL)-2-NITROSOSULFANYL-ETHYL]AMINO-5-OXO-PENTANOATE × 1 EDO 1,2-ETHANEDIOL × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；PEG 2000 MME, 25% (w/v), 0.1 M MES, pH 6.5
|
Resolution 1.29 Å R-free 0.182 |
| 6ATR Crystal structure of hGSTA1-1 complexed with two GSH analogues in each subunit Deposited 2017-08-29 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
2–222（221 aa）
|
Not recorded | BWS L-gamma-glutamyl-L-alanylglycine × 1 GSN 2-AMINO-5-[1-(CARBOXYLATOMETHYLCARBAMOYL)-2-NITROSOSULFANYL-ETHYL]AMINO-5-OXO-PENTANOATE × 1 EDO 1,2-ETHANEDIOL × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；PEG 2000 MME, 25% (w/v), 0.1 M MES, pH 6.5
|
Resolution 1.29 Å R-free 0.182 |
| 6YAW Crystal structure of human GSTA1-1 bound to the glutathione adduct of cinnamaldehyde Deposited 2020-03-13 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Not recorded | P9H (2~{S})-2-azanyl-5-[[(2~{R})-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-3-[(1~{R})-3-oxidanylidene-1-phenyl-propyl]sulfanyl-propan-2-yl]amino]-5-oxidanylidene-pentanoic acid × 2 GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；Tris-HCl 0.1M pH 7.5, PEG4000 18%
|
Resolution 2.19 Å R-free 0.247 |
| 7BIB Crystal structure of human GSTA1-1 bound to the glutathione adduct of hexyl-isothiocyanate Deposited 2021-01-12 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Not recorded | TZ8 (2~{R})-2-azanyl-5-[[(2~{R})-3-(hexylcarbamothioylsulfanyl)-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-propan-2-yl]amino]-5-oxidanylidene-pentanoic acid × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；Tris-HCl 0.1M pH 7.5, PEG4000 18%
|
Resolution 2.03 Å R-free 0.255 |
| 7BIC Crystal structure of human GSTA1-1 bound to allyl-isothiocyanate Deposited 2021-01-12 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Not recorded | 9AI N-prop-2-en-1-ylthioformamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；Tris-HCl 0.1M pH 7.5, PEG4000 18%
|
Resolution 2.46 Å R-free 0.277 |
| 7BIC Crystal structure of human GSTA1-1 bound to allyl-isothiocyanate Deposited 2021-01-12 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–222（222 aa）
Chain D
1–222（222 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；Tris-HCl 0.1M pH 7.5, PEG4000 18%
|
Resolution 2.46 Å R-free 0.277 |
| 8BHC K141H and S142H double mutant of hGSTA1-1 Deposited 2022-10-31 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–222（222 aa）
Chain D
1–222（222 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；289 K；20% w/v PEG 3350, 0.2 lithium citrate tribasic tetrahydrate
|
Resolution 1.56 Å R-free 0.188 |
| 8BHC K141H and S142H double mutant of hGSTA1-1 Deposited 2022-10-31 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；289 K；20% w/v PEG 3350, 0.2 lithium citrate tribasic tetrahydrate
|
Resolution 1.56 Å R-free 0.188 |
| 8BHE K141H and S142H double mutant of hGSTA1-1 Deposited 2022-10-31 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–222（222 aa）
Chain B
1–222（222 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；289 K；PEG 4000 17-20% w/v, Na malonate 0.2 M
|
Resolution 1.87 Å R-free 0.239 |