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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P0C6X7 New Search
32PDB entries
45Biological assembly
64chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1UK4 Crystal structure of SARS Coronavirus Main Proteinase (3CLpro) Complexed With An Inhibitor Deposited 2003-08-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 3241–3546（306 aa）
Chain B 3241–3546（306 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；PEG 6000, MES, DMSO, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
Resolution 2.50 Å R-free 0.231
2XYQ Crystal structure of the nsp16 nsp10 SARS coronavirus complex Deposited 2010-11-18 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 6776–7065（290 aa） Fragment：RESIDUES 6776-7065
Chain B 4240–4361（122 aa） Fragment：RESIDUES 4240-4361
Not recorded CL CHLORIDE ION × 2 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 NA SODIUM ION × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；0.1M CHES, 1.52M MGCL2, pH 9
Resolution 2.00 Å R-free 0.227
2XYR Crystal structure of the nsp16 nsp10 SARS coronavirus complex Deposited 2010-11-18 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 6776–7067（292 aa） Fragment：RESIDUES 6776-7067
Chain B 4240–4361（122 aa） Fragment：RESIDUES 4240-4361
Not recorded NA SODIUM ION × 1 CL CHLORIDE ION × 5 SFG SINEFUNGIN × 1 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；0.1M CHES, 1.52M MGCL2, pH 9
Resolution 2.50 Å R-free 0.235
2XYV Crystal structure of the nsp16 nsp10 SARS coronavirus complex Deposited 2010-11-19 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 6776–7067（292 aa） Fragment：RESIDUES 6776-7065
Chain B 4240–4361（122 aa） Fragment：RESIDUES 4240-4361
Mutation：YES NA SODIUM ION × 3 CL CHLORIDE ION × 5 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 8.5；67 MM M CHES, 0.99 M MGCL2-HEXAYDRATE, 33 MM TRIS-HCL, 8.3% (V/V) PEG 8000, FROZEN IN THE PRESENCE OF 15% (V/V) GLYCEROL, pH 8.5
Resolution 2.06 Å R-free 0.234
3EBN A Special Dimerization of SARS-CoV Main Protease C-Terminal Domain Due to Domain-swapping Deposited 2008-08-28 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3429–3546（118 aa） Fragment：UNP residues 3429-3546
Chain C 3429–3546（118 aa） Fragment：UNP residues 3429-3546
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；289 K；25% PEG3350, pH5.5, VAPOR DIFFUSION, SITTING DROP, temperature 289K
Resolution 2.40 Å R-free 0.243
3EBN A Special Dimerization of SARS-CoV Main Protease C-Terminal Domain Due to Domain-swapping Deposited 2008-08-28 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 3429–3546（118 aa） Fragment：UNP residues 3429-3546
Chain D 3429–3546（118 aa） Fragment：UNP residues 3429-3546
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；289 K；25% PEG3350, pH5.5, VAPOR DIFFUSION, SITTING DROP, temperature 289K
Resolution 2.40 Å R-free 0.243
3R24 Crystal structure of nsp10/nsp16 complex of SARS coronavirus Deposited 2011-03-13 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 6776–7073（298 aa）
Not recorded SAM S-ADENOSYLMETHIONINE × 1 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；293 K；2.0M NaCl, 0.1M NaH2PO4, 0.1M K2HPO4, 0.1M MES, pH5.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.00 Å R-free 0.222
4TWW Structure of SARS-3CL protease complex with a Bromobenzoyl (S,R)-N-decalin type inhibitor Deposited 2014-07-02 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3241–3546（306 aa）
Chain B 3241–3546（306 aa）
Not recorded 3A7 (2S)-2-({[(3S,4aR,8aS)-2-(4-bromobenzoyl)decahydroisoquinolin-3-yl]methyl}amino)-3-(1H-imidazol-5-yl)propanal × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；9-11%(w/v) of PEG20000, 100mM MES, 5mM DTT
Resolution 2.42 Å R-free 0.261
4TWY Structure of SARS-3CL protease complex with a phenylbenzoyl (S,R)-N-decalin type inhibitor Deposited 2014-07-02 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3241–3546（306 aa）
