当前蛋白身份：P19120
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差异标签只比较当前检索结果；所有PDB和assembly原始记录仍分别保留。
相关结构差异明细
一行代表一个 PDB 条目中的一个 biological assembly；同一蛋白的多个单体会分别列出。
| PDB 条目 | Assembly / 聚集状态 | 构建体 | 突变与修饰 | 配体、离子与非聚合物 | 实验方法 | 实验环境 | 结构质量 |
|---|---|---|---|---|---|---|---|
| 1ATR THREONINE 204 OF THE CHAPERONE PROTEIN HSC70 INFLUENCES THE STRUCTURE OF THE ACTIVE SITE BUT IS NOT ESSENTIAL FOR ATP HYDROLYSIS 提交 1993-08-09 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–386（386 aa）
|
未记录 | MG MAGNESIUM ION × 1 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 2.34 Å |
| 1ATS THREONINE 204 OF THE CHAPERONE PROTEIN HSC70 INFLUENCES THE STRUCTURE OF THE ACTIVE SITE BUT IS NOT ESSENTIAL FOR ATP HYDROLYSIS 提交 1993-08-09 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–386（386 aa）
|
未记录 | MG MAGNESIUM ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 2.43 Å |
| 1BA0 HEAT-SHOCK COGNATE 70KD PROTEIN 44KD ATPASE N-TERMINAL 1NGE 3 提交 1998-04-21 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–386（386 aa）
片段：44KD ATPASE N-TERMINAL FRAGMENT
|
突变：D206K | MG MAGNESIUM ION × 1 PO4 PHOSPHATE ION × 1 NA SODIUM ION × 1 CL CHLORIDE ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 9；20% PEG-8000 1.0M NACL 50MM CHES, PH 9 1MM MGATP, pH 9.0
|
分辨率 1.90 Å R-free 0.275 |
| 1BA1 HEAT-SHOCK COGNATE 70KD PROTEIN 44KD ATPASE N-TERMINAL MUTANT WITH CYS 17 REPLACED BY LYS 提交 1998-04-21 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–386（386 aa）
片段：44KD ATPASE N-TERMINAL FRAGMENT
|
突变：C17K | MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CL CHLORIDE ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 9；20% PEG-8000 1.0M NACL 50MM CHES, PH 9 1MM MGATP, pH 9.0
|
分辨率 1.70 Å R-free 0.244 |
| 1BUP T13S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN 提交 1998-09-03 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–386（386 aa）
片段：ATPASE FRAGMENT
|
突变：T13S | MG MAGNESIUM ION × 1 K POTASSIUM ION × 2 CL CHLORIDE ION × 2 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 9；pH 9.0
|
分辨率 1.70 Å R-free 0.220 |
| 1HPM HOW POTASSIUM AFFECTS THE ACTIVITY OF THE MOLECULAR CHAPERONE HSC70. II. POTASSIUM BINDS SPECIFICALLY IN THE ATPASE ACTIVE SITE 提交 1995-03-24 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–386（386 aa）
|
未记录 | MG MAGNESIUM ION × 1 PO4 PHOSPHATE ION × 1 K POTASSIUM ION × 2 CL CHLORIDE ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 1.70 Å |
| 1HX1 CRYSTAL STRUCTURE OF A BAG DOMAIN IN COMPLEX WITH THE HSC70 ATPASE DOMAIN 提交 2001-01-11 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
4–381（378 aa）
片段：ATPASE DOMAIN
|
未记录 | TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；PEG3350, Tris, Na-K-tartrate, glycerol, DTT, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
分辨率 1.90 Å R-free 0.279 |
| 1KAX 70KD HEAT SHOCK COGNATE PROTEIN ATPASE DOMAIN, K71M MUTANT 提交 1996-04-15 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–381（381 aa）
片段：ATPASE DOMAIN
|
突变：K71M | CL CHLORIDE ION × 2 MG MAGNESIUM ION × 1 K POTASSIUM ION × 3 ATP ADENOSINE-5'-TRIPHOSPHATE × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 1.70 Å R-free 0.264 |
| 1KAY 70KD HEAT SHOCK COGNATE PROTEIN ATPASE DOMAIN, K71A MUTANT 提交 1996-04-15 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–381（381 aa）
片段：ATPASE DOMAIN
|
突变：K71A | MG MAGNESIUM ION × 1 CL CHLORIDE ION × 2 K POTASSIUM ION × 3 ATP ADENOSINE-5'-TRIPHOSPHATE × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 1.70 Å R-free 0.243 |
| 1KAZ 70KD HEAT SHOCK COGNATE PROTEIN ATPASE DOMAIN, K71E MUTANT 提交 1996-04-15 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–381（381 aa）
