Current Protein Identity：P17787
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 2K58 NMR structures of the first transmembrane domain of the neuronal acetylcholine receptor beta 2 subunit Deposited 2008-06-25 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
231–265（35 aa）
Fragment：unp residues 231-265
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 5.5；303 K；Ionic strength (raw mmCIF value) 0.1；Pressure ambient
NMR sample composition
0.83 mM [U-100% 15N] nAChR TM1, 0.5 mM DSS, 125 mM DPC, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2K59 NMR structures of the second transmembrane domain of the neuronal acetylcholine receptor beta 2 subunit Deposited 2008-06-25 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
264–291（28 aa）
Fragment：UNP residues 264-291
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 5；303 K；Ionic strength (raw mmCIF value) 0.25；Pressure ambient
NMR sample composition
3-5 mM [U-100% 15N] nAChR TM2, 0.5 mM DSS, 450-750 mM DPC, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2KSR NMR structures of TM domain of the n-Acetylcholine receptor b2 subunit Deposited 2010-01-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
231–330（100 aa）
Chain A
453–486（34 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 3.8；313 K；Ionic strength (raw mmCIF value) 0；Pressure ambient
NMR sample composition
0.2 mM [U-100% 13C; U-100% 15N] TM123, 50% HFIP/50% H2O | 50% HFIP/50% H2O
NMR sample composition
0.2 mM [U-100% 13C; U-100% 15N] TM1234, 50% HFIP/ 50% H2O | 50% HFIP/ 50% H2O
|
Resolution not provided |
| 2LM2 NMR structures of the transmembrane domains of the AChR b2 subunit Deposited 2011-11-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
231–330（100 aa）
Fragment：Helical transmembrane region, residues 234-330 and residues 458-484
Chain A
458–486（29 aa）
Fragment：Helical transmembrane region, residues 234-330 and residues 458-484
|
Mutation：R231E, R232E, K233E, L292S, V294S, L296S, K299E, T327E Mutation：R231E, R232E, K233E, L292S, V294S, L296S, K299E, T327E | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 4.65；318 K；Pressure ambient
NMR sample composition
0.25 mM [U-100% 13C; U-100% 15N] protein, 5 mM sodium acetate, 1.5 % LDAO, 0.1 mM DSS, 5 % [U-100% 2H] D2O, 10 mM sodium chloride, 20 mM beta-mercaptoethanol, 95% H2O/5% D2O | 95% H2O/5% D2O
|
Resolution not provided |
| 5KXI X-ray structure of the human Alpha4Beta2 nicotinic receptor Deposited 2016-07-20 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
26–355（330 aa）
Fragment：UNP residues 26-355,446-502,UNP residues 26-353,446-502
Chain B
446–502（57 aa）
Fragment：UNP residues 26-355,446-502,UNP residues 26-353,446-502
Chain C
26–355（330 aa）
Fragment：UNP residues 26-355,446-502,UNP residues 26-353,446-502
Chain C
446–502（57 aa）
Fragment：UNP residues 26-355,446-502,UNP residues 26-353,446-502
Chain E
26–355（330 aa）
Fragment：UNP residues 26-355,446-502,UNP residues 26-353,446-502
Chain E
446–502（57 aa）
Fragment：UNP residues 26-355,446-502,UNP residues 26-353,446-502
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 NCT (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE × 2 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.05 M ADA pH 6.8, 12.5% PEG 1500 and 10% PEG 1000
|
Resolution 3.94 Å R-free 0.307 |
| 6CNJ Structure of the 2alpha3beta stiochiometry of the human Alpha4Beta2 nicotinic receptor Deposited 2018-03-08 | Assembly 1 Other combination Heteromer；Protein × 11 PDB declaration: undecameric（11） Consistent with protein count |
Chain B
26–353（328 aa）
Chain B
446–502（57 aa）
Chain C
26–353（328 aa）
Chain C
446–502（57 aa）
Chain E
26–353（328 aa）
Chain E
446–502（57 aa）
|
Mutation：Glu-Arg linker was inserted in the MX-M4 junction between Gln420-Ser421 in the beta 2 subunit. Mutation：Glu-Arg linker was inserted in the MX-M4 junction between Gln420-Ser421 in the beta 2 subunit. Mutation：Glu-Arg linker was inserted in the MX-M4 junction between Gln420-Ser421 in the beta 2 subunit. Mutation：Glu-Arg linker was inserted in the MX-M4 junction between Gln420-Ser421 in the beta 2 subunit. Mutation：Glu-Arg linker was inserted in the MX-M4 junction between Gln420-Ser421 in the beta 2 subunit. Mutation：Glu-Arg linker was inserted in the MX-M4 junction between Gln420-Ser421 in the beta 2 subunit. | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 NCT (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE × 2 Y01 CHOLESTEROL HEMISUCCINATE × 10 NA SODIUM ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；4 second blot time
|
Resolution 3.70 Å |
| 6CNK Structure of the 3alpha2beta stiochiometry of the human Alpha4Beta2 nicotinic receptor Deposited 2018-03-08 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain C
26–353（328 aa）
Chain C
446–502（57 aa）
Chain E
26–353（328 aa）
Chain E
446–502（57 aa）
|