Not recorded 3BL (2S)-2-({[(3S,4aR,8aS)-2-(biphenyl-4-ylcarbonyl)decahydroisoquinolin-3-yl]methyl}amino)-3-(1H-imidazol-5-yl)propanal × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；10%(w/v) of PEG20000, 100mM MES, 5mM DTT
Resolution 1.60 Å R-free 0.319
4WY3 Structure of SARS-3CL protease complex with a phenylbenzoyl (R,S)-N-decalin type inhibitor Deposited 2014-11-15 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 3241–3546（306 aa）
Not recorded 3X5 (2S)-2-({[(3R,4aS,8aR)-2-(biphenyl-4-ylcarbonyl)decahydroisoquinolin-3-yl]methyl}amino)-3-(1H-imidazol-5-yl)propanal × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；10%(w/v) PEG20000, 100mM MES, 5 mM DTT
Resolution 1.89 Å R-free 0.299
5B6O Crystal structure of MS8104 Deposited 2016-05-31 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3241–3556（316 aa）
Chain B 3241–3556（316 aa）
Mutation：C145A Mutation：C145A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.3；293 K；Sodium Chloride, PEG 4000 , pH 7.3, temperature 293K
Resolution 2.20 Å R-free 0.254
5C5N Structure of SARS-3CL protease complex with a phenyl-beta-alanyl (R,S)-N-decalin type inhibitor Deposited 2015-06-21 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 3241–3546（306 aa）
Mutation：R188I SLH (2S)-3-(1H-imidazol-5-yl)-2-({[(3R,4aS,8aR)-2-(N-phenyl-beta-alanyl)decahydroisoquinolin-3-yl]methyl}amino)propanal × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；10%(w/v) of PEG20000, 100mM MES, 5mM DTT
Resolution 1.69 Å R-free 0.321
5C5N Structure of SARS-3CL protease complex with a phenyl-beta-alanyl (R,S)-N-decalin type inhibitor Deposited 2015-06-21 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3241–3546（306 aa）
Mutation：R188I SLH (2S)-3-(1H-imidazol-5-yl)-2-({[(3R,4aS,8aR)-2-(N-phenyl-beta-alanyl)decahydroisoquinolin-3-yl]methyl}amino)propanal × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；10%(w/v) of PEG20000, 100mM MES, 5mM DTT
Resolution 1.69 Å R-free 0.321
5C5O Structure of SARS-3CL protease complex with a phenyl-beta-alanyl (S,R)-N-decalin type inhibitor Deposited 2015-06-21 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 3241–3546（306 aa）
Mutation：R188I SDJ (2S)-3-(1H-imidazol-5-yl)-2-({[(3S,4aR,8aS)-2-(N-phenyl-beta-alanyl)decahydroisoquinolin-3-yl]methyl}amino)propanal × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；10% (w/v) PEG 20000, 100mM MES, 5mM DTT
Resolution 1.50 Å R-free 0.271
5C5O Structure of SARS-3CL protease complex with a phenyl-beta-alanyl (S,R)-N-decalin type inhibitor Deposited 2015-06-21 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 3241–3546（306 aa）
Mutation：R188I SDJ (2S)-3-(1H-imidazol-5-yl)-2-({[(3S,4aR,8aS)-2-(N-phenyl-beta-alanyl)decahydroisoquinolin-3-yl]methyl}amino)propanal × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；10% (w/v) PEG 20000, 100mM MES, 5mM DTT
Resolution 1.50 Å R-free 0.271
5C5O Structure of SARS-3CL protease complex with a phenyl-beta-alanyl (S,R)-N-decalin type inhibitor Deposited 2015-06-21 Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3241–3546（306 aa）
Chain B 3241–3546（306 aa）
Mutation：R188I Mutation：R188I SDJ (2S)-3-(1H-imidazol-5-yl)-2-({[(3S,4aR,8aS)-2-(N-phenyl-beta-alanyl)decahydroisoquinolin-3-yl]methyl}amino)propanal × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；10% (w/v) PEG 20000, 100mM MES, 5mM DTT
Resolution 1.50 Å R-free 0.271
5C8S Crystal structure of the SARS coronavirus nsp14-nsp10 complex with functional ligands SAH and GpppA Deposited 2015-06-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 4231–4369（139 aa）
Chain B 5903–6429（527 aa）
Not recorded ZN ZINC ION × 5 MG MAGNESIUM ION × 1 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 G3A GUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；289 K；15% (v/v) tacsimate pH 7.0, 0.1 M HEPES pH 7.0, and 2% (w/v) polyethylene glycol 3350
Resolution 3.33 Å R-free 0.259
