当前蛋白身份：P0AD64
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相关结构差异明细
一行代表一个 PDB 条目中的一个 biological assembly；同一蛋白的多个单体会分别列出。
| PDB 条目 | Assembly / 聚集状态 | 构建体 | 突变与修饰 | 配体、离子与非聚合物 | 实验方法 | 实验环境 | 结构质量 |
|---|---|---|---|---|---|---|---|
| 2G2U Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) complex 提交 2006-02-16 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
22–286（265 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
EVAPORATION；pH 6.5；293 K；30% Ammonium SO4,25mM cacodylate, 10mM BisTris, 25mM NaCl , pH 6.5, EVAPORATION, temperature 293K
|
分辨率 1.60 Å R-free 0.186 |
| 2G2W Crystal Structure of the SHV D104K Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) complex 提交 2006-02-16 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
22–286（265 aa）
|
突变：D104K | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
EVAPORATION；pH 6.5；293 K；4% PEG 8000, 25mM cacodylate, 10 mM BisTris, 25mM NaCl, pH 6.5, EVAPORATION, temperature 293K
|
分辨率 1.80 Å R-free 0.222 |
| 2H0Y Crystal structure of the M69V E166A double mutant of SHV-1 b-lactamase complexed to sulbactam 提交 2006-05-15 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–286（265 aa）
|
突变：M69V, E166A | TSL TRANS-ENAMINE INTERMEDIATE OF SULBACTAM × 1 MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 ESA ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；20% PEG 6000, 0.1 M HEPES, 0.56mM Cymal-6. Crystal soaked for 10 minutes in 50mM sublactam prior to freezing and data collection, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
分辨率 1.70 Å R-free 0.211 |
| 2H10 Crystal structure of the M69V E166A double mutant of SHV-1 b-lactamase complexed to tazobactam 提交 2006-05-15 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–286（265 aa）
|
突变：M69V, E166A | TBE TAZOBACTAM INTERMEDIATE × 1 MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；20% PEG 6000, 0.1M HEPES, 0.56mM Cymal-6. Crystal soaked for 10 minutes in 50mM tazobactam prior to freezing and data collection, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
分辨率 1.75 Å R-free 0.190 |
| 2ZD8 SHV-1 class A beta-lactamase complexed with meropenem 提交 2007-11-20 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–286（265 aa）
|
未记录 | MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 MER (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7；296 K；25% PEG6000, 0.1M HEPES, CYMAL-6, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 296K
|
分辨率 1.05 Å R-free 0.168 |
| 3C4O Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) E73M/S130K/S146M complex 提交 2008-01-30 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
22–286（265 aa）
|
未记录 | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8.4；292 K；37.5% Ammonium Sulfate, 100mM Tris HCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 292K
|
分辨率 1.70 Å R-free 0.196 |
| 3C4P Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) E73M complex 提交 2008-01-30 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
22–286（265 aa）
|
未记录 | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8.4；292 K；37.5% Ammonium Sulfate, 100mM Tris HCl, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 292K
|
分辨率 1.75 Å R-free 0.207 |
| 3D4F SHV-1 beta-lactamase complex with LN1-255 提交 2008-05-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–286（286 aa）
|
未记录 | MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 LN1 (3R)-4-{[(3,4-dihydroxyphenyl)acetyl]oxy}-N-(2-formylindolizin-3-yl)-3-sulfino-D-valine × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；30% PEG6000, 0.1M HEPES pH7. 0.56mM Cymal-6, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
分辨率 1.55 Å R-free 0.197 |
| 3MKE SHV-1 beta-lactamase complex with LP06 提交 2010-04-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–286（265 aa）
|
未记录 | MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 CB4 PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE × 1 CZ6 2-[(~{Z})-[1-(2-azanyl-1,3-thiazol-4-yl)-2-oxidanylidene-2-[[(6~{S})-4,4,6-trimethyl-1,3,2-dioxaborinan-2-yl]methylamino]ethylidene]amino]oxy-2-methyl-propanoic acid × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；20-30% PEG 6000, 0.1M HEPES, 0.56Mm Cymal-6, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 293.0K
|
分辨率 1.75 Å R-free 0.181 |
| 3MKF SHV-1 beta-lactamase complex with GB0301 提交 2010-04-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–286（265 aa）
|
未记录 | CZ7 ({[(2R)-2-{[(4-ethyl-2,3-dioxo-3,4-dihydropyrazin-1(2H)-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}methyl)boronic acid × 1 MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；20-30% PEG 6000, 0.1M HEPES, 0.56Mm Cymal-6, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 293.0K