Mutation：;Glu-Arg linker was inserted in the MX-M4 junction between Gln420-Ser421 in the beta 2 subunit.,Glu-Arg linker was inserted in the MX-M4 junction between Gln420-Ser421 in the beta 2 subunit. ; Mutation：;Glu-Arg linker was inserted in the MX-M4 junction between Gln420-Ser421 in the beta 2 subunit.,Glu-Arg linker was inserted in the MX-M4 junction between Gln420-Ser421 in the beta 2 subunit. ; Mutation：;Glu-Arg linker was inserted in the MX-M4 junction between Gln420-Ser421 in the beta 2 subunit.,Glu-Arg linker was inserted in the MX-M4 junction between Gln420-Ser421 in the beta 2 subunit. ; Mutation：;Glu-Arg linker was inserted in the MX-M4 junction between Gln420-Ser421 in the beta 2 subunit.,Glu-Arg linker was inserted in the MX-M4 junction between Gln420-Ser421 in the beta 2 subunit. ; | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 Y01 CHOLESTEROL HEMISUCCINATE × 10 NA SODIUM ION × 1 NCT (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE × 3 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；4 second blot time
|
Resolution 3.90 Å |
| 6UR8 CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline Deposited 2019-10-22 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
26–351（326 aa）
Chain B
442–502（61 aa）
Chain C
26–351（326 aa）
Chain C
442–502（61 aa）
Chain E
26–351（326 aa）
Chain E
442–502（61 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 QMR VARENICLINE × 2 BMA beta-D-mannopyranose × 3 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.71 Å |
| 6USF CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor with varenicline in complex with anti-BRIL synthetic antibody BAK5 Deposited 2019-10-26 | Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
26–351（326 aa）
Chain B
442–502（61 aa）
Chain C
26–351（326 aa）
Chain C
442–502（61 aa）
Chain E
26–351（326 aa）
Chain E
442–502（61 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 QMR VARENICLINE × 2 BMA beta-D-mannopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.87 Å |
| 8SSZ The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium Deposited 2023-05-09 | Assembly 1 Other combination Heteromer；Protein × 11 PDB declaration: undecameric（11） Consistent with protein count |
Chain B
26–502（477 aa）
Chain C
26–502（477 aa）
Chain E
26–502（477 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ACH ACETYLCHOLINE × 2 CA CALCIUM ION × 2 NA SODIUM ION × 1 OCT N-OCTANE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.64 Å |
| 8ST0 The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine Deposited 2023-05-09 | Assembly 1 Other combination Heteromer；Protein × 11 PDB declaration: undecameric（11） Consistent with protein count |
Chain B
26–502（477 aa）
Chain C
26–502（477 aa）
Chain E
26–502（477 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ACH ACETYLCHOLINE × 2 OCT N-OCTANE × 1 NA SODIUM ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.40 Å |
| 8ST1 The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium Deposited 2023-05-09 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain C
26–355（330 aa）
Fragment：UNP residues 26-355,442-502
Chain C
442–502（61 aa）
Fragment：UNP residues 26-355,442-502
Chain E
26–355（330 aa）
Fragment：UNP residues 26-355,442-502
Chain E
442–502（61 aa）
Fragment：UNP residues 26-355,442-502
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ACH ACETYLCHOLINE × 3 CA CALCIUM ION × 4 NA SODIUM ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.41 Å |
| 8ST2 The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine Deposited 2023-05-09 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain C
26–355（330 aa）
Fragment：UNP residues 26-355,442-502
Chain C
442–502（61 aa）
Fragment：UNP residues 26-355,442-502
Chain E
26–355（330 aa）
Fragment：UNP residues 26-355,442-502
Chain E
442–502（61 aa）
Fragment：UNP residues 26-355,442-502
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 ACH ACETYLCHOLINE × 3 NA SODIUM ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.94 Å |
| 8ST3 The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium Deposited 2023-05-09 | Assembly 1 Other combination Heteromer；Protein × 11 PDB declaration: undecameric（11） Consistent with protein count |
Chain B
26–355（330 aa）
Fragment：UNP residues 26-355,442-502
Chain B
442–502（61 aa）
Fragment：UNP residues 26-355,442-502
Chain C
26–355（330 aa）
Fragment：UNP residues 26-355,442-502
Chain C
442–502（61 aa）
Fragment：UNP residues 26-355,442-502
Chain E
26–355（330 aa）
Fragment：UNP residues 26-355,442-502
Chain E
442–502（61 aa）
Fragment：UNP residues 26-355,442-502
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ACH ACETYLCHOLINE × 2 CA CALCIUM ION × 3 NA SODIUM ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.93 Å |
| 8ST4 The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine Deposited 2023-05-09 | Assembly 1 Other combination Heteromer；Protein × 11 PDB declaration: undecameric（11） Consistent with protein count |
Chain B
26–355（330 aa）
Fragment：UNP residues 26-355,442-502
Chain B
442–502（61 aa）
Fragment：UNP residues 26-355,442-502
Chain C
26–355（330 aa）
Fragment：UNP residues 26-355,442-502
Chain C
442–502（61 aa）
Fragment：UNP residues 26-355,442-502
Chain E
26–355（330 aa）
Fragment：UNP residues 26-355,442-502
Chain E
442–502（61 aa）
Fragment：UNP residues 26-355,442-502
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ACH ACETYLCHOLINE × 2 NA SODIUM ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.35 Å |