5C8S Crystal structure of the SARS coronavirus nsp14-nsp10 complex with functional ligands SAH and GpppA Deposited 2015-06-26 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 4231–4369（139 aa）
Chain D 5903–6429（527 aa）
Not recorded ZN ZINC ION × 5 MG MAGNESIUM ION × 1 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 G3A GUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；289 K；15% (v/v) tacsimate pH 7.0, 0.1 M HEPES pH 7.0, and 2% (w/v) polyethylene glycol 3350
Resolution 3.33 Å R-free 0.259
5C8T Crystal structure of the SARS coronavirus nsp14-nsp10 complex with functional ligand SAM Deposited 2015-06-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 4231–4369（139 aa）
Chain B 5903–6429（527 aa）
Not recorded ZN ZINC ION × 5 MG MAGNESIUM ION × 1 SAM S-ADENOSYLMETHIONINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；15% (v/v) tacsimate pH 7.0, 0.1 M HEPES pH 7.0, and 2% (w/v) polyethylene glycol 3,350
Resolution 3.20 Å R-free 0.265
5C8T Crystal structure of the SARS coronavirus nsp14-nsp10 complex with functional ligand SAM Deposited 2015-06-26 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 4231–4369（139 aa）
Chain D 5903–6429（527 aa）
Not recorded ZN ZINC ION × 5 MG MAGNESIUM ION × 1 SAM S-ADENOSYLMETHIONINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；15% (v/v) tacsimate pH 7.0, 0.1 M HEPES pH 7.0, and 2% (w/v) polyethylene glycol 3,350
Resolution 3.20 Å R-free 0.265
5C8U Crystal structure of the SARS coronavirus nsp14-nsp10 complex Deposited 2015-06-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 4231–4369（139 aa）
Chain B 5903–6429（527 aa）
Not recorded ZN ZINC ION × 5 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；15% (v/v) tacsimate pH 7.0, 0.1 M HEPES pH 7.0, 2% (w/v) polyethylene glycol 3350
Resolution 3.40 Å R-free 0.266
5C8U Crystal structure of the SARS coronavirus nsp14-nsp10 complex Deposited 2015-06-26 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 4231–4369（139 aa）
Chain D 5903–6429（527 aa）
Not recorded ZN ZINC ION × 5 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；15% (v/v) tacsimate pH 7.0, 0.1 M HEPES pH 7.0, 2% (w/v) polyethylene glycol 3350
Resolution 3.40 Å R-free 0.266
5E6J Structure of SARS PLpro bound to a Lys48-linked di-ubiquitin activity based probe Deposited 2015-10-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1541–1856（316 aa） Fragment：UNP Residues 1541-1856
Not recorded ACT ACETATE ION × 1 NI NICKEL (II) ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；285 K；0.1 M MES, 0.1 M lithium acetate, 17% PEG 6000
Resolution 2.85 Å R-free 0.264
5E6J Structure of SARS PLpro bound to a Lys48-linked di-ubiquitin activity based probe Deposited 2015-10-09 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain D 1541–1856（316 aa） Fragment：UNP Residues 1541-1856
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；285 K；0.1 M MES, 0.1 M lithium acetate, 17% PEG 6000
Resolution 2.85 Å R-free 0.264
5F22 C-terminal domain of SARS-CoV nsp8 complex with nsp7 Deposited 2015-12-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 3989–4117（129 aa） Fragment：UNP residues 3989-4117
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；0.2M magnesium acetate, PEG 3350
Resolution 2.15 Å R-free 0.252
5N19 Structure of SARS coronavirus main protease in complex with the alpha-ketoamide (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide Deposited 2017-02-05 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3241–3546（306 aa）
Not recorded D03 (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide × 2 DMS DIMETHYL SULFOXIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；6 - 8% polyethylene glycol 6000, 0.1 M MES, pH 6.0
Resolution 1.62 Å R-free 0.200
5N5O Structure of SARS coronavirus main protease in complex with the alpha-ketoamide (S)-N-benzyl-3-((S)-2-cinnamamido-3-cyclopropylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide (Cinnamoyl-cyclopropylalanine-GlnLactam-CO-CO-NH-benzyl) Deposited 2017-02-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3241–3546（306 aa）