片段：ATPASE DOMAIN
|
突变：K71E | MG MAGNESIUM ION × 1 K POTASSIUM ION × 3 CL CHLORIDE ION × 2 ATP ADENOSINE-5'-TRIPHOSPHATE × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 1.70 Å R-free 0.234 |
| 1NGA STRUCTURAL BASIS OF THE 70-KILODALTON HEAT SHOCK COGNATE PROTEIN ATP HYDROLYTIC ACTIVITY, II. STRUCTURE OF THE ACTIVE SITE WITH ADP OR ATP BOUND TO WILD TYPE AND MUTANT ATPASE FRAGMENT 提交 1994-05-17 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–386（386 aa）
|
未记录 | MG MAGNESIUM ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 2.18 Å |
| 1NGB STRUCTURAL BASIS OF THE 70-KILODALTON HEAT SHOCK COGNATE PROTEIN ATP HYDROLYTIC ACTIVITY, II. STRUCTURE OF THE ACTIVE SITE WITH ADP OR ATP BOUND TO WILD TYPE AND MUTANT ATPASE FRAGMENT 提交 1994-05-17 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–386（386 aa）
|
未记录 | MG MAGNESIUM ION × 1 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 2.18 Å |
| 1NGC STRUCTURAL BASIS OF THE 70-KILODALTON HEAT SHOCK COGNATE PROTEIN ATP HYDROLYTIC ACTIVITY, II. STRUCTURE OF THE ACTIVE SITE WITH ADP OR ATP BOUND TO WILD TYPE AND MUTANT ATPASE FRAGMENT 提交 1994-05-17 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–386（386 aa）
|
未记录 | MG MAGNESIUM ION × 1 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 2.20 Å |
| 1NGD STRUCTURAL BASIS OF THE 70-KILODALTON HEAT SHOCK COGNATE PROTEIN ATP HYDROLYTIC ACTIVITY, II. STRUCTURE OF THE ACTIVE SITE WITH ADP OR ATP BOUND TO WILD TYPE AND MUTANT ATPASE FRAGMENT 提交 1994-05-17 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–386（386 aa）
|
未记录 | MG MAGNESIUM ION × 1 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 2.18 Å |
| 1NGE STRUCTURAL BASIS OF THE 70-KILODALTON HEAT SHOCK COGNATE PROTEIN ATP HYDROLYTIC ACTIVITY, II. STRUCTURE OF THE ACTIVE SITE WITH ADP OR ATP BOUND TO WILD TYPE AND MUTANT ATPASE FRAGMENT 提交 1994-05-17 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–386（386 aa）
|
未记录 | ATP ADENOSINE-5'-TRIPHOSPHATE × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 2.05 Å |
| 1NGF STRUCTURAL BASIS OF THE 70-KILODALTON HEAT SHOCK COGNATE PROTEIN ATP HYDROLYTIC ACTIVITY, II. STRUCTURE OF THE ACTIVE SITE WITH ADP OR ATP BOUND TO WILD TYPE AND MUTANT ATPASE FRAGMENT 提交 1994-05-17 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–386（386 aa）
|
未记录 | ATP ADENOSINE-5'-TRIPHOSPHATE × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 2.17 Å |
| 1NGG STRUCTURAL BASIS OF THE 70-KILODALTON HEAT SHOCK COGNATE PROTEIN ATP HYDROLYTIC ACTIVITY, II. STRUCTURE OF THE ACTIVE SITE WITH ADP OR ATP BOUND TO WILD TYPE AND MUTANT ATPASE FRAGMENT 提交 1994-05-17 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–386（386 aa）
|
未记录 | MG MAGNESIUM ION × 1 ATP ADENOSINE-5'-TRIPHOSPHATE × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 2.19 Å |
| 1NGH STRUCTURAL BASIS OF THE 70-KILODALTON HEAT SHOCK COGNATE PROTEIN ATP HYDROLYTIC ACTIVITY, II. STRUCTURE OF THE ACTIVE SITE WITH ADP OR ATP BOUND TO WILD TYPE AND MUTANT ATPASE FRAGMENT 提交 1994-05-17 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–386（386 aa）
|
未记录 | ATP ADENOSINE-5'-TRIPHOSPHATE × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 2.23 Å |
| 1NGI STRUCTURAL BASIS OF THE 70-KILODALTON HEAT SHOCK COGNATE PROTEIN ATP HYDROLYTIC ACTIVITY, II. STRUCTURE OF THE ACTIVE SITE WITH ADP OR ATP BOUND TO WILD TYPE AND MUTANT ATPASE FRAGMENT 提交 1994-05-17 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–386（386 aa）
|
未记录 | CA CALCIUM ION × 1 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 2.15 Å |