|
分辨率 1.33 Å R-free 0.190 |
| 3MXR SHV-1 beta-lactamase complex with compound 1 提交 2010-05-07 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–286（265 aa）
|
未记录 | CZ8 ({[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-4-(4-hydroxyphenyl)butanoyl]amino}methyl)boronic acid × 1 MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；20-30% PEG 6000, 0.1M HEPES, 0.56Mm Cymal-6, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 293.0K
|
分辨率 1.30 Å R-free 0.203 |
| 3MXS SHV-1 beta-lactamase complex with compound 2 提交 2010-05-07 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–286（265 aa）
|
未记录 | CZ9 N-[(dihydroxyboranyl)methyl]-Nalpha-[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]-D-tyrosinamide × 1 MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；20-30% PEG 6000, 0.1M HEPES, 0.56Mm Cymal-6, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 293.0K
|
分辨率 1.24 Å R-free 0.194 |
| 3N4I Crystal structure of the SHV-1 D104E beta-lactamase/beta-lactamase inhibitor protein (BLIP) complex 提交 2010-05-21 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
22–286（265 aa）
|
突变：D104E | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；40% ammonium sulfate, 100mM Tris, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
分辨率 1.56 Å R-free 0.179 |
| 3OPH ESBL R164S mutant of SHV-1 beta-lactamase 提交 2010-09-01 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–286（286 aa）
|
突变：R164S | MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；295 K；21-30% PEG 6000, 0.5mM cymal-6, 100mM HEPES buffer, pH 6.6-7.6, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
分辨率 1.34 Å R-free 0.190 |
| 3OPL ESBL R164H mutant SHV-1 beta-lactamase 提交 2010-09-01 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–286（286 aa）
|
突变：R164H | MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；295 K；21-30% PEG 6000, 0.5mM cymal-6, 100mM HEPES buffer, pH 6.6-7.6, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
分辨率 1.80 Å R-free 0.228 |
| 3OPP ESBL R164S mutant of SHV-1 beta-lactamase complexed with SA2-13 提交 2010-09-01 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–286（286 aa）
|
突变：R164S | SA2 (3R)-4-[(4-CARBOXYBUTANOYL)OXY]-N-[(1E)-3-OXOPROP-1-EN-1-YL]-3-SULFINO-D-VALINE × 1 MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；295 K；21-30% PEG 6000, 0.5mM cymal-6, 100mM HEPES buffer, pH 6.6-7.6, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
分辨率 1.80 Å R-free 0.192 |
| 3OPR ESBL R164H mutant of SHV-1 beta-lactamase complexed to SA2-13 提交 2010-09-01 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–286（286 aa）
|
突变：R164H | MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 SA2 (3R)-4-[(4-CARBOXYBUTANOYL)OXY]-N-[(1E)-3-OXOPROP-1-EN-1-YL]-3-SULFINO-D-VALINE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；295 K；21-30% PEG6000, 0.5mM cymal-6, 100mM HEPES buffer, pH 6.6-7.6, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
分辨率 1.65 Å R-free 0.211 |
| 4FCF K234R: apo structure of inhibitor resistant beta-lactamase 提交 2012-05-24 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–286（265 aa）
片段：unp residues 22-286
|
突变：K234R | MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 TAU 2-AMINOETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7；296 K；21-30% PEG6K, 0.1M Hepes pH 6.6-7.6, 0.56mM cymal-6, VAPOR DIFFUSION, SITTING DROP, temperature 296K
|
分辨率 1.09 Å R-free 0.150 |
| 4FD8 Structure of apo S70C SHV beta-lactamase 提交 2012-05-26 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–286（265 aa）
片段：unp residues 22-286
|
突变：S70C | MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；296 K；21-30% PEG6k, 0.1M hepes pH 6.8-7.8, 0.56mM cymal-6, VAPOR DIFFUSION, SITTING DROP, temperature 296K
|
分辨率 1.52 Å R-free 0.197 |
| 4FH2 Structure of s70c beta-lactamase bound to sulbactam 提交 2012-06-05 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–286（265 aa）
片段：unp residues 22-286
|
突变：S70C | MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 0RN SULBACTAM × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；296 K；21-30%PEG6k, 0.1M hepes, 0.56mM cymal-6, VAPOR DIFFUSION, SITTING DROP, temperature 296K
|
分辨率 1.44 Å R-free 0.220 |
| 4FH4 high-resolution structure of apo wt SHV-1 beta-lactamase 提交 2012-06-05 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–286（265 aa）
片段：unp residues 22-286
|
未记录 | MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；296 K；21-30% peg6k, 0.1M hepes, 0.56mM cymal-6, pH 6.8-7.8, VAPOR DIFFUSION, SITTING DROP, temperature 296K
|
分辨率 1.09 Å R-free 0.166 |
| 4GD6 SHV-1 beta-lactamase in complex with penam sulfone SA1-204 提交 2012-07-31 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–286（286 aa）