Not recorded 8O5 (2~{R},3~{S})-3-[[(2~{S})-3-cyclopropyl-2-[[(~{E})-3-phenylprop-2-enoyl]amino]propanoyl]amino]-2-oxidanyl-4-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-~{N}-(phenylmethyl)butanamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；6 - 8% polyethylene glycol 6000, 0.1 M MES, pH 6.0
Resolution 2.00 Å R-free 0.252
5TL6 Crystal structure of SARS-CoV papain-like protease in complex with the C-terminal domain of human ISG15 Deposited 2016-10-10 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 1541–1855（315 aa） Fragment：UNP residues 1541-1855
Not recorded ZN ZINC ION × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M lithium sulfate, 0.1 M Bis-tris [pH 6.5], 22% PEG 3350, supplemented with 30% (v/v) glycerol additive in a 1:5 dilution
Resolution 2.62 Å R-free 0.250
5TL6 Crystal structure of SARS-CoV papain-like protease in complex with the C-terminal domain of human ISG15 Deposited 2016-10-10 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 1541–1855（315 aa） Fragment：UNP residues 1541-1855
Not recorded ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M lithium sulfate, 0.1 M Bis-tris [pH 6.5], 22% PEG 3350, supplemented with 30% (v/v) glycerol additive in a 1:5 dilution
Resolution 2.62 Å R-free 0.250
5TL7 Crystal structure of SARS-CoV papain-like protease in complex with C-terminal domain mouse ISG15 Deposited 2016-10-10 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 1541–1855（315 aa） Fragment：UNP residues 1541-1855
Not recorded ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；65% (v/v) MPD, 0.1 M Tris [pH 8.0], supplemented with 30% (w/v) Trimethylamine N-oxide dihydrate additive in a 1:5 dilution
Resolution 2.44 Å R-free 0.267
5TL7 Crystal structure of SARS-CoV papain-like protease in complex with C-terminal domain mouse ISG15 Deposited 2016-10-10 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 1541–1855（315 aa） Fragment：UNP residues 1541-1855
Not recorded ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；65% (v/v) MPD, 0.1 M Tris [pH 8.0], supplemented with 30% (w/v) Trimethylamine N-oxide dihydrate additive in a 1:5 dilution
Resolution 2.44 Å R-free 0.267
6JYT Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis Deposited 2019-04-28 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 5302–5902（601 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) ZN ZINC ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；289 K；12% w/v polyethylene glycol 20000, 2M ammonium sulfate, 0.1M MES monohydrate pH 6.5
Resolution 2.80 Å R-free 0.292
6JYT Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis Deposited 2019-04-28 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 5302–5902（601 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) ZN ZINC ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；289 K；12% w/v polyethylene glycol 20000, 2M ammonium sulfate, 0.1M MES monohydrate pH 6.5
Resolution 2.80 Å R-free 0.292
6NUR SARS-Coronavirus NSP12 bound to NSP7 and NSP8 co-factors Deposited 2019-02-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 4370–5300（931 aa） Fragment：UNP residues 4370-5300
Chain C 3837–3919（83 aa） Fragment：UNP residues 3837-3919
Not recorded ZN ZINC ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；n-dodecyl-beta-D-maltopyranoside was added just prior to spotting samples onto holey EM grids.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
6NUS SARS-Coronavirus NSP12 bound to NSP8 co-factor Deposited 2019-02-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 4370–5300（931 aa） Fragment：UNP residues 4370-5300
Not recorded ZN ZINC ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；n-dodecyl-beta-D-maltopyranoside was added just prior to spotting samples onto holey EM grids.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