| 1NGJ STRUCTURAL BASIS OF THE 70-KILODALTON HEAT SHOCK COGNATE PROTEIN ATP HYDROLYTIC ACTIVITY, II. STRUCTURE OF THE ACTIVE SITE WITH ADP OR ATP BOUND TO WILD TYPE AND MUTANT ATPASE FRAGMENT 提交 1994-05-17 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–386（386 aa）
|
未记录 | MG MAGNESIUM ION × 1 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 2.10 Å |
| 1QQM D199S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN 提交 1999-06-07 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
4–381（378 aa）
片段：HSC70 ATPASE FRAGMENT
|
突变：D199S | MG MAGNESIUM ION × 1 K POTASSIUM ION × 1 CL CHLORIDE ION × 2 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 9；277 K；POLYETHYLENE GLYCOL 8000, POTASSIUM CHLORIDE, pH 9, VAPOR DIFFUSION, HANGING DROP, temperature 4K
|
分辨率 1.90 Å R-free 0.234 |
| 1QQN D206S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN 提交 1999-06-07 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
4–381（378 aa）
片段：HSC70 ATPASE FRAGMENT
|
突变：D206S | K POTASSIUM ION × 2 CL CHLORIDE ION × 2 MG MAGNESIUM ION × 1 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 9；277 K；POLYETHYLENE GLYCOL 8000, POTASSIUM CHLORIDE, pH 9, VAPOR DIFFUSION, HANGING DROP, temperature 4K
|
分辨率 1.90 Å R-free 0.229 |
| 1QQO E175S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN 提交 1999-06-07 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
4–381（378 aa）
|
突变：E175S | MG MAGNESIUM ION × 1 CL CHLORIDE ION × 2 K POTASSIUM ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 9；277 K；POLYETHYLENE GLYCOL 8000, POTASSIUM CHLORIDE, pH 9, VAPOR DIFFUSION, HANGING DROP, temperature 4K
|
分辨率 1.90 Å R-free 0.239 |
| 1YUW crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant 提交 2005-02-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–554（554 aa）
|
突变：E213A, D214A | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
MICROBATCH；pH 8；289 K；PEG8000,trimethyl amine oxide, pH 8.0, microbatch, temperature 289K
|
分辨率 2.60 Å R-free 0.297 |
| 2BUP T13G Mutant of the ATPASE fragment of Bovine HSC70 提交 1998-09-08 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–381（381 aa）
片段：ATPASE
|
突变：T13G | PO4 PHOSPHATE ION × 1 MG MAGNESIUM ION × 1 K POTASSIUM ION × 2 CL CHLORIDE ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ATP ADENOSINE-5'-TRIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 9；pH 9.0
|
分辨率 1.70 Å R-free 0.224 |
| 2QW9 Crystal structure of bovine hsc70 (1-394aa)in the apo state 提交 2007-08-10 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–394（394 aa）
|
未记录 | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
microbatch under oil；pH 8；289 K；PEG3350, Calcium Acetate, pH 8.0, microbatch under oil, temperature 289K
|
分辨率 1.85 Å R-free 0.236 |
| 2QW9 Crystal structure of bovine hsc70 (1-394aa)in the apo state 提交 2007-08-10 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–394（394 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
microbatch under oil；pH 8；289 K；PEG3350, Calcium Acetate, pH 8.0, microbatch under oil, temperature 289K
|
分辨率 1.85 Å R-free 0.236 |
| 2QWL Crystal structure of bovine hsc70 (1-394aa)in the ADP state 提交 2007-08-10 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–394（394 aa）
|
未记录 | MG MAGNESIUM ION × 1 NA SODIUM ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
microbatch under oil；pH 8；289 K；PEG3350, Calcium Acetate, pH 8.0, microbatch under oil, temperature 289K
|
分辨率 1.75 Å R-free 0.209 |
| 2QWL Crystal structure of bovine hsc70 (1-394aa)in the ADP state 提交 2007-08-10 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–394（394 aa）
|
未记录 | MG MAGNESIUM ION × 1 NA SODIUM ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
microbatch under oil；pH 8；289 K；PEG3350, Calcium Acetate, pH 8.0, microbatch under oil, temperature 289K
