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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P20366 New Search
9PDB entries
9Biological assembly
9chain/assembly records
Main Difference Dimensions in This Set
Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2KS9 Solution conformation of substance P in water complexed with NK1R Deposited 2009-12-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 58–68（11 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 5.5；298 K；Ionic strength (raw mmCIF value) minimum；Pressure ambient
NMR sample composition 3.7 mM Substance P-1, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
2KSA Substance P in DMPC/CHAPS isotropic q=0.25 bicelles as a ligand for NK1R Deposited 2009-12-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 58–68（11 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 5.5；298 K；Ionic strength (raw mmCIF value) minimum；Pressure ambient
NMR sample composition 3.7 mM Substance P-1, 18.5 mM DMPC-2, 74.0 mM CHAPS-3, unapplicable mM H2O-4, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
2KSB Substance P in isotropic q=0.25 DMPC/CHAPS/GM1 bicelles as a ligand for NK1R Deposited 2009-12-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 58–68（11 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 5.5；298 K；Ionic strength (raw mmCIF value) minimum；Pressure ambient
NMR sample composition 3.92 mM Substance P-1, 18.5 mM DMPC-2, 74.0 mM CHAPS-3, 5.55 mM GM1-4, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
7P02 Human Neurokinin 1 receptor (NK1R) substance P Gs complex Deposited 2021-06-29 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain P 58–68（11 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CLR CHOLESTEROL × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.87 Å
7RMG Substance P bound to active human neurokinin 1 receptor in complex with miniGs/q70 Deposited 2021-07-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain S 58–68（11 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
7RMH Substance P bound to active human neurokinin 1 receptor in complex with miniGs399 Deposited 2021-07-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain S 58–68（11 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
7VDM Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with substance P Deposited 2021-09-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain L 58–68（11 aa）
Not recorded CLR CHOLESTEROL × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.98 Å
8JBH Substance P bound to active human neurokinin 3 receptor in complex with Gq Deposited 2023-05-08 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 58–68（11 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 2.90 Å
8U26 Gaussian Mixture Models based single particle refinement - GPCR (Substance P bound to active human neurokinin 1 receptor in complex with miniGs399 from EMPIAR-10786) Deposited 2023-09-05 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain S 58–68（11 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.50 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.