7LCP N-terminal finger stabilizes feline drug GC376 in coronavirus 3CL protease Deposited 2021-01-11 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3241–3546（306 aa）
Not recorded UED N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide × 2 EDO 1,2-ETHANEDIOL × 2 CA CALCIUM ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6；295 K；7% PEG 8000, 1 mM MES pH 6.0, 1mM DTT, 3% ethylene glycol and 3% DMSO
Resolution 1.90 Å R-free 0.221
7LCQ N-terminal finger stabilizes feline drug GC376 in coronavirus 3CL protease Deposited 2021-01-11 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3241–3546（306 aa）
Not recorded EDO 1,2-ETHANEDIOL × 4 UED N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6；295 K；7% PEG 8000, 1 mM MES pH 6.0, 1mM DTT, 3% ethylene glycol and 3% DMSO
Resolution 2.15 Å R-free 0.223
8C0G SARS-CoV nsp16-nsp10 complexed with N7-GTP Deposited 2022-12-16 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 6776–7067（292 aa）
Chain B 4240–4361（122 aa）
Not recorded PEG DI(HYDROXYETHYL)ETHER × 2 SRC [[(2~{R},3~{S},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1,8-dihydropurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate × 1 NA SODIUM ION × 1 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293.15 K；67 MM M CHES, 0.99 M MGCL2-HEXAYDRATE, 33 MM TRIS-HCL, 8.3% (V/V) PEG 8000
Resolution 1.88 Å R-free 0.263
8CB3 SARS-CoV Macro domain complexed with 3-(N-morpholino)propanesulfonic acid Deposited 2023-01-25 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1000–1173（174 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；0.1 M Imidazole, 0.9 M NaCitrate, pH 7.9 0.2 M MOPS
Resolution 1.57 Å R-free 0.203
8CB3 SARS-CoV Macro domain complexed with 3-(N-morpholino)propanesulfonic acid Deposited 2023-01-25 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1000–1173（174 aa）
Not recorded MPO 3[N-MORPHOLINO]PROPANE SULFONIC ACID × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；0.1 M Imidazole, 0.9 M NaCitrate, pH 7.9 0.2 M MOPS
Resolution 1.57 Å R-free 0.203
8CB3 SARS-CoV Macro domain complexed with 3-(N-morpholino)propanesulfonic acid Deposited 2023-01-25 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 1000–1173（174 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；0.1 M Imidazole, 0.9 M NaCitrate, pH 7.9 0.2 M MOPS
Resolution 1.57 Å R-free 0.203
8YKK Crystal structure of SARS main protease in complex with X77 Deposited 2024-03-05 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3242–3539（298 aa）
Not recorded X77 N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1M Hepes pH7.5, 10% PEG8000, 8% Ethylene glycol
Resolution 2.30 Å R-free 0.248
9LZQ Crystal structure of SARS main protease in complex with Ibuzatrelvir Pomotrelvir Deposited 2025-02-22 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3242–3540（299 aa）
Chain B 3242–3540（299 aa）
Not recorded ZQB Pomotrelvir bound form × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；0.1M Hepes pH7.5, 10% PEG8000, 8% Ethylene glycol
Resolution 2.05 Å R-free 0.248
9MBV Crystal structure of SARS main protease complex with CCF0058981 Deposited 2025-03-17 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3242–3540（299 aa）
Chain B 3242–3540（299 aa）
Not recorded XIU 2-(benzotriazol-1-yl)-~{N}-[(3-chlorophenyl)methyl]-~{N}-[4-(1~{H}-imidazol-5-yl)phenyl]ethanamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.12M-0.21M Na2SO4, 20%-24% PEG3350
Resolution 1.94 Å R-free 0.244
9XG4 The crystal structure of SARS-CoV-1 Main protease in complex with inhibitor FD2-21 Deposited 2025-10-29 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 3241–3546（306 aa）
Not recorded A1EZ7 7-(5-azanylpyridin-3-yl)-2-(2-chlorophenyl)-5,7-diazaspiro[3.4]octane-6,8-dione × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；289.15 K；1.1 M Ammonium tartrate dibasic pH 7.0
Resolution 1.73 Å R-free 0.218

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.