|
分辨率 1.75 Å R-free 0.209 |
| 2QWM Crystal structure of bovine hsc70 (1-394aa)in the ADP*Vi state 提交 2007-08-10 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–394（394 aa）
|
未记录 | MG MAGNESIUM ION × 1 NA SODIUM ION × 2 VO4 VANADATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
microbatch under oil；pH 8；289 K；PEG3350, Calcium Acetate, pH 8.0, microbatch under oil, temperature 289K
|
分辨率 1.86 Å R-free 0.224 |
| 2QWM Crystal structure of bovine hsc70 (1-394aa)in the ADP*Vi state 提交 2007-08-10 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–394（394 aa）
|
未记录 | MG MAGNESIUM ION × 1 NA SODIUM ION × 2 VO4 VANADATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
microbatch under oil；pH 8；289 K；PEG3350, Calcium Acetate, pH 8.0, microbatch under oil, temperature 289K
|
分辨率 1.86 Å R-free 0.224 |
| 2QWN Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-386aa)R171C and bovine Auxilin (810-910aa)D876C in the ADP*Pi state 提交 2007-08-10 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–394（394 aa）
|
突变：R171C | PO4 PHOSPHATE ION × 1 NA SODIUM ION × 2 MG MAGNESIUM ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
microbatch under oil；pH 8；289 K；PEG3350, Ammonium Acetate, pH 8.0, microbatch under oil, temperature 289K
|
分辨率 2.40 Å R-free 0.279 |
| 2QWO Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-394aa)R171C and bovine Auxilin (810-910aa)D876C in the ADP*Pi form #1 提交 2007-08-10 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–394（394 aa）
|
突变：R171C | PO4 PHOSPHATE ION × 1 NA SODIUM ION × 2 MG MAGNESIUM ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ACY ACETIC ACID × 1 GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
microbatch under oil；pH 8.5；289 K；PEG3350, Ammonium Acetate, pH 8.5, microbatch under oil, temperature 289K
|
分辨率 1.70 Å R-free 0.222 |
| 2QWP Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-394aa)R171C and bovine Auxilin (810-910aa)D876C in the ADP*Pi form #2 提交 2007-08-10 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–394（394 aa）
|
突变：R171C | PO4 PHOSPHATE ION × 1 NA SODIUM ION × 2 MG MAGNESIUM ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ACY ACETIC ACID × 1 GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
microbatch under oil；pH 8.5；289 K；PEG3350, Ammonium Acetate, pH 8.5, microbatch under oil, temperature 289K
|
分辨率 1.75 Å R-free 0.243 |
| 2QWQ Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-394aa)R171C and bovine Auxilin (810-910aa)D876C in the AMPPNP hydrolyzed form 提交 2007-08-10 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–394（394 aa）
|
突变：R171C | PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ACY ACETIC ACID × 1 GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
microbatch under oil；pH 8.5；289 K；PEG3350, Ammonium Acetate, pH 8.5, microbatch under oil, temperature 289K
|
分辨率 2.21 Å R-free 0.295 |
| 2QWR Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-394aa)R171C and bovine Auxilin (810-910aa)D876C in the AMPPNP intact form 提交 2007-08-10 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–394（394 aa）
|
突变：R171C | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 ACY ACETIC ACID × 1 GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
microbatch under oil；pH 8.5；289 K；PEG3350, Ammonium Acetate, pH 8.5, microbatch under oil, temperature 289K
|
分辨率 2.21 Å R-free 0.294 |
| 3C7N Structure of the Hsp110:Hsc70 Nucleotide Exchange Complex 提交 2008-02-07 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
1–554（554 aa）
片段：residues 1-554
|
