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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P14941 New Search
14PDB entries
16Biological assembly
69chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1BXZ CRYSTAL STRUCTURE OF A THERMOPHILIC ALCOHOL DEHYDROGENASE SUBSTRATE COMPLEX FROM THERMOANAEROBACTER BROCKII Deposited 1998-10-09 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–352（352 aa） Fragment：NUCLEOTIDE-BINDING DOMAIN, CATALYTIC DOMAIN
Chain B 1–352（352 aa） Fragment：NUCLEOTIDE-BINDING DOMAIN, CATALYTIC DOMAIN
Chain C 1–352（352 aa） Fragment：NUCLEOTIDE-BINDING DOMAIN, CATALYTIC DOMAIN
Chain D 1–352（352 aa） Fragment：NUCLEOTIDE-BINDING DOMAIN, CATALYTIC DOMAIN
Not recorded ZN ZINC ION × 4 CL CHLORIDE ION × 4 MG MAGNESIUM ION × 4 SBT 2-BUTANOL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.8；pH 5.8
Resolution 2.99 Å R-free 0.264
1YKF NADP-DEPENDENT ALCOHOL DEHYDROGENASE FROM THERMOANAEROBIUM BROCKII Deposited 1996-03-25 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–352（352 aa）
Chain B 1–352（352 aa）
Chain C 1–352（352 aa）
Chain D 1–352（352 aa）
Not recorded ZN ZINC ION × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 8.2；pH 8.2
Resolution 2.50 Å R-free 0.267
2NVB Contribution of Pro275 to the Thermostability of the Alcohol Dehydrogenases (ADHs) Deposited 2006-11-12 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–352（352 aa）
Chain B 1–352（352 aa）
Chain C 1–352（352 aa）
Chain D 1–352（352 aa）
Mutation：P275D Mutation：P275D Mutation：P275D Mutation：P275D ZN ZINC ION × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.3；298 K；16%(w/v) PEG 4000, 50mM NaCl, 50mM Tris-HCl, VAPOR DIFFUSION, HANGING DROP, temperature 298K, pH 8.3
Resolution 2.80 Å R-free 0.278
2NVB Contribution of Pro275 to the Thermostability of the Alcohol Dehydrogenases (ADHs) Deposited 2006-11-12 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–352（352 aa）
Chain B 1–352（352 aa）
Mutation：P275D Mutation：P275D ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.3；298 K；16%(w/v) PEG 4000, 50mM NaCl, 50mM Tris-HCl, VAPOR DIFFUSION, HANGING DROP, temperature 298K, pH 8.3
Resolution 2.80 Å R-free 0.278
2NVB Contribution of Pro275 to the Thermostability of the Alcohol Dehydrogenases (ADHs) Deposited 2006-11-12 Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 1–352（352 aa）
Chain D 1–352（352 aa）
Mutation：P275D Mutation：P275D ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.3；298 K；16%(w/v) PEG 4000, 50mM NaCl, 50mM Tris-HCl, VAPOR DIFFUSION, HANGING DROP, temperature 298K, pH 8.3
Resolution 2.80 Å R-free 0.278
3FPC Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-294 of T. brockii ADH by E. histolytica ADH Deposited 2009-01-05 Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–152（152 aa）
Chain A 295–352（58 aa）
Chain B 1–152（152 aa）
Chain B 295–352（58 aa）
Chain C 1–152（152 aa）
Chain C 295–352（58 aa）
Chain D 1–152（152 aa）
Chain D 295–352（58 aa）
Not recorded ZN ZINC ION × 4 CAC CACODYLATE ION × 4 OXY OXYGEN MOLECULE × 1 EDO 1,2-ETHANEDIOL × 14 NO3 NITRATE ION × 2 IMD IMIDAZOLE × 1 NA SODIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；8mg/mL protein [25mM Tris-HCl, 50mM NaCl, 0.1mM DTT, 50mM ZnCl2 (pH=7.5)] was mixed with 0.001 ml of reservoir solution [16% (w/v) PEG 8000, 200mM magnesium acetate tetrahydrate, 100mM Cacodylate buffer (pH 6.5)], vapor diffusion, hanging drop, temperature 298K
Resolution 1.40 Å R-free 0.155
3FPL Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-295 of C. beijerinckii ADH by T. brockii ADH Deposited 2009-01-05 Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 153–295（143 aa）
Not recorded ZN ZINC ION × 4 CL CHLORIDE ION × 8 EDO 1,2-ETHANEDIOL × 4 CAC CACODYLATE ION × 4 PGE TRIETHYLENE GLYCOL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.6；298 K；Single crystals of apo-22(CTC) were obtained by the microbatch method under oil at 18 C, using the IMPAX 1-5 robot. The apo-22(CTC) (10mg/mL) was crystallized in a mixture containing 100mM ammonium acetate, 15% (w/v) PEG 4000, 25mM NaCl, 50mM DTT, 25mM ZnCl2 and 50mM tri-citrate dihydrate (pH sodium 5.6), Microbatch, temperature 298K
Resolution 1.90 Å R-free 0.172
3FSR Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-295 of T. brockii ADH by C. beijerinckii ADH Deposited 2009-01-11 Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–152（152 aa）
Chain A 296–352（57 aa）
Chain B 1–152（152 aa）
Chain B 296–352（57 aa）
Chain C 1–152（152 aa）
Chain C 296–352（57 aa）
Chain D 1–152（152 aa）
Chain D 296–352（57 aa）
Not recorded ZN ZINC ION × 6 EDO 1,2-ETHANEDIOL × 5 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；8mg/mL protein [25mM Tris-HCl, 50mM NaCl, 0.1mM DTT, 50mM ZnCl2 (pH=7.5)] was mixed with 0.001ml of reservoir solution [16% (w/v) PEG 8000, 200mM magnesium acetate tetrahydrate, 100mM Cacodylate buffer (pH 6.5)], vapor diffusion, hanging drop, temperature 298K
Resolution 2.20 Å R-free 0.220