|
未记录 | 17K (3R)-N-(2-formylindolizin-3-yl)-4-[(phenylacetyl)oxy]-3-sulfino-D-valine × 1 MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；25% PEG 6000, 100mM HEPES pH 7.0, 0.56mM Cymal-6, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
分辨率 1.53 Å R-free 0.194 |
| 4GD8 SHV-1 beta-lactamase in complex with penam sulfone SA3-53 提交 2012-07-31 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–286（286 aa）
|
未记录 | MXF (2S,3R)-4-(2-aminoethylcarbamoyloxy)-2-[(2-methanoylindolizin-3-yl)amino]-3-methyl-3-sulfino-butanoic acid × 1 MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；25% PEG 6000, 100mM HEPES pH7.0, 0.56mM Cymal-6, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
分辨率 1.60 Å R-free 0.242 |
| 4GDB SHV-1 in complex with 4H-pyrazolo[1,5-c][1,3]thiazole containing penem inhibitor 提交 2012-07-31 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–286（286 aa）
|
未记录 | 17O (7R)-6-formyl-7-(4H-pyrazolo[1,5-c][1,3]thiazol-2-yl)-4,7-dihydro-1,4-thiazepine-3-carboxylic acid × 1 MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；25% PEG 6000, 100mM HEPES pH7.0, 0.56mM Cymal-6, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
分辨率 1.84 Å R-free 0.234 |
| 4JPM Structure of SHV-1 beta-lactamase in complex with the 7-alkylidenecephalosporin DCM-1-10 at 1.14 Ang resolution 提交 2013-03-19 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–286（286 aa）
片段：SVH-1 beta-lactamase
|
未记录 | MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 1OG 7-alkylidenecephalosporin DCM-1-10, bound form × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；21-30% PEG 6000, 0.1M HEPES buffer, 0.56mM Cymal-6, pH 6.8-7.8, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
分辨率 1.14 Å R-free 0.164 |
| 4MBF Crystal structure of Penam sulfone PSR-4-157 bound to SHV-1 beta-lactamase 提交 2013-08-19 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–286（265 aa）
片段：unp residues 22-286
|
未记录 | MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 2AW 6-({(2R,3S)-3-carboxy-2-methyl-3-[(3-oxopropyl)amino]-2-sulfinopropyl}oxy)-6-oxohexanoic acid × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；21-30% PEG 6000, 0.1M HEPES buffer, 0.56mM Cymal-6, pH 6.8-7.8, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
分辨率 1.54 Å R-free 0.196 |
| 4MBH Penam sulfone PSR-3-226 bound to E166A variant of SHV-1 beta-lactamase 提交 2013-08-19 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–286（265 aa）
片段：SHV-1 beta-lactamase
|
突变：E166A | MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 0RJ 3-(formylamino)-L-alanine × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；21-30% PEG 6000, 0.1M HEPES. 0.56mM Cymal-6, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
分辨率 1.22 Å R-free 0.161 |
| 4MBK Crystal structure of K234R inhibitor-resistant variant of SHV beta-lactamase in complex with SA2-13 提交 2013-08-19 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–286（265 aa）
片段：SHV-1 beta-lactamase
|
突变：K234R | MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 SA2 (3R)-4-[(4-CARBOXYBUTANOYL)OXY]-N-[(1E)-3-OXOPROP-1-EN-1-YL]-3-SULFINO-D-VALINE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；21-30% PEG 6000, 0.1M HEPES, 0.56mM Cymal-6, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
分辨率 1.46 Å R-free 0.214 |
| 4R3B Crystal structure of SHV-1 b-lactamase in complex with 6b-(hydroxymethyl)penicillanic acid sulfone PSR-283A 提交 2014-08-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–286（265 aa）
片段：SHV-1 beta-lactamase
|
未记录 | MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 3GE N-[(1E)-2-formyl-3-hydroxyprop-1-en-1-yl]-3-[(S)-sulfino]-D-valine × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；21-30% PEG6000, 0.1M HEPES pH 6.2-8.2, 0.56mM Cymal-6, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
分辨率 1.37 Å R-free 0.172 |
| 4ZAM Crystal structure of SHV-1 beta-lactamase bound to avibactam 提交 2015-04-13 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–286（265 aa）
片段：UNP residues 22-286
|
未记录 | MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 NXL (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；25% PEG6000, 100 mM Tris, pH 7.5, 0.56 mM Cymal-6
|
分辨率 1.42 Å R-free 0.193 |
| 5EE8 Crystal structure of S02030 boronic acid inhibitor complexed to SHV-1 beta-lactamase 提交 2015-10-22 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–286（265 aa）
|
未记录 | ZXM 1-{(2R)-2-(dihydroxyboranyl)-2-[(thiophen-2-ylacetyl)amino]ethyl}-1H-1,2,3-triazole-4-carboxylic acid × 1 MA4 CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；20-30% PEG 6000, 100mM Tris pH 7.5, 0.56mM cymal-6
|
分辨率 1.54 Å R-free 0.175 |