未记录 | MG MAGNESIUM ION × 2 SO4 SULFATE ION × 4 BEF BERYLLIUM TRIFLUORIDE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 CL CHLORIDE ION × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；LiSO4, PEG 400, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
分辨率 3.12 Å R-free 0.283 |
| 3HSC THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN 提交 1995-03-24 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–386（386 aa）
|
未记录 | MG MAGNESIUM ION × 1 PO4 PHOSPHATE ION × 1 NA SODIUM ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION | mmCIF 未提供已读取条件 | 分辨率 1.93 Å |
| 4FL9 Crystal Structure of bovine hsc70(aa1-554)E213A/D214A at 1.9A Resolution 提交 2012-06-14 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–554（554 aa）
片段：UNP residues 1-554
|
突变：E213A, D214A | TMO trimethylamine oxide × 2 DTT 2,3-DIHYDROXY-1,4-DITHIOBUTANE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
MICROBATCH；pH 7.5；291 K；PEG8000,TRIMETHYL AMINE OXIDE , pH 7.5, Microbatch, temperature 291K
|
分辨率 1.90 Å R-free 0.232 |
| 6H54 CRYSTAL STRUCTURE OF BOVINE HSC70(AA1-554)E213A/D214A IN COMPLEX WITH INHIBITOR VER155008 提交 2018-07-23 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–554（554 aa）
|
未记录 | TMO trimethylamine oxide × 1 3FD 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
BATCH MODE；291 K；PEG 4000, TMAO, Glycerol
|
分辨率 2.02 Å R-free 0.258 |
| 7O6R Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with 1H-Indazole 提交 2021-04-12 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–554（554 aa）
|
突变：E213A, D214A | EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 LZ1 1H-indazole × 1 DMS DIMETHYL SULFOXIDE × 1 GOL GLYCEROL × 1 K POTASSIUM ION × 2 TMO trimethylamine oxide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
MICROBATCH；pH 7.5；291 K；PEG 8000, TMAO, potassium chloride, HEPES-NaOH, glycerol
|
分辨率 2.00 Å R-free 0.244 |
| 7ODB Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with triazine-derivative 提交 2021-04-29 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–554（554 aa）
|
突变：E213A, D214A | EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 K POTASSIUM ION × 2 GOL GLYCEROL × 3 V8Q 6-methyl-5-sulfanylidene-2H-1,2,4-triazin-3-one × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
MICROBATCH；pH 7.5；291 K；PEG 8000, TMAO. potassium chloride, HEPES-NaOH, glycerol
|
分辨率 1.66 Å R-free 0.208 |
| 7ODD Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with tricine 提交 2021-04-29 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–554（554 aa）
|
突变：E213A, D214A | GOL GLYCEROL × 3 VLS N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]glycine × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 K POTASSIUM ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
MICROBATCH；pH 7.5；291 K；PEG 8000, TMAO, HEPES-NaOH, glycerol
|
分辨率 1.98 Å R-free 0.245 |
| 7ODI Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with methanesulfonamide 提交 2021-04-29 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–554（554 aa）
|
突变：E213A, D214A | EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 V7Z methanesulfonamide × 2 GOL GLYCEROL × 2 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
MICROBATCH；pH 7.5；291 K；PEG 8000, TMAO, HEPES-NaOH, glycerol
|
分辨率 1.83 Å R-free 0.245 |
| 7PLK Crystal structure bovine Hsc70(aa1-554)E213A/D214A in complex with nicotinic-acid-derivative 提交 2021-08-31 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–554（554 aa）
|
突变：E213A, D214A | 7UE 5-pyrrol-1-ylpyridine-3-carboxylic acid × 1 K POTASSIUM ION × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
MICROBATCH；pH 7.5；291 K；PEG 8000, TMAO, potassium chloride, HEPES-NaOH, glycerol
|
分辨率 2.49 Å R-free 0.286 |