3FTN Q165E/S254K Double Mutant Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-295 of T. brockii ADH by C. beijerinckii ADH Deposited 2009-01-13 Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–152（152 aa）
Chain A 296–352（57 aa）
Chain B 1–152（152 aa）
Chain B 296–352（57 aa）
Chain C 1–152（152 aa）
Chain C 296–352（57 aa）
Chain D 1–152（152 aa）
Chain D 296–352（57 aa）
Mutation：Q165E, S254K Mutation：Q165E, S254K Mutation：Q165E, S254K Mutation：Q165E, S254K Mutation：Q165E, S254K Mutation：Q165E, S254K Mutation：Q165E, S254K Mutation：Q165E, S254K ZN ZINC ION × 4 ACT ACETATE ION × 4 EDO 1,2-ETHANEDIOL × 11 CL CHLORIDE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；8 mg/mL protein, 25 mM Tris-HCl, 50 mM NaCl, 0.1 mM DTT, 50 mM ZnCl2 (pH=7.5)] was mixed with 1 microliter of reservoir solution [16% (w/v) PEG8K, 200 mM magnesium acetate tetrahydrate, 100 mM Cacodylate buffer (pH 6.5), vapor diffusion, hanging drop, temperature 298K
Resolution 2.19 Å R-free 0.228
6SDM NADH-dependent variant of TBADH Deposited 2019-07-28 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–352（352 aa）
Chain B 1–352（352 aa）
Chain C 1–352（352 aa）
Chain D 1–352（352 aa）
Not recorded ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 5.5；298 K；20% w/v PEG 3K, sodium citrate pH 5.5
Resolution 2.85 Å R-free 0.238
7F3P Crystal structure of a nadp-dependent alcohol dehydrogenase mutant in apo form Deposited 2021-06-16 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–352（352 aa）
Chain B 1–352（352 aa）
Chain C 1–352（352 aa）
Chain D 1–352（352 aa）
Mutation：P84S, I86L Mutation：P84S, I86L Mutation：P84S, I86L Mutation：P84S, I86L ZN ZINC ION × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；295 K；PEG3350, NH4, citrate
Resolution 2.60 Å R-free 0.237
7UTC Crystal structure of secondary alcohol dehydrogenases from the Thermoanaerobacter ethanolicus with NADP and transition-state analogue inhibitor DMSO Deposited 2022-04-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–352（352 aa）
Chain B 1–352（352 aa）
Chain C 1–352（352 aa）
Chain D 1–352（352 aa）
Mutation：C295A Mutation：C295A Mutation：C295A Mutation：C295A ZN ZINC ION × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 4 DMS DIMETHYL SULFOXIDE × 35 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；295 K；0.6 M KCl, 12% PEG 3350, 50 mM HEPES-K buffer, pH 7.5
Resolution 1.85 Å R-free 0.227
7UUT Ternary complex crystal structure of secondary alcohol dehydrogenases from the Thermoanaerobacter ethanolicus mutants C295A and I86A provides better understanding of catalytic mechanism Deposited 2022-04-28 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–352（352 aa）
Chain B 1–352（352 aa）
Chain C 1–352（352 aa）
Chain D 1–352（352 aa）
Mutation：I86A Mutation：I86A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：I86A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：I86A Non-standard monomer：Yes (specific site not provided by mmCIF) ZN ZINC ION × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 4 2RP (2R)-pentan-2-ol × 4 K POTASSIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；0.6 M KCl, 12% PEG 3350, 50 mM HEPES buffer pH 7.5
Resolution 1.89 Å R-free 0.231
7UX4 Crystallographic snapshots of ternary complexes of thermophilic secondary alcohol dehydrogenase from Thermoanaerobacter pseudoethanolicus reveal the dynamics of ligand exchange and the proton relay network. Deposited 2022-05-04 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–352（352 aa）
Chain B 1–352（352 aa）
Chain C 1–352（352 aa）
Chain D 1–352（352 aa）
Mutation：I86A Mutation：I86A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：I86A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：I86A Non-standard monomer：Yes (specific site not provided by mmCIF) ZN ZINC ION × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 4 K POTASSIUM ION × 8 NWO (1S,3S)-3-methylcyclohexan-1-ol × 3 CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；295 K；0.6 M KCl,12% PEG 3350, 50 mM HEPES-K buffer, pH 7.5
Resolution 2.23 Å R-free 0.204
7XL5 Crystal structure of the H42T/A85G/I86A mutant of a nadp-dependent alcohol dehydrogenase Deposited 2022-04-21 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 2–352（351 aa）
Chain B 2–352（351 aa）
Chain C 2–352（351 aa）
Chain D 2–352（351 aa）
Mutation：H42T, A85G, I86A Mutation：H42T, A85G, I86A Mutation：H42T, A85G, I86A Mutation：H42T, A85G, I86A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.2 M Magnesium acetate tetrahydrate, 15% (w/v) PEG 3350
Resolution 2.60 Å R-free 0.225
7XY9 Cryo-EM structure of secondary alcohol dehydrogenases TbSADH after carrier-free immobilization based on weak intermolecular interactions Deposited 2022-06-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 2–352（351 aa）
Chain B 2–352（351 aa）
Chain C 2–352（351 aa）
Chain D 2–352（351 aa）
Mutation：I86N Mutation：I86N Mutation：I86N Mutation：I86N ZN ZINC ION × 4 MG MAGNESIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.12 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.